Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders.

abstract：:Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are largely recognized to promote invasion and metastasis in various cancers, and collagen XVII is essential for the survival of colon and lung cancer stem cells. We ...

journal_title：Scientific reports

authors： Moilanen JM,Löffek S,Kokkonen N,Salo S,Väyrynen JP,Hurskainen T,Manninen A,Riihilä P,Heljasvaara R,Franzke CW,Kähäri VM,Salo T,Mäkinen MJ,Tasanen K

更新日期：2017-03-22 00:00:00

abstract：:We evaluated the in-vitro effect of potassium on CD4+ T cells and the role of urinary potassium as a potential biomarker of disease activity in patients with ulcerative colitis (UC). This prospective observational cohort study included healthy controls (n = 18) and UC patients [n = 30, median age: 40 (IQR: 28-46) year...

journal_title：Scientific reports

authors： Goyal S,Rampal R,Kedia S,Mahajan S,Bopanna S,Yadav DP,Jain S,Singh AK,Wari MN,Makharia G,Awasthi A,Ahuja V

更新日期：2017-12-22 00:00:00

abstract：:Prostate cancer is the most commonly diagnosed cancer in men with African American men disproportionally suffering from the burden of this disease. Biomarkers that could discriminate indolent from aggressive and drug resistance disease are lacking. MicroRNAs are small non-coding RNAs that affect numerous physiological...

journal_title：Scientific reports

authors： Cagle P,Niture S,Srivastava A,Ramalinga M,Aqeel R,Rios-Colon L,Chimeh U,Suy S,Collins SP,Dahiya R,Kumar D

更新日期：2019-07-05 00:00:00

abstract：:Single nucleotide variations (SNVs) can result in loss or gain of protein functional sites. We analyzed the effects of SNVs on enzyme active sites, ligand binding sites, and various types of post translational modification (PTM) sites. We found that, for most types of protein functional sites, the SNV pattern differs ...

journal_title：Scientific reports

authors： Pan Y,Yan C,Hu Y,Fan Y,Pan Q,Wan Q,Torcivia-Rodriguez J,Mazumder R

更新日期：2017-02-08 00:00:00

abstract：:The ability of radial glial progenitors (RGPs) to generate cortical neurons is determined by local extracellular factors and signaling pathways intrinsic to RGPs. Here we find that GPR157, an orphan G protein-coupled receptor, localizes to RGPs' primary cilia exposed to the cerebrospinal fluid (CSF). GPR157 couples wi...

journal_title：Scientific reports

authors： Takeo Y,Kurabayashi N,Nguyen MD,Sanada K

更新日期：2016-05-04 00:00:00

abstract：:Receptivity is a limited time in which uterine endometrium can establish a successful dialogue with blastocyst. This study was to investigate the effect of asynchronous embryo transfer on uterine receptivity in mice. Embryos under different stages were transferred into two oviduct sides of a recipient mouse on day 1 o...

journal_title：Scientific reports

authors： Li SJ,Wang TS,Qin FN,Huang Z,Liang XH,Gao F,Song Z,Yang ZM

更新日期：2015-11-04 00:00:00

abstract：:The present study used 16S rRNA gene amplicon sequencing to assess the impact on salivary microbiome of different grades of dental and periodontal disease and the combination of both (hereinafter referred to as oral disease), in terms of bacterial diversity, co-occurrence network patterns and predictive models. Our sc...

journal_title：Scientific reports

authors： Relvas M,Regueira-Iglesias A,Balsa-Castro C,Salazar F,Pacheco JJ,Cabral C,Henriques C,Tomás I

更新日期：2021-01-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Rogawa A,Ogata S,Mougi A

更新日期：2019-10-15 00:00:00

abstract：:Pulsatile motion occurs in the cardiac systolic period and leads to significantly larger displacement of water molecules as it is observed during diffusion weighted image acquisition. Obvious pulsatile motion arises in the brain stem and basal ganglia and might affect the corticospinal tract. So far there is no consen...

journal_title：Scientific reports

authors： Bopp MHA,Yang J,Nimsky C,Carl B

更新日期：2018-07-25 00:00:00

abstract：:We isolated a novel bacterial strain from a prokaryotic consortium associated to the psychrophilic marine ciliate Euplotes focardii, endemic of the Antarctic coastal seawater. The 16S rDNA sequencing and the phylogenetic analysis revealed the close evolutionary relationship to the Antarctic marine bacterium Marinomona...

journal_title：Scientific reports

authors： John MS,Nagoth JA,Ramasamy KP,Ballarini P,Mozzicafreddo M,Mancini A,Telatin A,Liò P,Giuli G,Natalello A,Miceli C,Pucciarelli S

更新日期：2020-06-23 00:00:00

abstract：:The aim of this systematic review was taken to investigate the efficacy and safety of docetaxel plus thalidomide vs. docetaxel alone for treating androgen-independent prostate cancer (AIPC). Data were collected from different databases independently by three researchers according to the pre-defined inclusion and exclu...

journal_title：Scientific reports

authors： Chen L,Qiu X,Wang R,Xie X

更新日期：2014-04-28 00:00:00

abstract：:The CRISPR/Cas9 system is a powerful method of editing genes by randomly introducing errors into the target sites. Here, we describe a CRISPR-based test for gene essentiality (CRISPR-E test) that allows the identification of essential genes. Specifically, we use sgRNA-mediated CRISPR/Cas9 to target the open reading fr...

journal_title：Scientific reports

authors： You Y,Ramachandra SG,Jin T

更新日期：2020-09-08 00:00:00

abstract：:The consumption of bovine milk and meat is considered a risk factor for colon- and breast cancer formation, and milk consumption has also been implicated in an increased risk for developing Multiple Sclerosis (MS). A number of highly related virus-like DNAs have been recently isolated from bovine milk and sera and fro...

journal_title：Scientific reports

authors： Eilebrecht S,Hotz-Wagenblatt A,Sarachaga V,Burk A,Falida K,Chakraborty D,Nikitina E,Tessmer C,Whitley C,Sauerland C,Gunst K,Grewe I,Bund T

更新日期：2018-02-12 00:00:00

abstract：:Anticarsia gemmatalis (velvetbean caterpillar) and Chrysodeixis includens (soybean looper) are two important defoliation pests of soybeans. In the present study, we have investigated the susceptibility and brush border membrane-binding properties of both species to Bacillus thuringiensis Cry1Ea toxin. Bioassays perfor...

journal_title：Scientific reports

authors： Bel Y,Zack M,Narva K,Escriche B

更新日期：2019-12-03 00:00:00

abstract：:Optical coherence tomography (OCT) is a valuable ancillary test in the diagnosis and management of chorioretinal disease. The evaluation of choroid thickness using OCT has become the focus of clinical applications. We report a linear artifact that acts as a confounding factor in choroidal thickness measurements by enh...

journal_title：Scientific reports

authors： Zuo C,Mi L,Yang S,Guo X,Xiao H,Liu X

更新日期：2017-08-16 00:00:00

abstract：:In situ measurements by the Curiosity rover provide a unique opportunity for studying the effects of dust on assets placed at the surface of Mars. Here we use in situ measurements of solar UV radiation to quantify the seasonal and interannual variability of dust accumulation on the sensor on the rover deck. We show th...

journal_title：Scientific reports

authors： Vicente-Retortillo Á,Martínez GM,Renno N,Newman CE,Ordonez-Etxeberria I,Lemmon MT,Richardson MI,Hueso R,Sánchez-Lavega A

更新日期：2018-12-04 00:00:00

abstract：:Ocular antigens are sequestered behind the blood-retina barrier and the ocular environment protects ocular tissues from autoimmune attack. The signals required to activate autoreactive T cells and allow them to cause disease in the eye remain in part unclear. In particular, the consequences of peripheral presentation ...

journal_title：Scientific reports

authors： Voigt V,Wikstrom ME,Kezic JM,Schuster IS,Fleming P,Makinen K,Daley SR,Andoniou CE,Degli-Esposti MA,Forrester JV

更新日期：2017-10-27 00:00:00

abstract：:PC4 is an abundant single-strand DNA binding protein that has been implicated in transcription and DNA repair. Here, we show that PC4 is involved in the cellular DNA damage response. To elucidate the role, we used the DT40 chicken B cell model, which produces clustered DNA lesions at Ig loci via the action of activati...

journal_title：Scientific reports

authors： Caldwell RB,Braselmann H,Schoetz U,Heuer S,Scherthan H,Zitzelsberger H

更新日期：2016-07-04 00:00:00

abstract：:We have studied both experimentally and theoretically the reprogrammable spin wave band structure in Permalloy(10 nm)/Cu(5 nm)/Permalloy(30 nm) nanowire arrays of width w = 280 nm and inter-wire separation in the range from 80 to 280 nm. We found that, depending on the inter-wire separation, the anti-parallel configur...

journal_title：Scientific reports

authors： Gubbiotti G,Zhou X,Haghshenasfard Z,Cottam MG,Adeyeye AO,Kostylev M

更新日期：2019-03-15 00:00:00

abstract：:This study aimed to develop a cationic nanosuspension of chitosan (CS) and methoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) for ocular delivery of diclofenac (DIC). MPEG-PCL-CS block polymer was synthesized by covalent coupling of MPEG-PCL with CS. The critical micelle concentration of the MPEG-PCL-CS blo...

journal_title：Scientific reports

authors： Shi S,Zhang Z,Luo Z,Yu J,Liang R,Li X,Chen H

更新日期：2015-06-12 00:00:00

abstract：:Patterns of temperature fluctuations in nature affect numerous biological processes, yet, empirical studies often utilize constant temperature treatments. This can limit our understanding of how thermally sensitive species respond to ecologically relevant temperatures. Research on turtles with temperature-dependent se...

journal_title：Scientific reports

authors： Carter AW,Sadd BM,Tuberville TD,Paitz RT,Bowden RM

更新日期：2018-01-08 00:00:00

abstract：:Owing to its simplicity and low temperature conditions, magnesiothermic reduction of silica is one of the most powerful methods for producing silicon nanostructures. However, incomplete reduction takes place in this process leaving unconverted silica under the silicon layer. This phenomenon limits the use of this meth...

journal_title：Scientific reports

authors： Kim KH,Lee DJ,Cho KM,Kim SJ,Park JK,Jung HT

更新日期：2015-03-11 00:00:00

abstract：:Natural biochemical systems are ubiquitously organized both in space and time. Engineering the spatial organization of biochemistry has emerged as a key theme of synthetic biology, with numerous technologies promising improved biosynthetic pathway performance. One strategy, however, may produce disparate results for d...

journal_title：Scientific reports

authors： Jakobson CM,Tullman-Ercek D,Mangan NM

更新日期：2018-05-29 00:00:00

abstract：:Essential oils are volatile compounds commonly used by several industries, easily degradable, which restrains their applications. Therefore, we developed and validated a methodology for producing microcapsules loaded with orange essential oil, using a spray-drying process. The experimental design results showed that t...

journal_title：Scientific reports

authors： Aguiar MCS,das Graças Fernandes da Silva MF,Fernandes JB,Forim MR

更新日期：2020-07-16 00:00:00

abstract：:Tract tracing with neuronal tracers not only represents a straightforward approach to identify axonal projection connection between regions of the nervous system at distance but also provides compelling evidence for axonal regeneration. An ideal neuronal tracer meets certain criteria including high labeling efficacy, ...

journal_title：Scientific reports

authors： Mi D,Yuan Y,Zhang Y,Niu J,Wang Y,Yan J,Yang Y,Hu W

更新日期：2019-07-09 00:00:00

abstract：:LL37 exerts a dual pathogenic role in psoriasis. Bound to self-DNA/RNA, LL37 licenses autoreactivity by stimulating plasmacytoid dendritic cells-(pDCs)-Type I interferon (IFN-I) and acts as autoantigen for pathogenic Th17-cells. In systemic lupus erythematosus (SLE), LL37 also triggers IFN-I in pDCs and is target of p...

journal_title：Scientific reports

authors： Lande R,Palazzo R,Gestermann N,Jandus C,Falchi M,Spadaro F,Riccieri V,James EA,Butera A,Boirivant M,Feldmeyer L,Surbeck I,Di Lucca J,Stuber F,Spinelli FR,Botti E,Marinari B,Bianchi L,Pica R,Cerbelli B,Giannakakis

更新日期：2020-04-03 00:00:00

abstract：:The spin-transfer nano-oscillator (STNO) offers the possibility of using the transfer of spin angular momentum via spin-polarized currents to generate microwave signals. However, at present STNO microwave emission mainly relies on both large drive currents and external magnetic fields. These issues hinder the implemen...

journal_title：Scientific reports

authors： Zeng Z,Finocchio G,Zhang B,Khalili Amiri P,Katine JA,Krivorotov IN,Huai Y,Langer J,Azzerboni B,Wang KL,Jiang H

更新日期：2013-01-01 00:00:00

abstract：:Influenza virus evolves constantly in an unpredictable fashion, making it necessary to vaccinate people annually for effective prevention and control of influenza. In general, however, during the first wave of an influenza outbreak caused by a newly emerging virus strain, influenza morbidity and mortality have been ob...

journal_title：Scientific reports

authors： Zheng M,Qu D,Wang H,Sun Z,Liu X,Chen J,Li C,Li X,Chen Z

更新日期：2016-06-29 00:00:00

abstract：:Mechanochemical synthesis of Si/Cu3Si-based composite as negative electrode materials for lithium ion battery is investigated. Results indicate that CuO is decomposed and alloyed with Si forming amorphous Cu-Si solid solution due to high energy impacting during high energy mechanical milling (HEMM). Upon carbonization...

journal_title：Scientific reports

authors： Hou SC,Chen TY,Wu YH,Chen HY,Lin XD,Chen YQ,Huang JL,Chang CC

更新日期：2018-08-23 00:00:00

abstract：:The profiles of time-contrast (TC) -curves from popular MRI injectors derived at the injection site of the attached tube-line system were compared. Variations of TC-profiles were previously reported to potentially influence image quality in time critical MRI measurements. TC-curves from five injectors obtained during ...

journal_title：Scientific reports

authors： Doppler M,Moser E,Klickovic U,Nasel C

更新日期：2020-11-11 00:00:00