Differential levels of Neurofilament Light protein in cerebrospinal fluid in patients with a wide range of neurodegenerative disorders.

abstract：:In zebrafish, the role of matrix metalloproteinases (MMPs) in the inflammatory phase of heart regeneration following cryoinjury remains poorly understood. Here, we demonstrated an increase in MMP enzymatic activity and elevated expression of mmp9 and mmp13 in the injured area (IA) of hearts from as early as 1 day post...

journal_title：Scientific reports

authors： Xu S,Webb SE,Lau TCK,Cheng SH

更新日期：2018-05-08 00:00:00

abstract：:The attenuated Sabin strains contained in the oral poliomyelitis vaccine are genetically unstable, and their circulation in poorly immunized populations can lead to the emergence of pathogenic circulating vaccine-derived polioviruses (cVDPVs). The recombinant nature of most cVDPV genomes and the preferential presence ...

journal_title：Scientific reports

authors： Bessaud M,Joffret ML,Blondel B,Delpeyroux F

更新日期：2016-12-13 00:00:00

abstract：:A key to the success of chimeric antigen receptor (CAR) T-cell based therapies greatly rely on the capacity to identify and target antigens with expression restrained to tumor cells. Here we present a strategy to generate CAR T-cells that are only effective locally (tumor tissue), potentially also increasing the choic...

journal_title：Scientific reports

authors： Juillerat A,Marechal A,Filhol JM,Valogne Y,Valton J,Duclert A,Duchateau P,Poirot L

更新日期：2017-01-20 00:00:00

abstract：:The controversial anti-proliferative effects of Echinacea purpurea (L.) Moench (Asteraceae) might be related to different plant metabolites contained in plant samples, extracts and products. The influence of bacterial endophytes on the synthesis of bioactive compounds in the medicinal plants has been previously demons...

journal_title：Scientific reports

authors： Maggini V,De Leo M,Granchi C,Tuccinardi T,Mengoni A,Gallo ER,Biffi S,Fani R,Pistelli L,Firenzuoli F,Bogani P

更新日期：2019-07-26 00:00:00

abstract：:A new bicentennial series of the Australian monsoon strength based on historical wind observations has allowed for the assessment of the variability of this system since the early 19th century. Our series covers a period in which the scarcity of meteorological observations in the area had precluded the evaluation of l...

journal_title：Scientific reports

authors： Gallego D,García-Herrera R,Peña-Ortiz C,Ribera P

更新日期：2017-11-23 00:00:00

abstract：:As a universal quantum character of quantum correlation, the freezing phenomenon is researched by geometry and quantum discord methods, respectively. In this paper, the properties of Rènyi discord is studied for two independent Dimer System coupled to two correlated Fermi-spin environments under the non-Markovian cond...

journal_title：Scientific reports

authors： Li XY,Zhu QS,Zhu MZ,Wu H,Wu SY,Zhu MC

更新日期：2019-10-14 00:00:00

abstract：:Tumour-associated macrophages mainly comprise immunosuppressive M2 phenotypes that promote tumour progression besides anti-tumoural M1 subsets. Selective depletion or reprogramming of M2 may represent an innovative anti-cancer strategy. The actin cytoskeleton is central for cellular homeostasis and is targeted for ant...

journal_title：Scientific reports

authors： Pergola C,Schubert K,Pace S,Ziereisen J,Nikels F,Scherer O,Hüttel S,Zahler S,Vollmar AM,Weinigel C,Rummler S,Müller R,Raasch M,Mosig A,Koeberle A,Werz O

更新日期：2017-01-30 00:00:00

abstract：:Calciprotein particles (CPP) are solid-phase calcium-phosphate bound to serum protein fetuin-A and dispersed as colloids in the blood. Recent clinical studies indicated that serum CPP levels were increased with decline of renal function and associated with inflammation and vascular calcification. However, CPP assays u...

journal_title：Scientific reports

authors： Miura Y,Iwazu Y,Shiizaki K,Akimoto T,Kotani K,Kurabayashi M,Kurosu H,Kuro-O M

更新日期：2018-01-19 00:00:00

abstract：:Traditional Protein-Protein Interaction (PPI) networks, which use a node and edge representation, lack some valuable information about the mechanistic details of biological processes. Mapping protein structures to these PPI networks not only provides structural details of each interaction but also helps us to find the...

journal_title：Scientific reports

authors： Halakou F,Kilic ES,Cukuroglu E,Keskin O,Gursoy A

更新日期：2017-08-03 00:00:00

abstract：:Biocontrol offers a promising alternative to synthetic fungicides for the control of a variety of pre- and post-harvest diseases of crops. Black rot, which is caused by the pathogenic fungus Ceratocytis fimbriata, is the most destructive post-harvest disease of sweet potato, but little is currently known about potenti...

journal_title：Scientific reports

authors： Jiang L,Jeong JC,Lee JS,Park JM,Yang JW,Lee MH,Choi SH,Kim CY,Kim DH,Kim SW,Lee J

更新日期：2019-11-08 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Ayaz Ahmed KB,Raman T,Veerappan A

更新日期：2018-03-20 00:00:00

abstract：:Artificial sheet materials, known as MetaSurfaces, have been applied to fully control both space and surface waves due to their exceptional abilities to dynamically tailor wave fronts and polarization states, while maintaining small footprints. However, previous and current designs and manufactured MetaSurfaces are li...

journal_title：Scientific reports

authors： La Spada L,Spooner C,Haq S,Hao Y

更新日期：2019-02-28 00:00:00

abstract：:People with ataxia-telangiectasia (A-T) display phenotypic variability with regard to progression of immunodeficiency, sino-pulmonary disease, and neurologic decline. To determine the association between differential gene expression, epigenetic state, and phenotypic variation among people with A-T, we performed transc...

journal_title：Scientific reports

authors： McGrath-Morrow SA,Ndeh R,Helmin KA,Khuder B,Rothblum-Oviatt C,Collaco JM,Wright J,Reyfman PA,Lederman HM,Singer BD

更新日期：2020-05-04 00:00:00

abstract：:One of the main challenges in quantum technologies is the ability to control individual quantum systems. This task becomes increasingly difficult as the dimension of the system grows. Here we propose a general setup for cyclic permutations Xd in d dimensions, a major primitive for constructing arbitrary qudit gates. U...

journal_title：Scientific reports

authors： Isdrailă TA,Kusko C,Ionicioiu R

更新日期：2019-04-19 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract of uncertain origin, which includes ulcerative colitis (UC) and Crohn's disease (CD). The composition of gut microbiota may change in IBD affected individuals, but whether dysbiosis is the cause or the consequence of infla...

journal_title：Scientific reports

authors： Santoru ML,Piras C,Murgia A,Palmas V,Camboni T,Liggi S,Ibba I,Lai MA,Orrù S,Blois S,Loizedda AL,Griffin JL,Usai P,Caboni P,Atzori L,Manzin A

更新日期：2017-08-25 00:00:00

abstract：:Junction-less nanowire transistors are being investigated to solve short channel effects in future CMOS technology. Here we demonstrate 8 nm diameter silicon nanowire junction-less transistors with metallic doping densities which demonstrate clear 1D electronic transport characteristics. The 1D regime allows excellent...

journal_title：Scientific reports

authors： Mirza MM,Schupp FJ,Mol JA,MacLaren DA,Briggs GAD,Paul DJ

更新日期：2017-06-07 00:00:00

abstract：:Symblepharon due to chemical burns affects ocular surface health, and there are currently no satisfactory treatments. To improve our understanding of symblepharon, an appropriate animal model is urgently needed. We established a rabbit model of superior conjunctival sac alkaline burn to evaluate symblepharon severity....

journal_title：Scientific reports

authors： Kang Y,Li S,Liu C,Liu M,Shi S,Xu M,He J,Zhang T

更新日期：2019-09-25 00:00:00

abstract：:Mass spectrometry (MS) for the detection of proteins is an indispensable tool for evaluating the biological processes of the proteome. Proteomics frequently requires proteolysis of proteins into peptide fragments. Proteins can be refractory to ideal proteolysis at the sequence level rendering them difficult to analyze...

journal_title：Scientific reports

authors： Reyna C,Mba Medie F,Champion MM,Champion PA

更新日期：2016-09-14 00:00:00

abstract：:Three dimensional hierarchical nanostructures have attracted great attention for electrochemical energy storage applications. In this work, self-supported TiO2@Ni(OH)2 core-shell nanowire arrays are prepared on carbon fiber paper via the combination of hydrothermal synthesis and chemical bath deposition. In this core-...

journal_title：Scientific reports

authors： Ke Q,Zheng M,Liu H,Guan C,Mao L,Wang J

更新日期：2015-09-10 00:00:00

abstract：:For the first time, soil core samples from the Jiuquan region have been analyzed for Pu isotopes for radioactive source identification and radiological assessment. The Jiuquan region is in downwind from the Lop Nor Chinese nuclear test (CNT) site. The high Pu inventories (13 to 546 Bq/m(2)) in most of the sampling loc...

journal_title：Scientific reports

authors： Bu W,Ni Y,Guo Q,Zheng J,Uchida S

更新日期：2015-07-17 00:00:00

abstract：:Multiple sclerosis (MS) is a neurodegenerative autoimmune disease, where chronic inflammation plays an essential role in its pathology. A feature of MS is the production of autoantibodies stimulated by an altered-peptide-ligand response and epitope spreading, resulting in loss of tolerance for self-proteins. The invol...

journal_title：Scientific reports

authors： Mørkholt AS,Kastaniegaard K,Trabjerg MS,Gopalasingam G,Niganze W,Larsen A,Stensballe A,Nielsen S,Nieland JD

更新日期：2018-05-04 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) drastically affects the population of Middle East countries with an ever-increasing number of overweight and obese individuals. The precise links between T2DM and gut microbiome composition remain elusive in these populations. Here, we performed 16 S rRNA and ITS2- gene based microbial ...

journal_title：Scientific reports

authors： Al Bataineh MT,Dash NR,Lassen PB,Banimfreg BH,Nada AM,Belda E,Clément K

更新日期：2020-06-15 00:00:00

abstract：:Fibrates, which are widely used lipidaemic-modulating drugs, are emerging environmental pollutants. However, fibrate concentrations in the environment have not been thoroughly surveyed. Here, we determined concentrations of the most commonly used fibrates and their metabolites in source water and drinking water sample...

journal_title：Scientific reports

authors： Ido A,Hiromori Y,Meng L,Usuda H,Nagase H,Yang M,Hu J,Nakanishi T

更新日期：2017-04-12 00:00:00

abstract：:A new species of fossil conifer wood, Podocarpoxylon donghuaiense sp. nov., is described from the late Eocene of Nadu Formation in Baise Basin of the Guangxi Province, South China. This fossil wood is characterized by distinct growth rings, circular to oval tracheids in cross section, 1-2-seriate opposite pits on radi...

journal_title：Scientific reports

authors： Li L,Jin JH,Quan C,Oskolski AA

更新日期：2016-08-30 00:00:00

abstract：:Humans bargaining over money tend to reject unfair offers, whilst chimpanzees bargaining over primary rewards of food do not show this same motivation to reject. Whether such reciprocal fairness represents a predominantly human motivation has generated considerable recent interest. We induced either moderate or severe...

journal_title：Scientific reports

authors： Wright ND,Hodgson K,Fleming SM,Symmonds M,Guitart-Masip M,Dolan RJ

更新日期：2012-01-01 00:00:00

abstract：:The ATP-binding cassette transporter TAPL translocates polypeptides from the cytosol into the lysosomal lumen. TAPL can be divided into two functional units: coreTAPL, active in ATP-dependent peptide translocation, and the N-terminal membrane spanning domain, TMD0, responsible for cellular localization and interaction...

journal_title：Scientific reports

authors： Bock C,Löhr F,Tumulka F,Reichel K,Würz J,Hummer G,Schäfer L,Tampé R,Joseph B,Bernhard F,Dötsch V,Abele R

更新日期：2018-10-23 00:00:00

abstract：:Intestinal fibrosis is thought to be a consequence of excessive tissue repair, and constitutes a common problem in patients with Crohn's disease (CD). While fibrosis seems to require inflammation as a prerequisite it is unclear whether the severity or persistence of inflammation influences the degree of fibrosis. Our ...

journal_title：Scientific reports

authors： Hünerwadel A,Fagagnini S,Rogler G,Lutz C,Jaeger SU,Mamie C,Weder B,Ruiz PA,Hausmann M

更新日期：2018-10-12 00:00:00

abstract：:This research investigates the applicability of an ANN and genetic algorithms for modeling and multiobjective optimization of the thermal conductivity and viscosity of water-based spinel-type MnFe2O4 nanofluid. Levenberg-Marquardt, quasi-Newton, and resilient backpropagation methods are employed to train the ANN. The ...

journal_title：Scientific reports

authors： Amani M,Amani P,Kasaeian A,Mahian O,Pop I,Wongwises S

更新日期：2017-12-12 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinases ErbB family and it is found to be overexpressed in gastric cancer. However, the mechanism of the regulation of the EGFR expression is still unknown. We used the Sequenom EpiTYPER assay to detect the methylation status of the EGFR prom...

journal_title：Scientific reports

authors： Weng X,Zhang H,Ye J,Kan M,Liu F,Wang T,Deng J,Tan Y,He L,Liu Y

更新日期：2015-05-11 00:00:00

abstract：:The human cervical cancer oncogene (HCCR) has been found to be overexpressed in a variety of human cancers. However, the level of expression of HCCR and its biological function in gastric cancer are largely unknown. In this study, we evaluated HCCR expression in several gastric cancer cell lines and in one normal gast...

journal_title：Scientific reports

authors： Zhang JL,Liu XZ,Wang PY,Chen GW,Jiang Y,Qiao SK,Zhu J,Wang X,Pan YS,Liu YC

更新日期：2016-04-07 00:00:00