Single florescent nanodiamond in a three dimensional ABEL trap.

abstract：:Next generation sequencing is transforming clinical medicine and genome research, providing a powerful route to establishing molecular diagnoses for genetic conditions; however, challenges remain given the volume and complexity of genetic variation. A number of methods integrate patient phenotype and genotypic data to...

journal_title：Scientific reports

authors： Pengelly RJ,Alom T,Zhang Z,Hunt D,Ennis S,Collins A

更新日期：2017-10-18 00:00:00

abstract：:Three-dimensional (3D) cell cultures produce more in vivo-like multicellular structures such as spheroids that cannot be obtained in two-dimensional (2D) cell cultures. Thus, they are increasingly employed as models for cancer and drug research, as well as tissue engineering. It has proven challenging to stabilize sph...

journal_title：Scientific reports

authors： Lou YR,Kanninen L,Kaehr B,Townson JL,Niklander J,Harjumäki R,Jeffrey Brinker C,Yliperttula M

更新日期：2015-09-01 00:00:00

abstract：:The current economics of the fish protein industry demand rapid, accurate and expressive prediction algorithms at every step of protein production especially with the challenge of global climate change. This help to predict and analyze functional and nutritional quality then consequently control food allergies in hype...

journal_title：Scientific reports

authors： Elaziz MA,Hemdan AM,Hassanien A,Oliva D,Xiong S

更新日期：2017-09-07 00:00:00

abstract：:One way of expediting materials development is to decrease the need for new experiments by making greater use of published literature. Here, we use data mining and automated image analysis to gather new insights on nanoporous gold (NPG) without conducting additional experiments or simulations. NPG is a three-dimension...

journal_title：Scientific reports

authors： McCue I,Stuckner J,Murayama M,Demkowicz MJ

更新日期：2018-04-30 00:00:00

abstract：:HMG domain transcription factor, Sox2, is a critical gene for the development of cochlear hair cells, the receptor cells for hearing, but this has been ascribed to expansion of the progenitors that become hair cells. Here, we show that Sox2 activated Atoh1, a transcription factor important for hair cell differentiatio...

journal_title：Scientific reports

authors： Kempfle JS,Turban JL,Edge AS

更新日期：2016-03-18 00:00:00

abstract：:Bats of the Rhinolophidae and Hipposideridae families, and Pteronotus parnellii, compensate for Doppler shifts generated by their own flight movement. They adjust their call frequency such that the frequency of echoes coming from ahead fall in a specialized frequency range of the hearing system, the auditory fovea, to...

journal_title：Scientific reports

authors： Schoeppler D,Schnitzler HU,Denzinger A

更新日期：2018-03-15 00:00:00

abstract：:Arbuscular mycorrhizal (AM) symbioses are an attractive means of improving the efficiency of soil phosphorus (P) that difficult to be used by plants and may provide a sustainable way of maintaining high yields while reducing P applications. However, quantifying the contribution of indigenous AM fungi on phosphorus upt...

journal_title：Scientific reports

authors： Hou L,Zhang X,Feng G,Li Z,Zhang Y,Cao N

更新日期：2021-01-13 00:00:00

abstract：:Sea-surface temperature (SST) warming events, which are projected to increase in frequency and intensity with climate change, represent major threats to coral reefs. How these events impact reef carbonate budgets, and thus the capacity of reefs to sustain vertical growth under rising sea levels, remains poorly quantif...

journal_title：Scientific reports

authors： Perry CT,Morgan KM

更新日期：2017-01-13 00:00:00

abstract：:Recently, we reported that chemokine (C-X-C motif) receptor (CXCR)4 and atypical chemokine receptor 3 regulate α1-adrenergic receptors (α1-AR) through the formation of hetero-oligomeric complexes. Whether α1-ARs also regulate chemokine receptor function within such heteromeric receptor complexes is unknown. We observe...

journal_title：Scientific reports

authors： Gao X,Albee LJ,Volkman BF,Gaponenko V,Majetschak M

更新日期：2018-02-09 00:00:00

abstract：:We demonstrate the optical orbital angular momentum conservation during the transfer process from subwavelength plasmonic vortex lens (PVLs) to light and the generating process of surface plasmon polaritons (SPPs). Illuminating plasmonic vortex lenses with beams carrying optical orbital angular momentum, the SP vortic...

journal_title：Scientific reports

authors： Yu H,Zhang H,Wang Y,Han S,Yang H,Xu X,Wang Z,Petrov V,Wang J

更新日期：2013-11-12 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for the treatment of Parkinson's disease (PD) and LRRK2 kinase inhibitors are currently being tested in early phase clinical trials. In order to ensure the highest chance of success, a biomarker-guided entry into clinical trials is key. LRRK2 phosp...

journal_title：Scientific reports

authors： Gonzalez-Hunt CP,Thacker EA,Toste CM,Boularand S,Deprets S,Dubois L,Sanders LH

更新日期：2020-10-14 00:00:00

abstract：:The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generated and integrated a ...

journal_title：Scientific reports

authors： Rodius S,Androsova G,Götz L,Liechti R,Crespo I,Merz S,Nazarov PV,de Klein N,Jeanty C,González-Rosa JM,Muller A,Bernardin F,Niclou SP,Vallar L,Mercader N,Ibberson M,Xenarios I,Azuaje F

更新日期：2016-05-31 00:00:00

abstract：:We have prepared and studied a family of cyanobiphenyl dimers with varying linking groups with a view to exploring how molecular structure dictates the stability of the nematic and twist-bend nematic mesophases. Using molecular modelling and 1D 1H NOESY NMR spectroscopy, we determine the angle between the two aromatic...

journal_title：Scientific reports

authors： Mandle RJ,Archbold CT,Sarju JP,Andrews JL,Goodby JW

更新日期：2016-11-07 00:00:00

abstract：:Grain size is an important trait influencing both the yield and quality of rice and its major determinant is glume size. However, how glume size is regulated remains largely unknown. Here, we report the characterization of OsKinesin-13A, which regulates cell elongation and glume length in rice. The mutant of OsKinesin...

journal_title：Scientific reports

authors： Deng ZY,Liu LT,Li T,Yan S,Kuang BJ,Huang SJ,Yan CJ,Wang T

更新日期：2015-03-25 00:00:00

abstract：:Bioerosion is a process with a high socio-economic impact that contributes to coastal retreat, and likely to increase with climate change. Whereas limestone bioerosion is well explained by a combination of mechanical and chemical pathways, the bioerosion mechanisms of silicates, which are harder and chemically more re...

journal_title：Scientific reports

authors： Daval D,Guyot F,Bolotov IN,Vikhrev IV,Kondakov AV,Lyubas AA,Bychkov AY,Yapaskurt VO,Cabié M,Pokrovsky OS

更新日期：2020-08-07 00:00:00

abstract：:Glycoside phosphorylases catalyze the phosphorolysis of oligosaccharides into sugar phosphates. Recently, we found a novel phosphorylase acting on β-1,2-glucooligosaccharides with degrees of polymerization of 3 or more (1,2-β-oligoglucan phosphorylase, SOGP) in glycoside hydrolase family (GH) 94. Here, we characterize...

journal_title：Scientific reports

authors： Nakajima M,Tanaka N,Furukawa N,Nihira T,Kodutsumi Y,Takahashi Y,Sugimoto N,Miyanaga A,Fushinobu S,Taguchi H,Nakai H

更新日期：2017-02-15 00:00:00

abstract：:IgLONs are members of the immunoglobulin superfamily of cell adhesion proteins implicated in the process of neuronal outgrowth, cell adhesion and subdomain target recognition. IgLONs form homophilic and heterophilic complexes on the cell surface that repress or promote growth depending on the neuronal population, the ...

journal_title：Scientific reports

authors： Sanz RL,Ferraro GB,Girouard MP,Fournier AE

更新日期：2017-08-11 00:00:00

abstract：:Two decades ago, a phenomenon resembling Landau damping was described in the synchronization of globally coupled oscillators: the evidence of a regime where the order parameter decays when linear theory predicts neutral stability for the incoherent state. We here show that such an effect is far more generic, as soon a...

journal_title：Scientific reports

authors： Qiu T,Zhang Y,Liu J,Bi H,Boccaletti S,Liu Z,Guan S

更新日期：2015-12-14 00:00:00

abstract：:Release of pro-inflammatory mediators by mast cells is a key feature of allergic disease. The 'dogma' is that IgE molecules merely sensitise mast cells by binding FcεRI prior to cross-linking by multivalent allergen, receptor aggregation and mast cell activation. However, certain monoclonal IgE antibodies have been sh...

journal_title：Scientific reports

authors： Bax HJ,Bowen H,Dodev TS,Sutton BJ,Gould HJ

更新日期：2015-04-20 00:00:00

abstract：:Plastic degradation rates in the marine environment are essential to understand. This study demonstrates that in plastic-microbial interaction experiments, residual monomeric and oligomeric content of PA6 significantly influences the development of dissolved organic carbon. While it is well recognized that additives i...

journal_title：Scientific reports

authors： Klaeger F,Tagg AS,Otto S,Bienmüller M,Sartorius I,Labrenz M

更新日期：2019-02-14 00:00:00

abstract：:Although the cognitive impairment in Alzheimer's disease (AD) is believed to be caused by amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), several postmortem studies have reported cognitive normal subjects with AD brain pathology. As the mechanism underlying these discrepancies has not been clarified, we foc...

journal_title：Scientific reports

authors： Kobayashi E,Nakano M,Kubota K,Himuro N,Mizoguchi S,Chikenji T,Otani M,Mizue Y,Nagaishi K,Fujimiya M

更新日期：2018-01-26 00:00:00

abstract：:The present study reports a natural infection of emus, Dromaius novaehollandiae, by the nematode Procyrnea uncinipenis. Five adult emus from a scientific breeding farm at North Fluminense State University located in the city of Campos dos Goytacazes, Rio de Janeiro state, Brazil were necropsied, and their gastrointest...

journal_title：Scientific reports

authors： Ederli NB,Gallo SSM,de Oliveira FCR

更新日期：2020-10-06 00:00:00

abstract：:Graphene derivatives (GD) are currently being evaluated for technological and biomedical applications owing to their unique physico-chemical properties over other carbon allotrope such as carbon nanotubes (CNTs). But, the possible association of their properties with underlying in vitro effects have not fully examined...

journal_title：Scientific reports

authors： Mittal S,Kumar V,Dhiman N,Chauhan LK,Pasricha R,Pandey AK

更新日期：2016-12-21 00:00:00

abstract：:The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is considered as a human carcinogenic or mutagenic compound that is produced from the co-condensation of creatinine and amino acids as meats cook at high temperatures. The cooking of meats at high temperatures produces fumes, and these fumes...

journal_title：Scientific reports

authors： Poudel BK,Choi J,Park JH,Doh KO,Byeon JH

更新日期：2017-09-07 00:00:00

abstract：:Cancer cells and non-cancer cells differ in their metabolism and they emit distinct volatile compound profiles, allowing to recognise cancer cells by their scent. Insect odorant receptors are excellent chemosensors with high sensitivity and a broad receptive range unmatched by current gas sensors. We thus investigated...

journal_title：Scientific reports

authors： Strauch M,Lüdke A,Münch D,Laudes T,Galizia CG,Martinelli E,Lavra L,Paolesse R,Ulivieri A,Catini A,Capuano R,Di Natale C

更新日期：2014-01-06 00:00:00

abstract：:Two-stage anaerobic digestion of palm oil mill effluent (POME) is a promising method for converting the waste from the largest agricultural industry in Southeast Asia into a clean and sustainable energy. This study investigates the degradation of acid-rich effluent from the dark fermentation stage for the production o...

journal_title：Scientific reports

authors： Mahmod SS,Azahar AM,Luthfi AAI,Abdul PM,Mastar MS,Anuar N,Takriff MS,Jahim JMD

更新日期：2020-06-08 00:00:00

abstract：:Large bowel preparation may cause a substantial change in the gut microbiota and metabolites. Here, we included a bowel prep group and a no-procedure control group and evaluated the effects of bowel prep on the stability of the gut microbiome and metabolome as well as on recovery. Gut microbiota and metabolome composi...

journal_title：Scientific reports

authors： Nagata N,Tohya M,Fukuda S,Suda W,Nishijima S,Takeuchi F,Ohsugi M,Tsujimoto T,Nakamura T,Shimomura A,Yanagisawa N,Hisada Y,Watanabe K,Imbe K,Akiyama J,Mizokami M,Miyoshi-Akiyama T,Uemura N,Hattori M

更新日期：2019-03-11 00:00:00

abstract：:Molecular imaging technique is an attractive tool to detect liver disease at early stage. This study aims to develop a simultaneous dual-isotope single photon emission computed tomography (SPECT)/CT imaging method to assist diagnosis of hepatic tumor and liver fibrosis. Animal models of liver fibrosis and orthotopic h...

journal_title：Scientific reports

authors： Guo Z,Gao M,Zhang D,Li Y,Song M,Zhuang R,Su X,Chen G,Liu T,Liu P,Wu H,Du J,Zhang X

更新日期：2016-07-05 00:00:00

abstract：:The values of physiological indices and the enzymes activities involved in the overwintering stage were studied in D. armandi larvae in each month from October 2014 to March 2015. The sorbitol, trehalose and glycerol values initially tended to increase as the ambient temperature decreased, before declining until the e...

journal_title：Scientific reports

authors： Wang J,Zhang RR,Gao GQ,Ma MY,Chen H

更新日期：2016-10-05 00:00:00

abstract：:Despite improvements in systemic therapy options for renal cancer, it remains one of the most drug-resistant malignancies. Interestingly, reports have shown that kahweol and cafestol, natural diterpenes extracted from coffee beans, exhibit anti-cancer activity. However, the multiple potential pharmacological actions o...

journal_title：Scientific reports

authors： Makino T,Izumi K,Hiratsuka K,Kano H,Shimada T,Nakano T,Kadomoto S,Naito R,Iwamoto H,Yaegashi H,Shigehara K,Kadono Y,Nakata H,Saito Y,Nakagawa-Goto K,Sakai N,Iwata Y,Wada T,Mizokami A

更新日期：2021-01-12 00:00:00