当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress.

Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress.

Abstract：

:Cold-inducible RNA-binding protein (CIRP), released into the circulation during sepsis, causes lung injury via an as yet unknown mechanism. Since endoplasmic reticulum (ER) stress is associated with acute lung injury (ALI), we hypothesized that CIRP causes ALI via induction of ER stress. To test this hypothesis, we studied the lungs of wild-type (WT) and CIRP knockout (KO) mice at 20 h after induction of sepsis by cecal ligation and puncture (CLP). WT mice had significantly more severe ALI than CIRP KO mice. Lung ER stress markers (BiP, pIRE1α, sXBP1, CHOP, cleaved caspase-12) were increased in septic WT mice, but not in septic CIRP KO mice. Effector pathways downstream from ER stress - apoptosis, NF-κB (p65), proinflammatory cytokines (IL-6, IL-1β), neutrophil chemoattractants (MIP-2, KC), neutrophil infiltration (MPO activity), lipid peroxidation (4-HNE), and nitric oxide (iNOS) - were significantly increased in WT mice, but only mildly elevated in CIRP KO mice. ER stress markers were increased in the lungs of healthy WT mice treated with recombinant murine CIRP, but not in the lungs of TLR4 KO mice. This suggests CIRP directly induces ER stress via TLR4 activation. In summary, CIRP induces lung ER stress and downstream responses to cause sepsis-associated ALI.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Khan MM,Yang WL,Brenner M,Bolognese AC,Wang P

doi

10.1038/srep41363

subject

Has Abstract

pub_date

2017-01-27 00:00:00

pages

41363

issn

2045-2322

pii

srep41363

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Covariance statistics and network analysis of brain PET imaging studies.

    abstract：:The analysis of structural and functional neuroimaging data using graph theory has increasingly become a popular approach for visualising and understanding anatomical and functional relationships between different cerebral areas. In this work we applied a network-based approach for brain PET studies using population-b...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39005-8

    authors： Veronese M,Moro L,Arcolin M,Dipasquale O,Rizzo G,Expert P,Khan W,Fisher PM,Svarer C,Bertoldo A,Howes O,Turkheimer FE

    更新日期：2019-02-21 00:00:00

  • TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye.

    abstract：:An intractable challenge in glaucoma treatment has been to identify druggable targets within the conventional aqueous humor outflow pathway, which is thought to be regulated/dysregulated by elusive mechanosensitive protein(s). Here, biochemical and functional analyses localized the putative mechanosensitive cation cha...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep30583

    authors： Ryskamp DA,Frye AM,Phuong TT,Yarishkin O,Jo AO,Xu Y,Lakk M,Iuso A,Redmon SN,Ambati B,Hageman G,Prestwich GD,Torrejon KY,Križaj D

    更新日期：2016-08-11 00:00:00

  • Identification of Small Molecule Enhancers of Immunotherapy for Melanoma.

    abstract：:Small molecule based targeted therapies for the treatment of metastatic melanoma hold promise but responses are often not durable, and tumors frequently relapse. Response to adoptive cell transfer (ACT)-based immunotherapy in melanoma patients are durable but patients develop resistance primarily due to loss of antige...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62369-1

    authors： Dextras C,Dashnyam M,Griner LAM,Sundaresan J,Chim B,Yu Z,Vodnala S,Lee CR,Hu X,Southall N,Marugan JJ,Jadhav A,Restifo NP,Acquavella N,Ferrer M,Singh A

    更新日期：2020-03-30 00:00:00

  • Assessment of Chicken Carcass Microbiome Responses During Processing in the Presence of Commercial Antimicrobials Using a Next Generation Sequencing Approach.

    abstract：:The purpose of this study was to 1) identify microbial compositional changes on chicken carcasses during processing, 2) determine the antimicrobial efficacy of peracetic acid (PAA) and Amplon (blend of sulfuric acid and sodium sulfate) at a poultry processing pilot plant scale, and 3) compare microbial communities bet...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep43354

    authors： Ae Kim S,Hong Park S,In Lee S,Owens CM,Ricke SC

    更新日期：2017-02-23 00:00:00

  • Formal Definitions of Unbounded Evolution and Innovation Reveal Universal Mechanisms for Open-Ended Evolution in Dynamical Systems.

    abstract：:Open-ended evolution (OEE) is relevant to a variety of biological, artificial and technological systems, but has been challenging to reproduce in silico. Most theoretical efforts focus on key aspects of open-ended evolution as it appears in biology. We recast the problem as a more general one in dynamical systems theo...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00810-8

    authors： Adams A,Zenil H,Davies PCW,Walker SI

    更新日期：2017-04-20 00:00:00

  • Author Correction: Evaporative deposition of polystyrene microparticles on PDMS surface.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-23132-9

    authors： Yu YS,Wang MC,Huang X

    更新日期：2018-03-19 00:00:00

  • Variations in biocorona formation related to defects in the structure of single walled carbon nanotubes and the hyperlipidemic disease state.

    abstract：:Ball-milling utilizes mechanical stress to modify properties of carbon nanotubes (CNTs) including size, capping, and functionalization. Ball-milling, however, may introduce structural defects resulting in altered CNT-biomolecule interactions. Nanomaterial-biomolecule interactions result in the formation of the biocoro...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08896-w

    authors： Raghavendra AJ,Fritz K,Fu S,Brown JM,Podila R,Shannahan JH

    更新日期：2017-08-16 00:00:00

  • Biogenically induced bedded chert formation in the alkaline palaeo-lake of the Green River Formation.

    abstract：:Rhythmically bedded cherts are observed in both pelagic marine and lacustrine deposits, but the formation mechanism in the latter remains highly uncertain. Our study of alternating chert-dolomite beds in the Eocene Green River Formation, Utah, USA reveals dense accumulations of organic-matter spheres (30-50 μm diamete...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52862-7

    authors： Kuma R,Hasegawa H,Yamamoto K,Yoshida H,Whiteside JH,Katsuta N,Ikeda M

    更新日期：2019-11-11 00:00:00

  • Novel 2-phenyloxypyrimidine derivative induces apoptosis and autophagy via inhibiting PI3K pathway and activating MAPK/ERK signaling in hepatocellular carcinoma cells.

    abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality globally. Because most patients are diagnosed at advanced stages of the disease, multi-targeted tyrosine kinase inhibitor sorafenib is the only available drug to show limited effectiveness. Novel and effective therapies are unmet me...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29199-8

    authors： Wang J,Sun P,Chen Y,Yao H,Wang S

    更新日期：2018-07-19 00:00:00

  • A multi-scale model for determining the effects of pathophysiology and metabolic disorders on tumor growth.

    abstract：:The search for efficient chemotherapy drugs and other anti-cancer treatments would benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progression. Because in vivo experimental methods are unable to isolate or control individual factors of the TME and in vitro models often do ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-59658-0

    authors： Nikmaneshi MR,Firoozabadi B,Mozafari A,Munn LL

    更新日期：2020-02-20 00:00:00

  • Abrupt climate shift in the Western Mediterranean Sea.

    abstract：:One century of oceanographic measurements has evidenced gradual increases in temperature and salinity of western Mediterranean water masses, even though the vertical stratification has basically remained unchanged. Starting in 2005, the basic structure of the intermediate and deep layers abruptly changed. We report he...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep23009

    authors： Schroeder K,Chiggiato J,Bryden HL,Borghini M,Ben Ismail S

    更新日期：2016-03-11 00:00:00

  • Ultrasensitive optical reflectivity in annular nanohole array on Photonic crystal slab based on bound states in the continuum.

    abstract：:We investigate optical bound states in the continuum (BICs) supported by a photonic crystal (PhC) slab penetrated with periodic annular holes theoretically. Ultrahigh-quality factor (Q-factor) resonances associated with BICs are obtained with a Q-factor more than 108. The BICs can be seen at nonzero incident angles by...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29930-5

    authors： Li Z,Zhu Q,Wang Y,Xie S

    更新日期：2018-08-20 00:00:00

  • Inactivation efficacy of atmospheric air plasma and airborne acoustic ultrasound against bacterial biofilms.

    abstract：:Biofilms are complex microbial communities that present serious contamination risks to our environment and health. In this study, atmospheric air plasma and airborne acoustic ultrasound technology were applied to inactivate Escherichia coli and Listeria innocua biofilms. Both technologies were efficient in controlling...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-021-81977-z

    authors： Patange AD,Simpson JC,Curtin JF,Burgess CM,Cullen PJ,Tiwari BK

    更新日期：2021-01-27 00:00:00

  • Phylogenetic analyses and in-seedling expression of ammonium and nitrate transporters in wheat.

    abstract：:Plants deploy several ammonium transporter (AMT) and nitrate transporter (NRT) genes to acquire NH4+ and NO3- from the soil into the roots and then transport them to other plant organs. Coding sequences of wheat genes obtained from ENSEMBL were aligned to known AMT and NRT sequences of Arabidopsis, barley, maize, rice...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-25430-8

    authors： Bajgain P,Russell B,Mohammadi M

    更新日期：2018-05-04 00:00:00

  • Local proliferation is the main source of rod microglia after optic nerve transection.

    abstract：:Microglia are the resident phagocytic cells with various functions in the central nervous system, and the morphologies of microglia imply the different stages and functions. In optical nerve transection (ONT) model in the retina, the retrograde degeneration of retinal ganglion cells (RGCs) induces microglial activatio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10788

    authors： Yuan TF,Liang YX,Peng B,Lin B,So KF

    更新日期：2015-06-02 00:00:00

  • The C-terminal region of Trypanosoma cruzi MASPs is antigenic and secreted via exovesicles.

    abstract：:Trypanosoma cruzi is the etiological agent of Chagas disease, a neglected and emerging tropical disease, endemic to South America and present in non-endemic regions due to human migration. The MASP multigene family is specific to T. cruzi, accounting for 6% of the parasite's genome and plays a key role in immune evasi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27293

    authors： De Pablos LM,Díaz Lozano IM,Jercic MI,Quinzada M,Giménez MJ,Calabuig E,Espino AM,Schijman AG,Zulantay I,Apt W,Osuna A

    更新日期：2016-06-08 00:00:00

  • PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2.

    abstract：:Postsynaptic density-95/Discs large/Zonula occludens-1 (PDZ) domain-mediated protein interactions play pivotal roles in various molecular biological events, including protein localisation, assembly, and signal transduction. Although the vertebrate regulator of planar cell polarity Van Gogh-like 2 (Vangl2) was recently...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12916

    authors： Nagaoka T,Tabuchi K,Kishi M

    更新日期：2015-08-10 00:00:00

  • Statistical learning in domestic chicks is modulated by strain and sex.

    abstract：:Statistical learning is a key mechanism for detecting regularities from a variety of sensory inputs. Precocial newborn domestic chicks provide an excellent model for (1) exploring unsupervised forms of statistical learning in a comparative perspective, and (2) elucidating the ecological function of statistical learnin...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72090-8

    authors： Santolin C,Rosa-Salva O,Lemaire BS,Regolin L,Vallortigara G

    更新日期：2020-09-15 00:00:00

  • Inclination not force is sensed by plants during shoot gravitropism.

    abstract：:Gravity perception plays a key role in how plants develop and adapt to environmental changes. However, more than a century after the pioneering work of Darwin, little is known on the sensing mechanism. Using a centrifugal device combined with growth kinematics imaging, we show that shoot gravitropic responses to stead...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35431

    authors： Chauvet H,Pouliquen O,Forterre Y,Legué V,Moulia B

    更新日期：2016-10-14 00:00:00

  • Long-term drug modification to the surface of mesenchymal stem cells by the avidin-biotin complex method.

    abstract：:Mesenchymal stem cells (MSCs) have various functions, making a significant contribution to tissue repair. On the other hand, the viability and function of MSCs are not lasting after an in vivo transplant, and the therapeutic effects of MSCs are limited. Although various chemical modification methods have been applied ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-17166-8

    authors： Takayama Y,Kusamori K,Hayashi M,Tanabe N,Matsuura S,Tsujimura M,Katsumi H,Sakane T,Nishikawa M,Yamamoto A

    更新日期：2017-12-05 00:00:00

  • Distribution and characteristics of rodent picornaviruses in China.

    abstract：:Rodents are important reservoir hosts of many important zoonotic viruses. The family Picornaviridae contains clinically important pathogens that infect humans and animals, and increasing numbers of rodent picornaviruses have recently been associated with zoonoses. We collected 574 pharyngeal and anal swab specimens fr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34381

    authors： Du J,Lu L,Liu F,Su H,Dong J,Sun L,Zhu Y,Ren X,Yang F,Guo F,Liu Q,Wu Z,Jin Q

    更新日期：2016-09-29 00:00:00

  • HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans.

    abstract：:HUWE1 is a HECT domain containing ubiquitin ligase implicated in neurogenesis, spermatogenesis and cancer development. The purpose of the current study is to investigate the role of HUWE1 in early embryo development. Here we demonstrate that Huwe1 is expressed in both nucleus and cytoplasm of preimplantation mouse emb...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep37928

    authors： Chen LJ,Xu WM,Yang M,Wang K,Chen Y,Huang XJ,Ma QH

    更新日期：2016-11-30 00:00:00

  • Molecular targets for diagnostic and intraoperative imaging of pancreatic ductal adenocarcinoma after neoadjuvant FOLFIRINOX treatment.

    abstract：:Neoadjuvant systemic treatment is increasingly being integrated in the standard treatment of pancreatic ductal adenocarcinoma (PDAC) patients to improve oncological outcomes. Current available imaging techniques remain unreliable in assessing response to therapies, as they cannot distinguish between (vital) tumor tiss...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-73242-6

    authors： Vuijk FA,de Muynck LDAN,Franken LC,Busch OR,Wilmink JW,Besselink MG,Bonsing BA,Bhairosingh SS,Kuppen PJK,Mieog JSD,Sier CFM,Vahrmeijer AL,Verheij J,Fariňa-Sarasqueta A,Swijnenburg RJ

    更新日期：2020-10-01 00:00:00

  • Porcine circovirus 2 (PCV-2) genetic variability under natural infection scenario reveals a complex network of viral quasispecies.

    abstract：:Porcine circovirus 2 (PCV-2) is a virus characterized by a high evolutionary rate, promoting the potential emergence of different genotypes and strains. Despite the likely relevance in the emergence of new PCV-2 variants, the subtle evolutionary patterns of PCV-2 at the individual-host level or over short transmission...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-33849-2

    authors： Correa-Fiz F,Franzo G,Llorens A,Segalés J,Kekarainen T

    更新日期：2018-10-19 00:00:00

  • Reconstructing the gradient source position from steady-state fluxes to small receptors.

    abstract：:Recovering the position of a source from the fluxes of diffusing particles through small receptors allows a biological cell to determine its relative position, spatial localization and guide it to a final target. However, how a source can be recovered from point fluxes remains unclear. Using the Narrow Escape approach...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-19355-5

    authors： Dobramysl U,Holcman D

    更新日期：2018-01-17 00:00:00

  • Nutrient quality of vertebrate dung as a diet for dung beetles.

    abstract：:At the basis of a trophic web, coprophagous animals like dung beetles (Scarabaeoidea) utilize resources that may have advantages (easy gain and handling) as well as drawbacks (formerly processed food). Several studies have characterized the nutrients, e.g. C/N ratios and organic matter content, for specific types of d...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-12265-y

    authors： Frank K,Brückner A,Hilpert A,Heethoff M,Blüthgen N

    更新日期：2017-09-22 00:00:00

  • Early life home microbiome and hyperactivity/inattention in school-age children.

    abstract：:This study evaluates the association between indoor microbial diversity early in life and hyperactivity/inattention symptoms in children at ages 10 and 15 years.A random sample enriched with subjects with hyperactivity/inattention at age 15 years was selected from the German LISA birth cohort. Bedroom floor dust was c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-53527-1

    authors： Casas L,Karvonen AM,Kirjavainen PV,Täubel M,Hyytiäinen H,Jayaprakash B,Lehmann I,Standl M,Pekkanen J,Heinrich J

    更新日期：2019-11-22 00:00:00

  • Iron acquisition in Pseudomonas aeruginosa by the siderophore pyoverdine: an intricate interacting network including periplasmic and membrane proteins.

    abstract：:Pyoverdine (PVDI) has been reported to act both as a siderophore for scavenging iron (a key nutrient) and a signaling molecule for the expression of virulence factors. This compound is itself part of a core set of virulence factors produced by Pseudomonas aeruginosa during infections. Once secreted into the bacterial ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56913-x

    authors： Bonneau A,Roche B,Schalk IJ

    更新日期：2020-01-10 00:00:00

  • Early Detection of Tomato Spotted Wilt Virus by Hyperspectral Imaging and Outlier Removal Auxiliary Classifier Generative Adversarial Nets (OR-AC-GAN).

    abstract：:Tomato spotted wilt virus is a wide-spread plant disease in the world. It can threaten thousands of plants with a persistent and propagative manner. Early disease detection is expected to be able to control the disease spread, to facilitate management practice, and further to guarantee accompanying economic benefits. ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-40066-y

    authors： Wang D,Vinson R,Holmes M,Seibel G,Bechar A,Nof S,Tao Y

    更新日期：2019-03-13 00:00:00

  • Quantum Search on Encrypted Data Based on Quantum Homomorphic Encryption.

    abstract：:We propose a homomorphic search protocol based on quantum homomorphic encryption, in which a client Alice with limited quantum ability can give her encrypted data to a powerful but untrusted quantum server and let the server search for her without decryption. By outsourcing the interactive key-update process to a trus...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-61791-9

    authors： Zhou Q,Lu S,Cui Y,Li L,Sun J

    更新日期：2020-03-20 00:00:00