Abstract：
:Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. Individuals with RA have a higher risk of periodontitis and periodontitis has been linked to RA through the production of enzymes by periodontal pathogens that citrullinate proteins. This linkage is supported by findings that periodontitis is associated with increased RA severity and treatment of periodontitis can improve the symptoms of RA. The possible mechanism for this association is through dysbiosis of the oral microbiota triggered by RA-induced systemic inflammation. We examined the RA status of subjects by measuring the number of tender and swollen joints, anti-citrullinated protein antibody and rheumatoid factor. Periodontal disease status and salivary cytokine levels were measured, and dental plaque analyzed by 16S rRNA high throughput sequencing. RA patients had a higher bacterial load, a more diverse microbiota, an increase in bacterial species associated with periodontal disease, more clinical attachment loss, and increased production of inflammatory mediators including IL-17, IL-2, TNF, and IFN-γ. Furthermore, changes in the oral microbiota were linked to worse RA conditions. Our study provides new insights into the bi-directional relationship between periodontitis and RA and suggest that monitoring the periodontal health of RA patients is particularly important.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Corrêa JD,Fernandes GR,Calderaro DC,Mendonça SMS,Silva JM,Albiero ML,Cunha FQ,Xiao E,Ferreira GA,Teixeira AL,Mukherjee C,Leys EJ,Silva TA,Graves DTdoi
10.1038/s41598-019-44674-6subject
Has Abstractpub_date
2019-06-10 00:00:00pages
8379issue
1issn
2045-2322pii
10.1038/s41598-019-44674-6journal_volume
9pub_type
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