Large-scale identification of human protein function using topological features of interaction network.

abstract：:Multiferroic BiFeO3 exhibits excellent magnetoelectric coupling critical for magnetic information processing with minimal power consumption. However, the degenerate nature of the easy spin axis in the (111) plane presents roadblocks for real world applications. Here, we explore the stabilization and switchability of t...

journal_title：Scientific reports

authors： Dixit H,Lee JH,Krogel JT,Okamoto S,Cooper VR

更新日期：2015-08-06 00:00:00

abstract：:Radiotherapy with protons and heavier ions landmarks a novel era in the field of high-precision cancer therapy. To identify patients most benefiting from this technologically demanding therapy, fast assessment of comparative treatment plans utilizing different ion species is urgently needed. Moreover, to overcome unce...

journal_title：Scientific reports

authors： Mein S,Choi K,Kopp B,Tessonnier T,Bauer J,Ferrari A,Haberer T,Debus J,Abdollahi A,Mairani A

更新日期：2018-10-04 00:00:00

abstract：:Caries is associated with shifts of microbiota in dental biofilms and primarily driven by frequent sucrose consumption. Data on environmentally induced in vivo microbiota shifts are scarce therefore we investigated the influence of frequent sucrose consumption on the oral biofilm. Splint systems containing enamel slab...

journal_title：Scientific reports

authors： Anderson AC,Rothballer M,Altenburger MJ,Woelber JP,Karygianni L,Lagkouvardos I,Hellwig E,Al-Ahmad A

更新日期：2018-09-21 00:00:00

abstract：:Crotoxin B (CB) is a catalytically active group IIA sPLA2 from Crotalus durissus terrificus snake venom. In contrast to most GIIA sPLA2s, CB exhibits anti-inflammatory effects, including the ability to inhibit leukocyte functions. Lipid droplets (LDs) are lipid-rich organelles associated with inflammation and recogniz...

journal_title：Scientific reports

authors： Giannotti KC,Leiguez E,Carvalho AEZ,Nascimento NG,Matsubara MH,Fortes-Dias CL,Moreira V,Teixeira C

更新日期：2017-06-22 00:00:00

abstract：:Understanding the molecular mechanisms underlying Alzheimer's disease (AD) is necessary for the diagnosis and treatment of this neurodegenerative disorder. It is therefore important to detect the most important genes and miRNAs, which are associated with molecular events, and studying their interactions for recognitio...

journal_title：Scientific reports

authors： Moradifard S,Hoseinbeyki M,Ganji SM,Minuchehr Z

更新日期：2018-03-19 00:00:00

abstract：:Whether hybridization generates or erodes species diversity has long been debated, but to date most studies have been conducted at small taxonomic scales. Salamanders (order Caudata) represent a taxonomic order in which hybridization plays a prevalent ecological and evolutionary role. We employed a recently developed ...

journal_title：Scientific reports

authors： Patton AH,Margres MJ,Epstein B,Eastman J,Harmon LJ,Storfer A

更新日期：2020-04-16 00:00:00

abstract：:We compared the effects of 12-week programs of resistance training (RT), high-intensity interval aerobic training (HIAT), and moderate-intensity continuous aerobic training (MICT). The primary goal was to evaluate the therapeutic effects of the exercise modalities for the management of nonalcoholic fatty liver disease...

journal_title：Scientific reports

authors： Oh S,So R,Shida T,Matsuo T,Kim B,Akiyama K,Isobe T,Okamoto Y,Tanaka K,Shoda J

更新日期：2017-02-22 00:00:00

abstract：:In the present work, we demonstrated the biosynthesis of silver nanoparticles (AgNPs) by highly stable, economic and eco-friendly method using leaf extract of Terminalia arjuna (T. arjuna) and employing as a catalyst for the degradation of methyl orange (MO), methylene blue (MB), congo red (CR) and 4- nitrophenol (4-N...

journal_title：Scientific reports

authors： Raj S,Singh H,Trivedi R,Soni V

更新日期：2020-06-15 00:00:00

abstract：:Fabric-based personal heating patches have small geometric profiles and can be attached to selected areas of garments for personal thermal management to enable significant energy savings in built environments. Scalable fabrication of such patches with high thermal performance at low applied voltage, high durability an...

journal_title：Scientific reports

authors： Hwang HJ,Devaraj H,Yang C,Gao Z,Chang CH,Lee H,Malhotra R

更新日期：2018-11-21 00:00:00

abstract：:Two important theories in spatial modelling relate to structural and spatial dependence. Structural dependence refers to environmental state-factor models, where an environmental property is modelled as a function of the states and interactions of environmental predictors, such as climate, parent material or relief. C...

journal_title：Scientific reports

authors： Behrens T,Viscarra Rossel RA

更新日期：2020-10-07 00:00:00

abstract：:Huntington's disease (HD) is a genetically-determined neurodegenerative disease. Characterising neuropathology in mouse models of HD is commonly restricted to cross-sectional ex vivo analyses, beset by tissue fixation issues. In vivo longitudinal magnetic resonance imaging (MRI) allows for disease progression to be pr...

journal_title：Scientific reports

authors： Steventon JJ,Trueman RC,Ma D,Yhnell E,Bayram-Weston Z,Modat M,Cardoso J,Ourselin S,Lythgoe M,Stewart A,Rosser AE,Jones DK

更新日期：2016-09-01 00:00:00

abstract：:Yield-phenology relation is a critical issue affecting rainfed maize field productivity in semiarid east African Plateau (EAP). We first introduced Chinese ridge-furrow mulching (RFM) system to EAP, using three maize cultivars with early-, mid- and late-maturing traits as test materials. A two-year field experiment wa...

journal_title：Scientific reports

authors： Mo F,Wang JY,Li FM,Nguluu SN,Ren HX,Zhou H,Zhang J,Kariuki CW,Gicheru P,Kavagi L,Cheruiyot WK,Xiong YC

更新日期：2017-06-12 00:00:00

abstract：:In this work the chalcopyrite CuIn3Se5-xTex (x = 0~0.5) with space group through isoelectronic substitution of Te for Se have been prepared, and the crystal structure dilation has been observed with increasing Te content. This substitution allows the anion position displacement ∆u = 0.25-u to be zero at x ≈ 0.15. Howe...

journal_title：Scientific reports

authors： Lu Y,Chen S,Wu W,Du Z,Chao Y,Cui J

更新日期：2017-01-06 00:00:00

abstract：:The bulk-insulating topological insulators with tunable surface states are necessary for applications in spintronics and quantum computation. Here we present theoretical evidence for modulating the topological surface states and achieving the insulating bulk states in solid-solution (Bi(1-x)Sb(x))(2)Te(3). Our results...

journal_title：Scientific reports

authors： Niu C,Dai Y,Zhu Y,Ma Y,Yu L,Han S,Huang B

更新日期：2012-01-01 00:00:00

abstract：:Liver cancer stem cells (LCSCs) have attracted attention because they cause therapeutic resistance in hepatocellular carcinoma (HCC). Understanding the metabolism of LCSCs can be a key to developing therapeutic strategy, but metabolic characteristics have not yet been studied. Here, we systematically analyzed and comp...

journal_title：Scientific reports

authors： Hur W,Ryu JY,Kim HU,Hong SW,Lee EB,Lee SY,Yoon SK

更新日期：2017-04-03 00:00:00

abstract：:Accurate alignment of an intraocular lens (IOL) is indispensable for achieving accurate postoperative refractive outcomes. Thus, we evaluated decentration and tilt of single- and three-piece IOLs, as well as anterior chamber depth (ACD), at 3 hours, 24 hours, 2 weeks, and 4 weeks after cataract surgery, using swept-so...

journal_title：Scientific reports

authors： Sato T,Shibata S,Yoshida M,Hayashi K

更新日期：2018-07-06 00:00:00

abstract：:MicroRNAs (miRNAs) are noncoding RNAs which control gene expression by the suppression of translation or the degradation of mRNAs. Dre-miR-21 (miR-21) has been reported to impact cardiac valvulogenesis in zebrafish embryos. However, the target genes of miR-21 are still largely unknown. Here a tandem isobaric mass tag ...

journal_title：Scientific reports

authors： Wu Y,Lou QY,Ge F,Xiong Q

更新日期：2017-06-22 00:00:00

abstract：:Leptin signaling in the hypothalamus plays a crucial role in the regulation of body weight. Leptin resistance, in which leptin signaling is disrupted, is a major obstacle to the improvement of obesity. We herein demonstrated that protein tyrosine phosphatase receptor type J (Ptprj) is expressed in hypothalamic neurons...

journal_title：Scientific reports

authors： Shintani T,Higashi S,Suzuki R,Takeuchi Y,Ikaga R,Yamazaki T,Kobayashi K,Noda M

更新日期：2017-09-14 00:00:00

abstract：:The elastic responsiveness of single cellulose nanofibres is important for advanced analysis of biological tissues and their use in sophisticated functional materials. However, the mechanical responsiveness derived from the twisted structure of cellulose nanofibres (CNFs) has remained unexplored. In this study, finite...

journal_title：Scientific reports

authors： Uetani K,Uto T,Suzuki N

更新日期：2021-01-12 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Tsuneyoshi Y,Higuchi A,Negishi K,Tsubota K

更新日期：2020-04-16 00:00:00

abstract：:Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae, a well-known Chinese medicinal herb that presents anticancer effects in various types of cancer cell lines. In this study, we have successfully established zebrafish xenografts with 5 various human cancer cell lines; and validated these models with ant...

journal_title：Scientific reports

authors： Zhu XY,Guo DW,Lao QC,Xu YQ,Meng ZK,Xia B,Yang H,Li CQ,Li P

更新日期：2019-03-14 00:00:00

abstract：:Based on an inverted bulk band order, antimony thin films presumably could become topological insulators if quantum confinement effect opens up a gap in the bulk bands. Coupling between topological surface states (TSS) from opposite surfaces, however, tends to degrade or even destroy their novel characters. Here the e...

journal_title：Scientific reports

authors： Yao G,Luo Z,Pan F,Xu W,Feng YP,Wang XS

更新日期：2013-01-01 00:00:00

abstract：:The objective of this study was to determine if Ihh is required for fracture healing. Fibular fracture was created in adult Col2a1-CreERT2; Ihhfl/fl mice. Ihhfl/fl mice received Tamoxifen (TM) to delete Ihh. WT mice received Cyclopamine to inhibit Hh pathway. Callus tissue properties and Ihh pathway were analyzed at 1...

journal_title：Scientific reports

authors： Li S,Xiang C,Wei X,Li H,Li K,Sun X,Wang S,Zhang M,Deng J,Wang X,Li P,Li R,Zhang Y,Wei L

更新日期：2018-07-09 00:00:00

abstract：:DDX3, a subunit of CK1ε, phosphorylates Dvl2 to promote β-catenin activation. Overexpression of the Dvl2 protein results in potent activation of β-catenin/TCF signaling in colorectal cancer. Therefore, we hypothesized that DDX3 might promote tumor invasion via the CK1ε/Dvl2 axis due to β-catenin/TCF activation. Wester...

journal_title：Scientific reports

authors： He TY,Wu DW,Lin PL,Wang L,Huang CC,Chou MC,Lee H

更新日期：2016-02-19 00:00:00

abstract：:Fibulins are extracellular matrix proteins associated with elastic fibres. Homozygous Fibulin-4 mutations lead to life-threatening abnormalities such as aortic aneurysms. Aortic aneurysms in Fibulin-4 mutant mice were associated with upregulation of TGF-β signalling. How Fibulin-4 deficiency leads to deregulation of t...

journal_title：Scientific reports

authors： Ramnath NW,Hawinkels LJ,van Heijningen PM,te Riet L,Paauwe M,Vermeij M,Danser AH,Kanaar R,ten Dijke P,Essers J

更新日期：2015-11-26 00:00:00

abstract：:Patients with dengue virus (DENV) infection may also present acute viral encephalitis through an unknown mechanism. Here, we report that encephalitic DENV-infected mice exhibited progressive hunchback posture, limbic seizures, limbic weakness, paralysis, and lethality 7 days post-infection. These symptoms were accompa...

journal_title：Scientific reports

authors： Tsai TT,Chen CL,Lin YS,Chang CP,Tsai CC,Cheng YL,Huang CC,Ho CJ,Lee YC,Lin LT,Jhan MK,Lin CF

更新日期：2016-06-09 00:00:00

abstract：:Coral reefs all over the Indo-Pacific suffer from substantial damage caused by the crown-of-thorns seastar Acanthaster planci, a voracious predator that moves on and between reefs to seek out its coral prey. Chemoreception is thought to guide A. planci. As vision was recently introduced as another sense involved in se...

journal_title：Scientific reports

authors： Sigl R,Steibl S,Laforsch C

更新日期：2016-08-01 00:00:00

abstract：:Here we present spatio-temporal localization of Kremen1, a transmembrane receptor, in the mammalian cochlea, and investigate its role in the formation of sensory organs in mammal and fish model organisms. We show that Kremen1 is expressed in prosensory cells during cochlear development and in supporting cells of the a...

journal_title：Scientific reports

authors： Mulvaney JF,Thompkins C,Noda T,Nishimura K,Sun WW,Lin SY,Coffin A,Dabdoub A

更新日期：2016-08-23 00:00:00

abstract：:Viral infection triggers a series of signaling cascades, which converge to activate the transcription factors nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3), thereby inducing the transcription of type I interferons (IFNs). Although not fully characterized, these innate antiviral responses are fine...

journal_title：Scientific reports

authors： Zhang H,Wang D,Zhong H,Luo R,Shang M,Liu D,Chen H,Fang L,Xiao S

更新日期：2015-06-10 00:00:00

abstract：:Cyclophilin A (CyPA), secreted by vascular smooth muscle cells in response to oxidative stress, is important in the pathogenesis of progressive peripheral arterial occlusion disease (PAOD), which is common among chronic kidney disease. We explored the prevalence of PAOD in Taiwan's elderly (≥ 65 years old) population ...

journal_title：Scientific reports

authors： Liu MC,Lee YW,Lee PT,Chang CS,Tai YL,Yu JR,Su XT,Hsu LW,Lin SH,Wu CH,Liu PY

更新日期：2015-04-24 00:00:00