Abstract:
:Exhibiting a red-shifted absorption/scattering feature compared to conventional plasmonic metals, titanium nitride nanoparticles (TiN NPs) look as very promising candidates for biomedical applications, but these applications are still underexplored despite the presence of extensive data for conventional plasmonic counterparts. Here, we report the fabrication of ultrapure, size-tunable TiN NPs by methods of femtosecond laser ablation in liquids and their biological testing. We show that TiN NPs demonstrate strong and broad plasmonic peak around 640-700 nm with a significant tail over 800 nm even for small NPs sizes (<7 nm). In vitro tests of laser-synthesized TiN NPs on cellular models evidence their low cytotoxicity and excellent cell uptake. We finally demonstrate a strong photothermal therapy effect on U87-MG cancer cell cultures using TiN NPs as sensitizers of local hyperthermia under near-infrared laser excitation. Based on absorption band in the region of relative tissue transparency and acceptable biocompatibility, laser-synthesized TiN NPs promise the advancement of biomedical modalities employing plasmonic effects, including absorption/scattering contrast imaging, photothermal therapy, photoacoustic imaging and SERS.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Popov AA,Tselikov G,Dumas N,Berard C,Metwally K,Jones N,Al-Kattan A,Larrat B,Braguer D,Mensah S,Da Silva A,Estève MA,Kabashin AVdoi
10.1038/s41598-018-37519-1subject
Has Abstractpub_date
2019-02-04 00:00:00pages
1194issue
1issn
2045-2322pii
10.1038/s41598-018-37519-1journal_volume
9pub_type
杂志文章abstract::High-risk human papillomavirus (HPV) type 16, which is responsible for greater than 50% of cervical cancer cases, is the most prevalent and lethal HPV type. However, the molecular mechanisms of cervical carcinogenesis remain elusive, particularly the early steps of HPV infection that may transform normal cervical epit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07653
更新日期:2015-01-07 00:00:00
abstract::At the present study, a one-dimensional model for the flat sheet direct contact membrane distillation (DCMD) for desalination purposes is proposed. Flows and membrane properties have been estimated by appropriate temperature-dependent correlations. Results show that the numerical model is in a very good agreement with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73964-7
更新日期:2020-10-08 00:00:00
abstract::Holography--originally developed for correcting spherical aberration in transmission electron microscopes--is now used in a wide range of disciplines that involve the propagation of waves, including light optics, electron microscopy, acoustics and seismology. In electron microscopy, the two primary modes of holography...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07020
更新日期:2014-11-12 00:00:00
abstract::Several lines of evidence indicate that Fibronectin Extra Domain A (EDA) promotes metastatic capacity of tumor cells by engaging cell surface α9β1 integrins. This interaction mediated by the C-C loop of EDA activates pro-oncogenic signaling pathways leading to epithelial to mesenchymal transition (EMT) of tumor cells,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep37151
更新日期:2016-11-16 00:00:00
abstract::Cylindrical silk gland (CY) spigots distinguish a large clade of modern spiders, the CY spigot clade, which includes all entelegyne spiders and their closest relatives. Following a widespread paradigm, CYs and their spigots are only known to occur in female spiders and they produce silk used in the construction of egg...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-63521-7
更新日期:2020-04-20 00:00:00
abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-018-21594-5
更新日期:2018-03-06 00:00:00
abstract::The potential of Massively Parallel Sequencing (MPS) technology to vastly expand the capabilities of human identification led to the emergence of different MPS platforms that use forensically relevant genetic markers. Two of the MPS platforms that are currently available are the MiSeq® FGx™ Forensic Genomics System (I...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00510-3
更新日期:2017-03-24 00:00:00
abstract::The receptor guanylate cyclases (rGCs) in animals serve as sensitive chemoreceptors to detect both chemical and environmental cues. In reproduction, rGCs were shown to be expressed on sperm and serve as receptors for egg-derived sperm-activating and sperm-attracting factors in some echinoderms and mammals. However, sp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51224-7
更新日期:2019-10-10 00:00:00
abstract::The Farnesoid X receptor (FXR) regulates bile salt, glucose and cholesterol homeostasis by binding to DNA response elements, thereby activating gene expression (direct transactivation). FXR also inhibits the immune response via tethering to NF-κB (tethering transrepression). FXR activation therefore has therapeutic po...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep14086
更新日期:2015-09-15 00:00:00
abstract::Quantum information science addresses how the processing and transmission of information are affected by uniquely quantum mechanical phenomena. Combination of two-qubit gates has been used to realize quantum circuits, however, scalability is becoming a critical problem. The use of three-qubit gates may simplify the st...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45353
更新日期:2017-03-31 00:00:00
abstract::Transplacental transmission (TPT) of wild-type Indian BTV-1 had never been experimentally proved. This study was first time investigated TPT of Indian BTV-1 (isolated from aborted and stillborn goat fetal spleens). The sequential pathology, virological and immune cell kinetics (CD4+, CD8+ T-lymphocytes and NK cells in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-58268-0
更新日期:2020-02-07 00:00:00
abstract::Cervical carcinoma is the fourth most common cause of death in woman, caused by human papillomavirus (HPV) infections and arising from the cervix. Cytoskeleton-associated protein 2 (CKAP2), also known as tumor-associated microtubule-associated protein, has been linked to tumorigenic effects. In the present study, we s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01832-y
更新日期:2017-05-18 00:00:00
abstract::We propose a new express method of the correlation characterization of the particles suspended in the volume of optically transparent medium. It utilizes inline digital holography technique for obtaining two images of the adjacent layers from the investigated volume with subsequent matching of the cross-correlation fu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43840
更新日期:2017-03-02 00:00:00
abstract::A new method combining aqueous solution printing with UV Laser crystallization (UVLC) and post annealing is developed to deposit highly transparent and conductive Aluminum doped Zinc Oxide (AZO) films. This technique is able to rapidly produce large area AZO films with better structural and optoelectronic properties t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15517
更新日期:2015-10-30 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-57571-0
更新日期:2020-01-14 00:00:00
abstract::A robust method is presented for the segmentation of the full cerebral vasculature in 4-dimensional (4D) computed tomography (CT). The method consists of candidate vessel selection, feature extraction, random forest classification and postprocessing. Image features include among others the weighted temporal variance i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15617-w
更新日期:2017-11-15 00:00:00
abstract::Diabetic nephropathy is characterised by the excessive amount of extracellular matrix in glomeruli and tubulointerstitial space. Lysyl oxidase-like 2 (LOXL2) is elevated in renal fibrosis and known to play key roles in ECM stabilisation by facilitating collagen cross-links, epithelial to mesenchymal transition and myo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27462-6
更新日期:2018-06-21 00:00:00
abstract::Caffeine modifies vascular/cardiac contractility. Embryonic exposure to caffeine altered cardiac functions in offspring. This study determined chronic influence of prenatal caffeine on vessel functions in offspring. Pregnant Sprague-Dawley rats (5-month-old) were exposed to high dose of caffeine, their offspring (5-mo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep13225
更新日期:2015-08-17 00:00:00
abstract::Traditionally, dynamic atomic force microscopy (AFM) techniques are based on the analysis of the quasi-steady state response of the cantilever deflection in terms of Fourier analysis. Here we describe a technique that instead exploits the often disregarded transient response of the cantilever through a relatively mode...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49104-1
更新日期:2019-09-03 00:00:00
abstract::Protective antigen (PA) of Bacillus anthracis is being considered as a vaccine candidate against anthrax and its production has been explored in several heterologous host systems. Since the systems tested introduced adverse issues such as inclusion body formation and endotoxin contamination, the production from B. ant...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34196-y
更新日期:2018-10-31 00:00:00
abstract::Regime shift from grasslands to shrub-dominated landscapes occur worldwide driven by altered land-use and climate change, affecting landscape function, biodiversity, and productivity. Warming winter temperatures are a main driver of expansion of the native, evergreen shrub, Morella cerifera, in coastal landscapes. Shr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65161-3
更新日期:2020-05-19 00:00:00
abstract::Cathode materials always limit the performance of fuel cells while the commercial platinum-based catalysts hardly meet the requirements of low cost, durable and stable. Here a non-precious metal oxygen reduction reaction (ORR) electocatalyst based on titanium nitride/titanium carbonitride hierarchical structures (TNTC...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06712
更新日期:2014-10-22 00:00:00
abstract::The discovery of circulating tumour DNA molecules created a paradigm shift in tumour biomarkers as predictors of recurrence. Non-invasive prenatal testing (NIPT) to detect circulating cell-free foetal DNA in maternal plasma is increasingly recognised as a valuable substitute to perceive foetal copy number variation (C...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29381-y
更新日期:2018-07-25 00:00:00
abstract::Sulfonylureas are commonly used to treat type 2 diabetes mellitus. Despite awareness of their effects on cardiac physiology, a knowledge gap exists regarding their effects on cardiovascular events in real-world populations. Prior studies reported sulfonylurea-associated cardiovascular death but not serious arrhythmoge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66668-5
更新日期:2020-06-22 00:00:00
abstract::Transition metal cobalt (Co) nanoparticle was designed as catalyst to promote the conversion reaction of Sn to SnO2 during the delithiation process which is deemed as an irreversible reaction. The designed nanocomposite, named as SnO2/Co3O4/reduced-graphene-oxide (rGO), was synthesized by a simple two-step method comp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09164
更新日期:2015-03-17 00:00:00
abstract::Proper structural organization of spiral ganglion (SG) innervation is crucial for normal hearing function. However, molecular mechanisms underlying the developmental formation of this precise organization remain not well understood. Here, we report in the developing mouse cochlea that deleted in colorectal cancer (Dcc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23799
更新日期:2016-04-04 00:00:00
abstract::The correlations between early responses and the variations in physical density and primary tumor volume (TV) according to cone-beam computed tomography (CBCT) during chemoradiotherapy for non-small cell lung cancer (NSCLC) patients were investigated. 54 patients with inoperable and locally advanced NSCLC were include...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14548-w
更新日期:2017-11-07 00:00:00
abstract::Novel pain killers without adverse effects are urgently needed. Opioids induce central and intestinal side effects such as respiratory depression, sedation, addiction, and constipation. We have recently shown that a newly designed agonist with a reduced acid dissociation constant (pKa) abolished pain by selectively ac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27313-4
更新日期:2018-06-12 00:00:00
abstract::Connectivity is fundamentally important for shaping the resilience of complex human and natural networks when systems are disturbed. Ecosystem resilience is, in part, shaped by the spatial arrangement of habitats, the permeability and fluxes between them, the stabilising functions performed by organisms, their dispers...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-021-80987-1
更新日期:2021-01-13 00:00:00
abstract::Cyanobacteria are attractive microbial hosts for production of chemicals using light and CO2. However, their low productivity of chemicals is a major challenge for commercial applications. This is mostly due to their relatively slow growth rate and carbon partitioning toward biomass rather than products. Many cyanobac...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57319-5
更新日期:2020-01-15 00:00:00