Abstract:
:To understand the impact of PIK3CA mutations on clinical characteristics and treatment response to epidermal growth factor tyrosine kinase inhibitors (EGFR TKIs) of lung adenocarcinoma, we examined PIK3CA and EGFR mutations in lung adenocarcinoma patients, and analyzed their clinical outcomes. Surgically excised tumor, bronchoscopy biopsy/brushing specimens and pleural effusions were prospectively collected from 1029 patients. PIK3CA and EGFR mutations were analyzed by RT-PCR and direct sequencing. In EGFR TKI-nave specimens, PIK3CA mutation rate was 1.8% (14/760). Twelve patients had coexisting PIK3CA and EGFR mutations. Among the 344 EGFR TKI-treated EGFR mutant patients, there was no significant difference in treatment response (p = 0.476) and progression-free survival (p = 0.401) of EGFR TKI between PIK3CA mutation-positive and negative patients. The PIK3CA mutation rate in lung adenocarcinoma with acquired resistance to EGFR TKI is not higher than that in EGFR TKI-naïve tissue specimens (2.9% (6/207) vs. 1.8%; p = 0.344). Of the 74 patients with paired specimens (TKI-naïve and acquired resistance to TKIs) only one patient (1.4%) developed acquired PIK3CA (E545K) mutation, and he also had acquired EGFR (T790M) mutation. In conclusion, PIK3CA mutation may not be associated with primary resistance to EGFR TKI among lung adenocarcinoma patients. Acquired PIK3CA mutation related to EGFR TKI treatment is rare.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wu SG,Chang YL,Yu CJ,Yang PC,Shih JYdoi
10.1038/srep35249subject
Has Abstractpub_date
2016-10-13 00:00:00pages
35249issn
2045-2322pii
srep35249journal_volume
6pub_type
杂志文章abstract::Exhibiting a red-shifted absorption/scattering feature compared to conventional plasmonic metals, titanium nitride nanoparticles (TiN NPs) look as very promising candidates for biomedical applications, but these applications are still underexplored despite the presence of extensive data for conventional plasmonic coun...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37519-1
更新日期:2019-02-04 00:00:00
abstract::Transient hepatic steatosis upon liver resection supposes functional relationships between lipid metabolism and liver regeneration. Repin1 has been suggested as candidate gene for obesity and dyslipidemia by regulating key genes of lipid metabolism and lipid storage. Herein, we characterized the regenerative potential...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35325-3
更新日期:2018-11-15 00:00:00
abstract::Peste des petits ruminants (PPR) is a highly contagious and devastating viral disease affecting mainly sheep and goats, but also a large number of wild species within the order Artiodactyla. A better understanding of PPR transmission dynamics in multi-host systems is necessary to efficiently control the disease, in pa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41232-y
更新日期:2019-03-18 00:00:00
abstract::Functional neuroimaging, using genetically-encoded Ca2+ sensors in larval zebrafish, offers a powerful combination of high spatiotemporal resolution and higher vertebrate relevance for quantitative neuropharmacological profiling. Here we use zebrafish larvae with pan-neuronal expression of GCaMP6s, combined with light...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06646-6
更新日期:2017-07-26 00:00:00
abstract::Olfactory dysfunction is a robust and early sign for Parkinson's disease (PD). Previous studies have revealed its association with dementia and related neural changes in PD. Yet, how olfactory dysfunction affects white matter (WM) microstructure in newly diagnosed and untreated PD remains unclear. Here we comprehensiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12947-7
更新日期:2017-10-02 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-019-43507-w
更新日期:2019-06-05 00:00:00
abstract::The oral environment affects not only oral health, but also general health, and the importance of oral self-care has recently been recognised. Although toothbrushes are the most important self-care product, there are few toothbrushes that have an inhibitory effect on oral bacteria. In the present study, monofilaments ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80646-x
更新日期:2021-01-08 00:00:00
abstract::Psychological factors, specific lifestyles and environmental stressors may influence etiopathogenesis and evolution of chronic diseases. We investigate the association between Chronic Inflammatory Bowel Diseases (IBD) and psychological dimensions such as personality traits, defence mechanisms, and Alexithymia, i.e. de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41786
更新日期:2017-02-02 00:00:00
abstract::RFeO3 orthoferrites, where R is a rare-earth ion of the lanthanide series, are attracting attention mostly because of their promising fast spin dynamics. The magnetic properties of these materials seem to crucially depend on whether the magnetizations of the R and Fe ions' weak ferromagnetic (WFM) components are paral...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37529
更新日期:2016-11-25 00:00:00
abstract::In this paper, a novel explanation on high directive emission of Fabry-Perot resonator antenna with subwavelength metasurface is proposed. Based on image theory and effective constitutive parameter retrieval, the whole Fabry-Perot resonant cavity structure composed of a single-layer metasurface with square ring elemen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11141-z
更新日期:2017-09-13 00:00:00
abstract::On the basis of diet induced obesity and KO mice models, nitric oxide is implied to play an important role in the initiation of dyslipidemia induced insulin resistance. However, outcomes using iNOS KO mice have so far remained inconclusive. The present study aimed to assess IR in iNOS KO mice after 5 weeks of LFD feed...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41009
更新日期:2017-01-20 00:00:00
abstract::Abiotic stress significantly impacts growth and yield of crop plants. It is imperative for crop improvement to discover and utilize stress-tolerant functional genes. In this study, genes responding to abiotic stresses, such as freezing, salt and osmotic stress, were screened from a cDNA yeast library that was construc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37859-y
更新日期:2019-01-15 00:00:00
abstract::Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. Individuals with RA have a higher risk of periodontitis and periodontitis has been linked to RA through the production of enzymes by periodontal pathogens that citrullinate proteins. This linkage is supported by findings that perio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44674-6
更新日期:2019-06-10 00:00:00
abstract::Bagging is an efficient method to improve fruit colour development. This work reported a transcriptome analysis using bagging-treated red Chinese sand pear peels. In total, 8,870 differentially expressed genes were further analysed by a weighted gene co-expression network analysis and early-, middle- and late light-re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00069-z
更新日期:2017-03-03 00:00:00
abstract::This paper describes two different electrochemical affinity biosensing approaches for the simple, fast and bisulfite and PCR-free quantification of 5-methylated cytosines (5-mC) in DNA using the anti-5-mC antibody as biorecognition element. One of the biosensing approaches used the anti-5-mC as capture bioreceptor and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24902-1
更新日期:2018-04-23 00:00:00
abstract::Disseminated tumor cells (DTCs) in the bone marrow (BM) and circulating tumor cells (CTCs) in blood of breast cancer patients (pts) are known to correlate with worse outcome. Here we demonstrate a different prognostic value of DTCs and CTCs and explain these findings by early clodronate intake. CTCs (n = 376 pts) were...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26355
更新日期:2016-05-23 00:00:00
abstract::Thiamine monophosphate kinase (ThiL) catalyzes the last step of thiamine pyrophosphate (TPP) synthesis, the ATP-dependent phosphorylation of thiamine monophosphate (TMP) to thiamine pyrophosphate. We solved the structure of ThiL from the human pathogen A. baumanii in complex with a pair of substrates TMP and a non-hyd...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40558-x
更新日期:2019-03-13 00:00:00
abstract::For augmentation or reconstruction of urinary bladder after cystectomy, bladder urothelium derived from human induced pluripotent stem cells (hiPSCs) has recently received focus. However, previous studies have only shown the emergence of cells expressing some urothelial markers among derivatives of hiPSCs, and no repo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46848-8
更新日期:2019-07-19 00:00:00
abstract::Metagenomics brings in new discoveries and insights into the uncultured microbial world. One fundamental task in metagenomics analysis is to determine the taxonomy of raw sequence fragments. Modern sequencing technologies produce relatively short fragments and greatly increase the number of fragments, and thus make th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-09947-y
更新日期:2017-08-25 00:00:00
abstract::Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand the pathogenesis of the disease and to develop treatment strategies. Wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00489-x
更新日期:2017-03-24 00:00:00
abstract::The CRISPR/Cas9 system is a powerful method of editing genes by randomly introducing errors into the target sites. Here, we describe a CRISPR-based test for gene essentiality (CRISPR-E test) that allows the identification of essential genes. Specifically, we use sgRNA-mediated CRISPR/Cas9 to target the open reading fr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71690-8
更新日期:2020-09-08 00:00:00
abstract::This work provides new insights into the dynamics of silica nanoparticle-based removal of organic fluids (here oil) from naturally occurring porous media. We have used 4D (time-resolved 3D) imaging at pore-scale using X-ray computed micro-tomography (μCT) technique. The captured 3D tomographic time-series data reveal ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29569-2
更新日期:2018-07-24 00:00:00
abstract::We have purified the mammalian synaptophysin/synaptobrevin (SYP/VAMP2) complex to homogeneity in the presence of cholesterol and determined the 3D EM structure by single particle reconstruction. The structure reveals that SYP and VAMP2 assemble into a hexameric ring wherein 6 SYP molecules bind 6 VAMP2 dimers. Using t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13659
更新日期:2015-09-03 00:00:00
abstract::The recent reaching of 20% of conversion efficiency by solar cells based on metal hybrid perovskites (MHP), e.g., the methylammonium (MA) lead iodide, CH3NH3PbI3 (MAPbI3), has excited the scientific community devoted to the photovoltaic materials. However, the toxicity of Pb is a hindrance for large scale commercial o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47192-7
更新日期:2019-07-30 00:00:00
abstract::Classical swine fever virus (CSFV) non-structural protein 3 (NS3) is a multifunctional non-structural protein that plays a major role in viral replication. However, how exactly NS3 exerts these functions remains unknown. Here, we identified tumour necrosis factor receptor-associated factor 6 (TRAF6) as a novel NS3-int...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06934-1
更新日期:2017-07-27 00:00:00
abstract::Increasingly researchers are looking to bring together perspectives across multiple scales, or to combine insights from different techniques, for the same region of interest. To this end, correlative microscopy has already yielded substantial new insights in two dimensions (2D). Here we develop correlative tomography ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04711
更新日期:2014-04-16 00:00:00
abstract::Graphene has shown enormous potential for innovation in various research fields. The current chemical approaches based on exfoliation of graphite via graphite oxide (GO) are potential for large-scale synthesis of graphene but suffer from high cost, great operation difficulties, and serious waste discharge. We report a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03439
更新日期:2013-12-06 00:00:00
abstract::Electrosprays operate in several modes depending on the flow rate and electric potential. This allows the deposition of droplets containing nanoparticles into discrete nanodot arrays to fabricate various electronic devices. In this study, seven different suspensions with varying properties were investigated. In the dr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05175-6
更新日期:2017-07-11 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) pollutions often occur in marine and other saline environment, largely due to anthropogenic activities. However, study of the PAHs-degradation genotypes in halophiles is limited, compared with the mesophilic terrestrial PAHs degraders. In this study, a bacterial consortium (CY-1...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12979-z
更新日期:2017-10-02 00:00:00
abstract::The wheat avenin-like proteins (ALP) are considered atypical gluten constituents and have shown positive effects on dough properties revealed using a transgenic approach. However, to date the genetic architecture of ALP genes is unclear, making it impossible to be utilized in wheat breeding. In the current study, thre...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30692
更新日期:2016-08-09 00:00:00