Abstract：
:A decrease in the elasticity of the ocular lens during aging is associated with loss of the accommodative ability of the eye, leading to presbyopia. Although near vision impairment is a social issue affecting the length of healthy life expectancy and productivity of elderly people, an effective treatment to improve near vision has not yet become available. Here we examined the effect of Enterococcus faecium WB2000, Lactobacillus pentosus TJ515, and resveratrol on lens elasticity in rats, where the stiffness of the ocular lens increases exponentially during the aging process. A combination of WB2000 and resveratrol improved lens elasticity not only in the long term but also with just short-term treatment. In addition, TJ515 decreased stiffness in the eye lens with long-term treatment. Therefore, the oral administration of WB2000 and resveratrol or TJ515 may be a potential approach for managing the progression of near vision impairment.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Nagashima H,Sasaki N,Amano S,Nakamura S,Hayano M,Tsubota Kdoi
10.1038/s41598-021-81748-wsubject
Has Abstractpub_date
2021-01-26 00:00:00pages
2174issue
1issn
2045-2322pii
10.1038/s41598-021-81748-wjournal_volume
11pub_type
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