Abstract：
:The expression level of folate receptor alpha (FRα) is located highly rate in ovarian cancer though it is remained absent in normal tissues. This highly tumor restricted expression profile makes FRα a promising target for tumor therapy and diagnosis. In this research we report a FRα binding peptide C7(Met-His-Thr-Ala-Pro-Gly-Trp-Gly-Tyr-Arg-Leu-Ser) discovered by phage display and this peptide showed specific binding to FRα expressing cells by cell ELISA and flow cytometry. Tumor targeting ability of C7 was proved in vivo by both phage homing experiment and fluorescence imaging. C7 can be internalized by SKOV3 cells and its affinity to FRα was determined by MST. The molecular recognition was revealed by structure modeling, suggesting its binding mode with FRα.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xing L,Xu Y,Sun K,Wang H,Zhang F,Zhou Z,Zhang J,Zhang F,Caliskan B,Qiu Z,Wang Mdoi
10.1038/s41598-018-26683-zsubject
Has Abstractpub_date
2018-05-30 00:00:00pages
8426issue
1issn
2045-2322pii
10.1038/s41598-018-26683-zjournal_volume
8pub_type
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