Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson's disease.

abstract：:Interfacial charge transfer from photoexcited ruthenium-based N3 dye molecules into ZnO thin films received controversial interpretations. To identify the physical origin for the delayed electron transfer in ZnO compared to TiO2, we probe directly the electronic structure at both dye-semiconductor interfaces by applyi...

journal_title：Scientific reports

authors： Borgwardt M,Wilke M,Kampen T,Mähl S,Xiao M,Spiccia L,Lange KM,Kiyan IY,Aziz EF

更新日期：2016-04-13 00:00:00

abstract：:In this study, we developed a novel poly (lactic-co-glycolic acid)-dextran (PLD)-based nanodelivery system to enhance the anticancer potential of cisplatin (CDDP) in osteosarcoma cells. A nanosized CDDP-loaded PLGA-DX nanoparticle (PLD/CDDP) controlled the release rate of CDDP up to 48 h. In vitro cytotoxicity assay s...

journal_title：Scientific reports

authors： Liu P,Sun L,Zhou DS,Zhang P,Wang YH,Li D,Li QH,Feng RJ

更新日期：2015-12-01 00:00:00

abstract：:GabR from Bacillus subtilis is a transcriptional regulator of the MocR subfamily of GntR regulators. The MocR architecture is characterized by the presence of an N-terminal winged-Helix-Turn-Helix domain and a C-terminal domain folded as the pyridoxal 5'-phosphate (PLP) dependent aspartate aminotransferase (AAT). The ...

journal_title：Scientific reports

authors： Frezzini M,Guidoni L,Pascarella S

更新日期：2019-12-17 00:00:00

abstract：:Plasmonic metamaterials have overcome fundamental limitations in conventional optics by their capability to engineer material resonances and dispersions at will, holding great promise for sensing applications. Recent demonstrations of metamaterial sensors, however, have mainly relied on their resonant nature for stron...

journal_title：Scientific reports

authors： Ishikawa A,Hara S,Tanaka T,Hayashi Y,Tsuruta K

更新日期：2017-06-09 00:00:00

abstract：:We set out to determine the usability of serum neurofilament light chain (sNfL), serum glial fibrillary acidic protein (sGFAP), and retinal parameters by using optical coherence tomography (OCT) as reliable biomarkers of the progression of oxaliplatin-induced peripheral neuropathy (OIPN). Forty-three patients schedule...

journal_title：Scientific reports

authors： Kim SH,Choi MK,Park NY,Hyun JW,Lee MY,Kim HJ,Jung SK,Cha Y

更新日期：2020-05-14 00:00:00

abstract：:Liver failure, whether arising directly from acute liver failure or from decompensated chronic liver disease is an increasing problem worldwide and results in many deaths. In the UK only 10% of individuals requiring a liver transplant receive one. Thus the need for alternative treatments is paramount. A BioArtificial ...

journal_title：Scientific reports

authors： Selden C,Bundy J,Erro E,Puschmann E,Miller M,Kahn D,Hodgson H,Fuller B,Gonzalez-Molina J,Le Lay A,Gibbons S,Chalmers S,Modi S,Thomas A,Kilbride P,Isaacs A,Ginsburg R,Ilsley H,Thomson D,Chinnery G,Mankahla N,Loo

更新日期：2017-11-06 00:00:00

abstract：:Altered metabolism is considered as a hallmark of cancer. Here we investigated expression of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) 2 lyase (HMGCL), an essential enzyme in ketogenesis, which produces ketone bodies by the breakdown of fatty acids to supply energy, in nasopharyngeal carcinoma (NPC). The express...

journal_title：Scientific reports

authors： Luo W,Qin L,Li B,Liao Z,Liang J,Xiao X,Xiao X,Mo Y,Huang G,Zhang Z,Zhou X,Li P

更新日期：2017-09-20 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis is an important component of neuroendocrine stress regulation and coping behavior. Transcriptome profiles of the hypothalamus and adrenal gland were assessed to identify molecular pathways and candidate genes for coping behavior in pigs. Ten each of high- (HR) and low- (LR...

journal_title：Scientific reports

authors： Gley K,Murani E,Trakooljul N,Zebunke M,Puppe B,Wimmers K,Ponsuksili S

更新日期：2019-09-10 00:00:00

abstract：:This research presents an analysis of the frequencies and vibration modes of the structure of the superficial seiches of Lake Chapala using mathematical modelling and measurements. The HAMSOM model was run with wind fields from coastal meteorological stations and for different lake storage levels. The lake water level...

journal_title：Scientific reports

authors： Avalos Cueva D,Monzón CO,Filonov A,Tereshchenko I,Limón Covarrubias P,Galaviz González JR

更新日期：2019-08-14 00:00:00

abstract：:Difficulties in the production of lignin from rice straw because of high silica content in the recovered lignin reduce its recovery yield and applications as bio-fuel and aromatic chemicals. Therefore, the objective of this study is to develop a novel method to reduce the silica content in lignin from rice straw more ...

journal_title：Scientific reports

authors： Do NH,Pham HH,Le TM,Lauwaert J,Diels L,Verberckmoes A,Do NHN,Tran VT,Le PK

更新日期：2020-12-04 00:00:00

abstract：:Epigenetic mechanisms are known to exert control over gene expression and determine cell fate. Genetic mutations in epigenetic regulators are responsible for several neurologic disorders. Mutations of the chromatin remodeling protein Lsh/HELLS can cause the human Immunodeficiency, Centromere instability and Facial ano...

journal_title：Scientific reports

authors： Han Y,Ren J,Lee E,Xu X,Yu W,Muegge K

更新日期：2017-04-25 00:00:00

abstract：:The Paleozoic Dniepr-Donets Basin in Belarus, Ukraine, and Russia forms a major hydrocarbon province. Although well- and seismic data have established a 20 km thick stratigraphy, field-studies of its sediments are scarce. The inverted Donbas segment (Ukraine) exposes the middle Carboniferous part of the basin's strati...

journal_title：Scientific reports

authors： van Hinsbergen DJ,Abels HA,Bosch W,Boekhout F,Kitchka A,Hamers M,van der Meer DG,Geluk M,Stephenson RA

更新日期：2015-03-20 00:00:00

abstract：:At the Ediacaran/Cambrian boundary, ecosystems witnessed an unparalleled biological innovation: the appearance of shelled animals. Here, we report new paleoecological and paleobiological data on Cloudina, which was one of the most abundant shelled animals at the end of the Ediacaran. We report the close association of...

journal_title：Scientific reports

authors： Becker-Kerber B,Pacheco MLAF,Rudnitzki ID,Galante D,Rodrigues F,Leme JM

更新日期：2017-07-14 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Cánovas D,Studt L,Marcos AT,Strauss J

更新日期：2020-03-06 00:00:00

abstract：:Achieving 180° magnetization reversal with an electric field rather than a current or magnetic field is a fundamental challenge and represents a technological breakthrough towards new memory cell designs. Here we propose a mesoscale morphological engineering approach to accomplishing full 180° magnetization reversals ...

journal_title：Scientific reports

authors： Wang JJ,Hu JM,Ma J,Zhang JX,Chen LQ,Nan CW

更新日期：2014-12-16 00:00:00

abstract：:Hydrogen is known to be present as an impurity in amorphous oxide semiconductors at the 0.1% level. Using amorphous ZnO as a simplified model system, we show that the hydrogens pair up at oxygen vacancies in the amorphous network, where they form metal-H-metal bridge bonds. These bonds are shown to create filled defec...

journal_title：Scientific reports

authors： Li H,Guo Y,Robertson J

更新日期：2017-12-04 00:00:00

abstract：:In bacteria, selective promoter recognition by RNA polymerase is achieved by its association with σ factors, accessory subunits able to direct RNA polymerase "core enzyme" (E) to different promoter sequences. Using Chromatin Immunoprecipitation-sequencing (ChIP-seq), we searched for promoters bound by the σ(S)-associa...

journal_title：Scientific reports

authors： Peano C,Wolf J,Demol J,Rossi E,Petiti L,De Bellis G,Geiselmann J,Egli T,Lacour S,Landini P

更新日期：2015-05-28 00:00:00

abstract：:Microtubules (MTs) are long cylindrical structures of the cytoskeleton that control cell division, intracellular transport, and the shape of cells. MTs also form bundles, which are particularly prominent in neurons, where they help define axons and dendrites. MTs are bio-electrochemical transistors that form nonlinear...

journal_title：Scientific reports

authors： Cantero MDR,Villa Etchegoyen C,Perez PL,Scarinci N,Cantiello HF

更新日期：2018-08-09 00:00:00

abstract：:The Csf1r locus encodes the receptor for macrophage colony-stimulating factor, which controls the proliferation, differentiation and survival of macrophages. The 300 bp Fms intronic regulatory element (FIRE), within the second intron of Csf1r, is necessary and sufficient to direct macrophage-specific transcription. We...

journal_title：Scientific reports

authors： Hume DA,Wollscheid-Lengeling E,Rojo R,Pridans C

更新日期：2017-12-07 00:00:00

abstract：:Coxsackievirus A24 variant (CVA24v) is a major causative agent of acute hemorrhagic conjunctivitis outbreaks worldwide, yet the evolutionary and transmission dynamics of the virus remain unclear. To address this, we analyzed and compared the 3C and partial VP1 gene regions of CVA24v isolates obtained from five outbrea...

journal_title：Scientific reports

authors： Fonseca MC,Pupo-Meriño M,García-González LA,Resik S,Hung LH,Muné M,Rodríguez H,Morier L,Norder H,Sarmiento L

更新日期：2020-08-13 00:00:00

abstract：:To overcome drug resistance caused by apoptosis deficiency in patients with non-small cell lung carcinoma (NSCLC), there is a need to identify other means of triggering apoptosis-independent cancer cell death. We are the first to report that isogambogenic acid (iso-GNA) can induce apoptosis-independent autophagic cell...

journal_title：Scientific reports

authors： Yang J,Zhou Y,Cheng X,Fan Y,He S,Li S,Ye H,Xie C,Wu W,Li C,Pei H,Li L,Wei Z,Peng A,Wei Y,Li W,Chen L

更新日期：2015-01-09 00:00:00

abstract：:Doping with the optimum concentration of carriers (electrons or holes) can modify the physical properties of materials. Therefore, improved ways to achieve carrier doping have been pursued extensively for more than 50 years. Metal-intercalation is one of the most important techniques for electron doping of organic / i...

journal_title：Scientific reports

authors： Takahei Y,Tomita K,Itoh Y,Ashida K,Lee JH,Nishimoto N,Kimura T,Kudo K,Nohara M,Kubozono Y,Kambe T

更新日期：2016-01-06 00:00:00

abstract：:Circularly polarized laser sources with small footprints and high efficiencies can possess advanced functionalities in optical communication and biophotonic integrated systems. However, the conventional lasers with additional circular-polarization converters are bulky and hardly compatible with nanophotonic circuits, ...

journal_title：Scientific reports

authors： Liao WC,Liao SW,Chen KJ,Hsiao YH,Chang SW,Kuo HC,Shih MH

更新日期：2016-05-25 00:00:00

abstract：:As an important online information retaining and processing function, working memory plays critical roles in many other cognitive functions. Several long-term factors, such as age, addiction and diseases, have been affirmed to impair working memory, but whether or how the short-term factors, like painful stimuli or em...

journal_title：Scientific reports

authors： Chen M,Wang YZ,Ma CC,Li QZ,Zhou H,Fu J,Yang QQ,Zhang YM,Liu Y,Cao JL

更新日期：2017-07-03 00:00:00

abstract：:The objective of this study was to determine the prevalence of sexual dysfunction in Saudi and non-Saudi female health care providers in Jeddah, Saudi Arabia. One -hundred twenty (60 Saudi and 60 non-Saudi) sexually active female health care professionals in Jeddah, Saudi Arabia, were anonymously surveyed using the En...

journal_title：Scientific reports

authors： Rouzi AA,Sahly N,Sawan D,Kafy S,Alzaban F

更新日期：2015-01-20 00:00:00

abstract：:Statins are well known to have muscle toxicity problem. Herba Cistanches (HC) is a Chinese herb traditionally used for pain in the loins and knees. Our previous in vitro study suggested that it could protect against statin-induced muscle toxicity. However, its in vivo protective effect has never been investigated. The...

journal_title：Scientific reports

authors： Wat E,Ng CF,Koon CM,Zhang C,Gao S,Tomlinson B,Lau CBS

更新日期：2017-08-24 00:00:00

abstract：:Gamma radiation is a commonly used adjuvant treatment for abdominally localized cancer. Since its therapeutic potential is limited due to gastrointestinal (GI) syndrome, elucidation of the regenerative response following radiation-induced gut injury is needed to develop a preventive treatment. Previously, we showed th...

journal_title：Scientific reports

authors： Orzechowska EJ,Katano T,Bialkowska AB,Yang VW

更新日期：2020-10-27 00:00:00

abstract：:Little is known about the effects of posterior tethers on the development of proximal junctional kyphosis (PJK). We evaluated the ability of posterior tethers to the proximal motion segment stiffness in long instrumented spinal instrumentation and fusion using a whole body human FE model. A series of finite element (F...

journal_title：Scientific reports

authors： Yagi M,Nakahira Y,Watanabe K,Nakamura M,Matsumoto M,Iwamoto M

更新日期：2020-02-26 00:00:00

abstract：:Resistance of cancer cells to radiotherapy is a major clinical problem in cancer treatment. Therefore, understanding the molecular basis of cellular resistance to radiotherapy and identification of novel targets are essential for improving treatment efficacy for cancer patients. Our previous studies have demonstrated ...

journal_title：Scientific reports

authors： Chen S,Zhang Y,Zhang D

更新日期：2015-09-30 00:00:00

abstract：:We recently showed that spinal cord injury (SCI) leads to a decrease in mRNA editing of serotonin receptor 2C (5-HT2CR) contributing to post-SCI spasticity. Here we study post-SCI mRNA editing and global gene expression using massively parallel sequencing. Evidence is presented that the decrease in 5-HT2CR editing is ...

journal_title：Scientific reports

authors： Di Narzo AF,Kozlenkov A,Ge Y,Zhang B,Sanelli L,May Z,Li Y,Fouad K,Cardozo C,Koonin EV,Bennett DJ,Dracheva S

更新日期：2015-07-30 00:00:00