Abstract:
:We investigated whether maternal metabolic environment affects mesenchymal stromal/stem cells (MSCs) from umbilical cord's Wharton's Jelly (WJ) on a molecular level, and potentially render them unsuitable for clinical use in multiple recipients. In this pilot study on umbilical cords post partum from healthy non-obese (BMI = 19-25; n = 7) and obese (BMI ≥ 30; n = 7) donors undergoing elective Cesarean section, we found that WJ MSC from obese donors showed slower population doubling and a stronger immunosuppressive activity. Genome-wide DNA methylation of triple positive (CD73+CD90+CD105+) WJ MSCs found 67 genes with at least one CpG site where the methylation difference was ≥0.2 in four or more obese donors. Only one gene, PNPLA7, demonstrated significant difference on methylome, transcriptome and protein level. Although the number of analysed donors is limited, our data suggest that the altered metabolic environment related to excessive body weight might bear consequences on the WJ MSCs.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Badraiq H,Cvoro A,Galleu A,Simon M,Miere C,Hobbs C,Schulz R,Siow R,Dazzi F,Ilic Ddoi
10.1038/s41598-017-18034-1subject
Has Abstractpub_date
2017-12-14 00:00:00pages
17595issue
1issn
2045-2322pii
10.1038/s41598-017-18034-1journal_volume
7pub_type
杂志文章abstract::During spring of 2009, a new influenza virus AH1N1 spread in the world causing acute respiratory illness and death, resulting in the first influenza pandemic since 1968. Blood levels of potentially-toxic and essential elements of 40 pneumonia and confirmed AH1N1 were evaluated against two different groups of controls,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01284
更新日期:2013-01-01 00:00:00
abstract::Mutations affecting the transcription factor FOXP2 cause a rare form of severe speech and language disorder. Although it is clear that sufficient FOXP2 expression is crucial for normal brain development, little is known about how this transcription factor is regulated. To investigate post-translational mechanisms for ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20911
更新日期:2016-02-12 00:00:00
abstract::In lung cancer a deregulation of Transforming Growth Factor-β (TGFβ) signaling has been observed. Yet, the impact of TGFβ in squamous cell carcinoma of the lung (LUSC) remained to be determined. We combined phenotypic and transcriptome-wide studies and showed that the stimulation of the LUSC cell line SK-MES1 with TGF...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27912-1
更新日期:2018-06-22 00:00:00
abstract::Whereas epidemiologic studies consistently identify different rates and types of problematic behavior in boys and girls, there has been little research examining the ecocultural context in which these gender differences in child behavior problems develop, especially in non-Western settings. This qualitative study in r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43972-3
更新日期:2019-05-21 00:00:00
abstract::Arbuscular mycorrhizal (AM) symbioses are an attractive means of improving the efficiency of soil phosphorus (P) that difficult to be used by plants and may provide a sustainable way of maintaining high yields while reducing P applications. However, quantifying the contribution of indigenous AM fungi on phosphorus upt...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80074-x
更新日期:2021-01-13 00:00:00
abstract::In the current report, we describe the identification of three genetically distinct groups of prophages integrated into three different chromosomal sites of human gut-associated Bifidobacterium breve and Bifidobacterium longum strains. These bifidobacterial prophages are distantly related to temperate actinobacterioph...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31181-3
更新日期:2018-08-24 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-55967-1
更新日期:2019-12-24 00:00:00
abstract::We report an experimental demonstration of positive-negative sub-wavelength interference without correlation. Typically, people can achieve sub-wavelength effects with correlation measurement no matter by using bi-photon or thermal light sources. In this paper, we adopt a thermal light source, and we count the realiza...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-82030-9
更新日期:2021-01-28 00:00:00
abstract::Lambdoid craniosynostosis (LC) is a rare non-syndromic craniosynostosis characterised by fusion of the lambdoid sutures at the back of the head. Surgical correction including the spring assisted cranioplasty is the only option to correct the asymmetry at the skull in LC. However, the aesthetic outcome from spring assi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75747-6
更新日期:2020-10-29 00:00:00
abstract::The role of Toll-like receptor-2 (TLR2) in radio-resistance remained largely unknown. TLR2 knockout (TLR2(-/-)) mice received radiation of 6.5 Gy, and then were studied. We found that radiation resulted in more severe mortality and morbidity rates in TLR2(-/-) mice. The cause of death in TLR2(-/-) mice may be severe a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13004
更新日期:2015-08-13 00:00:00
abstract::The stickiness of cooked rice is important for eating quality and consumer acceptance. The first molecular understanding of stickiness is obtained from leaching and molecular structural characteristics during cooking. Starch is a highly branched glucose polymer. We find (i) the molecular size of leached amylopectin is...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43713
更新日期:2017-03-06 00:00:00
abstract::Rho GTPases are master regulators of the eukaryotic cytoskeleton. The activation of Rho GTPases is governed by Rho guanine nucleotide exchange factors (GEFs). Three RhoGEF isoforms are produced by the gene ARHGEF25; p63RhoGEF580, GEFT and a recently discovered longer isoform of 619 amino acids (p63RhoGEF619). The subc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36825
更新日期:2016-11-11 00:00:00
abstract::Plants perceive and respond to volatile signals in their environment. Herbivore-infested plants release volatile organic compounds (VOCs) which can initiate systemic defense reactions within the plant and contribute to plant-plant communication. Here, for Ipomoea batatas (sweet potato) leaves we show that among variou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53946-0
更新日期:2019-11-22 00:00:00
abstract::Perceptual decisions are biased by recent perceptual history-a phenomenon termed 'serial dependence.' Here, we investigated what aspects of perceptual decisions lead to serial dependence, and disambiguated the influences of low-level sensory information, prior choices and motor actions. Participants discriminated whet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80128-0
更新日期:2021-01-12 00:00:00
abstract::Structural neuroimaging studies of posttraumatic stress disorder (PTSD) have typically reported reduced cortical thickness (CT) and gray matter volume (GMV) in subcortical structures and networks involved in memory retrieval, emotional processing and regulation, and fear acquisition and extinction. Although PTSD is mo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80776-2
更新日期:2021-01-19 00:00:00
abstract::The distribution of carbon from a branch setting pod in alfalfa was investigated during the seed development of seeds to determine the relative contribution of pod and leaf photoassimilates to the total C balance and to investigate the partitioning of these photoassimilates to other plant organs. A 13Clabeling procedu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42026
更新日期:2017-02-07 00:00:00
abstract::Amyloid-β(Aβ) PET positivity in patients with suspected cerebral amyloid angiopathy (CAA) MRI markers is predictive of a worse cognitive trajectory, and it provides insights into the underlying vascular pathology (CAA vs. hypertensive angiopathy) to facilitate prognostic prediction and appropriate treatment decisions....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75664-8
更新日期:2020-11-02 00:00:00
abstract::Diapause, a programmed developmental arrest, is common in insects, enabling them to survive adverse seasons. It is well established that pupal diapause is regulated by ecdysteroids secreted by the prothoracic glands (PGs), with cessation of ecdysteroid secretion after pupal ecdysis leading to pupal diapause. A major f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41651
更新日期:2017-01-31 00:00:00
abstract::The critical importance of human milk to infants and even human civilization has been well established. Yet our understanding of the milk microbiome has been limited to cataloguing OTUs and computation of community diversity. To the best of our knowledge, there has been no report on the bacterial interactions within t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08275
更新日期:2015-02-05 00:00:00
abstract::Ocular involvement in leukemia is considered rare. Ocular symptoms can be the presenting signs of leukemia, they can appear after diagnosis has been established, or they can be the first manifestation of a relapse after remission. We report, to the best of our knowledge for the first time, the ocular manifestation of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58654-8
更新日期:2020-02-06 00:00:00
abstract::Human CD4+ T cells play an important role in the immune response to Mycobacterium tuberculosis (MTB). However, little is known about the spectratyping characteristics of the CD4+ T-cell receptor (TCR) α- and β-chains CDR3 region in tuberculosis (TB) patients. We sorted MTB peptide E7-bound CD4+ T cells by using E7/HLA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28344-7
更新日期:2018-07-02 00:00:00
abstract::Two new indolizidine alkaloids crepidatumines A (1) and B (2) together with the stereoisomer of dendrocrepidine B (3) and known analog dendrocrepine (4) were isolated from D. crepidatum. Their structures were determined by HR-ESI-MS, NMR, and Electronic Circular Dichroism (ECD) experiments together with comparison of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66552-2
更新日期:2020-06-12 00:00:00
abstract::The spatial distributions of diverse facilities are often understood in terms of the optimization of the commute distance or the economic profit. Incorporating more general objective functions into such optimization framework may be useful, helping the policy decisions to meet various social and economic demands. As a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65337-x
更新日期:2020-05-25 00:00:00
abstract::The extraction and encoding of acoustical temporal regularities are fundamental for human cognitive auditory abilities such as speech or beat entrainment. Because the comparison of the neural sensitivity to temporal regularities between human and animals is fundamental to relate non-invasive measures of auditory proce...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16774-8
更新日期:2017-11-30 00:00:00
abstract::The therapeutic potential of targeting CD4+Foxp3+ regulatory T cells (Tregs) remains controversial under the condition of neuroinflammation. This study aims to explore the neuroprotective role of Tregs in optic nerve ischemia (ONI) and evaluate the therapeutic strategy of Tregs transfer with a focus on targeting the m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37805
更新日期:2016-11-25 00:00:00
abstract::A major issue in human olfaction research is to characterize the main dimensions that organize the space of odors. The present study examines this question and shows that, beside pleasantness, trigeminal sensations, and particularly irritation, play an important role. These results were consistent along two different ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-26510-5
更新日期:2018-05-31 00:00:00
abstract::Congenital cataract is the most frequent inherited ocular disorder and the most leading cause of lifelong visual loss. The screening of pathogenic mutations can be very challenging in some cases, for congenital cataracts are clinically and genetically heterogeneous diseases. The aim of this study is to investigate the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01182-9
更新日期:2017-04-27 00:00:00
abstract::A rapid and early diagnostic test to identify the encephalopathic babies at risk of adverse outcome may accelerate the development of neuroprotectants. We examined if a whole blood transcriptomic signature measured soon after birth, predicts adverse neurodevelopmental outcome eighteen months after neonatal encephalopa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70131-w
更新日期:2020-08-04 00:00:00
abstract::PEA3 transcription factor subfamily is present in a variety of tissues with branching morphogenesis, and play a particularly significant role in neural circuit formation and specificity. Many target genes in axon guidance and cell-cell adhesion pathways have been identified for Pea3 transcription factor (but not for E...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75089-3
更新日期:2020-10-23 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-26061-9
更新日期:2018-05-15 00:00:00