Prognostic significance of neutrophil-to-lymphocyte ratio in prostate cancer: evidence from 16,266 patients.

abstract：:Metalloproteinases (MMPs) contribute to tissue remodeling and acute inflammation not only by degrading extracellular matrix proteins but also by controlling the influx of chemokines through the regulation and shedding of syndecans. B-lymphocytes, in addition to their well-known function as antibody producing cells, pa...

journal_title：Scientific reports

authors： Ali MF,Dasari H,Van Keulen VP,Cornec D,Vasmatzis G,Peikert T,Carmona EM

更新日期：2017-06-20 00:00:00

abstract：:Atherosclerosis is a chronic inflammatory disease characterized by the infiltration of pro-inflammatory macrophages into a lipid-laden plaque. ITCH is an E3 ubiquitin ligase that has been shown to polarize macrophages to an anti-inflammatory phenotype. We therefore investigated the effect of ITCH deficiency on the dev...

journal_title：Scientific reports

authors： Stöhr R,Mavilio M,Marino A,Casagrande V,Kappel B,Möllmann J,Menghini R,Melino G,Federici M

更新日期：2015-03-17 00:00:00

abstract：:We report a daily-updated sequenced/species Tree Of Life (sTOL) as a reference for the increasing number of cellular organisms with their genomes sequenced. The sTOL builds on a likelihood-based weight calibration algorithm to consolidate NCBI taxonomy information in concert with unbiased sampling of molecular charact...

journal_title：Scientific reports

authors： Fang H,Oates ME,Pethica RB,Greenwood JM,Sardar AJ,Rackham OJ,Donoghue PC,Stamatakis A,de Lima Morais DA,Gough J

更新日期：2013-01-01 00:00:00

abstract：:Delivery and expression of recombinant genes, a key methodology for many applications in biological research, remains a challenge especially for mature neurons. Here, we report easy, highly efficient and well tolerated transduction of adult peripheral and central neuronal populations of diverse species in culture usin...

journal_title：Scientific reports

authors： Levin E,Diekmann H,Fischer D

更新日期：2016-12-13 00:00:00

abstract：:We compared the prognostic value of nutritional or volumetric parameters measured by body composition in hospitalized patients on maintenance hemodialysis. We conducted a cohort study to assess the association of different parameters of body composition with all-cause mortality in inpatients admitted to our nephrology...

journal_title：Scientific reports

authors： Wu B,Yan C,Zhang S,Ge Y,Xu X,Wang Y,Xu L,Zhang C,Huang Z,Ren H,Wu J,Xing C,Mao H

更新日期：2020-06-23 00:00:00

abstract：:The study aimed to compare the tumor response to and complications of doxorubicin-eluting CalliSphere bead-transarterial chemoembolization (DEB-TACE) using small- and medium-sized beads in patients with hepatocellular carcinoma (HCC) who underwent multiple rounds of oncology therapies. Sixty patients with intermediate...

journal_title：Scientific reports

authors： Wang CY,Xia JG,Yang ZQ,Zhou WZ,Chen WH,Qi CJ,Gu JP,Wang Q

更新日期：2020-03-10 00:00:00

abstract：:The interaction between matter and electromagnetic radiation provides a rich understanding of what the matter is composed of and how it can be quantified using spectrometers. In many cases, however, the calibration of the spectrometer changes as a function of time (such as in electron spectrometers), or the absolute c...

journal_title：Scientific reports

authors： Chatzidakis M,Botton GA

更新日期：2019-02-14 00:00:00

abstract：:Carbonatites, usually occurring within intra-continental rift-related settings, have strong light rare earth element (LREE) enrichment; they rarely contain economic heavy REE (HREE). Here, we report the identification of Late Triassic HREE-Mo-rich carbonatites in the northernmost Qinling orogen. The rocks contain abun...

journal_title：Scientific reports

authors： Song W,Xu C,Smith MP,Kynicky J,Huang K,Wei C,Zhou L,Shu Q

更新日期：2016-11-18 00:00:00

abstract：:Breast cancer transcriptome acquires a myriad of regulation changes, and splicing is critical for the cell to "tailor-make" specific functional transcripts. We systematically revealed splicing signatures of the three most common types of breast tumors using RNA sequencing: TNBC, non-TNBC and HER2-positive breast cance...

journal_title：Scientific reports

authors： Eswaran J,Horvath A,Godbole S,Reddy SD,Mudvari P,Ohshiro K,Cyanam D,Nair S,Fuqua SA,Polyak K,Florea LD,Kumar R

更新日期：2013-01-01 00:00:00

abstract：:Loss-of-function mutations in TREM2 cause Nasu-Hakola disease (NHD), a rare genetic disease characterized by early-onset dementia with leukoencephalopathy and bone cysts. An NHD-associated mutation, c.482 + 2 T > C, disrupts the splice donor site of intron 3 and causes aberrant skipping of exon 3, resulting in the los...

journal_title：Scientific reports

authors： Yanaizu M,Sakai K,Tosaki Y,Kino Y,Satoh JI

更新日期：2018-05-02 00:00:00

abstract：:Mitochondria play an essential role in bioenergetics and cellular Ca[Formula: see text] handling. The mitochondrial permeability transition pore (mPTP) is a non-specific channel located in the inner mitochondrial membrane. Long-lasting openings of the pore allow the rapid passage of ions and large molecules, which can...

journal_title：Scientific reports

authors： Wacquier B,Combettes L,Dupont G

更新日期：2020-03-03 00:00:00

abstract：:Gapmer antisense oligonucleotides cleave target RNA effectively in vivo, and is considered as promising therapeutics. Especially, gapmers modified with locked nucleic acid (LNA) shows potent knockdown activity; however, they also cause hepatotoxic side effects. For developing safe and effective gapmer drugs, a deeper ...

journal_title：Scientific reports

authors： Kasuya T,Hori S,Watanabe A,Nakajima M,Gahara Y,Rokushima M,Yanagimoto T,Kugimiya A

更新日期：2016-07-27 00:00:00

abstract：:In the chemical mechanical polishing process of semiconductor manufacturing, the concentration of 'large' particles ([Formula: see text]0.5 μm) in the slurry, which is considerably larger in size than the main abrasives ([Formula: see text] 0.1 μm), is a critical parameter that strongly influences manufacturing defect...

journal_title：Scientific reports

authors： Lee M,Kim D,Heo TY,Park T,Kim W,Choi D,Kim H,Kim J

更新日期：2020-09-07 00:00:00

abstract：:Congruence theory has many applications in physical, social, biological and technological systems. Congruence arithmetic has been a fundamental tool for data security and computer algebra. However, much less attention was devoted to the topological features of congruence relations among natural numbers. Here, we explo...

journal_title：Scientific reports

authors： Yan XY,Wang WX,Chen GR,Shi DH

更新日期：2016-03-31 00:00:00

abstract：:We present a novel, non-invasive magnetic resonance imaging (MRI) technique to assess real-time dynamic vasomodulation of the microvascular bed. Unlike existing perfusion imaging techniques, our method is sensitive only to blood volume and not flow velocity. Using graded gas challenges and a long-life, blood-pool T 1-...

journal_title：Scientific reports

authors： Ganesh T,Estrada M,Yeger H,Duffin J,Cheng HL

更新日期：2017-08-07 00:00:00

abstract：:Aconiti Lateralis Radix Praeparata (Fuzi) is obtained from processed daughter roots of Aconitum carmichaeli, a toxic plant with a high medical value well known in Chinese medicine. In addition to the known toxic alkaloids (aconitine, mesaconitine, and hypaconitine) and bioactive alkaloids (benzoylaconine, benzoylmesac...

journal_title：Scientific reports

authors： He F,Wang CJ,Xie Y,Cheng CS,Liu ZQ,Liu L,Zhou H

更新日期：2017-10-12 00:00:00

abstract：:Antimicrobial stewardship programmes (ASP) are aimed at optimising antimicrobial utilization. However, only few studies have focused on paediatric intensive care units (PICU), where inappropriate antibiotic use occurs frequently. We assessed the effect and safety of a once weekly paediatric infectious disease (PID) wa...

journal_title：Scientific reports

authors： Renk H,Sarmisak E,Spott C,Kumpf M,Hofbeck M,Hölzl F

更新日期：2020-06-01 00:00:00

abstract：:A novel imaging-driven technique with an integrated fluorescence signature to enable automated enumeration of two species of cyanobacteria and an alga of somewhat similar morphology to one of the cyanobacteria is presented to demonstrate proof-of-concept that high accuracy, imaging-based, rapid water quality analysis ...

journal_title：Scientific reports

authors： Jin C,Mesquita MMF,Deglint JL,Emelko MB,Wong A

更新日期：2018-06-13 00:00:00

abstract：:Soil microorganisms have important influences on plant growth and health. In this study, four black pepper fields consecutively monocultured for 12, 18, 28 and 38 years were selected for investigating the effect of planting age on rhizosphere and non-rhizosphere soil microbial communities and soil physicochemical prop...

journal_title：Scientific reports

authors： Li Z,Zu C,Wang C,Yang J,Yu H,Wu H

更新日期：2016-10-24 00:00:00

abstract：:Circulating tumor DNA (ctDNA) has become an attractive biomarker in human oncology, and its use may be informative in canine cancer. Thus, we used droplet digital PCR or PCR for antigen receptor rearrangement, to explore tumor-specific point mutations, copy number alterations, and chromosomal rearrangements in the pla...

journal_title：Scientific reports

authors： Prouteau A,Denis JA,De Fornel P,Cadieu E,Derrien T,Kergal C,Botherel N,Ulvé R,Rault M,Bouzidi A,François R,Dorso L,Lespagnol A,Devauchelle P,Abadie J,André C,Hédan B

更新日期：2021-01-13 00:00:00

abstract：:We used swept-source (SS) optical coherence tomography (OCT) and OCT angiography (OCTA) to investigate the effects of moderate physical exercise on retinal and choroidal vessel densities (VDs) and thicknesses in children. One eye in each of 40 myopic children (mean age, 11.70 years) and 18 emmetropic children (mean ag...

journal_title：Scientific reports

authors： Li S,Pan Y,Xu J,Li X,Spiegel DP,Bao J,Chen H

更新日期：2021-01-21 00:00:00

abstract：:Biomolecules for OMIC analysis of microbial communities are commonly extracted by bead-beating or ultra-sonication, but both showed varying yields. In addition to that, different disruption pressures are necessary to lyse bacteria and fungi. However, the disruption efficiency and yields comparing bead-beating and ultr...

journal_title：Scientific reports

authors： Starke R,Jehmlich N,Alfaro T,Dohnalkova A,Capek P,Bell SL,Hofmockel KS

更新日期：2019-04-04 00:00:00

abstract：:The physiological importance of CD151 tetraspanin is known from somatic cells and its outside-in signalling through integrins was described. In male germ cells, two tetraspanins, CD9 and CD81, are involved in sperm-egg membrane fusion, and similarly to integrins, they occupy characteristic regions. We report here on a...

journal_title：Scientific reports

authors： Jankovicova J,Frolikova M,Palenikova V,Valaskova E,Cerny J,Secova P,Bartokova M,Horovska L,Manaskova-Postlerova P,Antalikova J,Komrskova K

更新日期：2020-03-09 00:00:00

abstract：:Application of PCR to multiplexing assays is not trivial; it requires multiple fluorescent labels for amplicon detection and sophisticated software for data interpretation. Alternative PCR-free methods exploiting new concepts in nanotechnology exhibit high sensitivities but require multiple labeling and/or amplificati...

journal_title：Scientific reports

authors： Papadakis G,Tsortos A,Kordas A,Tiniakou I,Morou E,Vontas J,Kardassis D,Gizeli E

更新日期：2013-01-01 00:00:00

abstract：:Today, despite decades of developments in medicine and the growing interest in precision healthcare, vast majority of diagnoses happen once patients begin to show noticeable signs of illness. Early indication and detection of diseases, however, can provide patients and carers with the chance of early intervention, bet...

journal_title：Scientific reports

authors： Li Y,Rao S,Solares JRA,Hassaine A,Ramakrishnan R,Canoy D,Zhu Y,Rahimi K,Salimi-Khorshidi G

更新日期：2020-04-28 00:00:00

abstract：:Pancreatic cancer is predominantly lethal, and is primarily treated using gemcitabine, with increasing resistance. Therefore, novel agents that increase tumor sensitivity to gemcitabine are needed. Histone deacetylase (HDAC) inhibitors are emerging therapeutic agents, since HDAC plays an important role in cancer initi...

journal_title：Scientific reports

authors： Lee HS,Park SB,Kim SA,Kwon SK,Cha H,Lee DY,Ro S,Cho JM,Song SY

更新日期：2017-01-30 00:00:00

abstract：:We present the first complete, closed genome sequences of Streptococcus pyogenes strains NCTC 8198T and CCUG 4207T, the type strain of the type species of the genus Streptococcus and an important human pathogen that causes a wide range of infectious diseases. S. pyogenes NCTC 8198T and CCUG 4207T are derived from depo...

journal_title：Scientific reports

authors： Salvà-Serra F,Jaén-Luchoro D,Jakobsson HE,Gonzales-Siles L,Karlsson R,Busquets A,Gomila M,Bennasar-Figueras A,Russell JE,Fazal MA,Alexander S,Moore ERB

更新日期：2020-07-15 00:00:00

abstract：:By using silver nanoplatelets with a widely tunable localized surface plasmon resonance (LSPR), and their corresponding local field enhancement, here we show large manipulation of plasmonic enhanced upconversion in NaYF4:Yb(3+)/Er(3+) nanocrystals at the single particle level. In particular, we show that when the plas...

journal_title：Scientific reports

authors： Wang YL,Mohammadi Estakhri N,Johnson A,Li HY,Xu LX,Zhang Z,Alù A,Wang QQ,Shih CK

更新日期：2015-05-15 00:00:00

abstract：:Hypertension is a public health issue in Iran. The study aimed to estimate the prevalence, awareness, treatment, and control of hypertension, and to explore their determinants among 10,040 Kurdish adults from Ravansar Non-Communicable Disease (RaNCD) cohort study in Iran. Univariate, and multivariate analyses were use...

journal_title：Scientific reports

authors： Rajati F,Hamzeh B,Pasdar Y,Safari R,Moradinazar M,Shakiba E,Bazargan-Hejazi S,Karim H,Najafi F

更新日期：2019-08-27 00:00:00

abstract：:Atherosclerosis is a progressive disease leading to loss of vascular homeostasis and entails fibrosis, macrophage foam cell formation, and smooth muscle cell proliferation. Recent studies have reported that epidermal growth factor receptor (EGFR) is involved vascular pathophysiology and in the regulation of oxidative ...

journal_title：Scientific reports

authors： Wang L,Huang Z,Huang W,Chen X,Shan P,Zhong P,Khan Z,Wang J,Fang Q,Liang G,Wang Y

更新日期：2017-04-04 00:00:00