Dopaminergic modulation of performance monitoring in Parkinson's disease: An event-related potential study.

Abstract:

:Monitoring one's actions is essential for goal-directed performance. In the event-related potential (ERP), errors are followed by fronto-centrally distributed negativities. These error(-related) negativity (Ne/ERN) amplitudes are often found to be attenuated in patients with Parkinson's disease (PD) compared to healthy controls (HC). Although Ne/ERN has been proposed to be related to dopaminergic neuronal activity, previous research did not find evidence for effects of dopaminergic medication on Ne/ERN amplitudes in PD. We examined 13 PD patients "on" and "off" dopaminergic medication. Their response-locked ERP amplitudes (obtained on correct [Nc/CRN] and error [Ne/ERN] trials of a flanker task) were compared to those of 13 HC who were tested twice as well, without receiving dopaminergic medication. While PD patients committed more errors than HC, error rates were not significantly modulated by dopaminergic medication. PD patients showed reduced Ne/ERN amplitudes relative to HC; however, this attenuation of response-locked ERP amplitudes was not specific to errors in this study. PD-related attenuation of response-locked ERP amplitudes was most pronounced when PD patients were on medication. These results suggest overdosing of dopaminergic pathways that are relatively spared in PD, but that are related to the generation of the Ne/ERN, notably pathways targeted on the medial prefrontal cortex.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Seer C,Lange F,Loens S,Wegner F,Schrader C,Dressler D,Dengler R,Kopp B

doi

10.1038/srep41222

subject

Has Abstract

pub_date

2017-01-24 00:00:00

pages

41222

issn

2045-2322

pii

srep41222

journal_volume

7

pub_type

杂志文章
  • Rate-dependent interface capture beyond the coffee-ring effect.

    abstract::The mechanism of droplet drying is a widely concerned fundamental issue since controlling the deposition morphology of droplet has significant influence on printing, biology pattern, self-assembling and other solution-based devices fabrication. Here we reveal a striking different kinetics-controlled deposition regime ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep24628

    authors: Li Y,Yang Q,Li M,Song Y

    更新日期:2016-04-19 00:00:00

  • Synthesis and Characterization of Zirconium Nitride Nanopowders by Internal Gelation and Carbothermic Nitridation.

    abstract::Zirconium compounds has been widely attention over the last decades due to its excellent physical and chemical properties. Zirconium nitride nanopowders were synthesized via a simple direct carbothermic nitridation process of internal gel derived zirconia in the presence of nano-sized carbon black. The effects of reac...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55450-x

    authors: Zhao S,Ma J,Xu R,Lin X,Cheng X,Hao S,Zhao X,Deng C,Liu B

    更新日期:2019-12-16 00:00:00

  • Differential responses of gut microbiota to the same prebiotic formula in oligotrophic and eutrophic batch fermentation systems.

    abstract::The same prebiotics have produced inconsistent effects on microbiota when evaluated in different batch fermentation studies. To understand the reasons behind these discrepancies, we compared impact of one prebiotic formula on the same inoculated fecal microbiota in two frequently used batch systems: phosphate-buffered...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13469

    authors: Long W,Xue Z,Zhang Q,Feng Z,Bridgewater L,Wang L,Zhao L,Pang X

    更新日期:2015-08-25 00:00:00

  • Architecture and subunit arrangement of the complete Saccharomyces cerevisiae COMPASS complex.

    abstract::Methylation of histone H3 lysine 4 (H3K4) is catalyzed by the multi-component COMPASS or COMPASS-like complex, which is highly conserved from yeast to human, and plays essential roles in gene expression and transcription, cell cycle progression, and DNA repair. Here we present a cryo-EM map of the complete S. cerevisi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35609-8

    authors: Wang Y,Ding Z,Liu X,Bao Y,Huang M,Wong CCL,Hong X,Cong Y

    更新日期:2018-11-27 00:00:00

  • Independent and combined effects of dietary iron composition and selected risk factors on the risk of NAFLD in a Chinese population.

    abstract::Iron is an essential mineral required for most forms of life. However, very little is known in relation to the different forms of dietary iron on the development of NAFLD. The aims of this study were to investigate the effects of iron intake from different food types on risk of NAFLD and whether this effect may be mod...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40449-1

    authors: Peng XE,Xu SH,Liu W,Hu Z,Lin Z,Lin X

    更新日期:2019-03-11 00:00:00

  • Acoustic levitation with optimized reflective metamaterials.

    abstract::The simplest and most commonly used acoustic levitator is comprised of a transmitter and an opposing reflecting surface. This type of device, however, is only able to levitate objects along one direction, at distances multiple of half of a wavelength. In this work, we show how a customised reflective acoustic metamate...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-60978-4

    authors: Polychronopoulos S,Memoli G

    更新日期:2020-03-06 00:00:00

  • Development of Alendronate-conjugated Poly (lactic-co-glycolic acid)-Dextran Nanoparticles for Active Targeting of Cisplatin in Osteosarcoma.

    abstract::In this study, we developed a novel poly (lactic-co-glycolic acid)-dextran (PLD)-based nanodelivery system to enhance the anticancer potential of cisplatin (CDDP) in osteosarcoma cells. A nanosized CDDP-loaded PLGA-DX nanoparticle (PLD/CDDP) controlled the release rate of CDDP up to 48 h. In vitro cytotoxicity assay s...

    journal_title:Scientific reports

    pub_type: 杂志文章,收录出版

    doi:10.1038/srep17387

    authors: Liu P,Sun L,Zhou DS,Zhang P,Wang YH,Li D,Li QH,Feng RJ

    更新日期:2015-12-01 00:00:00

  • A low pKa ligand inhibits cancer-associated pain in mice by activating peripheral mu-opioid receptors.

    abstract::The newly designed fentanyl derivative [( ±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide] (NFEPP) was recently shown to produce analgesia selectively via peripheral mu-opioid receptors (MOR) at acidic pH in rat inflamed tissues. Here, we examined the pH-dependency of NFEPP binding to brain MOR and it...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75509-4

    authors: Baamonde A,Menéndez L,González-Rodríguez S,Lastra A,Seitz V,Stein C,Machelska H

    更新日期:2020-10-29 00:00:00

  • Prediction of Mortality and Postoperative Complications using the Hip-Multidimensional Frailty Score in Elderly Patients with Hip Fracture.

    abstract::High mortality and dependent living after hip fracture pose a significant public health concern. Retrospective study was conducted with 481 hip fracture patients (≥65 years of age) undergoing surgery from March 2009 to May 2014. The Hip-MFS was calculated by Comprehensive Geriatric Assessment (CGA). The primary outcom...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep42966

    authors: Choi JY,Cho KJ,Kim SW,Yoon SJ,Kang MG,Kim KI,Lee YK,Koo KH,Kim CH

    更新日期:2017-02-24 00:00:00

  • Quantum speedup, non-Markovianity and formation of bound state.

    abstract::In this paper, we investigate the relationship between the quantum speedup, non-Markovianity and formation of a system-environment bound state. Previous results show a monotonic relation between these three such that providing bound states with more negative energy can lead to a higher degree of non-Markovianity, and ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51290-x

    authors: Ahansaz B,Ektesabi A

    更新日期:2019-10-18 00:00:00

  • The Identification of a 1916 Irish Rebel: New Approach for Estimating Relatedness From Low Coverage Homozygous Genomes.

    abstract::Thomas Kent was an Irish rebel who was executed by British forces in the aftermath of the Easter Rising armed insurrection of 1916 and buried in a shallow grave on Cork prison's grounds. In 2015, ninety-nine years after his death, a state funeral was offered to his living family to honor his role in the struggle for I...

    journal_title:Scientific reports

    pub_type: 历史文章,杂志文章

    doi:10.1038/srep41529

    authors: Fernandes D,Sirak K,Novak M,Finarelli JA,Byrne J,Connolly E,Carlsson JE,Ferretti E,Pinhasi R,Carlsson J

    更新日期:2017-01-30 00:00:00

  • Collagen morphology and texture analysis: from statistics to classification.

    abstract::In this study we present an image analysis methodology capable of quantifying morphological changes in tissue collagen fibril organization caused by pathological conditions. Texture analysis based on first-order statistics (FOS) and second-order statistics such as gray level co-occurrence matrix (GLCM) was explored to...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02190

    authors: Mostaço-Guidolin LB,Ko AC,Wang F,Xiang B,Hewko M,Tian G,Major A,Shiomi M,Sowa MG

    更新日期:2013-01-01 00:00:00

  • Reactive oxygen species scavenging mechanisms associated with polyethylene glycol mediated osmotic stress tolerance in Chinese potato.

    abstract::Influence of polyethylene glycol (PEG) mediated osmotic stress on reactive oxygen species (ROS) scavenging machinery of Chinese potato (Solenostemon rotundifolius (Poir.) J. K. Morton) was investigated. Five genotypes of Chinese potato were raised in Murashige and Skoog (MS) basal medium containing 6-benzylaminopurine...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-62317-z

    authors: Sahoo MR,Devi TR,Dasgupta M,Nongdam P,Prakash N

    更新日期:2020-03-25 00:00:00

  • Time-to-death approach to reveal chronic and cumulative toxicity of a fungicide for honeybees not revealed with the standard ten-day test.

    abstract::Synthetic fungicides are pesticides widely used in agriculture to control phytopathogenic fungi. The systemicity, persistency and intense application of some of these fungicides, such as boscalid, leads to long periods of exposure for honeybees via contaminated water, pollen and nectar. We exposed adult honeybees in t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-24746-9

    authors: Simon-Delso N,San Martin G,Bruneau E,Hautier L

    更新日期:2018-05-08 00:00:00

  • Associations between VDR Gene Polymorphisms and Osteoporosis Risk and Bone Mineral Density in Postmenopausal Women: A systematic review and Meta-Analysis.

    abstract::Results on the relationships between vitamin D receptor (VDR) gene polymorphisms and postmenopausal osteoporosis (PMOP) susceptibility and bone mineral density (BMD) are conflicting. The aim of the study is to identify more eligible studies that calculated pooled OR and WMD with 95% CI to assess their associations. Ov...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析,评审

    doi:10.1038/s41598-017-18670-7

    authors: Zhang L,Yin X,Wang J,Xu D,Wang Y,Yang J,Tao Y,Zhang S,Feng X,Yan C

    更新日期:2018-01-17 00:00:00

  • Discovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1).

    abstract::Disordered proteins are highly prevalent in biological systems, they control myriad signaling and regulatory processes, and their levels and/or cellular localization are often altered in human disease. In contrast to folded proteins, disordered proteins, due to conformational heterogeneity and dynamics, are not consid...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15686

    authors: Iconaru LI,Ban D,Bharatham K,Ramanathan A,Zhang W,Shelat AA,Zuo J,Kriwacki RW

    更新日期:2015-10-28 00:00:00

  • PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4.

    abstract::The promyelocytic leukemia (PML) protein is an essential component of PML nuclear bodies (PML NBs) frequently lost in cancer. PML NBs coordinate chromosomal regions via modification of nuclear proteins that in turn may regulate genes in the vicinity of these bodies. However, few PML NB-associated genes have been ident...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45038

    authors: Salsman J,Stathakis A,Parker E,Chung D,Anthes LE,Koskowich KL,Lahsaee S,Gaston D,Kukurba KR,Smith KS,Chute IC,Léger D,Frost LD,Montgomery SB,Lewis SM,Eskiw C,Dellaire G

    更新日期:2017-03-23 00:00:00

  • Smooth and flat phase-locked Kerr frequency comb generation by higher order mode suppression.

    abstract::High-Q microresonator is perceived as a promising platform for optical frequency comb generation, via dissipative soliton formation. In order to achieve a higher quality factor and obtain the necessary anomalous dispersion, multi-mode waveguides were previously implemented in Si3N4 microresonators. However, coupling b...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26255

    authors: Huang SW,Liu H,Yang J,Yu M,Kwong DL,Wong CW

    更新日期:2016-05-16 00:00:00

  • Fiddler crab bioturbation determines consistent changes in bacterial communities across contrasting environmental conditions.

    abstract::Ecosystem functions are regulated by compositional and functional traits of bacterial communities, shaped by stochastic and deterministic processes. Biogeographical studies have revealed microbial community taxonomy in a given ecosystem to change alongside varying environmental characteristics. Considering that stable...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40315-0

    authors: Booth JM,Fusi M,Marasco R,Mbobo T,Daffonchio D

    更新日期:2019-03-06 00:00:00

  • From cartoon to real time MRI: in vivo monitoring of phagocyte migration in mouse brain.

    abstract::Recent studies have demonstrated that immune cells play an important role in the pathogenesis of many neurological conditions. Immune cells constantly survey the brain microvasculature for irregularities in levels of factors that signal homeostasis. Immune responses are initiated when necessary, resulting in mobilisat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06997

    authors: Mori Y,Chen T,Fujisawa T,Kobashi S,Ohno K,Yoshida S,Tago Y,Komai Y,Hata Y,Yoshioka Y

    更新日期:2014-11-11 00:00:00

  • BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma.

    abstract::Despite advances in therapy, glioblastoma remains an incurable disease with a dismal prognosis. Recent studies have implicated cancer stem cells within glioblastoma (glioma stem cells, GSCs) as mediators of therapeutic resistance and tumor progression. In this study, we investigated the role of the transforming growth...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51270-1

    authors: Sachdeva R,Wu M,Johnson K,Kim H,Celebre A,Shahzad U,Graham MS,Kessler JA,Chuang JH,Karamchandani J,Bredel M,Verhaak R,Das S

    更新日期:2019-10-10 00:00:00

  • Impact of HCV core gene quasispecies on hepatocellular carcinoma risk among HALT-C trial patients.

    abstract::Mutations at positions 70 and/or 91 in the core protein of genotype-1b, hepatitis C virus (HCV) are associated with hepatocellular carcinoma (HCC) risk in Asian patients. To evaluate this in a US population, the relationship between the percentage of 70 and/or 91 mutant HCV quasispecies in baseline serum samples of ch...

    journal_title:Scientific reports

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1038/srep27025

    authors: El-Shamy A,Pendleton M,Eng FJ,Doyle EH,Bashir A,Branch AD

    更新日期:2016-06-01 00:00:00

  • A comparison study of radiation effective dose in ECG-Gated Coronary CT Angiography and calcium scoring examinations performed with a dual-source CT scanner.

    abstract::In this report we have evaluated radiation effective dose received by patients during ECG-gated CCTA examinations based on gender, heart rate, tube voltage protocol and body mass index (BMI). A total of 1,824 patients were retrospectively recruited (1,139 men and 685 women) and they were divided into Group 1 (CCTA wit...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40758-5

    authors: Sabarudin A,Siong TW,Chin AW,Hoong NK,Karim MKA

    更新日期:2019-03-13 00:00:00

  • The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis.

    abstract::Hepatic stellate cells (HSCs) known as "master producers" and macrophages as "master regulators", are the key cell types that strongly contribute to the progression of liver fibrosis. Since Notch signaling regulates multiple cellular processes, we aimed to study the role of Notch signaling in HSCs differentiation and ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18272

    authors: Bansal R,van Baarlen J,Storm G,Prakash J

    更新日期:2015-12-14 00:00:00

  • Identification of candidate aberrantly methylated and differentially expressed genes in Esophageal squamous cell carcinoma.

    abstract::Aberrant methylated genes (DMGs) play an important role in the etiology and pathogenesis of esophageal squamous cell carcinoma (ESCC). In this study, we aimed to integrate three cohorts profile datasets to ascertain aberrant methylated-differentially expressed genes and pathways associated with ESCC by comprehensive b...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66847-4

    authors: Han BA,Yang XP,Hosseini DK,Zhang P,Zhang Y,Yu JT,Chen S,Zhang F,Zhou T,Sun HY

    更新日期:2020-06-16 00:00:00

  • Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene.

    abstract::Among the biologically active triterpenes, friedelin has the most-rearranged structure produced by the oxidosqualene cyclases and is the only one containing a cetonic group. In this study, we cloned and functionally characterized friedelin synthase and one cycloartenol synthase from Maytenus ilicifolia (Celastraceae)....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep36858

    authors: Souza-Moreira TM,Alves TB,Pinheiro KA,Felippe LG,De Lima GM,Watanabe TF,Barbosa CC,Santos VA,Lopes NP,Valentini SR,Guido RV,Furlan M,Zanelli CF

    更新日期:2016-11-22 00:00:00

  • Dynamical Casimir-Polder force on a two-level atom with superposition state in a cavity comprising a dielectric.

    abstract::We study the dynamical Casimir-Polder force on a two-level atom with different initial states in the one-dimensional dielectric cavity with output coupling, and obtain the analytical expression of the expectation value of dynamical Casimir-Polder force. Results show that the expectation values of dynamical Casimir-Pol...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68546-6

    authors: Long Y,Wang W,Zhang X,Yang H,Zheng T

    更新日期:2020-07-20 00:00:00

  • Smoking Gun or Circumstantial Evidence? Comparison of Statistical Learning Methods using Functional Annotations for Prioritizing Risk Variants.

    abstract::Although technology has triumphed in facilitating routine genome sequencing, new challenges have been created for the data-analyst. Genome-scale surveys of human variation generate volumes of data that far exceed capabilities for laboratory characterization. By incorporating functional annotations as predictors, stati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13373

    authors: Gagliano SA,Ravji R,Barnes MR,Weale ME,Knight J

    更新日期:2015-08-24 00:00:00

  • Facile reduction of graphene oxide suspensions and films using glass wafers.

    abstract::This paper reports a facile and green method for conversion of graphene oxide (GO) into graphene by low-temperature heating (80 °C) in the presence of a glass wafer. Compared to conventional GO chemical reduction methods, the presented approach is easy-scalable, operationally simple, and based on the use of a non-toxi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32488-x

    authors: Rabchinskii MK,Dideikin AT,Kirilenko DA,Baidakova MV,Shnitov VV,Roth F,Konyakhin SV,Besedina NA,Pavlov SI,Kuricyn RA,Lebedeva NM,Brunkov PN,Vul' AY

    更新日期:2018-09-20 00:00:00

  • Shared somatosensory and motor functions in musicians.

    abstract::Skilled individuals are characterized by fine-tuned perceptual and motor functions. Here, we tested the idea that the sensory and motor functions of highly-trained individuals are coupled. We assessed the relationships among multifaceted somatosensory and motor functions of expert pianists. The results demonstrated a ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37632

    authors: Hosoda M,Furuya S

    更新日期:2016-11-25 00:00:00