当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Transarterial chemoembolization with medium-sized doxorubicin-eluting Callisphere is safe and effective for patients with hepatocellular carcinoma.

Transarterial chemoembolization with medium-sized doxorubicin-eluting Callisphere is safe and effective for patients with hepatocellular carcinoma.

Abstract：

:The study aimed to compare the tumor response to and complications of doxorubicin-eluting CalliSphere bead-transarterial chemoembolization (DEB-TACE) using small- and medium-sized beads in patients with hepatocellular carcinoma (HCC) who underwent multiple rounds of oncology therapies. Sixty patients with intermediate stage HCC who had previously received multiple oncology therapies underwent DEB-TACE with CalliSpheres of 100-300 μm (small bead group, n = 34) or 300-500 μm (medium bead group, n = 26) in diameter between October 2016 and December 2018. Adverse events and the response rate of the index tumor based on the modified Response Evaluation Criteria in Solid Tumors at 3 months post-TACE were compared between the groups. The rates of complete response, partial response, stable disease, and progressive disease were 35.4%, 29.4%, 17.6%, and 17.6%, respectively, for the small bead group and 33.1%, 23.1%, 20.8%, and 23.0%, respectively, for the medium bead group, showing no significant between-group differences (P > 0.05). Common Terminology Criteria for Adverse Events version 4.0 grade 3/4 adverse events were reported in 8 patients in the small bead group and in no patients in the medium bead group, showing a significant group difference (P < 0.01). Major complications included 8 events of ischemic hepatitis, 2 of biloma, and 2 of severe liver abscess. DEB-TACE using CalliSpheres of 300-500 μm was associated with a comparable rate of tumor response but lower rate of complications compared with that using CalliSpheres of 100-300 μm for HCC treatment in patients who had already undergone multiple rounds of oncology therapies.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wang CY,Xia JG,Yang ZQ,Zhou WZ,Chen WH,Qi CJ,Gu JP,Wang Q

doi

10.1038/s41598-020-61209-6

subject

Has Abstract

pub_date

2020-03-10 00:00:00

pages

4434

issue

1

issn

2045-2322

pii

10.1038/s41598-020-61209-6

journal_volume

10

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Graph distance for complex networks.

    abstract：:Networks are widely used as a tool for describing diverse real complex systems and have been successfully applied to many fields. The distance between networks is one of the most fundamental concepts for properly classifying real networks, detecting temporal changes in network structures, and effectively predicting th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34944

    authors： Shimada Y,Hirata Y,Ikeguchi T,Aihara K

    更新日期：2016-10-11 00:00:00

  • UniBic: Sequential row-based biclustering algorithm for analysis of gene expression data.

    abstract：:Biclustering algorithms, which aim to provide an effective and efficient way to analyze gene expression data by finding a group of genes with trend-preserving expression patterns under certain conditions, have been widely developed since Morgan et al. pioneered a work about partitioning a data matrix into submatrices ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23466

    authors： Wang Z,Li G,Robinson RW,Huang X

    更新日期：2016-03-22 00:00:00

  • On the near-wall accumulation of injectable particles in the microcirculation: smaller is not better.

    abstract：:Although most nanofabrication techniques can control nano/micro particle (NMP) size over a wide range, the majority of NMPs for biomedical applications exhibits a diameter of ~100 nm. Here, the vascular distribution of spherical particles, from 10 to 1,000 nm in diameter, is studied using intravital microscopy and com...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02079

    authors： Lee TR,Choi M,Kopacz AM,Yun SH,Liu WK,Decuzzi P

    更新日期：2013-01-01 00:00:00

  • Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure.

    abstract：:Methamphetamine (METH) is a highly addictive psychostimulant that causes long-lasting effects in the brain and increases the risk of developing neurodegenerative diseases. The cellular and molecular effects of METH in the brain are functionally linked to alterations in glutamate levels. Despite the well-documented eff...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80917-7

    authors： Jones B,Balasubramaniam M,Lebowitz JJ,Taylor A,Villalta F,Khoshbouei H,Grueter C,Grueter B,Dash C,Pandhare J

    更新日期：2021-01-14 00:00:00

  • Differential Responses of Plasma Adropin Concentrations To Dietary Glucose or Fructose Consumption In Humans.

    abstract：:Adropin is a peptide hormone encoded by the Energy Homeostasis Associated (ENHO) gene whose physiological role in humans remains incompletely defined. Here we investigated the impact of dietary interventions that affect systemic glucose and lipid metabolism on plasma adropin concentrations in humans. Consumption of gl...

    journal_title：Scientific reports

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/srep14691

    authors： Butler AA,St-Onge MP,Siebert EA,Medici V,Stanhope KL,Havel PJ

    更新日期：2015-10-05 00:00:00

  • In-vivo Dynamics of the Human Hippocampus across the Menstrual Cycle.

    abstract：:Sex hormones fluctuate during the menstrual cycle. Evidence from animal studies suggests similar subtle fluctuations in hippocampal structure, predominantly linked to estrogen. Hippocampal abnormalities have been observed in several neuropsychiatric pathologies with prominent sexual dimorphism. Yet, the potential impa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32833

    authors： Barth C,Steele CJ,Mueller K,Rekkas VP,Arélin K,Pampel A,Burmann I,Kratzsch J,Villringer A,Sacher J

    更新日期：2016-10-07 00:00:00

  • Climate change drives trait-shifts in coral reef communities.

    abstract：:Climate change is expected to have profound, partly unforeseeable effects on the composition of functional traits of complex ecosystems, such as coral reefs, and some ecosystem properties are at risk of disappearing. This study applies a novel spatially explicit, individual-based model to explore three critical life h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-38962-4

    authors： Kubicek A,Breckling B,Hoegh-Guldberg O,Reuter H

    更新日期：2019-03-06 00:00:00

  • Strain differences in arsenic-induced oxidative lesion via arsenic biomethylation between C57BL/6J and 129X1/SvJ mice.

    abstract：:Arsenic is a common environmental and occupational toxicant with dramatic species differences in its susceptibility and metabolism. Mouse strain variability may provide a better understanding of the arsenic pathological profile but is largely unknown. Here we investigated oxidative lesion induced by acute arsenic expo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44424

    authors： Wu R,Wu X,Wang H,Fang X,Li Y,Gao L,Sun G,Pi J,Xu Y

    更新日期：2017-03-17 00:00:00

  • Monitoring of tumor growth and vascularization with repetitive ultrasonography in the chicken chorioallantoic-membrane-assay.

    abstract：:The chorioallantoic-membrane (CAM)-assay is an established model for in vivo tumor research. Contrary to rodent-xenograft-models, the CAM-assay does not require breeding of immunodeficient strains due to native immunodeficiency. This allows xenografts to grow on the non-innervated CAM without pain or impairment for th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-75660-y

    authors： Eckrich J,Kugler P,Buhr CR,Ernst BP,Mendler S,Baumgart J,Brieger J,Wiesmann N

    更新日期：2020-10-29 00:00:00

  • A mechanistic study of gold nanoparticle radiosensitisation using targeted microbeam irradiation.

    abstract：:Gold nanoparticles (GNPs) have been demonstrated as effective radiosensitizing agents in a range of preclinical models using broad field sources of various energies. This study aimed to distinguish between these mechanisms by applying subcellular targeting using a soft X-ray microbeam in combination with GNPs. DNA dam...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep44752

    authors： Ghita M,McMahon SJ,Taggart LE,Butterworth KT,Schettino G,Prise KM

    更新日期：2017-03-16 00:00:00

  • The efficacy and safety of docetaxel plus thalidomide vs. docetaxel alone in patients with androgen-independent prostate cancer: a systematic review.

    abstract：:The aim of this systematic review was taken to investigate the efficacy and safety of docetaxel plus thalidomide vs. docetaxel alone for treating androgen-independent prostate cancer (AIPC). Data were collected from different databases independently by three researchers according to the pre-defined inclusion and exclu...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析,评审

    doi：10.1038/srep04818

    authors： Chen L,Qiu X,Wang R,Xie X

    更新日期：2014-04-28 00:00:00

  • DDX3 localizes to the centrosome and prevents multipolar mitosis by epigenetically and translationally modulating p53 expression.

    abstract：:The DEAD-box RNA helicase DDX3 plays divergent roles in tumorigenesis, however, its function in mitosis is unclear. Immunofluorescence indicated that DDX3 localized to centrosome throughout the cell cycle and colocalized with centrosome-associated p53 during mitosis in HCT116 and U2OS cells. DDX3 depletion promoted ch...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09779-w

    authors： Chen WJ,Wang WT,Tsai TY,Li HK,Lee YW

    更新日期：2017-08-25 00:00:00

  • Satellite gravity measurement monitoring terrestrial water storage change and drought in the continental United States.

    abstract：:We use satellite gravity measurements in the Gravity Recovery and Climate Experiment (GRACE) to estimate terrestrial water storage (TWS) change in the continental United States (US) from 2003 to 2012, and establish a GRACE-based Hydrological Drought Index (GHDI) for drought monitoring. GRACE-inferred TWS exhibits oppo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19909

    authors： Yi H,Wen L

    更新日期：2016-01-27 00:00:00

  • Peritoneal Dialysis Catheter Emplacement by Advanced Laparoscopy: 8-year Experience from a Medical Center of China.

    abstract：:Laparoscopic experience and relevant reports about PD catheter emplacement in Chinese patients are seldom. In this study, we described our experience with advanced laparoscopy for PD catheter implantation in Chinese patients. There were one hundred and thirty Chinese patients accepted advanced laparoscopic approach fo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09596-1

    authors： Mo M,Ju Y,Hu H,Zhang W,Pan J,Zheng Q,Chen J,Su L,Dou X

    更新日期：2017-08-22 00:00:00

  • Gearing Up the Human Ankle-Foot System to Reduce Energy Cost of Fast Walking.

    abstract：:During locomotion, the human ankle-foot system dynamically alters its gearing, or leverage of the ankle joint on the ground. Shifting ankle-foot gearing regulates speed of plantarflexor (i.e., calf muscle) contraction, which influences economy of force production. Here, we tested the hypothesis that manipulating ankle...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65626-5

    authors： Ray SF,Takahashi KZ

    更新日期：2020-05-29 00:00:00

  • Giant moving vortex mass in thick magnetic nanodots.

    abstract：:Magnetic vortex is one of the simplest topologically non-trivial textures in condensed matter physics. It is the ground state of submicron magnetic elements (dots) of different shapes: cylindrical, square etc. So far, the vast majority of the vortex dynamics studies were focused on thin dots with thickness 5-50 nm and...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13881

    authors： Guslienko KY,Kakazei GN,Ding J,Liu XM,Adeyeye AO

    更新日期：2015-09-10 00:00:00

  • Modular approach to customise sample preparation procedures for viral metagenomics: a reproducible protocol for virome analysis.

    abstract：:A major limitation for better understanding the role of the human gut virome in health and disease is the lack of validated methods that allow high throughput virome analysis. To overcome this, we evaluated the quantitative effect of homogenisation, centrifugation, filtration, chloroform treatment and random amplifica...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16532

    authors： Conceição-Neto N,Zeller M,Lefrère H,De Bruyn P,Beller L,Deboutte W,Yinda CK,Lavigne R,Maes P,Van Ranst M,Heylen E,Matthijnssens J

    更新日期：2015-11-12 00:00:00

  • The lag-phase during diauxic growth is a trade-off between fast adaptation and high growth rate.

    abstract：:Bi-phasic or diauxic growth is often observed when microbes are grown in a chemically defined medium containing two sugars (for example glucose and lactose). Typically, the two growth stages are separated by an often lengthy phase of arrested growth, the so-called lag-phase. Diauxic growth is usually interpreted as an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25191

    authors： Chu D,Barnes DJ

    更新日期：2016-04-29 00:00:00

  • Expression analysis of Cell wall invertase under abiotic stress conditions influencing specialized metabolism in Catharanthus roseus.

    abstract：:Catharanthus roseus is a commercial source for anti-cancer terpenoid indole alkaloids (TIAs: vincristine and vinblastine). Inherent levels of these TIAs are very low, hence research studies need to focus on enhancing their levels in planta. Since primary metabolism provides precursors for specialized-metabolism, eleva...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33415-w

    authors： Nishanth MJ,Sheshadri SA,Rathore SS,Srinidhi S,Simon B

    更新日期：2018-10-10 00:00:00

  • Vascularised endosteal bone tissue in armoured sauropod dinosaurs.

    abstract：:The presence of well-vascularised, endosteal bone in the medullary region of long bones of nonavian dinosaurs has been invoked as being homologous to medullary bone, a specialised bone tissue formed during ovulation in birds. However, similar bone tissues can result as a pathological response in modern birds and in no...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24858

    authors： Chinsamy A,Cerda I,Powell J

    更新日期：2016-04-26 00:00:00

  • Compact wideband plasmonic filter with flat-top transmission response based on corrugated metal-insulator-metal ring resonator.

    abstract：ABSTARCT:We demonstrate a novel route to control the filtering of spoof localized surface plasmons (LSPs) on the corrugated metal-insulator-metal (MIM) ring resonator. The spoof LSPs resonance modes can be effectively tuned to achieve broad passband (covering the quadrupole mode and the hexapole mode) by selecting prop...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-14708-y

    authors： Yang L,Zhou YJ,Zhang C,Xiao QX

    更新日期：2017-10-27 00:00:00

  • Arsenite-loaded nanoparticles inhibit PARP-1 to overcome multidrug resistance in hepatocellular carcinoma cells.

    abstract：:Hepatocellular carcinoma (HCC) is one of the highest incidences in cancers; however, traditional chemotherapy often suffers from low efficiency caused by drug resistance. Herein, we report an arsenite-loaded dual-drug (doxorubicin and arsenic trioxide, i.e., DOX and ATO) nanomedicine system (FeAsOx@SiO2-DOX, Combo NP)...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep31009

    authors： Liu H,Zhang Z,Chi X,Zhao Z,Huang D,Jin J,Gao J

    更新日期：2016-08-03 00:00:00

  • A map of the PGC-1α- and NT-PGC-1α-regulated transcriptional network in brown adipose tissue.

    abstract：:Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α play crucial roles in regulating cold-induced thermogenesis in brown adipose tissue (BAT). PGC-1α and NT-PGC-1α are highly induced by cold in BAT and subsequently bind to and coactivate many transcription factors to regulate expression of genes involv...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26244-4

    authors： Chang JS,Ghosh S,Newman S,Salbaum JM

    更新日期：2018-05-18 00:00:00

  • Association between Macular Thickness Profiles and Visual Function in Healthy Eyes: The Singapore Epidemiology of Eye Diseases (SEED) Study.

    abstract：:This study aimed to evaluate the association between optical coherence tomography (OCT)-measured retinal layer thickness parameters with clinical and patient-centred visual outcomes in healthy eyes. Participants aged 40 and above were recruited from the Singapore Epidemiology of Eye Diseases Study, a multi-ethnic popu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63063-y

    authors： Poh S,Tham YC,Chee ML,Dai W,Majithia S,Soh ZD,Fenwick EK,Tao Y,Thakur S,Rim TH,Sabanayagam C,Cheng CY

    更新日期：2020-04-09 00:00:00

  • Polychlorinated dibenzo-p-dioxins and dibenzofurans formed from sucralose at high temperatures.

    abstract：:Sucralose is a widely-used artificial high-intensity sweetener. Although doubts have been raised about the safety of sucralose by several researchers, it can still be found in a broad range of foods and beverages worldwide, including in baked goods. Sucralose may decompose at high temperatures, and participate in chlo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02946

    authors： Dong S,Liu G,Hu J,Zheng M

    更新日期：2013-10-15 00:00:00

  • In-situ detection based on the biofilm hydrophilicity for environmental biofilm formation.

    abstract：:A biofilm has a unique structure composed of microorganisms, extracellular polymeric substances (EPSs), etc., and it is layered on a substrate in water. In material science, it is important to detect the biofilm formed on a surface to prevent biofouling. EPSs, the major component of the biofilm, mainly consist of poly...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-44167-6

    authors： Tanaka N,Kogo T,Hirai N,Ogawa A,Kanematsu H,Takahara J,Awazu A,Fujita N,Haruzono Y,Ichida S,Tanaka Y

    更新日期：2019-05-30 00:00:00

  • Specification of jaw identity by the Hand2 transcription factor.

    abstract：:Acquisition of the lower jaw (mandible) was evolutionarily important for jawed vertebrates. In humans, syndromic craniofacial malformations often accompany jaw anomalies. The basic helix-loop-helix transcription factor Hand2, which is conserved among jawed vertebrates, is expressed in the neural crest in the mandibula...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28405

    authors： Funato N,Kokubo H,Nakamura M,Yanagisawa H,Saga Y

    更新日期：2016-06-22 00:00:00

  • ROS induced distribution of mitochondria to filopodia by Myo19 depends on a class specific tryptophan in the motor domain.

    abstract：:The role of the actin cytoskeleton in relation to mitochondria function and dynamics is only recently beginning to be recognized. Myo19 is an actin-based motor that is bound to the outer mitochondrial membrane and promotes the localization of mitochondria to filopodia in response to glucose starvation. However, how gl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-11002-9

    authors： Shneyer BI,Ušaj M,Wiesel-Motiuk N,Regev R,Henn A

    更新日期：2017-09-14 00:00:00

  • A new perspective on the 137Cs retention mechanism in surface soils during the early stage after the Fukushima nuclear accident.

    abstract：:The Fukushima Daiichi nuclear power plant accident caused serious radiocesium (137Cs) contamination of the soil in multiple terrestrial ecosystems. Soil is a complex system where minerals, organic matter, and microorganisms interact with each other; therefore, an improved understanding of the interactions of 137Cs wit...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43499-7

    authors： Koarashi J,Nishimura S,Atarashi-Andoh M,Muto K,Matsunaga T

    更新日期：2019-05-07 00:00:00

  • Tethered primary hepatocyte spheroids on polystyrene multi-well plates for high-throughput drug safety testing.

    abstract：:Hepatocyte spheroids are useful models for mimicking liver phenotypes in vitro because of their three-dimensionality. However, the lack of a biomaterial platform which allows the facile manipulation of spheroid cultures on a large scale severely limits their application in automated high-throughput drug safety testing...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61699-4

    authors： Tasnim F,Singh NH,Tan EKF,Xing J,Li H,Hissette S,Manesh S,Fulwood J,Gupta K,Ng CW,Xu S,Hill J,Yu H

    更新日期：2020-03-16 00:00:00