Abstract:
:Brown adipose tissue (BAT) plays a central role in regulating energy homeostasis, and may provide novel strategies for the treatment of human obesity. BAT-mediated thermogenesis is regulated by mitochondrial uncoupling protein 1 (UCP1) in classical brown and ectopic beige adipocytes, and is controlled by sympathetic nervous system (SNS). Previous work indicated that fish oil intake reduces fat accumulation and induces UCP1 expression in BAT; however, the detailed mechanism of this effect remains unclear. In this study, we investigated the effect of fish oil on energy expenditure and the SNS. Fish oil intake increased oxygen consumption and rectal temperature, with concomitant upregulation of UCP1 and the β3 adrenergic receptor (β3AR), two markers of beige adipocytes, in the interscapular BAT and inguinal white adipose tissue (WAT). Additionally, fish oil intake increased the elimination of urinary catecholamines and the noradrenaline (NA) turnover rate in interscapular BAT and inguinal WAT. Furthermore, the effects of fish oil on SNS-mediated energy expenditure were abolished in transient receptor potential vanilloid 1 (TRPV1) knockout mice. In conclusion, fish oil intake can induce UCP1 expression in classical brown and beige adipocytes via the SNS, thereby attenuating fat accumulation and ameliorating lipid metabolism.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kim M,Goto T,Yu R,Uchida K,Tominaga M,Kano Y,Takahashi N,Kawada Tdoi
10.1038/srep18013subject
Has Abstractpub_date
2015-12-17 00:00:00pages
18013issn
2045-2322pii
srep18013journal_volume
5pub_type
杂志文章abstract::Coherent Anti-Stokes Raman Spectroscopy (CARS) is performed on single spores (conidia) of the fungus Aspergillus nidulans in order to establish a baseline measurement for fungal spores. Chemical maps of single spores are generated and spectral differentiation between the cell wall and the cytoplasm is achieved. Princi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37978-6
更新日期:2019-02-11 00:00:00
abstract::The prognosis of pancreatic cancer remains dismal despite continuous and considerable efforts. Integrins (ITGs) are highly expressed in various malignant cancers. However, very few studies investigated the role of integrin α3 (ITGα3) in malignant cancers. Here, we determined the functional role of ITGα3 in pancreatic ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39628-x
更新日期:2019-02-26 00:00:00
abstract::Surface incident solar radiation (Rs) of reanalysis products is widely used in ecological conservation, agricultural production, civil engineering and various solar energy applications. It is of great importance to have a good knowledge of the uncertainty of reanalysis Rs products. In this study, we evaluated the Rs e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-60460-1
更新日期:2020-02-26 00:00:00
abstract::Acanthamoeba can cause visually destructive Acanthamoeba keratitis (AK) in contact lens (CL) users. The purpose of this study was to determine whether Acanthamoeba was present in the CL cases of CL wearers and to develop techniques to prevent the contaminations. To accomplish this, 512 CL case samples were collected f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69554-2
更新日期:2020-07-28 00:00:00
abstract::Adenosine receptors (ARs) are potential therapeutic targets for Parkinson's disease, diabetes, pain, stroke and cancers. Prediction of subtype selectivity is therefore important from both therapeutic and mechanistic perspectives. In this paper, we introduced a shape similarity profile as molecular descriptor, namely t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36595
更新日期:2016-11-04 00:00:00
abstract::Low back pain (LBP) is a widespread debilitating disorder of significant socio-economic importance and intervertebral disc (IVD) degeneration has been implicated in its pathogenesis. Despite its high prevalence the underlying causes of LBP and IVD degeneration are not well understood. Recent work in musculoskeletal de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12666-z
更新日期:2017-10-02 00:00:00
abstract::As it is altered by ionizing radiation, the vascular network is considered as a prime target in limiting normal tissue damage and improving tumor control in radiation therapy. Irradiation activates endothelial cells which then participate in the recruitment of circulating cells, especially by overexpressing cell adhes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05563-y
更新日期:2017-07-13 00:00:00
abstract::Development of multidrug resistance (MDR) is an almost universal phenomenon in patients with ovarian cancer, and this severely limits the ultimate success of chemotherapy in the clinic. Overexpression of the MDR1 gene and corresponding P-glycoprotein (Pgp) is one of the best known MDR mechanisms. MDR1 siRNA based stra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08509
更新日期:2015-02-17 00:00:00
abstract::The primary motor cortex (M1) is highly influenced by premotor/motor areas both within and across hemispheres. Dual site transcranial magnetic stimulation (dsTMS) has revealed interhemispheric interactions mainly at early latencies. Here, we used dsTMS to systematically investigate long-latency causal interactions bet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13708-2
更新日期:2017-11-02 00:00:00
abstract::A series of novel oxide catalysts, which contain three-dimensionally ordered macroporous (3DOM) and microporous structure, were firstly designed and successfully synthesized by simple method. In the as-prepared catalysts, 3DOM SiO2 is used as support and microporous K-OMS-2 oxide nanoparticles are supported on the wal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43894
更新日期:2017-04-26 00:00:00
abstract::Prolactin (PRL) is an anterior pituitary hormone with a broad range of functions. Its ability to stimulate lactogenesis, maternal behavior, growth and development, osmoregulation, and epithelial ion transport has been reported in many vertebrates. In our present study, we have targeted the zebrafish prl locus via tran...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18597
更新日期:2016-01-04 00:00:00
abstract::The ability to process time on the scale of milliseconds and seconds is essential for behaviour. A growing number of studies have started to focus on brain dynamics as a mechanism for temporal encoding. Although there is growing evidence in favour of this view from computational and in vitro studies, there is still a ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46053
更新日期:2017-04-10 00:00:00
abstract::There is a need to develop economical, efficient and widely available therapeutic approaches to enhance the rate of skin wound healing. The optimal outcome of wound healing is restoration to the pre-wound quality of health. In this study we investigate the cellular response to biological stimuli using functionalized n...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06903
更新日期:2014-11-11 00:00:00
abstract::To assess the metabolically beneficial effects of fenugreek (Trigonella foenum-graecum), C57BL/6J mice were fed a low- or high-fat diet for 16 weeks with or without 2% (w/w) fenugreek supplementation. Body weight, body composition, energy expenditure, food intake, and insulin/glucose tolerance were measured regularly,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12846-x
更新日期:2017-10-06 00:00:00
abstract::The aims of this study were, firstly, to assess the effect of concurrent peripheral artery disease (PAD) on the health-related quality of life (QOL) of people diagnosed with a small abdominal aortic aneurysm (AAA); and secondly, to test whether the peroxisome proliferator-activated receptor α agonist fenofibrate impro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-71454-4
更新日期:2020-09-03 00:00:00
abstract::To attach reliably on various inclined rough surfaces, many insects have evolved both claws and adhesive pads on their feet. However, the interaction between these organs still remains unclear. Here we designed an artificial attachment device, which mimics the structure and function of claws and adhesive pads, and tes...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26219
更新日期:2016-05-20 00:00:00
abstract::The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection b...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67827-4
更新日期:2020-07-09 00:00:00
abstract::Ecosystem carbon carrying capacity (CCC) is determined by prevailing climate and natural disturbance regimes, conditions that are projected to change significantly. The interaction of changing climate and its effects on disturbance regimes is expected to affect forest regeneration and growth, which may diminish forest...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02686-0
更新日期:2017-05-25 00:00:00
abstract::Understanding coupling of ferroic properties over grain boundaries and within clusters of grains in polycrystalline materials is hindered due to a lack of direct experimental methods to probe the behaviour of individual grains in the bulk of a material. Here, a variant of three-dimensional X-ray diffraction (3D-XRD) i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22820
更新日期:2016-03-09 00:00:00
abstract::Here, we report a newly designed knee plug to be used in the 3rd generation of Autologous Chondrocyte Implantation (ACI) in order to heal the damaged knee cartilage. It is composed of three components: The first component (Bone Portion) is a 3D printed hard scaffold with large pores (~ 850 µm), made by hydroxyapatite ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-73863-x
更新日期:2020-10-12 00:00:00
abstract::Nucleotide excision repair (NER) excises bulky DNA lesions induced by mutagens and carcinogens. The repair process includes recognition of DNA damage, excision of a short patch of nucleotides containing the damaged base, re-synthesis of a new DNA strand and ligation of the nicks to restore the sequence integrity. Muta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04894
更新日期:2014-05-08 00:00:00
abstract::As a nutritional factor, folic acid can prevent cardiac and neural defects during embryo development. Our previous study showed that arsenic impairs embryo development by down-regulating Dvr1/GDF1 expression in zebrafish. Here, we investigated whether folic acid could protect against arsenic-mediated embryo toxicity. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16093
更新日期:2015-11-05 00:00:00
abstract::Ascertaining the existence of hidden objects in a complex system, objects that cannot be observed from the external world, not only is curiosity-driven but also has significant practical applications. Generally, uncovering a hidden node in a complex network requires successful identification of its neighboring nodes, ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep03944
更新日期:2014-02-03 00:00:00
abstract::A variety of pathogenic bacteria infect host eukaryotic cells using protein toxins, which enter the cytosol and exert their cytotoxic effects. Anthrax lethal toxin, for example, utilizes the membrane-spanning translocase, protective antigen (PA) pore, to deliver the protein toxin lethal factor (LF) from the endosome i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11944
更新日期:2015-07-16 00:00:00
abstract::Programmed death-ligand 1 (PD-L1) acts as an immune checkpoint inhibitor in various cancers. PD-L1 is known to be more frequently expressed in EBV (+) gastric cancer (GC). However, the mechanisms underlying the regulation of PD-L1 expression in EBV (+) GC remain unclear. We investigated the basal and inducible PD-L1 e...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18132-0
更新日期:2017-12-19 00:00:00
abstract::Radopholus similis is an important migratory endoparasitic nematode, severely harms banana, citrus and many other commercial crops. Little is known about the molecular mechanism of infection and pathogenesis of R. similis. In this study, 64761 unigenes were generated from eggs, juveniles, females and males of R. simil...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-42724-7
更新日期:2019-04-18 00:00:00
abstract::Keratoconus is a common degenerative corneal disease that can lead to significant visual morbidity, and both genetic and environmental factors have been implicated in its pathogenesis. We compared the transcriptome of keratoconus and control epithelium using RNA-Seq. Epithelial tissues were obtained prior to surgery f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18480-x
更新日期:2018-01-10 00:00:00
abstract::Converging evidence supports the involvement of pro-inflammatory pathways and the gut microbiome in major depressive disorder (MDD). Pre-clinical and clinical studies suggest that decreasing pro-inflammatory signaling may provide clinical benefit in MDD. In this study, we used the chronic unpredictable stress (CUS) pa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38055-8
更新日期:2019-04-23 00:00:00
abstract::Imaging and histopathological studies have demonstrated that structural changes of the retina affect subjects with Alzheimer's disease (AD) or mild cognitive impairment (MCI). The aim of this study was to quantitatively investigate the retinal vessels in these disorders, using dynamic vessel analyzer (DVA) and optical...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37271-6
更新日期:2019-01-11 00:00:00
abstract::Grain boundary (GB) oxidation of proton-irradiated 304 nuclear grade stainless steel in primary water of pressurized water reactor was investigated. The investigation was conducted by studying microstructure of the oxide and oxide precursor formed at GB on an "atom-by-atom" basis by a combination of atom-probe tomogra...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80600-x
更新日期:2021-01-14 00:00:00