Identification of target genes for RNAi-mediated control of the Twospotted Spider Mite.

abstract：:High-grade gliomas are the most aggressive malignant brain tumors. Accurate pre-operative prognosis for this cohort can lead to better treatment planning. Conventional survival prediction based on clinical information is subjective and could be inaccurate. Recent radiomics studies have shown better prognosis by using ...

journal_title：Scientific reports

authors： Nie D,Lu J,Zhang H,Adeli E,Wang J,Yu Z,Liu L,Wang Q,Wu J,Shen D

更新日期：2019-01-31 00:00:00

abstract：:CobK catalyzes the essential reduction of the precorrin ring in the cobalamin biosynthetic pathway. The crystal structure of CobK reveals that the enzyme, despite not having the signature sequence, comprises two Rossmann fold domains which bind coenzyme and substrate respectively. The two parallel β-sheets have swappe...

journal_title：Scientific reports

authors： Gu S,Sushko O,Deery E,Warren MJ,Pickersgill RW

更新日期：2015-11-30 00:00:00

abstract：:The placenta forms a maternal-fetal junction that supports many physiological functions such as the supply of nutrition and exchange of gases and wastes. Establishing an in vitro culture model of human and non-human primate trophoblast stem/progenitor cells is important for investigating the process of early placental...

journal_title：Scientific reports

authors： Matsumoto S,Porter CJ,Ogasawara N,Iwatani C,Tsuchiya H,Seita Y,Chang YW,Okamoto I,Saitou M,Ema M,Perkins TJ,Stanford WL,Tanaka S

更新日期：2020-04-22 00:00:00

abstract：:Adiponectin regulates glucose and lipid metabolism, acting against metabolic syndrome and atherosclerosis. Accumulating evidence suggest that adiponectin acts on the brain including hypothalamic arcuate nucleus (ARC), where proopiomelanocortin (POMC) neurons play key roles in feeding regulation. Several studies have e...

journal_title：Scientific reports

authors： Suyama S,Maekawa F,Maejima Y,Kubota N,Kadowaki T,Yada T

更新日期：2016-08-09 00:00:00

abstract：:Local polarization of a magnetic layer, a well-known method for storing information, has found its place in numerous applications such as the popular magnetic drawing board toy or the widespread credit cards and computer hard drives. Here we experimentally show that a similar principle can be applied for imprinting th...

journal_title：Scientific reports

authors： Brisbois J,Motta M,Avila JI,Shaw G,Devillers T,Dempsey NM,Veerapandian SK,Colson P,Vanderheyden B,Vanderbemden P,Ortiz WA,Nguyen ND,Kramer RB,Silhanek AV

更新日期：2016-06-06 00:00:00

abstract：:Antigen-presenting cells including dendritic cells (DCs) express mannan receptors (MR) on their surface, which can be exploited in cancer therapy by designing immune-stimulatory viruses coated with mannan-modified capsids that then bind to DCs and initiate a potent immune response. Although the combination of anti-ang...

journal_title：Scientific reports

authors： Wang Y,Zhang J,Wu Y,Ding ZY,Luo XM,Liu J,Zhong WN,Deng GH,Xia XY,Deng YT,Wei YQ,Jiang Y

更新日期：2015-06-18 00:00:00

abstract：:We previously developed red lettuce (Lactuca sativa L.) cultivars with high flavonoid and phenolic acid content and demonstrated their anti-diabetic effect. Here we report on developing three fertile and true-breeding lettuce lines enriched with flavonoids with reported beneficial health effects. These lines were iden...

journal_title：Scientific reports

authors： Gurdon C,Poulev A,Armas I,Satorov S,Tsai M,Raskin I

更新日期：2019-03-01 00:00:00

abstract：:Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood test...

journal_title：Scientific reports

authors： Yokota T,Kinugawa S,Hirabayashi K,Yamato M,Takada S,Suga T,Nakano I,Fukushima A,Matsushima S,Okita K,Tsutsui H

更新日期：2021-01-26 00:00:00

abstract：:Molecular behaviour of liquid water under proton irradiation is of great importance to a number of technological and medical applications. The highly energetic proton generates a time-varying field that is highly localized and heterogeneous at the molecular scale, and massive electronic excitations are produced as a r...

journal_title：Scientific reports

authors： Reeves KG,Kanai Y

更新日期：2017-01-13 00:00:00

abstract：:Mequindox (MEQ) is a synthetic antimicrobial agent of quinoxaline-1,4-dioxide group (QdNOs). The liver is regarded as the toxicity target of QdNOs, and the role of N → O group-associated various toxicities mediated by QdNOs is well recognized. However, the mechanism underlying the in vivo effects of MEQ on the liver, ...

journal_title：Scientific reports

authors： Liu Q,Lei Z,Huang A,Wu Q,Xie S,Awais I,Dai M,Wang X,Yuan Z

更新日期：2017-02-03 00:00:00

abstract：:Carbonic acid (H2CO3) forms in small amounts when CO2 dissolves in H2O, yet decomposes rapidly under ambient conditions of temperature and pressure. Despite its fleeting existence, H2CO3 plays an important role in the global carbon cycle and in biological carbonate-containing systems. The short lifetime in water and p...

journal_title：Scientific reports

authors： Wang H,Zeuschner J,Eremets M,Troyan I,Willams J

更新日期：2016-01-27 00:00:00

abstract：:Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1, PFI-1, and Bromos...

journal_title：Scientific reports

authors： Roberts TC,Etxaniz U,Dall'Agnese A,Wu SY,Chiang CM,Brennan PE,Wood MJA,Puri PL

更新日期：2017-07-21 00:00:00

abstract：:Advancing the design of thin-film composite membrane surfaces is one of the most promising pathways to deal with treating varying water qualities and increase their long-term stability and permeability. Although plasma technologies have been explored for surface modification of bulk micro and ultrafiltration membrane ...

journal_title：Scientific reports

authors： Reis R,Dumée LF,Tardy BL,Dagastine R,Orbell JD,Schutz JA,Duke MC

更新日期：2016-07-01 00:00:00

abstract：:Biological control mechanisms of plant diseases have been intensively studied. However, how plant pathogens respond to and resist or alleviate biocontrol agents remains largely unknown. In this study, a comparative transcriptome analysis was performed to elucidate how the pathogen of sclerotinia stem rot, Sclerotinia ...

journal_title：Scientific reports

authors： Yang X,Zhang L,Xiang Y,Du L,Huang X,Liu Y

更新日期：2020-07-28 00:00:00

abstract：:Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial pharmacological target for several central nervous system disorders. In this study, we aimed to monitor in vivo regional changes of mGluR1 related to neuroinflammation in the brains of rats after pilocarpine-induced status epilepticus (PISE) using longitu...

journal_title：Scientific reports

authors： Yamasaki T,Fujinaga M,Mori W,Zhang Y,Wakizaka H,Nengaki N,Xie L,Hatori A,Zhang MR

更新日期：2017-11-02 00:00:00

abstract：:Neonatal Fc-receptor (FcRn), the major histocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across cell layers, extending IgG half-life in circulation and providing newborns with humoral immunity. IgG1 and IgG2 have similar half-lives, yet IgG2 displays lower foetal than matern...

journal_title：Scientific reports

authors： Stapleton NM,Brinkhaus M,Armour KL,Bentlage AEH,de Taeye SW,Temming AR,Mok JY,Brasser G,Maas M,van Esch WJE,Clark MR,Williamson LM,van der Schoot CE,Vidarsson G

更新日期：2019-05-14 00:00:00

abstract：:Solar powered hydrogen evolution reaction (HER) is one of the key reactions in solar-to-chemical energy conversion. It is desirable to develop photocathodic materials that exhibit high activity toward photoelectrochemical (PEC) HER at more positive potentials because a higher potential means a lower overpotential for ...

journal_title：Scientific reports

authors： Yang Y,Xu D,Wu Q,Diao P

更新日期：2016-10-17 00:00:00

abstract：:Routine antimicrobial susceptibility testing (AST) can prevent deaths due to bacteria and reduce the spread of multi-drug-resistance, but cannot be regularly performed in resource-limited-settings due to technological challenges, high-costs, and lack of trained professionals. We demonstrate an automated and cost-effec...

journal_title：Scientific reports

authors： Feng S,Tseng D,Di Carlo D,Garner OB,Ozcan A

更新日期：2016-12-15 00:00:00

abstract：:Ziziphus is a genus of spiny shrubs and small trees in the Rhamnaceae family. This group has a controversial taxonomy, with more than 200 species described, including Chinese jujube (Ziziphus jujuba Mill. var. jujuba) and Indian jujube (Z. mauritiana), as well as several other important cultivated fruit crops. Using 2...

journal_title：Scientific reports

authors： Xu C,Gao J,Du Z,Li D,Wang Z,Li Y,Pang X

更新日期：2016-08-17 00:00:00

abstract：:Bisphosphonates have benefits in breast cancer and multiple myeloma patients and have been used with adoptive immunotherapy with γδ T cells expressing Vγ2 Vδ2 TCRs. Although treatment with γδ T cells is safe, it has shown limited efficacy. Present bisphosphonates stimulate γδ T cells but were designed to inhibit bone ...

journal_title：Scientific reports

authors： Tanaka Y,Iwasaki M,Murata-Hirai K,Matsumoto K,Hayashi K,Okamura H,Sugie T,Minato N,Morita CT,Toi M

更新日期：2017-07-20 00:00:00

abstract：:Pedobacter schmidteae sp. nov. strain EGT (Collection de Souches de l'Unité des Rickettsie CSUR P6417 = Colección Española de Cultivos Tipo CECT 9771) is a new Pedobacter species isolated from the planarian Schmidtea mediterranea. Schmidtea mediterranea are flatworms living in freshwater and exhibiting an unusual abil...

journal_title：Scientific reports

authors： Kangale LJ,Raoult D,Ghigo E,Fournier PE

更新日期：2020-04-09 00:00:00

abstract：:Biomolecules for OMIC analysis of microbial communities are commonly extracted by bead-beating or ultra-sonication, but both showed varying yields. In addition to that, different disruption pressures are necessary to lyse bacteria and fungi. However, the disruption efficiency and yields comparing bead-beating and ultr...

journal_title：Scientific reports

authors： Starke R,Jehmlich N,Alfaro T,Dohnalkova A,Capek P,Bell SL,Hofmockel KS

更新日期：2019-04-04 00:00:00

abstract：:Macro- and micro-environmental factors modulate parasite loads in fish, determining parasitic abundances, diversity, and interaction dynamics. In this study, seasonal variations in larval ectoparasites on fish larvae in the northern Humboldt Current System (HCS) were evaluated using a delta-gamma generalized linear mo...

journal_title：Scientific reports

authors： Paredes LD,Landaeta MF,Molinet C,González MT

更新日期：2021-01-12 00:00:00

abstract：:Manipulating the polarization states of electromagnetic (EM) waves, a fundamental issue in optics, attracted intensive attention recently. However, most of the devices realized so far are either too bulky in size, and/or are passive with only specific functionalities. Here we combine theory and experiment to demonstra...

journal_title：Scientific reports

authors： Xu HX,Sun S,Tang S,Ma S,He Q,Wang GM,Cai T,Li HP,Zhou L

更新日期：2016-06-08 00:00:00

abstract：:Efficient interventions to reduce blood triglycerides are few; newer and more tolerable intervention targets are needed. Understanding the molecular mechanisms underlying blood triglyceride levels variation is key to identifying new therapies. To explore the role of epigenetic mechanisms on triglyceride levels, a bloo...

journal_title：Scientific reports

authors： Truong V,Huang S,Dennis J,Lemire M,Zwingerman N,Aïssi D,Kassam I,Perret C,Wells P,Morange PE,Wilson M,Trégouët DA,Gagnon F

更新日期：2017-09-11 00:00:00

abstract：:Pioneering epidemiological work has established strong association of sedentary lifestyle and obesity with the risk of colorectal cancer, while the detailed underlying mechanism remains unknown. Here we show that Hotair (HOX transcript antisense RNA) is a pro-adipogenic long non-coding RNA highly expressed in gluteal-...

journal_title：Scientific reports

authors： Lu X,Bai D,Liu X,Zhou C,Yang G

更新日期：2017-03-31 00:00:00

abstract：:Low-noise millimetre-wave signals are valuable for digital sampling systems, arbitrary waveform generation for ultra-wideband communications, and coherent radar systems. However, the phase noise of widely used conventional signal generators (SGs) will increase as the millimetre-wave frequency increases. Our goal has b...

journal_title：Scientific reports

authors： Ishizawa A,Nishikawa T,Goto T,Hitachi K,Sogawa T,Gotoh H

更新日期：2016-05-17 00:00:00

abstract：:RNA interference has had major advances as a developing tool for pest management. In laboratory experiments, double-stranded RNA (dsRNA) is often administered to the insect by genetic modification of the crop, or synthesized in vitro and topically applied to the crop. Here, we engineered genetically modified yeast tha...

journal_title：Scientific reports

authors： Murphy KA,Tabuloc CA,Cervantes KR,Chiu JC

更新日期：2016-03-02 00:00:00

abstract：:The accumulation of mannosyl-glycerate (MG), the salinity stress response osmolyte of Thermococcales, was investigated as a function of hydrostatic pressure in Thermococcus barophilus strain MP, a hyperthermophilic, piezophilic archaeon isolated from the Snake Pit site (MAR), which grows optimally at 40 MPa. Strain MP...

journal_title：Scientific reports

authors： Cario A,Jebbar M,Thiel A,Kervarec N,Oger PM

更新日期：2016-07-05 00:00:00

abstract：:We investigate the steerability of two-qubit Bell-diagonal states under projective measurements by the steering party. In the simplest nontrivial scenario of two projective measurements, we solve this problem completely by virtue of the connection between the steering problem and the joint-measurement problem. A neces...

journal_title：Scientific reports

authors： Quan Q,Zhu H,Liu SY,Fei SM,Fan H,Yang WL

更新日期：2016-02-25 00:00:00