Abstract：
:Aluminium adjuvants remain the most widely used and effective adjuvants in vaccination and immunotherapy. Herein, the particle size distribution (PSD) of aluminium oxyhydroxide and aluminium hydroxyphosphate adjuvants was elucidated in attempt to correlate these properties with the biological responses observed post vaccination. Heightened solubility and potentially the generation of Al(3+) in the lysosomal environment were positively correlated with an increase in cell mortality in vitro, potentially generating a greater inflammatory response at the site of simulated injection. The cellular uptake of aluminium based adjuvants (ABAs) used in clinically approved vaccinations are compared to a commonly used experimental ABA, in an in vitro THP-1 cell model. Using lumogallion as a direct-fluorescent molecular probe for aluminium, complemented with transmission electron microscopy provides further insight into the morphology of internalised particulates, driven by the physicochemical variations of the ABAs investigated. We demonstrate that not all aluminium adjuvants are equal neither in terms of their physical properties nor their biological reactivity and potential toxicities both at the injection site and beyond. High loading of aluminium oxyhydroxide in the cytoplasm of THP-1 cells without immediate cytotoxicity might predispose this form of aluminium adjuvant to its subsequent transport throughout the body including access to the brain.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Mold M,Shardlow E,Exley Cdoi
10.1038/srep31578subject
Has Abstractpub_date
2016-08-12 00:00:00pages
31578issn
2045-2322pii
srep31578journal_volume
6pub_type
杂志文章abstract：:End stage renal disease (ESRD) patients depend on hemodialysis (HD) as a life-sustaining treatment, but HD membrane properties play a critical role in blood activation during HD and can lead to severe patient outcomes. This study reports on a series of investigations on the common clinical HD membranes available in Ca...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71755-8
更新日期：2020-09-09 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-62443-8
更新日期：2020-03-24 00:00:00
abstract：:The GntR family transcription regulator HpaR1 identified from Xanthomonas campestris pv. campestris has been previously shown to positively regulate the genes responsible for hypersensitive reaction and pathogenicity and to autorepress its own expression. Here, we demonstrated that HpaR1 is a global regulator that pos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19862
更新日期：2016-01-28 00:00:00
abstract：:Mercury pollution in soil poses serious risks to human health through consumption of contaminated vegetables. We used a meta-analysis to examine the mercury enrichment ability of different vegetables and the main factors affecting mercury uptake. We drew the following conclusions. (1) Plants with a lower bioconcentrat...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-19519-3
更新日期：2018-01-19 00:00:00
abstract：:An analysis of Candida albicans ABC transporters identified conserved related α-helical sequence motifs immediately C-terminal of each Walker A sequence. Despite the occurrence of these motifs in ABC subfamilies of other yeasts and higher eukaryotes, their roles in protein function remained unexplored. In this study w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27132
更新日期：2016-06-02 00:00:00
abstract：:By means of first principles calculation and experiments, a detailed mechanism is proposed to include the stages of slip, adjustment, and expansion for the HCP → FCC phase transformation with the prismatic relation of [Formula: see text] and [Formula: see text] in titanium. It is revealed that the formation of four FC...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20257-9
更新日期：2018-01-31 00:00:00
abstract：:Most studies on buoyant microplastics in the marine environment rely on sea surface sampling. Consequently, microplastic amounts can be underestimated, as turbulence leads to vertical mixing. Models that correct for vertical mixing are based on limited data. In this study we report measurements of the depth profile of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33882
更新日期：2016-10-10 00:00:00
abstract：:Survival of many species, from insects and birds to human and non-human mammals, requires synchronized activity. Among humans, synchrony occurs even at the level of autonomic functioning; people interacting often show mutual, simultaneous changes in activity of the sympathetic or parasympathetic branches of the autono...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44667-5
更新日期：2019-06-03 00:00:00
abstract：:This paper proposes a novel approach to sulfur removal by adding zinc during the digestion process. The effects of zinc dosage on the concentrations of different valence sulfur in sodium aluminate solution were investigated at length to find that high-valence sulfur (S2O32-, SO32-, SO42-) concentration in sodium alumi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17499-4
更新日期：2017-12-07 00:00:00
abstract：:In patients with atherosclerotic cardiovascular disease (ASCVD) under statin treatment, the influence of on-treatment level of high-density lipoprotein cholesterol (HDL-C) on cardiovascular (CV) events is controversial. Statin-treated patients were selected from the Taiwanese Secondary Prevention for patients with Ath...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78828-8
更新日期：2020-12-14 00:00:00
abstract：:Two-dimensional (2D) porous carbon AC-SPN-3 possessing of amazing high micropore volume ratio of 83% and large surface area of about 1069 m(2) g(-1) is high-yield obtained by pyrolysis of natural waste Pistachio nutshells with KOH activation. The AC-SPN-3 has a curved 2D lamellar morphology with the thickness of each ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05545
更新日期：2014-07-02 00:00:00
abstract：:The hypothalamic-pituitary-adrenal (HPA) axis regulates responses to internal and external stressors. Many patients diagnosed with conditions such as depression or anxiety also have hyperactivity of the HPA axis. Hyper-stimulation of the HPA axis results in sustained elevated levels of glucocorticoids which impair neu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39867-y
更新日期：2019-03-01 00:00:00
abstract：:Several studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential as...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep15300
更新日期：2015-10-16 00:00:00
abstract：:Psoriatic skin differs distinctly from normal skin by its thickened epidermis. Most gene expression comparisons utilize full-thickness biopsies, with substantial amount of dermis. We assayed the transcriptomes of normal, lesional, and non-lesional psoriatic epidermis, sampled as split-thickness skin grafts, with 5'-en...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22745
更新日期：2016-03-15 00:00:00
abstract：:DNA N6-methyldeoxyadenosine (6 mA) modifications were first found more than 60 years ago but were thought to be only widespread in prokaryotes and unicellular eukaryotes. With the development of high-throughput sequencing technology, 6 mA modifications were found in different multicellular eukaryotes by using experime...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49430-4
更新日期：2019-09-11 00:00:00
abstract：:Carbon uptake by terrestrial ecosystems is increasing along with the rising of atmospheric CO2 concentration. Embedded in this trend, recent studies suggested that the interannual variability (IAV) of global carbon fluxes may be dominated by semi-arid ecosystems, but the underlying mechanisms of this high variability ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39748
更新日期：2016-12-23 00:00:00
abstract：:Polymorphisms contribute to inter-individual differences and show a promising predictive role for chemotherapy-related toxicity in colon cancer (CC). TOSCA is a multicentre, randomized, non-inferiority, phase III study conducted in high-risk stage II/stage III CC patients treated with 6 vs 3 months of FOLFOX-4 or XELO...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-019-47627-1
更新日期：2019-08-08 00:00:00
abstract：:Feynman once asked physicists to build better electron microscopes to be able to watch biology at work. While electron microscopes can now provide atomic resolution, electron beam induced specimen damage precludes high resolution imaging of sensitive materials, such as single proteins or polymers. Here, we use simulat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01841-x
更新日期：2017-05-10 00:00:00
abstract：:The degree of tumor removal at surgery is a major factor in predicting outcome for ovarian cancer. A single multimodality agent that can be used with magnetic resonance (MR) for staging and pre-surgical planning, and with optical imaging to aid surgical removal of tumors, would present a new paradigm for ovarian cance...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38991
更新日期：2016-12-22 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-68522-0
更新日期：2020-07-10 00:00:00
abstract：:Pregnane X receptor (PXR) regulates glucose and lipid metabolism, but little is known of the nutritional regulation of PXR function. We investigated the genome wide effects of the nutritional status on the PXR mediated gene regulation in the liver. Mice were treated with a PXR ligand pregnenolone 16α-carbonitrile (PCN...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53101-9
更新日期：2019-11-13 00:00:00
abstract：:MUC5B rs35705950 (G/T) is strongly associated with idiopathic pulmonary fibrosis (IPF) and also contributes to the risk of interstitial lung disease (ILD) in rheumatoid arthritis (RA-ILD) and chronic hypersensitivity pneumonitis (CHP). Due to this, we evaluated the implication of MUC5B rs35705950 in antisynthetase syn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58400-0
更新日期：2020-01-29 00:00:00
abstract：:The annotation of protein function is a vital step to elucidate the essence of life at a molecular level, and it is also meritorious in biomedical and pharmaceutical industry. Developments of sequencing technology result in constant expansion of the gap between the number of the known sequences and their functions. Th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37179
更新日期：2016-11-16 00:00:00
abstract：:Ancestral stress can program stress sensitivity and health trajectories across multiple generations. While ancestral stress is uncontrollable to the filial generations, it is critical to identify therapies that overcome transgenerational programming. Here we report that prenatal stress in rats generates a transgenerat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37814
更新日期：2016-11-24 00:00:00
abstract：:Electroceutical wound dressings, especially those involving current flow with silver based electrodes, show promise for treating biofilm infections. However, their mechanism of action is poorly understood. We have developed an in vitro agar based model using a bioluminescent strain of Pseudomonas aeruginosa to measure...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37891-y
更新日期：2019-02-14 00:00:00
abstract：:In East Greenland, a dramatic increase of tuberculosis (TB) incidence has been observed in recent years. Classical genotyping suggests a genetically similar Mycobacterium tuberculosis (Mtb) strain population as cause, however, precise transmission patterns are unclear. We performed whole genome sequencing (WGS) of Mtb...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33180
更新日期：2016-09-12 00:00:00
abstract：:Prognostic biomarkers serve a variety of purposes in cancer treatment and research, such as prediction of cancer progression, and treatment eligibility. Despite growing interest in multi-omic data integration for defining prognostic biomarkers, validated methods have been slow to emerge. Given that breast cancer has b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23494-0
更新日期：2018-03-26 00:00:00
abstract：:Sugarcane (Saccharum spp. hybrids) is a potential lignocellulosic feedstock for biofuel production due to its exceptional biomass accumulation ability, high convertible carbohydrate content and a favorable energy input/output ratio. Genetic modification of biofuel traits to improve biomass conversion requires an under...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30033-4
更新日期：2018-08-02 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-28343-8
更新日期：2018-07-03 00:00:00
abstract：:Despite improvements in systemic therapy options for renal cancer, it remains one of the most drug-resistant malignancies. Interestingly, reports have shown that kahweol and cafestol, natural diterpenes extracted from coffee beans, exhibit anti-cancer activity. However, the multiple potential pharmacological actions o...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80302-4
更新日期：2021-01-12 00:00:00
