Arsenite-loaded nanoparticles inhibit PARP-1 to overcome multidrug resistance in hepatocellular carcinoma cells.

abstract：:We reconstructed the radiological dose for birds observed at 300 census sites in the 50-km northwest area affected by the accident at the Fukushima Daiichi nuclear power plant over 2011-2014. Substituting the ambient dose rate measured at the census points (from 0.16 to 31 μGy h(-1)) with the dose rate reconstructed f...

journal_title：Scientific reports

authors： Garnier-Laplace J,Beaugelin-Seiller K,Della-Vedova C,Métivier JM,Ritz C,Mousseau TA,Møller AP

更新日期：2015-11-16 00:00:00

abstract：:Nitrogen-doped graphene oxides (GO:Nx) were synthesized by a partial reduction of graphene oxide (GO) using urea [CO(NH2)2]. Their electronic/bonding structures were investigated using X-ray absorption near-edge structure (XANES), valence-band photoemission spectroscopy (VB-PES), X-ray emission spectroscopy (XES) and ...

journal_title：Scientific reports

authors： Chuang CH,Ray SC,Mazumder D,Sharma S,Ganguly A,Papakonstantinou P,Chiou JW,Tsai HM,Shiu HW,Chen CH,Lin HJ,Guo J,Pong WF

更新日期：2017-02-10 00:00:00

abstract：:Although prolactin (PRL) and its receptor (PRLR) have been detected in glioblastoma multiforme (GBM), their role in its pathogenesis remains unclear. Our aim was to explore their contribution in GBM pathogenesis. We detected PRL and PRLR in all GBM cell lines tested. PRLR activation or overexpression using plasmid tra...

journal_title：Scientific reports

authors： Asad AS,Nicola Candia AJ,Gonzalez N,Zuccato CF,Abt A,Orrillo SJ,Lastra Y,De Simone E,Boutillon F,Goffin V,Seilicovich A,Pisera DA,Ferraris MJ,Candolfi M

更新日期：2019-12-20 00:00:00

abstract：:Pyrophosphate (PPi) is produced by anabolic reactions and serves as an energy donor in the cytosol of plant cells; however, its accumulation to toxic levels disrupts several common biosynthetic pathways and is lethal. Before acquiring photosynthetic capacity, young seedlings must endure a short but critical heterotrop...

journal_title：Scientific reports

authors： Ferjani A,Kawade K,Asaoka M,Oikawa A,Okada T,Mochizuki A,Maeshima M,Hirai MY,Saito K,Tsukaya H

更新日期：2018-10-02 00:00:00

abstract：:Endothelial cells are spatially close to osteoblasts and regulate osteogenesis. Moreover, they are sensitive to mechanical stimuli, therefore we hypothesized that they are implicated in the regulation of bone metabolism during unloading. Conditioned media from endothelial cells (EC-CM) subjected to simulated micrograv...

journal_title：Scientific reports

authors： Veeriah V,Zanniti A,Paone R,Chatterjee S,Rucci N,Teti A,Capulli M

更新日期：2016-07-19 00:00:00

abstract：:Protein degradation is an essential mechanism for maintaining proteostasis in response to internal and external perturbations. Disruption of this process is implicated in many human diseases. We present a new technique, QUAD (Quantification of Azidohomoalanine Degradation), to analyze the global degradation rates in t...

journal_title：Scientific reports

authors： McClatchy DB,Martínez-Bartolomé S,Gao Y,Lavallée-Adam M,Yates JR 3rd

更新日期：2020-09-29 00:00:00

abstract：:Selenium and selenium nanoparticles (SeNPs) are extensively used in biomedicine, electronics and some other industrial applications. The bioproduction of SeNPs is gaining interest as a green method to manufacture these biotechnologically relevant products. Several microorganisms have been used for the production of Se...

journal_title：Scientific reports

authors： Fernández-Llamosas H,Castro L,Blázquez ML,Díaz E,Carmona M

更新日期：2017-11-22 00:00:00

abstract：:A new, extraordinary palaeontinid Hallakkungis amisanus Nam, Wang &Szwedo, gen. et sp. nov., from the Upper Triassic of the Amisan Formation in Boryeong City, Korea is described. It is the first Palaeontinidae from Korea. The newly described taxon displays a mosaic of characters present in presumed ancestors of this i...

journal_title：Scientific reports

authors： Nam KS,Wang Y,Ren D,Kim JH,Szwedo J

更新日期：2017-01-18 00:00:00

abstract：:The apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) family proteins bind RNA and single-stranded DNA, and create C-to-U base modifications through cytidine deaminase activity. APOBEC3G restricts human immunodeficiency virus 1 (HIV-1) infection by creating hypermutations in proviral DNA, while HIV-1-e...

journal_title：Scientific reports

authors： Chen R,Zhao X,Wang Y,Xie Y,Liu J

更新日期：2017-01-18 00:00:00

abstract：:In many cancers, incidence, treatment efficacy and overall prognosis vary between geographic populations. Studies disentangling the contributing factors may help in both understanding cancer biology and tailoring therapeutic interventions. Ancestry estimation in such studies should preferably be driven by genomic data...

journal_title：Scientific reports

authors： Huang Q,Baudis M

更新日期：2020-03-16 00:00:00

abstract：:Video game play induces a generalized recovery of a range of spatial visual functions in the amblyopic brain. Here we ask whether video game play also alters temporal processing in the amblyopic brain. When visual targets are presented in rapid succession, correct identification of the first target (T1) can interfere ...

journal_title：Scientific reports

authors： Li RW,Ngo CV,Levi DM

更新日期：2015-02-26 00:00:00

abstract：:The significance of antibodies directed against paternal epitopes in the context of obstetric disorders is discussed controversially. In this study anti-HLA and anti-MIC-A antibodies were analysed in sera of women with uneventful pregnancy (n = 101), preeclampsia (PE, n = 55) and gestational diabetes (GDM, n = 36) usi...

journal_title：Scientific reports

authors： Küssel L,Herkner H,Wahrmann M,Eskandary F,Doberer K,Binder J,Pateisky P,Zeisler H,Böhmig GA,Bond G

更新日期：2017-10-19 00:00:00

abstract：:Porosity and permeability are the key factors in assessing the hydrocarbon productivity of unconventional (shale) reservoirs, which are complex in nature due to their heterogeneous mineralogy and poorly connected nano- and micro-pore systems. Experimental efforts to measure these petrophysical properties posse many li...

journal_title：Scientific reports

authors： Goral J,Panja P,Deo M,Andrew M,Linden S,Schwarz JO,Wiegmann A

更新日期：2020-01-08 00:00:00

abstract：:Glucosinolates (GSLs) and their hydrolysis products present in Brassicales play important roles in plants against herbivores and pathogens as well as in the protection of human health. To elucidate the molecular mechanisms underlying the formation of species-specific GSLs and their hydrolysed products in Raphanus sati...

journal_title：Scientific reports

authors： Wang J,Qiu Y,Wang X,Yue Z,Yang X,Chen X,Zhang X,Shen D,Wang H,Song J,He H,Li X

更新日期：2017-11-22 00:00:00

abstract：:Two of the most common nonhuman animals that interact with humans are domestic dogs (Canis familiaris) and cats (Felis catus). In contrast to dogs, the ability of domestic cats to communicate with humans has not been explored thoroughly. We used a habituation-dishabituation method to investigate whether domestic cats ...

journal_title：Scientific reports

authors： Saito A,Shinozuka K,Ito Y,Hasegawa T

更新日期：2019-04-04 00:00:00

abstract：:Unexpectedly large ocean waves or 'rogues' are sometimes claimed to be the cause of damage to ships at sea and to offshore structures. While wind-driven wave models are capable of predicting the average characteristics of waves, the maximum height of rogues that may occur is yet unknown. Rogues form in the open ocean ...

journal_title：Scientific reports

authors： Donelan MA,Magnusson AK

更新日期：2017-03-08 00:00:00

abstract：:Advances in Big Data make it possible to make short-term forecasts for market trends from previously unexplored sources. Trading strategies were recently developed by exploiting a link between the online search activity of certain terms semantically related to finance and market movements. Here we build on these earli...

journal_title：Scientific reports

authors： Zhong X,Raghib M

更新日期：2019-09-18 00:00:00

abstract：:Upon illumination, a dielectric microsphere (μS) can generate a photonic nanojet (PNJ), which plays a role in the super-resolution imaging of a sample placed in the μS's immediate proximity. Recent microscopy implementations pioneered this concept but, despite the experimental characterization and theoretical modeling...

journal_title：Scientific reports

authors： Migliozzi D,Gijs MAM,Huszka G

更新日期：2018-10-12 00:00:00

abstract：:Natural history collections are often plagued by missing or inaccurate metadata for collection items, particularly for specimens that are difficult to verify or rare. Avian eggshell in particular can be challenging to identify due to extensive morphological ambiguity among taxa. Species identifications can be improved...

journal_title：Scientific reports

authors： Grealy A,Langmore NE,Joseph L,Holleley CE

更新日期：2021-01-15 00:00:00

abstract：:On-surface reactions based on Ullmann coupling are known to proceed on coinage-metal substrates (e.g. Au, Ag, Cu), with the chemistry of the surface strongly influencing the reaction progression. In addition, the topography of the surface may be expected to affect the local adsorption geometry of the reactants as well...

journal_title：Scientific reports

authors： Judd CJ,Haddow SL,Champness NR,Saywell A

更新日期：2017-11-06 00:00:00

abstract：:The nonsynonymous SCN10A single nucleotide polymorphism (SNP) rs6795970 has been reported to associate with PR interval and atrial fibrillation (AF) and in strong linkage disequilibrium (LD) with the AF-associated SNP rs6800541. In this study, we investigated whether rs6795970 polymorphisms are associated with AF recu...

journal_title：Scientific reports

authors： Wu H,Xu J,Chen S,Zhou G,Qi B,Wei Y,Hu E,Tang D,Chen G,Li H,Zhao L,Shi Y,Liu S

更新日期：2017-03-10 00:00:00

abstract：:The nutrient ecological stoichiometry of plants and soil is important for the growth and dynamics of species, but the stoichiometric relationships among leaf, litter, and soil remain poorly understood. We analyzed the carbon (C), nitrogen (N), and phosphorus (P) stoichiometry of the leaves, litter, and soil for 31 spe...

journal_title：Scientific reports

authors： Zhang G,Zhang P,Peng S,Chen Y,Cao Y

更新日期：2017-09-18 00:00:00

abstract：:Visual loss caused by retinopathy of prematurity (ROP) will be prevented if treatment-requiring ROP (TR-ROP) can be predicted. In this retrospective study including 418 infants with ≤32 weeks of gestational age (GA) and/or ≤1500 grams of birthweight, we attempted to identify useful predictors. We also examined the eff...

journal_title：Scientific reports

authors： Arima M,Tsukamoto S,Fujiwara K,Murayama M,Fujikawa K,Sonoda KH

更新日期：2017-06-20 00:00:00

abstract：:The fine-tuning of gene expression contributes to both basic science and applications. Here, we develop a novel gene expression technology termed CRITGI (CRISPR/Transposon gene integration). CRITGI uses CRISPR/Cas9 to integrate multiple copies of the plasmid pTy1 into Ty1 loci, budding yeast retrotransposons. The pTy1...

journal_title：Scientific reports

authors： Hanasaki M,Masumoto H

更新日期：2019-10-25 00:00:00

abstract：:Colloidal based films have been widely developed for a wide range of applications including chemical and electrical barrier coatings, photonic materials, biomaterials, and pharmaceutical oral drug delivery. Many previous studies investigate methods to generate uniformity or desired stratification of the final componen...

journal_title：Scientific reports

authors： Kaewpetch T,Gilchrist JF

更新日期：2020-06-24 00:00:00

abstract：:Myocyte Enhancer Factor 2 (MEF2) mediates cardiac remodelling in heart failure (HF) and is also a target of β-adrenergic signalling, a front-line treatment for HF. We identified global gene transcription networks involved in HF with and without β-blocker treatment. Experimental HF by transverse aortic constriction (TA...

journal_title：Scientific reports

authors： Tobin SW,Hashemi S,Dadson K,Turdi S,Ebrahimian K,Zhao J,Sweeney G,Grigull J,McDermott JC

更新日期：2017-06-30 00:00:00

abstract：:An intensified and continuous West Nile virus (WNV) spread across northern Italy has been observed since 2008, which caused more than one hundred reported human infections until 2016. Veneto is one of the Italian regions where WNV is considered endemic, and the greatest intensity of circulation was observed during 201...

journal_title：Scientific reports

authors： Marini G,Rosà R,Pugliese A,Rizzoli A,Rizzo C,Russo F,Montarsi F,Capelli G

更新日期：2018-09-18 00:00:00

abstract：:We conducted two online surveys about antibiotics targeted at the Japanese general population in March 2017 and February 2018. In total, 6,982 participants completed the questionnaire. Factors associated with knowledge of antibiotics, knowledge of antimicrobial resistance (AMR) and appropriate behavioural changes were...

journal_title：Scientific reports

authors： Tsuzuki S,Fujitsuka N,Horiuchi K,Ijichi S,Gu Y,Fujitomo Y,Takahashi R,Ohmagari N

更新日期：2020-02-26 00:00:00

abstract：:Ball-milling utilizes mechanical stress to modify properties of carbon nanotubes (CNTs) including size, capping, and functionalization. Ball-milling, however, may introduce structural defects resulting in altered CNT-biomolecule interactions. Nanomaterial-biomolecule interactions result in the formation of the biocoro...

journal_title：Scientific reports

authors： Raghavendra AJ,Fritz K,Fu S,Brown JM,Podila R,Shannahan JH

更新日期：2017-08-16 00:00:00

abstract：:The causes of the severest crisis in the history of life around the Permian-Triassic boundary (PTB) remain controversial. Here we report that the latest Permian alluvial plains in Shanxi, North China, went through a rapid transition from meandering rivers to braided rivers and aeolian systems. Soil carbonate carbon is...

journal_title：Scientific reports

authors： Zhu Z,Liu Y,Kuang H,Benton MJ,Newell AJ,Xu H,An W,Ji S,Xu S,Peng N,Zhai Q

更新日期：2019-11-14 00:00:00