Abstract：
:To overcome drug resistance caused by apoptosis deficiency in patients with non-small cell lung carcinoma (NSCLC), there is a need to identify other means of triggering apoptosis-independent cancer cell death. We are the first to report that isogambogenic acid (iso-GNA) can induce apoptosis-independent autophagic cell death in human NSCLC cells. Several features of the iso-GNA-treated NSCLC cells indicated that iso-GNA induced autophagic cell death. First, there was no evidence of apoptosis or cleaved caspase 3 accumulation and activation. Second, iso-GNA treatment induced the formation of autophagic vacuoles, increased LC3 conversion, caused the appearance of autophagosomes and increased the expression of autophagy-related proteins. These findings provide evidence that iso-GNA induces autophagy in NSCLC cells. Third, iso-GNA-induced cell death was inhibited by autophagic inhibitors or by selective ablation of Atg7 and Beclin 1 genes. Furthermore, the mTOR inhibitor rapamycin increased iso-GNA-induced cell death by enhancing autophagy. Finally, a xenograft model provided additional evidence that iso-GNA exhibited anticancer effect through inducing autophagy-dependent cell death in NSCLC cells. Taken together, our results demonstrated that iso-GNA exhibited an anticancer effect by inducing autophagy-dependent cell death in NSCLC cells, which may be an effective chemotherapeutic agent that can be used against NSCLC in a clinical setting.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Yang J,Zhou Y,Cheng X,Fan Y,He S,Li S,Ye H,Xie C,Wu W,Li C,Pei H,Li L,Wei Z,Peng A,Wei Y,Li W,Chen Ldoi
10.1038/srep07697subject
Has Abstractpub_date
2015-01-09 00:00:00pages
7697issn
2045-2322pii
srep07697journal_volume
5pub_type
杂志文章abstract：:NETs constitute a network of DNA and proteins released by neutrophils in response to infectious and immunologic triggers. NET proteins are recognized as autoantigens in ANCA vasculitis; limited knowledge is available in other autoimmune pathologies. The composition of NETs produced ex vivo by resting and Phorbol-myris...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
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更新日期：2019-05-28 00:00:00
abstract：:In April 2012 we carried out a 1-year hematological study on a population of wild Japanese monkeys inhabiting the forest area of Fukushima City. This area is located 70 km from the Fukushima Daiichi Nuclear Power Plant (NPP), which released a large amount of radioactive material into the environment following the Grea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05793
更新日期：2014-07-24 00:00:00
abstract：:Acute physical exercise improves memory functions by increasing neural plasticity in the hippocampus. In animals, a single session of physical exercise has been shown to boost anandamide (AEA), an endocannabinoid known to promote hippocampal plasticity. Hippocampal neuronal networks encode episodic memory representati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72108-1
更新日期：2020-09-18 00:00:00
abstract：:Platinum resistance is one of the most challenging problems in ovarian cancer treatment. High-throughput functional siRNA screening identified tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE-1) as a gene that confers cells resistant to cisplatin. Conversely enforced over-expression of TIE-1 was va...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31069-2
更新日期：2018-09-04 00:00:00
abstract：:Pure iron has been confirmed as a promising biodegradable metal. However, the degradation rate of pure iron should be accelerated to meet the clinical requirements. In this work, two different designs of platinum disc arrays, including sizes of Φ20 μm × S5 μm and Φ4 μm × S4 μm, have been coated on the surface of pure ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23627
更新日期：2016-04-01 00:00:00
abstract：:Statins are well known to have muscle toxicity problem. Herba Cistanches (HC) is a Chinese herb traditionally used for pain in the loins and knees. Our previous in vitro study suggested that it could protect against statin-induced muscle toxicity. However, its in vivo protective effect has never been investigated. The...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-08-24 00:00:00
abstract：:Optical thermometry based on the up-conversion intensity ratio of thermally coupled levels of rare earth ions has been widely studied to achieve an inaccessible temperature measurement in submicron scale. In this work, a novel optical temperature sensing strategy based on the energy transfer from charge transfer bands...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-07-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-07-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-04-26 00:00:00
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journal_title：Scientific reports
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更新日期：2020-10-26 00:00:00
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更新日期：2018-10-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-02-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-11-22 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-05-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-08-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-01-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-07-27 00:00:00
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更新日期：2020-03-24 00:00:00
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更新日期：2017-03-06 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-05-19 00:00:00
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journal_title：Scientific reports
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更新日期：2019-11-20 00:00:00
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journal_title：Scientific reports
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更新日期：2016-11-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-12-16 00:00:00
