Multi-petal cyclamen flowers produced by AGAMOUS chimeric repressor expression.

abstract：:Ample attention has focused on cancer drug delivery via prodrug nanoparticles due to their high drug loading property and comparatively lower side effects. In this study, we designed a PEG-DOX-Cur prodrug nanoparticle for simultaneous delivery of doxorubicin (DOX) and curcumin (Cur) as a combination therapy to treat c...

journal_title：Scientific reports

authors： Zhang Y,Yang C,Wang W,Liu J,Liu Q,Huang F,Chu L,Gao H,Li C,Kong D,Liu Q,Liu J

更新日期：2016-02-15 00:00:00

abstract：:L-R (left and right) symmetry breaking during embryogenesis and the establishment of asymmetric body plan are key issues in developmental biology, but the onset including the handedness-determining gene locus still remains unknown. Using pure dextral (DD) and sinistral (dd) strains of the pond snail Lymnaea stagnalis ...

journal_title：Scientific reports

authors： Kuroda R,Fujikura K,Abe M,Hosoiri Y,Asakawa S,Shimizu M,Umeda S,Ichikawa F,Takahashi H

更新日期：2016-10-06 00:00:00

abstract：:PCR inhibitors in clinical specimens negatively affect the sensitivity of diagnostic PCR and RT-PCR or may even cause false-negative results. To overcome PCR inhibition, increase the sensitivity of the assays and simplify the detection protocols, simple methods based on quantitative nested real-time PCR and RT-PCR wer...

journal_title：Scientific reports

authors： Cai D,Behrmann O,Hufert F,Dame G,Urban G

更新日期：2018-02-21 00:00:00

abstract：:High-throughput technologies have identified significant changes in patterns of mRNA expression over cancer development but the functional significance of these changes often rests upon the assumption that observed changes in levels of mRNA accurately reflect changes in levels of their encoded proteins. We systematica...

journal_title：Scientific reports

authors： Zhang M,Matyunina LV,Walker LD,Chen W,Xiao H,Benigno BB,Wu R,McDonald JF

更新日期：2017-08-15 00:00:00

abstract：:The aim of this study was to assess the association between the shoulder tenderness and the inflammatory changes on magnetic resonance imaging (MRI) in the rheumatoid shoulder. Forty-one shoulders of 41 patients with rheumatoid arthritis (RA) were examined. We evaluated synovitis, erosion and bone marrow edema, by cou...

journal_title：Scientific reports

authors： Shinagawa S,Okamura K,Yonemoto Y,Shitara H,Suto T,Sakane H,Dam TT,Tajika T,Tsushima Y,Takagishi K,Chikuda H

更新日期：2019-12-20 00:00:00

abstract：:The herbal medicine berberine (BBR) has been recently shown to be an AMP-activated protein kinase (AMPK) productive activator with various properties that induce anti-inflammatory responses. We investigated the effects of BBR on the mechanisms of mucosal CD4+T cell activation in vitro and on the inflammatory responses...

journal_title：Scientific reports

authors： Takahara M,Takaki A,Hiraoka S,Adachi T,Shimomura Y,Matsushita H,Nguyen TTT,Koike K,Ikeda A,Takashima S,Yamasaki Y,Inokuchi T,Kinugasa H,Sugihara Y,Harada K,Eikawa S,Morita H,Udono H,Okada H

更新日期：2019-08-15 00:00:00

abstract：:In this study, a novel resorufin thionocarbonate-based Hg2+-selective signaling probe (RT) for microfluidic paper-based analytical device (μPAD) applications is reported. The designed probe, RT, was readily synthesized by the one-step reaction of resorufin with phenyl thionochloroformate. The RT probe displayed a prom...

journal_title：Scientific reports

authors： Choi MG,Park SY,Park KY,Chang SK

更新日期：2019-03-04 00:00:00

abstract：:The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...

journal_title：Scientific reports

authors： Lopes-Marques M,Serrano C,Cardoso AR,Salazar R,Seixas S,Amorim A,Azevedo L,Prata MJ

更新日期：2020-07-14 00:00:00

abstract：:Oral microbiome dysbiosis has been associated with various local and systemic human diseases such as dental caries, periodontal disease, obesity, and cardiovascular disease. Bacterial composition may be affected by age, oral health, diet, and geography, although information about the natural variation found in the gen...

journal_title：Scientific reports

authors： Burcham ZM,Garneau NL,Comstock SS,Tucker RM,Knight R,Metcalf JL,Genetics of Taste Lab Citizen Scientists.

更新日期：2020-02-07 00:00:00

abstract：:Insulin-like growth factor-I (IGF-I) is involved in the maturation and maintenance of neurons, and impaired IGF-I signaling has been shown to play a role in various neurological diseases including stroke. The aim of the present study was to investigate the efficacy of an optimized IGF-I variant by adding a 40 kDa poly...

journal_title：Scientific reports

authors： Parker K,Berretta A,Saenger S,Sivaramakrishnan M,Shirley SA,Metzger F,Clarkson AN

更新日期：2017-03-21 00:00:00

abstract：:Multiple approaches utilizing viral and DNA vectors have shown promise in the development of an effective vaccine against HIV. In this study, an alternative replication-defective flavivirus vector, RepliVax (RV), was evaluated for the delivery of HIV-1 immunogens. Recombinant RV-HIV viruses were engineered to stably e...

journal_title：Scientific reports

authors： Giel-Moloney M,Esteban M,Oakes BH,Vaine M,Asbach B,Wagner R,Mize GJ,Spies AG,McElrath J,Perreau M,Roger T,Ives A,Calandra T,Weiss D,Perdiguero B,Kibler KV,Jacobs B,Ding S,Tomaras GD,Montefiori DC,Ferrari G,Yates

更新日期：2019-12-27 00:00:00

abstract：:Increased filaggrin expression was found to be correlated with severity scores in chronic spontaneous urticaria (CSU); however, the role of filaggrin breakdown products (FBPs) in CSU has not been studied. We collected stratum corneum (SC) specimens from the volar forearms of 10 CSU patients, 10 AD patients, and 10 hea...

journal_title：Scientific reports

authors： Pham DL,Lim KM,Joo KM,Park HS,Leung DYM,Ye YM

更新日期：2017-05-02 00:00:00

abstract：:Progressive evolution, or the tendency towards increasing complexity, is a controversial issue in biology, which resolution entails a proper measurement of complexity. Genomes are the best entities to address this challenge, as they encode the historical information of a species' biotic and environmental interactions....

journal_title：Scientific reports

authors： Moya A,Oliver JL,Verdú M,Delaye L,Arnau V,Bernaola-Galván P,de la Fuente R,Díaz W,Gómez-Martín C,González FM,Latorre A,Lebrón R,Román-Roldán R

更新日期：2020-11-04 00:00:00

abstract：:Around 350 million tonnes of plastics are annually produced worldwide. A remarkable percentage of these products is dispersed in the environment, finally reaching and dispersed in the marine environment. Recent field surveys detected microplastics' concentrations in the Mediterranean Sea. The most commonly polymers fo...

journal_title：Scientific reports

authors： Corbari L,Maltese A,Capodici F,Mangano MC,Sarà G,Ciraolo G

更新日期：2020-11-16 00:00:00

abstract：:Multigene expression signatures provide a molecular subdivision of early breast cancer associated with patient outcome. A gap remains in the validation of such signatures in clinical treatment groups of patients within population-based cohorts of unselected primary breast cancer representing contemporary disease stage...

journal_title：Scientific reports

authors： Vallon-Christersson J,Häkkinen J,Hegardt C,Saal LH,Larsson C,Ehinger A,Lindman H,Olofsson H,Sjöblom T,Wärnberg F,Ryden L,Loman N,Malmberg M,Borg Å,Staaf J

更新日期：2019-08-21 00:00:00

abstract：:Skin ageing is an inevitable consequence of life and accelerated by exposure to ultraviolet (UV) rays. Senescence is an irreversible growth arrest and senescent cells accumulate in ageing tissues, at sites of age-related pathologies and in pre-neoplastic lesions. Conventionally, senescent cells have been detected by s...

journal_title：Scientific reports

authors： Wang AS,Ong PF,Chojnowski A,Clavel C,Dreesen O

更新日期：2017-11-15 00:00:00

abstract：:Objectum-sexuality (OS) is a sexual orientation which has received little attention in the academic literature. Individuals who identify as OS experience emotional, romantic and/or sexual feelings towards inanimate objects (e.g. a bridge, a statue). We tested 34 OS individuals and 88 controls, and provide the first em...

journal_title：Scientific reports

authors： Simner J,Hughes JEA,Sagiv N

更新日期：2019-12-27 00:00:00

abstract：:Studies of past human-landscape interactions rely upon the integration of archaeological, biological and geological information within their geographical context. However, detecting the often ephemeral traces of human activities at a landscape scale remains difficult with conventional archaeological field survey. Geop...

journal_title：Scientific reports

authors： De Smedt P,Van Meirvenne M,Herremans D,De Reu J,Saey T,Meerschman E,Crombé P,De Clercq W

更新日期：2013-01-01 00:00:00

abstract：:We have designed a fully automated optical microscope running at high-speed and achieving a very high spatial resolution. In order to overcome the resolution limit of optical microscopes, it exploits the localized surface plasmon resonance phenomenon. The customized setup using a polarization analyzer, based on liquid...

journal_title：Scientific reports

authors： Alexandrov A,Asada T,De Lellis G,Di Crescenzo A,Gentile V,Naka T,Tioukov V,Umemoto A

更新日期：2020-11-02 00:00:00

abstract：:Theoretical model required for the evolution of regular dislocation pattern should simultaneously take into account both static distribution and dynamic evolution of dislocation pattern. In principle, there exists a stable uniformly moving dislocation with both core and far field advancing at the same constant velocit...

journal_title：Scientific reports

authors： Li P,Zhang ZF

更新日期：2017-06-22 00:00:00

abstract：:Establishing the architecture of gene regulatory networks (GRNs) relies on chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-Seq) methods that provide genome-wide transcription factor binding sites (TFBSs). ChIP-Seq furnishes millions of short reads that, after alignment, describe the genom...

journal_title：Scientific reports

authors： Ouma WZ,Mejia-Guerra MK,Yilmaz A,Pareja-Tobes P,Li W,Doseff AI,Grotewold E

更新日期：2015-03-02 00:00:00

abstract：:The MADS-box transcription factors play essential roles in many physiological and biochemical processes of plants, especially in fruit ripening. Here, a tomato MADS-box gene, SlCMB1, was isolated. SlCMB1 expression declined with the fruit ripening from immature green to B + 7 (7 days after Breaker) fruits in the wild ...

journal_title：Scientific reports

authors： Zhang J,Hu Z,Yao Q,Guo X,Nguyen V,Li F,Chen G

更新日期：2018-02-21 00:00:00

abstract：:Facial emotion perception plays a key role in interpersonal communication and is a precursor for a variety of socio-cognitive abilities. One brain region thought to support emotion perception is the inferior frontal cortex (IFC). The current study aimed to examine whether modulating neural activity in the IFC using hi...

journal_title：Scientific reports

authors： Penton T,Dixon L,Evans LJ,Banissy MJ

更新日期：2017-09-12 00:00:00

abstract：:A histoanatomical context is imperative in an analysis of gene expression in a cell in a tissue to elucidate physiological function of the cell. In this study, we made technical advances in fluorescence laser microdissection (LMD) in combination with the absolute quantification of small amounts of mRNAs from a region ...

journal_title：Scientific reports

authors： Yoshioka W,Endo N,Kurashige A,Haijima A,Endo T,Shibata T,Nishiyama R,Kakeyama M,Tohyama C

更新日期：2012-01-01 00:00:00

abstract：:Epidermal electronic systems (EESs) are skin-like electronic systems, which can be used to measure several physiological parameters from the skin. This paper presents materials and a simple, straightforward fabrication process for skin-conformable inkjet-printed temperature sensors. Epidermal temperature sensors are a...

journal_title：Scientific reports

authors： Vuorinen T,Niittynen J,Kankkunen T,Kraft TM,Mäntysalo M

更新日期：2016-10-18 00:00:00

abstract：:Liver stage Plasmodium parasites reside in a parasitophorous vacuole (PV) that associates with lysosomes. It has previously been shown that these organelles can have beneficial as well as harmful effects on the parasite. Yet it is not clear how the association of lysosomes with the parasite is controlled and how inter...

journal_title：Scientific reports

authors： Niklaus L,Agop-Nersesian C,Schmuckli-Maurer J,Wacker R,Grünig V,Heussler VT

更新日期：2019-05-28 00:00:00

abstract：:Human fetuin-B plays a key physiological role in human fertility through its inhibitory action on ovastacin, a member of the astacin family of metallopeptidases. The inhibitor consists of tandem cystatin-like domains (CY1 and CY2), which are connected by a linker containing a "CPDCP-trunk" and followed by a C-terminal...

journal_title：Scientific reports

authors： Guevara T,Körschgen H,Cuppari A,Schmitz C,Kuske M,Yiallouros I,Floehr J,Jahnen-Dechent W,Stöcker W,Gomis-Rüth FX

更新日期：2019-10-11 00:00:00

abstract：:Granules enriched with anammox bacteria are essential in enhancing the treatment of ammonia-rich wastewater, but little is known about how anammox bacteria grow and multiply inside granules. Here, we combined metatranscriptomics, quantitative PCR and 16S rRNA gene sequencing to study the changes in community compositi...

journal_title：Scientific reports

authors： Bagchi S,Lamendella R,Strutt S,Van Loosdrecht MC,Saikaly PE

更新日期：2016-06-20 00:00:00

abstract：:We report a water decomposition mode called 'Aquaionic Splitting (AiS)' by means of iron corrosion in aqueous solution. In this paper, we investigated the phenomenon by controlling the reaction between iron and water. A pseudo-sacrificial protection method with oil paint was employed to select the anode and cathode fo...

journal_title：Scientific reports

authors： Murakami S,Zhang L,Watanabe S

更新日期：2020-02-03 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

journal_title：Scientific reports

authors： Boel A,Steyaert W,De Rocker N,Menten B,Callewaert B,De Paepe A,Coucke P,Willaert A

更新日期：2018-10-29 00:00:00