Using nanoBRET and CRISPR/Cas9 to monitor proximity to a genome-edited protein in real-time.

abstract：:Gastrointestinal (g.i.) large cell lymphoma is currently regarded as diffuse large B-cell lymphoma (DLBCL) despite a more favorable clinical outcome compared to other DLBCL. Cluster analyses on a transcriptome signature of NF-κB target genes of 30 g.i. marginal zone B-cell lymphomas (MZBL; 8 g.i. MZBL, 22 large cell M...

journal_title：Scientific reports

authors： Barth TFE,Kraus JM,Lausser L,Flossbach L,Schulte L,Holzmann K,Kestler HA,Möller P

更新日期：2017-07-20 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) affects more women than men, suggesting gender to play a major role in disease evolution. However, studies investigating gender differences in HFpEF are limited. In the present study we aimed to describe gender differences in a well-characterized HFpEF cohort. Con...

journal_title：Scientific reports

authors： Duca F,Zotter-Tufaro C,Kammerlander AA,Aschauer S,Binder C,Mascherbauer J,Bonderman D

更新日期：2018-01-18 00:00:00

abstract：:Congenital ptosis may be associated with abnormalities of visual development and function, including amblyopia, strabismus and refractive errors. However, the prevalence estimates of these abnormalities vary widely. We performed a systematic review and meta-analysis to estimate the prevalence of amblyopia, strabismus ...

journal_title：Scientific reports

authors： Wang Y,Xu Y,Liu X,Lou L,Ye J

更新日期：2018-05-29 00:00:00

abstract：:Molybdenum disulfide (MoS2) has been attracting much attentions due to its excellent electrical and optical properties. We report here the synthesis of large-scale and uniform MoS2 nanosheets with vertically standing morphology using chemical vapor deposition method. TEM observations clearly reveal the growth mechanis...

journal_title：Scientific reports

authors： Li H,Wu H,Yuan S,Qian H

更新日期：2016-02-18 00:00:00

abstract：:Models on how perceptual and cognitive information on others' mental states are treated by the cognitive architecture are often framed as duplex models considering two independent systems. In the context of the neuroscience of empathy analogous systems have been described. Using event-related potentials (i.e., ERPs) t...

journal_title：Scientific reports

authors： Sessa P,Meconi F,Han S

更新日期：2014-12-11 00:00:00

abstract：:We propose a polarization beam splitter (PBS) with a footprint of only 600 × 790 nm2 operating at a wavelength of λ = 1550 nm, which is the smallest PBS ever demonstrated. This device uses CMOS-compatible materials, namely, silicon and silica. The present PBS comprises two Si waveguides with different geometrical aspe...

journal_title：Scientific reports

authors： Lai MS,Huang CC

更新日期：2017-07-03 00:00:00

abstract：:Living organisms in drying environments build anisotropic structures and exhibit directionality through self-organization of biopolymers. However, the process of macro-scale assembly is still unknown. Here, we introduce a dissipative structure through a non-equilibrium process between hydration and deposition in the d...

journal_title：Scientific reports

authors： Okeyoshi K,Okajima MK,Kaneko T

更新日期：2017-07-21 00:00:00

abstract：:Faithful DNA replication is a prerequisite for cell proliferation. Several cytological studies have shown that chromosome structures alter in the S-phase of the cell cycle. However, the molecular mechanisms behind the alteration of chromosome structures associated with DNA replication have not been elucidated. Here, w...

journal_title：Scientific reports

authors： Ruan K,Yamamoto TG,Asakawa H,Chikashige Y,Kimura H,Masukata H,Haraguchi T,Hiraoka Y

更新日期：2015-07-30 00:00:00

abstract：:Early diagnosis of Parkinson's disease (PD) remains a challenge to date. New evidence highlights the potential clinical value of circulating trace amines (TAs) in early-stage PD and their involvement in disease progression. A new ultra performance chromatography mass spectrometry (UPLC-MS/MS) method was developed to q...

journal_title：Scientific reports

authors： D'Andrea G,Pizzolato G,Gucciardi A,Stocchero M,Giordano G,Baraldi E,Leon A

更新日期：2019-04-16 00:00:00

abstract：:Exposure to stress during early life affects subsequent behaviors and increases the vulnerability to adult pathologies, a phenomenon that has been well documented in humans and rodents. In this study, we introduce a chronic unpredictable stress protocol adapted to young zebrafish, which is an increasingly popular vert...

journal_title：Scientific reports

authors： Golla A,Østby H,Kermen F

更新日期：2020-06-25 00:00:00

abstract：:Our understanding of the structure and regulation of Plasmodium vivax genes is limited by our inability to grow the parasites in long-term in vitro cultures. Most P. vivax studies must therefore rely on patient samples, which typically display a low proportion of parasites and asynchronous parasites. Here, we present ...

journal_title：Scientific reports

authors： Kim A,Popovici J,Vantaux A,Samreth R,Bin S,Kim S,Roesch C,Liang L,Davies H,Felgner P,Herrera S,Arévalo-Herrera M,Ménard D,Serre D

更新日期：2017-08-10 00:00:00

abstract：:Most of the current studies on myocardial strain are mainly applied in patients with sinus rhythm because the image quality of arrhythmias obtained with conventional scanning sequences does not meet diagnostic needs. Here, we intend to assess left ventricular (LV) global myocardial strain in patients with arrhythmias ...

journal_title：Scientific reports

authors： Chen H,Xie RM,Zhao L,Zhang XY,Zhao YK,Wang Z,Xie GX,Ma XH

更新日期：2020-06-09 00:00:00

abstract：:Leaf senescence provides a unique window to explore the age-dependent programmed degradation at organ label in plants. Here, spectral domain optical coherence tomography (SD-OCT) has been used to study in vivo senescing leaf microstructural changes in the deciduous plant Acer serrulatum Hayata. Hayata leaves show autu...

journal_title：Scientific reports

authors： Anna T,Chakraborty S,Cheng CY,Srivastava V,Chiou A,Kuo WC

更新日期：2019-02-04 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is one of the most common inflammatory diseases resulting from habitual smoking. Impaired clearance of apoptotic cell by airway macrophages contributes to lung inflammation. Milk fat globule-EGF factor 8 (MFG-E8), as a link between apoptotic cells and phagocytes, facilitate...

journal_title：Scientific reports

authors： Wang Y,Luo G,Chen J,Jiang R,Zhu J,Hu N,Huang W,Cheng G,Jia M,Su B,Zhang N,Cui T

更新日期：2017-02-14 00:00:00

abstract：:The prognosis of pancreatic cancer remains dismal despite continuous and considerable efforts. Integrins (ITGs) are highly expressed in various malignant cancers. However, very few studies investigated the role of integrin α3 (ITGα3) in malignant cancers. Here, we determined the functional role of ITGα3 in pancreatic ...

journal_title：Scientific reports

authors： Lee J,Lee J,Choi C,Kim JH

更新日期：2019-02-26 00:00:00

abstract：:Deforestation associated with the initial settlement of New Zealand is a dramatic example of how humans can alter landscapes through fire. However, evidence linking early human presence and land-cover change is inferential in most continental sites. We employed a multi-proxy approach to reconstruct anthropogenic land ...

journal_title：Scientific reports

authors： Argiriadis E,Battistel D,McWethy DB,Vecchiato M,Kirchgeorg T,Kehrwald NM,Whitlock C,Wilmshurst JM,Barbante C

更新日期：2018-08-14 00:00:00

abstract：:The graft-versus-leukemia effect reminds us to observe the allogeneic cell elicited anti-tumor immune responses. Here we immunized recipient B6 mice with different types of allogenic leukocytes and found that vaccination with allogenic dendritic cells (alloDC) elicited the most efficient protection against broad-spect...

journal_title：Scientific reports

authors： Wang C,Li Z,Zhu Z,Chai Y,Wu Y,Yuan Z,Chang Z,Wang Z,Zhang M

更新日期：2019-10-29 00:00:00

abstract：:The interaction between cellulase enzymes and their substrates is of central importance to several technological and scientific challenges. Here we report that the binding of cellulose binding modules (CBM) from Trichoderma reesei cellulases Cel6A and Cel7A show a major difference in how they interact with substrates ...

journal_title：Scientific reports

authors： Arola S,Linder MB

更新日期：2016-10-17 00:00:00

abstract：:Silicene is an exciting two-dimensional material that shares many of graphene's electronic properties, but differs in its structural buckling. This buckling allows opening a bandgap in silicene through the application of a perpendicular electric field. Here we show that this buckling also enables highly effective modu...

journal_title：Scientific reports

authors： Al-Dirini F,Hossain FM,Mohammed MA,Nirmalathas A,Skafidas E

更新日期：2015-10-06 00:00:00

abstract：:Herein, water-oxidation reaction by cobalt(II) phthalocyanine, N,N'-bis (salicylidene) ethylenediamino cobalt(II), nickel(II) Schiff base (N,N'-bis (salicylidene)ethylenediamino nickel(II), nickel(II)) phthalocyanine-tetrasulfonate tetrasodium, manganese(II) phthalocyanine, 5,10,15,20-Tetraphenyl-21H,23H-porphine mang...

journal_title：Scientific reports

authors： Najafpour MM,Feizi H

更新日期：2019-05-16 00:00:00

abstract：:Increasing the thermostability of proteins is often crucial for their successful use as analytic, synthetic or therapeutic tools. Most rational thermostabilization strategies were developed on small two-state proteins and, unsurprisingly, they tend to fail when applied to the much more abundant, larger, non-fully coop...

journal_title：Scientific reports

authors： Lamazares E,Clemente I,Bueno M,Velázquez-Campoy A,Sancho J

更新日期：2015-03-16 00:00:00

abstract：:We provide a unified and exact framework for the variance-based uncertainty relations. This unified framework not only recovers some well-known previous uncertainty relations, but also fixes the deficiencies of them. Utilizing the unified framework, we can construct the new uncertainty relations in both product and su...

journal_title：Scientific reports

authors： Zheng X,Ma SQ,Zhang GF,Fan H,Liu WM

更新日期：2020-01-10 00:00:00

abstract：:Worldwide, Bartonella infections are known to inflict a wide range of mammals and, within rodents alone, more than 20 Bartonella species have been detected. There is, however, a lack of studies on the presence of Bartonella spp. in rodents in the Baltic region. We analysed 580 individuals belonging to eight small rode...

journal_title：Scientific reports

authors： Mardosaitė-Busaitienė D,Radzijevskaja J,Balčiauskas L,Bratchikov M,Jurgelevičius V,Paulauskas A

更新日期：2019-08-26 00:00:00

abstract：:Supercontinuum generation in Kerr media has become a staple of nonlinear optics. It has been celebrated for advancing the understanding of soliton propagation as well as its many applications in a broad range of fields. Coherent spectral broadening of laser light is now commonly performed in laboratories and used in c...

journal_title：Scientific reports

authors： Ciret C,Gorza SP,Husko C,Roelkens G,Kuyken B,Leo F

更新日期：2018-11-21 00:00:00

abstract：:We have recently reported that Kupffer cells consist of two subsets, radio-resistant resident CD68+ Kupffer cells and radio-sensitive recruited CD11b+ Kupffer cells/macrophages (Mφs). Non-alcoholic steatohepatitis (NASH) is characterized not only by hepatic steatosis but also chronic inflammation and fibrosis. In the ...

journal_title：Scientific reports

authors： Nakashima H,Nakashima M,Kinoshita M,Ikarashi M,Miyazaki H,Hanaka H,Imaki J,Seki S

更新日期：2016-10-06 00:00:00

abstract：:Sepsis induced cardiac dysfunction (SIC) is a severe complication to sepsis which significantly worsens patient outcomes. It is known that bacteria have the capacity to release outer membrane vesicles (OMVs), which are nano-sized bilayered vesicles composed of lipids and proteins, that can induce a fatal inflammatory ...

journal_title：Scientific reports

authors： Svennerholm K,Park KS,Wikström J,Lässer C,Crescitelli R,Shelke GV,Jang SC,Suzuki S,Bandeira E,Olofsson CS,Lötvall J

更新日期：2017-12-12 00:00:00

abstract：:Event-free survival (EFS) is considered the most reliable surrogate endpoint for overall survival (OS) in randomised controlled trials (RCTs) of adjuvant therapies for malignant tumours. However, the surrogacy of intermediate endpoints such as EFS for OS in trials of patients with osteosarcoma has not been investigate...

journal_title：Scientific reports

authors： Tanaka K,Kawano M,Iwasaki T,Matsuda S,Itonaga I,Tsumura H

更新日期：2020-05-22 00:00:00

abstract：:The cysteine-rich PLAC8 domain of unknown function occurs in proteins found in most Eukaryotes. PLAC8-proteins play important yet diverse roles in different organisms, such as control of cell proliferation in animals and plants or heavy metal resistance in plants and fungi. Mammalian Onzin can be either pro-proliferat...

journal_title：Scientific reports

authors： Daghino S,Di Vietro L,Petiti L,Martino E,Dallabona C,Lodi T,Perotto S

更新日期：2019-04-29 00:00:00

abstract：:Neutrophil elastase (NE) suppresses IL-8/CXCL8 in human airway smooth muscle cells (hASM) while stimulating its production in respiratory epithelial cells. This differential effect is mediated by the selective induction of NKRF and dysregulation in chronic inflammatory diseases. We hypothesized that the differential a...

journal_title：Scientific reports

authors： Ho SC,Wu SM,Feng PH,Liu WT,Chen KY,Chuang HC,Chan YF,Kuo LW,Lee KY

更新日期：2017-03-21 00:00:00

abstract：:Organic-inorganic halide perovskite nanocrystals or quantum dots (PQDs) are excellent candidates for optoelectronic applications, such as lasers, solar cells, light emitting diodes, and single photon sources. However, the potential applications of PQDs can expand once the photoluminescence, and in particular, the blin...

journal_title：Scientific reports

authors： Trinh CT,Minh DN,Ahn KJ,Kang Y,Lee KG

更新日期：2020-02-07 00:00:00