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Conformations and molecular interactions of poly-γ-glutamic acid as a soluble microbial product in aqueous solutions.

Abstract：

:Soluble microbial products (SMPs) are of significant concern in the natural environment and in engineered systems. In this work, poly-γ-glutamic acid (γ-PGA), which is predominantly produced by Bacillus sp., was investigated in terms of pH-induced conformational changes and molecular interactions in aqueous solutions; accordingly, its sedimentation coefficient distribution and viscosity were also elucidated. Experimental results indicate that pH has a significant impact on the structure and molecular interactions of γ-PGA. The conformation of the γ-PGA acid form (γ-PGA-H) is rod-like while that of the γ-PGA sodium form (γ-PGA-Na) is sphere-like. The transformation from α-helix to random coil in the γ-PGA secondary structure is primarily responsible for this shape variation. The intramolecular hydrogen bonds in the γ-PGA-H structure decrease and intramolecular electrostatic repulsion increases as pH increases; however, the sedimentation coefficient distributions of γ-PGA are dependent on intermolecular interactions rather than intramolecular interactions. Concentration has a more substantial effect on intermolecular electrostatic repulsion and chain entanglement at higher pH values. Consequently, the sedimentation coefficient distributions of γ-PGA shift significantly at pH 8.9 from 0.1 to 1.0 g/L, and the viscosity of γ-PGA (5% w/v) significantly increases as pH increases from 2.3 to 6.0.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wang LL,Chen JT,Wang LF,Wu S,Zhang GZ,Yu HQ,Ye XD,Shi QS

doi

10.1038/s41598-017-13152-2

subject

Has Abstract

pub_date

2017-10-06 00:00:00

pages

12787

issue

1

issn

2045-2322

pii

10.1038/s41598-017-13152-2

journal_volume

7

pub_type

杂志文章

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