当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > On the near-wall accumulation of injectable particles in the microcirculation: smaller is not better.

On the near-wall accumulation of injectable particles in the microcirculation: smaller is not better.

Abstract：

:Although most nanofabrication techniques can control nano/micro particle (NMP) size over a wide range, the majority of NMPs for biomedical applications exhibits a diameter of ~100 nm. Here, the vascular distribution of spherical particles, from 10 to 1,000 nm in diameter, is studied using intravital microscopy and computational modeling. Small NMPs (≤100 nm) are observed to move with Red Blood Cells (RBCs), presenting an uniform radial distribution and limited near-wall accumulation. Larger NMPs tend to preferentially accumulate next to the vessel walls, in a size-dependent manner (~70% for 1,000 nm NMPs). RBC-NMP geometrical interference only is responsible for this behavior. In a capillary flow, the effective radial dispersion coefficient of 1,000 nm particles is ~3-fold larger than Brownian diffusion. This suggests that sub-micron particles could deposit within diseased vascular districts more efficiently than conventional nanoparticles.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Lee TR,Choi M,Kopacz AM,Yun SH,Liu WK,Decuzzi P

doi

10.1038/srep02079

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

2079

issn

2045-2322

pii

srep02079

journal_volume

3

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Triplex real-time PCR--an improved method to detect a wide spectrum of mitochondrial DNA deletions in single cells.

    abstract：:Mitochondrial DNA (mtDNA) mutations are commonly found in the skeletal muscle of patients with mitochondrial disease, inflammatory myopathies and sarcopenia. The majority of these mutations are mtDNA deletions, which accumulate to high levels in individual muscle fibres causing a respiratory defect. Most mtDNA deletio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep09906

    authors： Rygiel KA,Grady JP,Taylor RW,Tuppen HA,Turnbull DM

    更新日期：2015-05-19 00:00:00

  • Methylation patterns of the IFN-γ gene in cervical cancer tissues.

    abstract：OBJECTIVE:To explore the relationship between methylation of interferon gamma (IFN-γ) gene and tumorigenesis in cervical cancer tissues, the biopsy specimens of cervical cancer and cervical intraepithelial neoplasia (CIN) (I-III) patients as well as normal controls were collected and analyzed. METHODS:The methylation ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06331

    authors： Ma D,Jiang C,Hu X,Liu H,Li Q,Li T,Yang Y,Li O

    更新日期：2014-09-11 00:00:00

  • Local adaptation to temperature and precipitation in naturally fragmented populations of Cephalotaxus oliveri, an endangered conifer endemic to China.

    abstract：:Cephalotaxus oliveri is an endangered tertiary relict conifer endemic to China. The species survives in a wide range from west to east with heterogeneous climatic conditions. Precipitation and temperature are main restrictive factors for distribution of C. oliveri. In order to comprehend the mechanism of adaptive evol...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25031

    authors： Wang T,Wang Z,Xia F,Su Y

    更新日期：2016-04-26 00:00:00

  • Functional and morphological changes of the retinal vessels in Alzheimer's disease and mild cognitive impairment.

    abstract：:Imaging and histopathological studies have demonstrated that structural changes of the retina affect subjects with Alzheimer's disease (AD) or mild cognitive impairment (MCI). The aim of this study was to quantitatively investigate the retinal vessels in these disorders, using dynamic vessel analyzer (DVA) and optical...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37271-6

    authors： Querques G,Borrelli E,Sacconi R,De Vitis L,Leocani L,Santangelo R,Magnani G,Comi G,Bandello F

    更新日期：2019-01-11 00:00:00

  • 4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage.

    abstract：:Earlier studies showed that endogenous estrogens have neuroprotective effect against oxidative damage. The present study seeks to investigate the protective effect of various endogenous estrogen metabolites against oxidative neurotoxicity in vitro and in vivo. Using immortalized mouse hippocampal neuronal cells as an ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62984-y

    authors： Choi HJ,Lee AJ,Kang KS,Song JH,Zhu BT

    更新日期：2020-04-29 00:00:00

  • Individual-fMRI-approaches reveal cerebellum and visual communities to be functionally connected in obsessive compulsive disorder.

    abstract：:There is significant interest in understanding the pathophysiology of Obsessive-Compulsive Disorder (OCD) using resting-state fMRI (rsfMRI). Previous studies acknowledge abnormalities within and beyond the fronto-striato-limbic circuit in OCD that require further clarifications. However, limited information could be i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80346-6

    authors： Kashyap R,Eng GK,Bhattacharjee S,Gupta B,Ho R,Ho CSH,Zhang M,Mahendran R,Sim K,Chen SHA

    更新日期：2021-01-14 00:00:00

  • An approximate analytical solution of the Bethe equation for charged particles in the radiotherapeutic energy range.

    abstract：:Charged particles such as protons and carbon ions are an increasingly important tool in radiotherapy. There are however unresolved physics issues impeding optimal implementation, including estimation of dose deposition in non-homogeneous tissue, an essential aspect of treatment optimization. Monte Carlo (MC) methods c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10554-0

    authors： Grimes DR,Warren DR,Partridge M

    更新日期：2017-08-29 00:00:00

  • c-axis preferential orientation of hydroxyapatite accounts for the high wear resistance of the teeth of black carp (Mylopharyngodon piceus).

    abstract：:Biological armors such as mollusk shells have long been recognized and studied for their values in inspiring novel designs of engineering materials with higher toughness and strength. However, no material is invincible and biological armors also have their rivals. In this paper, our attention is focused on the teeth o...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23509

    authors： Fu J,He C,Xia B,Li Y,Feng Q,Yin Q,Shi X,Feng X,Wang H,Yao H

    更新日期：2016-03-22 00:00:00

  • Improving the anti-fouling property and permeate flux of hollow fiber composite nanofiltration membrane using β-cyclodextrin.

    abstract：:Hollow fiber composite NF membranes with improved anti-fouling property and water flux were prepared via interfacial polymerizationand layer-by-layer method using polyethylenimine (PEI), isophthaloyl dichloride (IPC), and β-cyclodextrin (β-CD). The chemical structures and the morphologies of the resultant NF membranes...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48908-5

    authors： He Y,Miao J,Jiang Z,Tu K,Yang H,Chen S,Zhang L,Zhang R

    更新日期：2019-08-27 00:00:00

  • Disequilibrium of fire-prone forests sets the stage for a rapid decline in conifer dominance during the 21st century.

    abstract：:The impacts of climatic changes on forests may appear gradually on time scales of years to centuries due to the long generation times of trees. Consequently, current forest extent may not reflect current climatic patterns. In contrast with these lagged responses, abrupt transitions in forests under climate change may ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24642-2

    authors： Serra-Diaz JM,Maxwell C,Lucash MS,Scheller RM,Laflower DM,Miller AD,Tepley AJ,Epstein HE,Anderson-Teixeira KJ,Thompson JR

    更新日期：2018-04-30 00:00:00

  • A gene browser of colorectal cancer with literature evidence and pre-computed regulatory information to identify key tumor suppressors and oncogenes.

    abstract：:Colorectal cancer (CRC) is a cancer of growing incidence that associates with a high mortality rate worldwide. There is a poor understanding of the heterogeneity of CRC with regard to causative genetic mutations and gene regulatory mechanisms. Previous studies have identified several susceptibility genes in small-scal...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30624

    authors： Zhao M,Liu Y,Huang F,Qu H

    更新日期：2016-08-01 00:00:00

  • Optimal Universal Uncertainty Relations.

    abstract：:We study universal uncertainty relations and present a method called joint probability distribution diagram to improve the majorization bounds constructed independently in [Phys. Rev. Lett. 111, 230401 (2013)] and [J. Phys. A. 46, 272002 (2013)]. The results give rise to state independent uncertainty relations satisfi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35735

    authors： Li T,Xiao Y,Ma T,Fei SM,Jing N,Li-Jost X,Wang ZX

    更新日期：2016-10-24 00:00:00

  • The efficacy and safety of docetaxel plus thalidomide vs. docetaxel alone in patients with androgen-independent prostate cancer: a systematic review.

    abstract：:The aim of this systematic review was taken to investigate the efficacy and safety of docetaxel plus thalidomide vs. docetaxel alone for treating androgen-independent prostate cancer (AIPC). Data were collected from different databases independently by three researchers according to the pre-defined inclusion and exclu...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析,评审

    doi：10.1038/srep04818

    authors： Chen L,Qiu X,Wang R,Xie X

    更新日期：2014-04-28 00:00:00

  • Arsenic resistance strategy in Pantoea sp. IMH: Organization, function and evolution of ars genes.

    abstract：:Pantoea sp. IMH is the only bacterium found in genus Pantoea with a high As resistance capacity, but its molecular mechanism is unknown. Herein, the organization, function, and evolution of ars genes in IMH are studied starting with analysis of the whole genome. Two ars systems - ars1 (arsR1B1C1H1) and ars2 (arsR2B2C2...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep39195

    authors： Wang L,Zhuang X,Zhuang G,Jing C

    更新日期：2016-12-14 00:00:00

  • The m6A-methylase complex recruits TREX and regulates mRNA export.

    abstract：:N6-methyladenosine (m6A) is the most abundant internal modification of eukaryotic mRNA. This modification has previously been shown to alter the export kinetics for mRNAs though the molecular details surrounding this phenomenon remain poorly understood. Recruitment of the TREX mRNA export complex to mRNA is driven by ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-32310-8

    authors： Lesbirel S,Viphakone N,Parker M,Parker J,Heath C,Sudbery I,Wilson SA

    更新日期：2018-09-14 00:00:00

  • The use of radiocobalt as a label improves imaging of EGFR using DOTA-conjugated Affibody molecule.

    abstract：:Several anti-cancer therapies target the epidermal growth factor receptor (EGFR). Radionuclide imaging of EGFR expression in tumours may aid in selection of optimal cancer therapy. The 111In-labelled DOTA-conjugated ZEGFR:2377 Affibody molecule was successfully used for imaging of EGFR-expressing xenografts in mice. A...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05700-7

    authors： Garousi J,Andersson KG,Dam JH,Olsen BB,Mitran B,Orlova A,Buijs J,Ståhl S,Löfblom J,Thisgaard H,Tolmachev V

    更新日期：2017-07-20 00:00:00

  • Using stable isotopes to analyse extinction risks and reintroduction opportunities of native species in invaded ecosystems.

    abstract：:Invasive non-native species have pervasive impacts on native biodiversity, including population extirpations and species extinctions. Identifying reasons why a population of a native species is extirpated following an invasion often relies on literature-based results of anecdotal observations. The well-established sch...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-78328-9

    authors： Haubrock PJ,Balzani P,Britton JR,Haase P

    更新日期：2020-12-10 00:00:00

  • Quantitative blood flow velocity imaging using laser speckle flowmetry.

    abstract：:Laser speckle flowmetry suffers from a debated quantification of the inverse relation between decorrelation time (τc) and blood flow velocity (V), i.e. 1/τc = αV. Using a modified microcirculation imager (integrated sidestream dark field - laser speckle contrast imaging [SDF-LSCI]), we experimentally investigate on th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25258

    authors： Nadort A,Kalkman K,van Leeuwen TG,Faber DJ

    更新日期：2016-04-29 00:00:00

  • Facile Synthesis of Cadmium-Free Zn-In-S:Ag/ZnS Nanocrystals for Bio-Imaging.

    abstract：:High quality cadmium-free Zn-In-S:Ag doped-nanocrystals (d-NCs) were synthesized via a simple one-step noninjection route using silver nitrate, indium acetate, zinc acetate, oleylamine, S powder and 1-dodecanethiol as starting materials in an organic phase. The size and optical properties can be effectively tailored b...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep24459

    authors： Xuan TT,Liu JQ,Yu CY,Xie RJ,Li HL

    更新日期：2016-04-14 00:00:00

  • Effectiveness of hysteroscopic resection of a uterine caesarean niche can be predicted: a prospective cohort study.

    abstract：:This study aimed to develop and validate a model for the preoperative prediction of the effectiveness of hysteroscopic resection of a uterine cesarean niche in patients with postmenstrual spotting. The predictive model was developed in a primary prospective cohort consisting of 208 patients with niche treated by hyste...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-74622-8

    authors： Zhu Q,He X,Jiang L,Liang G,Zhu C,Pan H,Zhang J,Huirne JA

    更新日期：2020-10-15 00:00:00

  • Identification of Symmetrical RNA Editing Events in the Mitochondria of Salvia miltiorrhiza by Strand-specific RNA Sequencing.

    abstract：:Salvia miltiorrhiza is one of the most widely-used medicinal plants. Here, we systematically analyzed the RNA editing events in its mitochondria. We developed a pipeline using REDItools to predict RNA editing events from stand-specific RNA-Seq data. The predictions were validated using reverse transcription, RT-PCR am...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep42250

    authors： Wu B,Chen H,Shao J,Zhang H,Wu K,Liu C

    更新日期：2017-02-10 00:00:00

  • Precursor and mature NGF live tracking: one versus many at a time in the axons.

    abstract：:The classical view of nerve growth factor (NGF) action in the nervous system is linked to its retrograde axonal transport. However, almost nothing is known on the trafficking properties of its unprocessed precursor proNGF, characterized by different and generally opposite biological functions with respect to its matur...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20272

    authors： De Nadai T,Marchetti L,Di Rienzo C,Calvello M,Signore G,Di Matteo P,Gobbo F,Turturro S,Meucci S,Viegi A,Beltram F,Luin S,Cattaneo A

    更新日期：2016-02-01 00:00:00

  • A cytosolic carbonic anhydrase molecular switch occurs in the gills of metamorphic sea lamprey.

    abstract：:Carbonic anhydrase plays a key role in CO2 transport, acid-base and ion regulation and metabolic processes in vertebrates. While several carbonic anhydrase isoforms have been identified in numerous vertebrate species, basal lineages such as the cyclostomes have remained largely unexamined. Here we investigate the repe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep33954

    authors： Ferreira-Martins D,McCormick SD,Campos A,Lopes-Marques M,Osório H,Coimbra J,Castro LF,Wilson JM

    更新日期：2016-10-05 00:00:00

  • Radiomic features and multilayer perceptron network classifier: a robust MRI classification strategy for distinguishing glioblastoma from primary central nervous system lymphoma.

    abstract：:We aimed to establish a high-performing and robust classification strategy, using magnetic resonance imaging (MRI), along with combinations of feature extraction and selection in human and machine learning using radiomics or deep features by employing a small dataset. Using diffusion and contrast-enhanced T1-weighted ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-42276-w

    authors： Yun J,Park JE,Lee H,Ham S,Kim N,Kim HS

    更新日期：2019-04-05 00:00:00

  • Hybrid sequencing and map finding (HySeMaFi): optional strategies for extensively deciphering gene splicing and expression in organisms without reference genome.

    abstract：:Using second-generation sequencing (SGS) RNA-Seq strategies, extensive alterative splicing prediction is impractical and high variability of isoforms expression quantification is inevitable in organisms without true reference dataset. we report the development of a novel analysis method, termed hybrid sequencing and m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43793

    authors： Ning G,Cheng X,Luo P,Liang F,Wang Z,Yu G,Li X,Wang D,Bao M

    更新日期：2017-03-08 00:00:00

  • IgE-binding residues analysis of the house dust mite allergen Der p 23.

    abstract：:House dust mites (HDMs) are one of the major causes of allergies in the world. The group 23 allergen, Der p 23, from Dermatophagoides pteronyssinus, is a major allergen amongst HDM-sensitized individuals. This study aims to determine the specific immunoglobulin E (sIgE) binding frequency and IgE-binding residues of re...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-79820-y

    authors： Pang SL,Matta SA,Sio YY,Ng YT,Say YH,Ng CL,Chew FT

    更新日期：2021-01-13 00:00:00

  • Genomic signatures of local adaptation reveal source-sink dynamics in a high gene flow fish species.

    abstract：:Understanding source-sink dynamics is important for conservation management, particularly when climatic events alter species' distributions. Following a 2011 'marine heatwave' in Western Australia, we observed high recruitment of the endemic fisheries target species Choerodon rubescens, towards the cooler (southern) e...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-09224-y

    authors： Cure K,Thomas L,Hobbs JA,Fairclough DV,Kennington WJ

    更新日期：2017-08-17 00:00:00

  • The metabolic flux regulation of Klebsiella pneumoniae based on quorum sensing system.

    abstract：:Quorum-sensing (QS) systems exist universally in bacteria to regulate multiple biological functions. Klebsiella pneumoniae, an industrially important bacterium that produces bio-based chemicals such as 2,3-butanediol and acetoin, can secrete a furanosyl borate diester (AI-2) as the signalling molecule mediating a QS s...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep38725

    authors： Sun S,Zhang H,Lu S,Lai C,Liu H,Zhu H

    更新日期：2016-12-07 00:00:00

  • Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol.

    abstract：:Activation of G protein-gated inwardly rectifying potassium (GIRK) channels leads to a hyperpolarization of the neuron's membrane potential, providing an important component of inhibition in the brain. In addition to the canonical G protein-activation pathway, GIRK channels are activated by small molecules but less is...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04681-x

    authors： Glaaser IW,Slesinger PA

    更新日期：2017-07-04 00:00:00

  • Southeastern China Boreal Winter Precipitation Anomalies are Dependent on Intensity of El Niño.

    abstract：:Previous studies reported that boreal winter precipitation in southeastern China (SEC) tends to increase during El Niño. In this study, however, we find that most weak El Niño events are accompanied by below-normal precipitation in SEC, although strong El Niño events are accompanied by above-normal precipitation in SE...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53496-5

    authors： Ke Z,Jiang X,Wang Z

    更新日期：2019-11-22 00:00:00