Glycosaminoglycans influence enzyme activity of MMP2 and MMP2/TIMP3 complex formation - Insights at cellular and molecular level.

abstract：:The relationship between the cuprate pseudogap (Δ(p)) and superconducting gap (Δ(s)) remains an unsolved mystery. Here, we present a temperature- and doping-dependent tunneling study of submicron Bi(2)Sr(2)CaCu(2)O(8+δ) intrinsic Josephson junctions, which provides a clear evidence that Δ(s) closes at a temperature T(...

journal_title：Scientific reports

authors： Ren JK,Zhu XB,Yu HF,Tian Y,Yang HF,Gu CZ,Wang NL,Ren YF,Zhao SP

更新日期：2012-01-01 00:00:00

abstract：:The synthetic Angiotensin Converting Enzyme (ACE) inhibitors have side effects and hence demands for natural ACE inhibitors have been rising. The aim of this study is to purify and introduce natural ACE inhibitors extracted from Zizyphus jujuba fruits. Proteins from Zizyphus jujuba were lysed by trypsin, papain and th...

journal_title：Scientific reports

authors： Memarpoor-Yazdi M,Zare-Zardini H,Mogharrab N,Navapour L

更新日期：2020-03-04 00:00:00

abstract：:Advanced age is associated with a decline in cognitive function, likely caused by a combination of modifiable and non-modifiable factors such as genetics and lifestyle choices. Mounting evidence suggests that humanin and other mitochondrial derived peptides play a role in several age-related conditions including neuro...

journal_title：Scientific reports

authors： Yen K,Wan J,Mehta HH,Miller B,Christensen A,Levine ME,Salomon MP,Brandhorst S,Xiao J,Kim SJ,Navarrete G,Campo D,Harry GJ,Longo V,Pike CJ,Mack WJ,Hodis HN,Crimmins EM,Cohen P

更新日期：2018-09-21 00:00:00

abstract：:Major depression (MDD) has been associated with an altered EEG frontal asymmetry measured in resting state; nevertheless, this association has showed a weak consistency across studies. In the present study, which starts from an evolutionistic view of psychiatric disorders, we investigated frontal asymmetry in MDD, usi...

journal_title：Scientific reports

authors： Spironelli C,Maffei A,Romeo Z,Piazzon G,Padovan G,Magnolfi G,Pasini I,Gomez Homen F,Concari G,Angrilli A

更新日期：2020-05-18 00:00:00

abstract：:Ten to twenty percent of the hepatocellular carcinoma (HCC) patients fulfilling the Milan criteria (MC) recurred within three years after orthotopic liver transplantation (OLT). We therefore utilize a training cohort to develop an improved prognostic model for predicting the recurrence in these patients. By univariate...

journal_title：Scientific reports

authors： Feng J,Wu J,Zhu R,Feng D,Yu L,Zhang Y,Bu D,Li C,Zhou Y,Si L,Liu Y,Liang Z,Xu J,Wu T

更新日期：2017-03-09 00:00:00

abstract：:Excess nitrite (NO2-) concentrations in water supplies is considered detrimental to the environment and human health, and is associated with incidence of stomach cancer. In this work, the authors describe a nitrite detection system based on the synthesis of gold nanoparticles (AuNPs) on reduced graphene oxide (rGO) us...

journal_title：Scientific reports

authors： Amanulla B,Palanisamy S,Chen SM,Chiu TW,Velusamy V,Hall JM,Chen TW,Ramaraj SK

更新日期：2017-10-27 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Yoshitake R,Saeki K,Eto S,Shinada M,Nakano R,Sugiya H,Endo Y,Fujita N,Nishimura R,Nakagawa T

更新日期：2020-10-28 00:00:00

abstract：:In this article, we experimentally and numerically investigate a planar terahertz metamaterial (MM) geometry capable of exhibiting independently tunable multi-band electromagnetically induced transparency effect (EIT). The MM structure exhibits multi-band EIT effect due to the strong near field coupling between the br...

journal_title：Scientific reports

authors： Sarkar R,Ghindani D,Devi KM,Prabhu SS,Ahmad A,Kumar G

更新日期：2019-12-02 00:00:00

abstract：:Deriving cell populations from human embryonic stem cells (hESCs) for cell-based therapy is considered a promising strategy to achieve functional cells, yet its translation to clinical practice depends on achieving fully defined differentiated cells. In this work, we generated a miRNA-responsive lethal mRNA construct ...

journal_title：Scientific reports

authors： Elovic E,Etzion S,Cohen S

更新日期：2019-10-10 00:00:00

abstract：:Cathode materials always limit the performance of fuel cells while the commercial platinum-based catalysts hardly meet the requirements of low cost, durable and stable. Here a non-precious metal oxygen reduction reaction (ORR) electocatalyst based on titanium nitride/titanium carbonitride hierarchical structures (TNTC...

journal_title：Scientific reports

authors： Jin Z,Li P,Xiao D

更新日期：2014-10-22 00:00:00

abstract：:Bimetallic Pd1-x Pt x solid-solution nanoparticles (NPs) display charging/discharging of hydrogen gas, which has relevance for fuel cell technologies; however, the constituent elements are immiscible in the bulk phase. We examined these material systems using high-energy synchrotron X-ray diffraction, X-ray absorption...

journal_title：Scientific reports

authors： Kumara LSR,Sakata O,Kobayashi H,Song C,Kohara S,Ina T,Yoshimoto T,Yoshioka S,Matsumura S,Kitagawa H

更新日期：2017-11-06 00:00:00

abstract：:A novel eco-friendly procedure was developed to produce safer, stable and highly pure zinc oxide nanoparticles (ZnO NPs) using microalgae Chlorella extract. The ZnO NPs were synthesized simply using zinc nitrate and microalgae Chlorella extract which conducted at ambient conditions. In this recipe, microalgae Chlorell...

journal_title：Scientific reports

authors： Khalafi T,Buazar F,Ghanemi K

更新日期：2019-05-03 00:00:00

abstract：:Novel pain killers without adverse effects are urgently needed. Opioids induce central and intestinal side effects such as respiratory depression, sedation, addiction, and constipation. We have recently shown that a newly designed agonist with a reduced acid dissociation constant (pKa) abolished pain by selectively ac...

journal_title：Scientific reports

authors： Spahn V,Del Vecchio G,Rodriguez-Gaztelumendi A,Temp J,Labuz D,Kloner M,Reidelbach M,Machelska H,Weber M,Stein C

更新日期：2018-06-12 00:00:00

abstract：:Domestication and selective breeding has resulted in over 1000 extant cattle breeds. Many of these breeds do not excel in important traits but are adapted to local environments. These adaptations are a valuable source of genetic material for efforts to improve commercial breeds. As a step toward this goal we identifie...

journal_title：Scientific reports

authors： Yurchenko AA,Daetwyler HD,Yudin N,Schnabel RD,Vander Jagt CJ,Soloshenko V,Lhasaranov B,Popov R,Taylor JF,Larkin DM

更新日期：2018-08-28 00:00:00

abstract：:Evasion of the potent tumour suppressor activity of p53 is one of the hurdles that must be overcome for cancer cells to escape normal regulation of cellular proliferation and survival. In addition to frequent loss of function mutations, p53 wild-type activity can also be suppressed post-translationally through several...

journal_title：Scientific reports

authors： Gerhart SV,Kellner WA,Thompson C,Pappalardi MB,Zhang XP,Montes de Oca R,Penebre E,Duncan K,Boriack-Sjodin A,Le B,Majer C,McCabe MT,Carpenter C,Johnson N,Kruger RG,Barbash O

更新日期：2018-06-26 00:00:00

abstract：:Aiming to promote low-cost production of protein-rich forage rice and resource recycling from wastewater treatment plants, a pot experiment was conducted to assess the possibility to substitute mineral fertilizers with composted sewage sludge (CSS) with/without top-dressing with treated municipal wastewater (TWW). Res...

journal_title：Scientific reports

authors： Phung LD,Ichikawa M,Pham DV,Sasaki A,Watanabe T

更新日期：2020-06-23 00:00:00

abstract：:We have sequenced the genome of the largest freshwater fish species of the world, the arapaima. Analysis of gene family dynamics and signatures of positive selection identified genes involved in the specific adaptations and unique features of this iconic species, in particular it's large size and fast growth. Genome s...

journal_title：Scientific reports

authors： Du K,Wuertz S,Adolfi M,Kneitz S,Stöck M,Oliveira M,Nóbrega R,Ormanns J,Kloas W,Feron R,Klopp C,Parrinello H,Journot L,He S,Postlethwait J,Meyer A,Guiguen Y,Schartl M

更新日期：2019-03-28 00:00:00

abstract：:African swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cells of the monocyte-macrophage lineage, affecting swine species and provoking severe economic losses and health threats. In the present study, four established porcine cell lines, IPAM-WT, IPAM-CD163, C∆2+ an...

journal_title：Scientific reports

authors： Sánchez EG,Riera E,Nogal M,Gallardo C,Fernández P,Bello-Morales R,López-Guerrero JA,Chitko-McKown CG,Richt JA,Revilla Y

更新日期：2017-09-04 00:00:00

abstract：:The killer toxin K1 is a virally encoded fungal A/B toxin acting by disrupting plasma membrane integrity. The connection of α and β constitutes a critical feature for toxin biology and for decades the formation of three disulphide bonds linking the major toxin subunits was accepted as status quo. Due to the absence of...

journal_title：Scientific reports

authors： Gier S,Lermen M,Schmitt MJ,Breinig F

更新日期：2019-09-11 00:00:00

abstract：:Effective promotion of air filtration applications proposed for fibers requires their real nanoscale diameter, optimized pore structure, and high service strength; however, creating such filter medium has proved to be a tremendous challenge. This study first establishes a strategy to design and fabricate novel poly(m-...

journal_title：Scientific reports

authors： Zhang S,Liu H,Yin X,Li Z,Yu J,Ding B

更新日期：2017-01-11 00:00:00

abstract：:Nedd4-2 (NEDD4L in humans) is a ubiquitin protein ligase best known for its role in regulating ion channel internalization and turnover. Nedd4-2 deletion in mice causes perinatal lethality associated with increased epithelial sodium channel (ENaC) expression in lung and kidney. Abundant data suggest that Nedd4-2 plays...

journal_title：Scientific reports

authors： Yanpallewar S,Wang T,Koh DC,Quarta E,Fulgenzi G,Tessarollo L

更新日期：2016-09-08 00:00:00

abstract：:This study was carried out to use hyperspectral imaging technique for determining color (L*, a* and b*) and eggshell strength and identifying cracked chicken eggs. Partial least squares (PLS) models based on full and selected wavelengths suggested by regression coefficient (RC) method were established to predict the f...

journal_title：Scientific reports

authors： Xie C,He Y

更新日期：2016-02-17 00:00:00

abstract：:Machine learning is a well-known approach for virtual screening. Recently, deep learning, a machine learning algorithm in artificial neural networks, has been applied to the advancement of precision medicine and drug discovery. In this study, we performed comparative studies between deep neural networks (DNN) and othe...

journal_title：Scientific reports

authors： Tsou LK,Yeh SH,Ueng SH,Chang CP,Song JS,Wu MH,Chang HF,Chen SR,Shih C,Chen CT,Ke YY

更新日期：2020-10-08 00:00:00

abstract：:Critical limb ischemia (CLI) is associated with a high risk of limb amputation. It has been shown that cell therapy is safe and has beneficial effects on ischemic clinical symptoms in patients with CLI. The aim of this study was to further investigate the outcomes of intramuscular injection of autologous bone-marrow m...

journal_title：Scientific reports

authors： Yusoff FM,Kajikawa M,Matsui S,Hashimoto H,Kishimoto S,Maruhashi T,Chowdhury M,Noma K,Nakashima A,Kihara Y,Sueda T,Higashi Y

更新日期：2019-05-22 00:00:00

abstract：:This study was carried out for rapid and noninvasive determination of the class of sorghum species by using the manifold dimensionality reduction (MDR) method and the nonlinear regression method of least squares support vector machines (LS-SVM) combing with the mid-infrared spectroscopy (MIRS) techniques. The methods ...

journal_title：Scientific reports

authors： Chen YM,Lin P,He JQ,He Y,Li XL

更新日期：2016-01-28 00:00:00

abstract：:Terrestrial plants typically take up nutrients through roots or mycorrhizae while freshwater plants additionally utilize leaves. Their nutrient uptake may be enhanced by root hairs whose occurrence is often negatively correlated with mycorrhizal colonization. Seagrasses utilize both leaves and roots and often form roo...

journal_title：Scientific reports

authors： Borovec O,Vohník M

更新日期：2018-07-17 00:00:00

abstract：:Electroceutical wound dressings, especially those involving current flow with silver based electrodes, show promise for treating biofilm infections. However, their mechanism of action is poorly understood. We have developed an in vitro agar based model using a bioluminescent strain of Pseudomonas aeruginosa to measure...

journal_title：Scientific reports

authors： Dusane DH,Lochab V,Jones T,Peters CW,Sindeldecker D,Das A,Roy S,Sen CK,Subramaniam VV,Wozniak DJ,Prakash S,Stoodley P

更新日期：2019-02-14 00:00:00

abstract：:In this work we study the entropy of the Gibbs state corresponding to a graph. The Gibbs state is obtained from the Laplacian, normalized Laplacian or adjacency matrices associated with a graph. We calculated the entropy of the Gibbs state for a few classes of graphs and studied their behavior with changing graph orde...

journal_title：Scientific reports

authors： Glos A,Krawiec A,Pawela Ł

更新日期：2021-01-11 00:00:00

abstract：:Myocyte Enhancer Factor 2 (MEF2) mediates cardiac remodelling in heart failure (HF) and is also a target of β-adrenergic signalling, a front-line treatment for HF. We identified global gene transcription networks involved in HF with and without β-blocker treatment. Experimental HF by transverse aortic constriction (TA...

journal_title：Scientific reports

authors： Tobin SW,Hashemi S,Dadson K,Turdi S,Ebrahimian K,Zhao J,Sweeney G,Grigull J,McDermott JC

更新日期：2017-06-30 00:00:00

abstract：:The cytoskeletal filament vimentin is inherent to the endothelial phenotype and is critical for the proper function of endothelial cells in adult mice. It is unclear, however, if the presence of vimentin is necessary during differentiation to the endothelial phenotype. Here we evaluated gene and protein expression of ...

journal_title：Scientific reports

authors： Boraas LC,Ahsan T

更新日期：2016-08-02 00:00:00