Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric.

abstract：:We discover and characterise strong quantum scars, or quantum eigenstates resembling classical periodic orbits, in two-dimensional quantum wells perturbed by local impurities. These scars are not explained by ordinary scar theory, which would require the existence of short, moderately unstable periodic orbits in the p...

journal_title：Scientific reports

authors： Luukko PJ,Drury B,Klales A,Kaplan L,Heller EJ,Räsänen E

更新日期：2016-11-28 00:00:00

abstract：:Increased activity of brown adipose tissue (BAT) activity in adults is thought to prevent obesity. Therefore, regulators of BAT activity might serve as anti-obesity therapy in future, but are not investigated thoroughly up to now. In our study, we assessed retrospectively the association of BAT activity with several e...

journal_title：Scientific reports

authors： Brendle C,Stefan N,Stef I,Ripkens S,Soekler M,la Fougère C,Nikolaou K,Pfannenberg C

更新日期：2019-02-13 00:00:00

abstract：:Heterocyclic amines (HCAs) are formed by cooking protein-rich foods, for instance, meat and fish, and are listed as possible human carcinogens. In the present study, the presence of five potential HCAs (IQ, MeIQ, MeIQx, 4,8-DiMeIQx, and PhIP) in cooked camel meat burgers was analyzed for the first time. The analysis w...

journal_title：Scientific reports

authors： Rizwan Khan M,Naushad M,Abdullah Alothman Z

更新日期：2017-05-10 00:00:00

abstract：:Irreversible electroporation (IRE) is a non-thermal ablation modality that has been shown to be safe and effective in its application to tumors that are close to risky areas. This study aims to assess the safety and efficacy of IRE for unresectable hilar cholangiocarcinoma. Nine patients from two medical centers in As...

journal_title：Scientific reports

authors： Hsiao CY,Yang PC,Li X,Huang KW

更新日期：2020-07-02 00:00:00

abstract：:Fundamental cell signaling mechanisms that regulate dynamic remodeling of the extracellular matrix (ECM) in mechanically loaded tissues are not yet clearly understood. Trabecular meshwork (TM) tissue in the eye is under constant mechanical stress and continuous remodeling of ECM is crucial to maintain normal aqueous h...

journal_title：Scientific reports

authors： Tellios N,Belrose JC,Tokarewicz AC,Hutnik C,Liu H,Leask A,Motolko M,Iijima M,Parapuram SK

更新日期：2017-04-11 00:00:00

abstract：:Kaposiform hemangioendothelioma (KHE) is a relatively rare vascular tumor with an aggressive and infiltrating nature. Previous studies have revealed an exclusive relationship between KHE and Kasabach-Merritt Phenomenon (KMP), which is associated with high morbidity and mortality. No universally accepted treatment moda...

journal_title：Scientific reports

authors： Wu HW,Wang X,Zhang L,Zhao HG,Wang YA,Su LX,Fan XD,Zheng JW

更新日期：2016-10-31 00:00:00

abstract：:The brain lacks a traditional lymphatic system for metabolite clearance. The existence of a "glymphatic system" where metabolites are removed from the brain's extracellular space by convective exchange between interstitial fluid (ISF) and cerebrospinal fluid (CSF) along the paravascular spaces (PVS) around cerebral bl...

journal_title：Scientific reports

authors： Kedarasetti RT,Drew PJ,Costanzo F

更新日期：2020-06-22 00:00:00

abstract：:Concussions carry devastating potential for cognitive, neurologic, and socio-emotional disease, but no objective test reliably identifies a concussion and its severity. A variety of neurological insults compromise sound processing, particularly in complex listening environments that place high demands on brain process...

journal_title：Scientific reports

authors： Kraus N,Thompson EC,Krizman J,Cook K,White-Schwoch T,LaBella CR

更新日期：2016-12-22 00:00:00

abstract：:Contact investigation is an important and effective active case-finding strategy, but there is a lack of research on congregate settings in countries with an intermediate incidence. This study determined the incidence of and risk factors for tuberculosis (TB) development after exposure in congregate settings. This ret...

journal_title：Scientific reports

authors： Park SY,Han S,Kim YM,Kim J,Lee S,Yang J,Kim UN,Park MS

更新日期：2020-01-28 00:00:00

abstract：:Environmental stimuli have the ability to generate specific representations of the rewards they predict and in so doing alter the selection and performance of reward-seeking actions. The basolateral amygdala participates in this process, but precisely how is unknown. To rectify this, we monitored, in near-real time, b...

journal_title：Scientific reports

authors： Malvaez M,Greenfield VY,Wang AS,Yorita AM,Feng L,Linker KE,Monbouquette HG,Wassum KM

更新日期：2015-07-27 00:00:00

abstract：:When acoustic signals from different sound sources are mixed upon arrival at the ears, the auditory system organizes these acoustic elements by their features. This study shows that individuals with autism spectrum disorder (ASD) performed better in terms of hearing a target sequence among distractors that had similar...

journal_title：Scientific reports

authors： Lin IF,Yamada T,Komine Y,Kato N,Kashino M

更新日期：2015-05-22 00:00:00

abstract：:The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory properties of cancer cells. To address this question, we experimentally me...

journal_title：Scientific reports

authors： Nair NU,Das A,Rogkoti VM,Fokkelman M,Marcotte R,de Jong CG,Koedoot E,Lee JS,Meilijson I,Hannenhalli S,Neel BG,de Water BV,Le Dévédec SE,Ruppin E

更新日期：2019-07-29 00:00:00

abstract：:Ferroelectric tunneling junctions (FTJs) with tunable tunneling electroresistance (TER) are promising for many emerging applications, including non-volatile memories and neurosynaptic computing. One of the key challenges in FTJs is the balance between the polarization value and the tunneling current. In order to achie...

journal_title：Scientific reports

authors： Ryu H,Wu H,Rao F,Zhu W

更新日期：2019-12-31 00:00:00

abstract：:Advances in lab-on-a-chip (LOC) devices have led to significant improvements in the on-chip manipulation, separation, sorting, and isolation of particles and cells. Among various LOC-based approaches such as inertia-based methods, acoustophoresis, and magnetophoresis, the planar-slanted-electrode dielectrophoresis (DE...

journal_title：Scientific reports

authors： Dalili A,Taatizadeh E,Tahmooressi H,Tasnim N,Rellstab-Sánchez PI,Shaunessy M,Najjaran H,Hoorfar M

更新日期：2020-07-16 00:00:00

abstract：:The emergence of metallic conduction in layered dichalcogenide semiconductor materials by chemical doping is one of key issues for two-dimensional (2D) materials engineering. At present, doping methods for layered dichalcogenide materials have been limited to an ion intercalation between layer units or electrostatic c...

journal_title：Scientific reports

authors： Kim SI,Hwang S,Kim SY,Lee WJ,Jung DW,Moon KS,Park HJ,Cho YJ,Cho YH,Kim JH,Yun DJ,Lee KH,Han IT,Lee K,Sohn Y

更新日期：2016-01-21 00:00:00

abstract：:Teleost fish exhibit a remarkable diversity in the control of sex determination, offering the opportunity to identify novel differentiation mechanisms and their ecological consequences. Here, we perform GWAS using 4715 fish and 46,501 SNP to map sex determination to three separate genomic locations in Atlantic salmon ...

journal_title：Scientific reports

authors： Kijas J,McWilliam S,Naval Sanchez M,Kube P,King H,Evans B,Nome T,Lien S,Verbyla K

更新日期：2018-04-04 00:00:00

abstract：:Biosorption is a cost-effective and simple technique for removing heavy metals and rare earth elements from aqueous solution. Here, metals were recovered from aqueous solutions using phosphorylated dry baker's yeast cells. The cells were phosphorylated using cyclo-triphosphate, Na3P3O9. The total P content of the phos...

journal_title：Scientific reports

authors： Ojima Y,Kosako S,Kihara M,Miyoshi N,Igarashi K,Azuma M

更新日期：2019-01-18 00:00:00

abstract：:Pre-mRNA splicing deposits multi-protein complexes, termed exon junction complexes (EJCs), on mRNAs near exon-exon junctions. The core of EJC consists of four proteins, eIF4AIII, MLN51, Y14 and Magoh. Y14 is a nuclear protein that can shuttle between the nucleus and the cytoplasm, and binds specifically to Magoh. Here...

journal_title：Scientific reports

authors： Kataoka N,Diem MD,Yoshida M,Hatai C,Dobashi I,Dreyfuss G,Hagiwara M,Ohno M

更新日期：2011-01-01 00:00:00

abstract：:Chronic kidney disease (CKD) is a public health problem that increases the risk of cardiovascular morbidity and mortality. Heart failure with preserved ejection fraction (HFpEF) characterized by left ventricular hypertrophy (LVH) and diastolic dysfunction is a common cardiovascular complication of CKD. MicroRNA-212 (m...

journal_title：Scientific reports

authors： Sárközy M,Gáspár R,Zvara Á,Siska A,Kővári B,Szűcs G,Márványkövi F,Kovács MG,Diószegi P,Bodai L,Zsindely N,Pipicz M,Gömöri K,Kiss K,Bencsik P,Cserni G,Puskás LG,Földesi I,Thum T,Bátkai S,Csont T

更新日期：2019-02-04 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Rueckert E,Čamernik J,Peters J,Babič J

更新日期：2020-04-16 00:00:00

abstract：:It will get entirely unusual derivatives with gratifying chemical bonding schemes for boron clusters by doping with lithium, the lightest alkalis. The geometric structures and electronic properties of the LiBn0/- (n = 10-20) clusters have been studied through Crystal structure AnaLYsis by Particle Swarm Optimization (...

journal_title：Scientific reports

authors： Shi H,Kuang X,Lu C

更新日期：2020-02-03 00:00:00

abstract：:The application of nitrogen (N) fertilizer deep in soil at the same time as mechanical transplanting of rice seedlings is an effective alternative to conventional broadcasting of fertilizer, but its effects on yields and profitability have not been analysed in detail. Here, we analysed the effects of a side deep appli...

journal_title：Scientific reports

authors： Zhu C,Xiang J,Zhang Y,Zhang Y,Zhu D,Chen H

更新日期：2019-04-04 00:00:00

abstract：:Appropriate isolation methods are essential for unravelling the relative contribution of extracellular vesicles (EVs) and the EV-free secretome to homeostasis and disease. We hypothesized that ultrafiltration followed by size exclusion chromatography (UF-SEC) provides well-matched concentrates of EVs and free secreted...

journal_title：Scientific reports

authors： Benedikter BJ,Bouwman FG,Vajen T,Heinzmann ACA,Grauls G,Mariman EC,Wouters EFM,Savelkoul PH,Lopez-Iglesias C,Koenen RR,Rohde GGU,Stassen FRM

更新日期：2017-11-10 00:00:00

abstract：:Metastasis is generally considered a characteristic of malignant tumors. Herein, we describe a patient with more than one hundred discrete Spitz nevi scattered all over her skin. Molecular analysis from three of the lesions identified a ROS1 fusion oncogene with identical genomic breakpoints, indicating that the nevi ...

journal_title：Scientific reports

authors： Raghavan SS,Kapler ES,Dinges MM,Bastian BC,Yeh I

更新日期：2020-10-01 00:00:00

abstract：:In this study, the toxic effects of phenoxyethanol (Phy-Et), which is widely used in cosmetic industry, has been investigated with Allium test by means of physiological, cytogenetic, anatomical and biochemical parameters. To determine the changes in physiological reactions weight gain, relative injury rate, germinatio...

journal_title：Scientific reports

authors： Akgündüz MÇ,Çavuşoğlu K,Yalçın E

更新日期：2020-01-27 00:00:00

abstract：:Two types of periodic and transient motions of large woodpeckers are considered. A drumming woodpecker may be modeled as a harmonic oscillator with a periodic forcing function. The transient behavior that occurs after the forcing is turned off suggests that the double knocks of Campephilus woodpeckers may be modeled i...

journal_title：Scientific reports

authors： Collins MD

更新日期：2017-10-02 00:00:00

abstract：:Critical regulation of bile acid (BA) pool size and composition occurs via an intensive molecular crosstalk between the liver and gut, orchestrated by the combined actions of the nuclear Farnesoid X receptor (FXR) and the enterokine fibroblast growth factor 19 (FGF19) with the final aim of reducing hepatic BA synthesi...

journal_title：Scientific reports

authors： Gadaleta RM,Scialpi N,Peres C,Cariello M,Ko B,Luo J,Porru E,Roda A,Sabbà C,Moschetta A

更新日期：2018-11-21 00:00:00

abstract：:A novel turn-off colorimetric sensor for sequence-specific recognition of single-stranded DNA (ssDNA) was established by combining Y-shaped DNA duplex and G-quadruplex-hemin DNAzyme. A G-rich single-stranded DNA (Oligo-1) displays peroxidase mimicking catalytic activity due to the specific binding with hemin in the pr...

journal_title：Scientific reports

authors： Zhang H,Li X,He F,Zhao M,Ling L

更新日期：2018-08-13 00:00:00

abstract：:Delivery and expression of recombinant genes, a key methodology for many applications in biological research, remains a challenge especially for mature neurons. Here, we report easy, highly efficient and well tolerated transduction of adult peripheral and central neuronal populations of diverse species in culture usin...

journal_title：Scientific reports

authors： Levin E,Diekmann H,Fischer D

更新日期：2016-12-13 00:00:00

abstract：:Unnatural chiral α-amino acids are widely used in fields of organic chemistry, biochemistry and medicinal chemistry, and their synthesis has attracted extensive attention. Although the asymmetric synthesis provides some efficient protocols, noble and elaborate catalysts, ligands and additives are usually required whic...

journal_title：Scientific reports

authors： Jiang M,Jin Y,Yang H,Fu H

更新日期：2016-05-17 00:00:00