Bicuspid aortic valve morphology and aortic valvular outflow jets: an experimental analysis using an MRI-compatible pulsatile flow circulation system.

abstract：:Damnacanthal, an anthraquinone present in noni plants, targets several tyrosine kinases and has antitumoral effects. This study aims at getting additional insight on the potential of damnacanthal as a natural antitumor compound. The direct effect of damnacanthal on c-Met was tested by in vitro activity assays. Additio...

journal_title：Scientific reports

authors： García-Vilas JA,Quesada AR,Medina MA

更新日期：2015-01-26 00:00:00

abstract：:We successfully realised plasmon-driven selective reduction reactions of 2-amino-5-nitrobenzenethiol (2A-5-NBT) to 3,3'-dimercapto-4,4'-diaminoazobenzene , an azobenzene derivative, using surface-enhanced Raman scattering (SERS) spectroscopy, and supported by the theoretical calculations. The SERS spectra demonstrated...

journal_title：Scientific reports

authors： Ding Q,Chen M,Li Y,Sun M

更新日期：2015-06-01 00:00:00

abstract：:The optical conversion of incoherent solar radiation into a bright, coherent laser beam enables the application of nonlinear optics to solar energy conversion and storage. Here, we present an architecture for solar pumped lasers that uses a luminescent solar concentrator to decouple the conventional trade-off between ...

journal_title：Scientific reports

authors： Reusswig PD,Nechayev S,Scherer JM,Hwang GW,Bawendi MG,Baldo MA,Rotschild C

更新日期：2015-10-05 00:00:00

abstract：:Increasing levels of human activity threaten wildlife populations through direct mortality, habitat degradation, and habitat fragmentation. Area closures can improve habitat quality for wildlife, but may be difficult to achieve where tourism or other economic drivers are a priority. Temporal closures that limit human ...

journal_title：Scientific reports

authors： Whittington J,Low P,Hunt B

更新日期：2019-03-07 00:00:00

abstract：:Stabilization exercise (SE) is evident for the management of chronic non-specific low back pain (LBP). The optimal dose-response-relationship for the utmost treatment success is, thus, still unknown. The purpose is to systematically review the dose-response-relationship of stabilisation exercises on pain and disabilit...

journal_title：Scientific reports

authors： Mueller J,Niederer D

更新日期：2020-10-09 00:00:00

abstract：:Worldwide, prostate cancer (PCa) is the second most common malignancy in males. We undertook a meta-analysis to compare the efficacy and safety of conventional laparoscopic radical prostatectomy with a transperitoneal (TLRP) approach, versus that of an extraperitoneal (ELRP) approach, for treatment of localized PCa. A...

journal_title：Scientific reports

authors： De Hong C,Liang Ren L,Qiang W,Jia W,Ying Chun H,Lu Y,Zheng Hua L,Heng Ping L,Shi Bing Y,Yun Xiang L

更新日期：2015-10-13 00:00:00

abstract：:Germline mutations in Mir96, one of three co-expressed polycistronic miRNA genes (Mir96, Mir182, Mir183), cause hereditary hearing loss in humans and mice. Transgenic FVB/NCrl- Tg(GFAP-Mir183,Mir96,Mir182)MDW1 mice (Tg1MDW), which overexpress this neurosensory-specific miRNA cluster in the inner ear, were developed as...

journal_title：Scientific reports

authors： Weston MD,Tarang S,Pierce ML,Pyakurel U,Rocha-Sanchez SM,McGee J,Walsh EJ,Soukup GA

更新日期：2018-02-23 00:00:00

abstract：:The introduction of antiretroviral drugs (ARVd) changed the prognosis of HIV infection from a deadly disease to a chronic disease. However, even with undetectable viral loads, patients still develop a wide range of pathologies, including cerebrovascular complications and stroke. It is hypothesized that toxic side effe...

journal_title：Scientific reports

authors： Bertrand L,Dygert L,Toborek M

更新日期：2016-12-23 00:00:00

abstract：:Strong hydrogen bonds such as F···H···F offer new strategies to fabricate molecular architectures exhibiting novel structures and properties. Along these lines and, to potentially realize hydrogen-bond mediated superexchange interactions in a frustrated material, we synthesized [H2F]2[Ni3F6(Fpy)12][SbF6]2 (Fpy = 3-flu...

journal_title：Scientific reports

authors： Manson JL,Brambleby J,Goddard PA,Spurgeon PM,Villa JA,Liu J,Ghannadzadeh S,Foronda F,Singleton J,Lancaster T,Clark SJ,Thomas IO,Xiao F,Williams RC,Pratt FL,Blundell SJ,Topping CV,Baines C,Campana C,Noll B

更新日期：2018-03-16 00:00:00

abstract：:The expression level of folate receptor alpha (FRα) is located highly rate in ovarian cancer though it is remained absent in normal tissues. This highly tumor restricted expression profile makes FRα a promising target for tumor therapy and diagnosis. In this research we report a FRα binding peptide C7(Met-His-Thr-Ala-...

journal_title：Scientific reports

authors： Xing L,Xu Y,Sun K,Wang H,Zhang F,Zhou Z,Zhang J,Zhang F,Caliskan B,Qiu Z,Wang M

更新日期：2018-05-30 00:00:00

abstract：:Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS can profo...

journal_title：Scientific reports

authors： Paramo T,Tomasio SM,Irvine KL,Bryant CE,Bond PJ

更新日期：2015-12-09 00:00:00

abstract：:Protein ubiquitination and degradation represent druggable vulnerabilities of cancer cells. We used gene expression and functional annotation analyses to identify genes in the ubiquitin pathway which are differentially expressed between normal breast and basal-like tumors. With this approach we identified 16 ubiquitin...

journal_title：Scientific reports

authors： Perez-Peña J,Corrales-Sánchez V,Amir E,Pandiella A,Ocana A

更新日期：2017-12-13 00:00:00

abstract：:Although extensive studies have focused on the development of acute mountain sickness (AMS), the exact mechanisms of AMS are still obscure. In this study, we used isobaric tags for relative and absolute quantitation (iTRAQ) proteomic analysis to identify novel AMS-associated biomarkers in human plasma. After 9 hours o...

journal_title：Scientific reports

authors： Lu H,Wang R,Li W,Xie H,Wang C,Hao Y,Sun Y,Jia Z

更新日期：2018-01-19 00:00:00

abstract：:Fatty alcohols have been identified as promising organic phase change materials (PCMs) for thermal energy storage, because of their suitable temperature range, nontoxicity and can be obtained from both natural and synthetic sources. Like all other organic PCMs, octadecanol (OD) as PCM suffers from low thermal conducti...

journal_title：Scientific reports

authors： Al-Ahmed A,Sarı A,Mazumder MAJ,Hekimoğlu G,Al-Sulaiman FA,Inamuddin

更新日期：2020-06-08 00:00:00

abstract：:In this work, we demonstrate theoretically and experimentally the possibility of tuning the electromagnetic properties of metamaterials with magnetic fields by incorporating amorphous magnetic microwires. The large permeability of these wires at microwave frequencies allows tuning the resonance of the metamaterial by ...

journal_title：Scientific reports

authors： Lopez-Dominguez V,Garcia MA,Marin P,Hernando A

更新日期：2017-08-24 00:00:00

abstract：:Detection of visible blind UV radiation is not only interesting but also of technologically important. Herein, we demonstrate the efficient detection of UV radiation by using cluster like ZnS quantum dot solid nanostructures prepared by simple reflux condensation technique. The short-chain ligand 3-mercaptopropionic a...

journal_title：Scientific reports

authors： Premkumar S,Nataraj D,Bharathi G,Ramya S,Thangadurai TD

更新日期：2019-12-10 00:00:00

abstract：:The mechanism by which enzymes arose from both abiotic and biological worlds remains an unsolved natural mystery. We postulate that an enzyme can emerge from any sequence of any functional polymer under permissive evolutionary conditions. To support this premise, we have arbitrarily chosen a 50-nucleotide DNA fragment...

journal_title：Scientific reports

authors： Gysbers R,Tram K,Gu J,Li Y

更新日期：2015-06-19 00:00:00

abstract：:How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that we...

journal_title：Scientific reports

authors： Honda Y,Higashibata A,Matsunaga Y,Yonezawa Y,Kawano T,Higashitani A,Kuriyama K,Shimazu T,Tanaka M,Szewczyk NJ,Ishioka N,Honda S

更新日期：2012-01-01 00:00:00

abstract：:In 2018, the World Health Organization identified the Zika virus (ZIKV) as a pathogen that should be prioritized for public health research due to its epidemic potential. In this study, whole-genome sequencing (WGS) of travel-acquired ZIKV infections was used to examine the limitations of phylogenetic analysis. WGS an...

journal_title：Scientific reports

authors： Kamelian K,Montoya V,Olmstead A,Dong W,Harrigan R,Morshed M,Joy JB

更新日期：2019-11-11 00:00:00

abstract：:Transistor biosensors are mass-fabrication-compatible devices of interest for point of care diagnosis as well as molecular interaction studies. While the actual transistor gates in processors reach the sub-10 nm range for optimum integration and power consumption, studies on design rules for the signal-to-noise ratio ...

journal_title：Scientific reports

authors： Kutovyi Y,Madrid I,Zadorozhnyi I,Boichuk N,Kim SH,Fujii T,Jalabert L,Offenhaeusser A,Vitusevich S,Clément N

更新日期：2020-07-29 00:00:00

abstract：:Natural sensory signals have nonlinear structures dynamically composed of the carrier frequencies and the variation of the amplitude (i.e., envelope). How the human brain processes the envelope information is still poorly understood, largely due to the conventional analysis failing to quantify it directly. Here, we us...

journal_title：Scientific reports

authors： Nguyen KT,Liang WK,Lee V,Chang WS,Muggleton NG,Yeh JR,Huang NE,Juan CH

更新日期：2019-11-15 00:00:00

abstract：:The large spin Hall effect in topological insulators (TIs) is very attractive for ultralow-power spintronic devices. However, evaluation of the spin Hall angle and spin-orbit torque (SOT) of TIs is usually performed on high-quality single-crystalline TI thin films grown on dedicated III-V semiconductor substrates. Her...

journal_title：Scientific reports

authors： Khang NHD,Nakano S,Shirokura T,Miyamoto Y,Hai PN

更新日期：2020-07-22 00:00:00

abstract：:Regulatory T cells (Tregs) expand in peripheral lymphoid organs and can produce immunosuppressive cytokines to support tumor growth. IL-10 abrogation efficiently induces Treg formation but dampens tumoral neuropilin-1 (Nrp-1) Treg signaling, which simultaneously augments Th1 and Th17 immunity. These effects are associ...

journal_title：Scientific reports

authors： Wang S,Gao X,Shen G,Wang W,Li J,Zhao J,Wei YQ,Edwards CK

更新日期：2016-04-14 00:00:00

abstract：:To evaluate the efficacy and safety of CyberKnife Stereotactic Body Radiation Therapy (SBRT) in the treatment of adrenal gland metastases (AGM), we designed a large-scale multicenter retrospective study to report the safety and efficacy of SBRT for inoperable AGM. In this study, 75 (61 males, 14 females) patients with...

journal_title：Scientific reports

authors： Zhao X,Zhu X,Zhuang H,Guo X,Song Y,Ju X,Wang P,Yuan Z,Zhang H

更新日期：2020-05-12 00:00:00

abstract：:Kinkarakawa-gami wallpapers are unique works of art produced in Japan between 1870 and 1905 and exported in European countries, although only few examples are nowadays present in Europe. So far, neither the wallpapers nor the composing materials have been characterised, limiting the effective conservation-restoration ...

journal_title：Scientific reports

authors： Piacenza E,Presentato A,Di Salvo F,Alduina R,Ferrara V,Minore V,Giannusa A,Sancataldo G,Chillura Martino DF

更新日期：2020-10-02 00:00:00

abstract：:Proper determination of agonist efficacy is essential in the assessment of agonist selectivity and signalling bias. Agonist efficacy is a relative term that is dependent on the system in which it is measured, especially being dependent on receptor expression level. The operational model (OM) of functional receptor ago...

journal_title：Scientific reports

authors： Jakubík J,Randáková A,Rudajev V,Zimčík P,El-Fakahany EE,Doležal V

更新日期：2019-03-15 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Taheri S,Abdullah TL,Rafii MY,Harikrishna JA,Werbrouck SPO,Teo CH,Sahebi M,Azizi P

更新日期：2019-11-05 00:00:00

abstract：:We measured the magnitude of submarine fresh groundwater discharge (SFGD) and associated nutrient inputs to Jocheon harbor, on Jeju Island, Korea, during four sampling periods, in order to determine the link between SFGD and Ulva sp. green tide development. Good correlations among salinity, 222Rn, and dissolved inorga...

journal_title：Scientific reports

authors： Kwon HK,Kang H,Oh YH,Park SR,Kim G

更新日期：2017-07-24 00:00:00

abstract：:Changes in land cover have become key components of global environmental change and represent the impact of human activity. To better understand the fundamental processes of land transition characteristics before and after the implementation of ecological programmes, we determined the dominant systematic changes in la...

journal_title：Scientific reports

authors： Zhao J,Yang Y,Zhao Q,Zhao Z

更新日期：2017-03-21 00:00:00

abstract：:In this article, we experimentally and numerically investigate a planar terahertz metamaterial (MM) geometry capable of exhibiting independently tunable multi-band electromagnetically induced transparency effect (EIT). The MM structure exhibits multi-band EIT effect due to the strong near field coupling between the br...

journal_title：Scientific reports

authors： Sarkar R,Ghindani D,Devi KM,Prabhu SS,Ahmad A,Kumar G

更新日期：2019-12-02 00:00:00