Abstract:
:Liver failure, whether arising directly from acute liver failure or from decompensated chronic liver disease is an increasing problem worldwide and results in many deaths. In the UK only 10% of individuals requiring a liver transplant receive one. Thus the need for alternative treatments is paramount. A BioArtificial Liver machine could temporarily replace the functions of the liver, buying time for the patient's liver to repair and regenerate. We have designed, implemented and tested a clinical-scale BioArtificial Liver machine containing a biomass derived from a hepatoblastoma cell-line cultured as three dimensional organoids, using a fluidised bed bioreactor, together with single-use bioprocessing equipment, with complete control of nutrient provision with feedback BioXpert recipe processes, and yielding good phenotypic liver functions. The methodology has been designed to meet specifications for GMP production, required for manufacture of advanced therapy medicinal products (ATMPs). In a porcine model of severe liver failure, damage was assured in all animals by surgical ischaemia in pigs with human sized livers (1.2-1.6 kg liver weights). The BioArtificial liver (UCLBAL) improved important prognostic clinical liver-related parameters, eg, a significant improvement in coagulation, reduction in vasopressor requirements, improvement in blood pH and in parameters of intracranial pressure (ICP) and oxygenation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Selden C,Bundy J,Erro E,Puschmann E,Miller M,Kahn D,Hodgson H,Fuller B,Gonzalez-Molina J,Le Lay A,Gibbons S,Chalmers S,Modi S,Thomas A,Kilbride P,Isaacs A,Ginsburg R,Ilsley H,Thomson D,Chinnery G,Mankahla N,Loodoi
10.1038/s41598-017-15021-4subject
Has Abstractpub_date
2017-11-06 00:00:00pages
14518issue
1issn
2045-2322pii
10.1038/s41598-017-15021-4journal_volume
7pub_type
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