Abstract：
:Chronic HIV infection results in impairment of gut-associated lymphoid tissue leading to systemic immune activation. We previously showed that in early SIV-infected rhesus macaques intestinal dysfunction is initiated with the induction of the IL-1β pathway in the small intestine and reversed by treatment with an exogenous Lactobacillus plantarum strain. Here, we provide evidence that the transcriptomes of L. plantarum and ileal microbiota are not altered shortly after SIV infection. L. plantarum adapts to the small intestine by expressing genes required for tolerating oxidative stress, modifying cell surface composition, and consumption of host glycans. The ileal microbiota of L. plantarum-containing healthy and SIV+ rhesus macaques also transcribed genes for host glycan metabolism as well as for cobalamin biosynthesis. Expression of these pathways by bacteria were proposed but not previously demonstrated in the mammalian small intestine.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Golomb BL,Hirao LA,Dandekar S,Marco MLdoi
10.1038/srep24723subject
Has Abstractpub_date
2016-04-22 00:00:00pages
24723issn
2045-2322pii
srep24723journal_volume
6pub_type
杂志文章abstract：:Parkinson's Disease can be understood as a disorder of motor habits. A prediction of this theory is that early stage Parkinson's patients will display fewer errors caused by interference from previously over-learned behaviours. We test this prediction in the domain of skilled typing, where actions are easy to record a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39294-z
更新日期：2019-03-04 00:00:00
abstract：:Mitochondria act as a platform for antiviral innate immunity, and the immune system depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors (RLR) signaling pathway via an adaptor molecule, mitochondrial antiviral signaling. We report that RLR-mediated antiviral innate immunity requires oxida...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05808-w
更新日期：2017-07-14 00:00:00
abstract：:Brown adipose tissue (BAT) plays a central role in regulating energy homeostasis, and may provide novel strategies for the treatment of human obesity. BAT-mediated thermogenesis is regulated by mitochondrial uncoupling protein 1 (UCP1) in classical brown and ectopic beige adipocytes, and is controlled by sympathetic n...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18013
更新日期：2015-12-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07124
更新日期：2014-11-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53562-y
更新日期：2019-11-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-04-30 00:00:00
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pub_type： 杂志文章
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更新日期：2017-04-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-01-12 00:00:00
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pub_type： 杂志文章
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更新日期：2015-12-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-04-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-22402-w
更新日期：2018-03-05 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-08-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-06-09 00:00:00
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pub_type： 杂志文章
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更新日期：2017-03-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73681-1
更新日期：2020-10-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68914-2
更新日期：2020-07-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep35278
更新日期：2016-10-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51418-z
更新日期：2019-10-21 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-10-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-09-08 00:00:00
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pub_type： 杂志文章
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更新日期：2020-06-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50773-1
更新日期：2019-10-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32833
更新日期：2016-10-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-10-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44976
更新日期：2017-03-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22284
更新日期：2016-03-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00877
更新日期：2012-01-01 00:00:00
