Whole exome sequencing reveals rare variants linked to congenital pouch colon.

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Ribeiro MBT,Guzzoni V,Hord JM,Lopes GN,de Cássia Marqueti R,de Andrade RV,Selistre-de-Araujo HS,Durigan JLQ

更新日期：2019-04-17 00:00:00

abstract：:The coincidence of flood flows in a mainstream and its tributaries may lead to catastrophic floods. In this paper, we investigated the flood coincidence risk under nonstationary conditions arising from climate changes. The coincidence probabilities considering flood occurrence dates and flood magnitudes were calculate...

journal_title：Scientific reports

authors： Feng Y,Shi P,Qu S,Mou S,Chen C,Dong F

更新日期：2020-02-25 00:00:00

abstract：:The Kidney Donor Profile Index (KDPI) was introduced in the United States in 2014 to guide the decision making of clinicians with respect to accepting or declining a donated kidney. To evaluate whether the KDPI can be applied to a European cohort, we retrospectively assessed 580 adult patients who underwent renal tran...

journal_title：Scientific reports

authors： Dahmen M,Becker F,Pavenstädt H,Suwelack B,Schütte-Nütgen K,Reuter S

更新日期：2019-08-02 00:00:00

abstract：:Users of social media often share their feelings or emotional states through their posts. In this study, we developed a deep learning model to identify a user's mental state based on his/her posting information. To this end, we collected posts from mental health communities in Reddit. By analyzing and learning posting...

journal_title：Scientific reports

authors： Kim J,Lee J,Park E,Han J

更新日期：2020-07-16 00:00:00

abstract：:Fine-motor impairment (FMI) is progressively expressed in early Parkinson's Disease (PD) patients and is now known to be evident in the immediate prodromal stage of the condition. The clinical techniques for detecting FMI may not be robust enough and here, we show that the subtle FMI of early PD patients can be effect...

journal_title：Scientific reports

authors： Iakovakis D,Chaudhuri KR,Klingelhoefer L,Bostantjopoulou S,Katsarou Z,Trivedi D,Reichmann H,Hadjidimitriou S,Charisis V,Hadjileontiadis LJ

更新日期：2020-07-28 00:00:00

abstract：:We propose to use Rabi oscillation as a probe to view the fractional Josepshon relation (FJR) associated with Majorana bound states (MBSs) expected in one-dimensional topological superconductors. The system consists of a quantum dot (QD) and an rf-SQUID with MBSs at the Josephson junction. Rabi oscillations between en...

journal_title：Scientific reports

authors： Wang Z,Liang QF,Yao DX,Hu X

更新日期：2015-07-08 00:00:00

abstract：:Evaluations of restoration success usually focus on the structural aspects of ecosystems. Pollination, as an important functional aspect, is often overlooked. Here, the shifts in pollinator assemblage and pollen limitation in the desert shrub Caragana microphylla were examined along a restoration gradient in Horqin Sa...

journal_title：Scientific reports

authors： Pan CC,Qu H,Feng Q,Liu LD,Zhao HL,Li YL,Li YQ,Zhang TH,Liu XP

更新日期：2017-12-04 00:00:00

abstract：:Intervertebral disc (IVD) degeneration is a leading cause of chronic low back pain that affects millions of people every year. Yet identification of the specific IVD causing this pain is based on qualitative visual interpretation rather than objective findings. One possible approach to diagnosing pain-associated IVD c...

journal_title：Scientific reports

authors： Bez M,Zhou Z,Sheyn D,Tawackoli W,Giaconi JC,Shapiro G,Ben David S,Gazit Z,Pelled G,Li D,Gazit D

更新日期：2018-11-26 00:00:00

abstract：:Beneficial and deleterious mutations change an organism's fitness but the distribution of these mutational effects on fitness are unknown. Several experimental, theoretical, and computational studies have explored this question but are limited because of experimental restrictions, or disconnect with physiology. Here w...

journal_title：Scientific reports

authors： Brajesh RG,Dutta D,Saini S

更新日期：2019-07-08 00:00:00

abstract：:We study the impact of the direction of magnetic flux on the electron motion in GaAs/InAs core/shell nanowires. At small tilt angles, when the magnetic field is aligned nearly parallel to the nanowire axis, we observe Aharonov-Bohm type h/e flux periodic magnetoconductance oscillations. These are attributed to transpo...

journal_title：Scientific reports

authors： Haas F,Wenz T,Zellekens P,Demarina N,Rieger T,Lepsa M,Grützmacher D,Lüth H,Schäpers T

更新日期：2016-04-19 00:00:00

abstract：:Site conditions and forest management affect dendrometric parameters of chestnut (Castanea sativa Mill.) coppices, but there is modest knowledge on the effect of stand dendrometric characters on physical and mechanical wood characteristics. The aim of this study was to verify these relationships in chestnut coppices t...

journal_title：Scientific reports

authors： Marini F,Manetti MC,Corona P,Portoghesi L,Vinciguerra V,Tamantini S,Kuzminsky E,Zikeli F,Romagnoli M

更新日期：2021-01-15 00:00:00

abstract：:Cryo-electron tomography (cryo-ET) is one of the most advanced technologies for the in situ visualization of molecular machines by producing three-dimensional (3D) biological structures. However, cryo-ET imaging has two serious disadvantages-low dose and low image contrast-which result in high-resolution information b...

journal_title：Scientific reports

authors： Huang X,Li S,Gao S

更新日期：2018-02-07 00:00:00

abstract：:A central goal of electronics based on correlated materials or 'Mottronics' is the ability to switch between distinct collective states with a control voltage. Small changes in structure and charge density near a transition can tip the balance between competing phases, leading to dramatic changes in electronic and mag...

journal_title：Scientific reports

authors： Liu M,Hoffman J,Wang J,Zhang J,Nelson-Cheeseman B,Bhattacharya A

更新日期：2013-01-01 00:00:00

abstract：:The current molecular docking study provided the Free Energy of Binding (FEB) for the interaction (nanotoxicity) between VDAC mitochondrial channels of three species (VDAC1-Mus musculus, VDAC1-Homo sapiens, VDAC2-Danio rerio) with SWCNT-H, SWCNT-OH, SWCNT-COOH carbon nanotubes. The general results showed that the FEB ...

journal_title：Scientific reports

authors： González-Durruthy M,Werhli AV,Seus V,Machado KS,Pazos A,Munteanu CR,González-Díaz H,Monserrat JM

更新日期：2017-10-16 00:00:00

abstract：:Emergence of polyphagous herbivorous insects entails significant adaptation to recognize, detoxify and digest a variety of host-plants. Despite of its biological and practical importance - since insects eat 20% of crops - no exhaustive analysis of gene repertoires required for adaptations in generalist insect herbivor...

journal_title：Scientific reports

authors： Gouin A,Bretaudeau A,Nam K,Gimenez S,Aury JM,Duvic B,Hilliou F,Durand N,Montagné N,Darboux I,Kuwar S,Chertemps T,Siaussat D,Bretschneider A,Moné Y,Ahn SJ,Hänniger S,Grenet AG,Neunemann D,Maumus F,Luyten I,Labadi

更新日期：2017-09-25 00:00:00

abstract：:In the chemical mechanical polishing process of semiconductor manufacturing, the concentration of 'large' particles ([Formula: see text]0.5 μm) in the slurry, which is considerably larger in size than the main abrasives ([Formula: see text] 0.1 μm), is a critical parameter that strongly influences manufacturing defect...

journal_title：Scientific reports

authors： Lee M,Kim D,Heo TY,Park T,Kim W,Choi D,Kim H,Kim J

更新日期：2020-09-07 00:00:00

abstract：:It is unknown whether YOD (young onset diabetes) and LOD (late onset diabetes) require similar insulin doses for intensive insulin therapy with a metformin add-on to achieve glycemic control. We analyzed data from our two previously performed randomized, controlled open-label trials. Patients were randomized to receiv...

journal_title：Scientific reports

authors： Li FF,Liu BL,Yin GP,Zhang DF,Zhai XF,Chen MY,Su XF,Wu JD,Ye L,Ma JH

更新日期：2017-11-27 00:00:00

abstract：:The aim of the current study is to assess whether total bile acid (TBA) level in first trimester pregnancy is associated with gestational diabetes mellitus (GDM). Biochemical parameters including serum TBA of 742 pregnant women were collected within 12 weeks of gestation and compared. At 24-28th weeks of gestation, 75...

journal_title：Scientific reports

authors： Hou W,Meng X,Zhao W,Pan J,Tang J,Huang Y,Tao M,Liu F,Jia W

更新日期：2016-09-26 00:00:00

abstract：:Obesity is highly heritable, but the specific genes influencing obesity related traits are largely unknown. Fibroblast growth factor 2 (FGF2) could influence adipocyte differentiation. However, the association of FGF2 polymorphisms and obesity remains unclear. This study aimed to investigate the associations of both t...

journal_title：Scientific reports

authors： Hao RH,Guo Y,Dong SS,Weng GZ,Yan H,Zhu DL,Chen XF,Chen JB,Yang TL

更新日期：2016-02-16 00:00:00

abstract：:Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer's disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and ana...

journal_title：Scientific reports

authors： Reimann H,Stopper H,Polak T,Lauer M,Herrmann MJ,Deckert J,Hintzsche H

更新日期：2020-12-17 00:00:00

abstract：:This study analyzed hourly mass concentration observations of PM2.5 (particulate matters with diameter less than 2.5 μm) at 512 stations in China from December 2013 to May 2015. We found that the mean concentrations of PM2.5 during the winter and spring of 2015 Dec. 2014 to Feb. 2015 and Mar. 2015 to May 2015) decreas...

journal_title：Scientific reports

authors： Wang X,Wang K,Su L

更新日期：2016-11-02 00:00:00

abstract：:Sterile liver inflammation and fibrosis are associated with many liver disorders of different etiologies. Both type 1 and type 2 inflammatory responses have been reported to contribute to liver pathology. However, the mechanisms controlling the balance between these responses are largely unknown. Natural killer T (NKT...

journal_title：Scientific reports

authors： Nilsson J,Hörnberg M,Schmidt-Christensen A,Linde K,Nilsson M,Carlus M,Erttmann SF,Mayans S,Holmberg D

更新日期：2020-12-11 00:00:00

abstract：:In this study, we made a comparative efficacy and safety assessment of two different fixed combinations of drugs, viz., tafluprost/timolol (TAF/TIM) and latanoprost/carteolol (LAT/CAR), by determining their effects on intraocular pressure (IOP) in ocular normotensive monkeys and examining their toxic effects on ocular...

journal_title：Scientific reports

authors： Fuwa M,Shimazaki A,Mieda M,Yamashita N,Akaishi T,Taniguchi T,Kato M

更新日期：2019-05-16 00:00:00

abstract：:It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility. Here we showed that the transient increase of interleukin-1β (IL-1β) after prolonged FS promoted adult seizure susceptibility, which was blocked by interleukin-1 receptor antagonist (IL-1Ra) within a critical time window. Post...

journal_title：Scientific reports

authors： Feng B,Tang Y,Chen B,Xu C,Wang Y,Dai Y,Wu D,Zhu J,Wang S,Zhou Y,Shi L,Hu W,Zhang X,Chen Z

更新日期：2016-02-23 00:00:00

abstract：:Given the prevalence of poor adherence to therapy and the biases of self-reporting across healthcare, we hypothesized that an engaging, personalized therapy may improve adherence and treatment outcomes in the home. We tested this hypothesis in the initial indication of amblyopia, a neurodevelopmental disorder for whic...

journal_title：Scientific reports

authors： Xiao S,Gaier ED,Mazow ML,Stout AU,Travers DA,Angjeli E,Wu HC,Binenbaum G,Hunter DG

更新日期：2020-05-20 00:00:00

abstract：:Although the anxiolytic-like effects of Xiaoyaosan, a Chinese herbal formula, have been described in many previous studies, its underlying mechanism remains undefined. The cytokine tumour necrosis factor-α (TNF-α) and its closely associated janus kinase 2 (JAK2)-signal transducer and activator of transcription (STAT3)...

journal_title：Scientific reports

authors： Li XJ,Ma QY,Jiang YM,Bai XH,Yan ZY,Liu Q,Pan QX,Liu YY,Chen JX

更新日期：2017-03-23 00:00:00

abstract：:We analyze the symmetry and topological features of a family of materials closely related to penta-graphene, derived from it by adsorption or substitution of different atoms. Our description is based on a novel approach, called topological quantum chemistry, that allows to characterize the topology of the electronic b...

journal_title：Scientific reports

authors： Bravo S,Correa J,Chico L,Pacheco M

更新日期：2019-09-04 00:00:00

abstract：:Development of conformal n-channel organic phototransistor (OPT) array is urgent for future applications of organic complementary circuits in portable and wearable electronics and optoelectronics. In this work, the ultrathin conformal OPT array based on air-stable n-type PTCDI-C13H27 was fabricated. The OPT array show...

journal_title：Scientific reports

authors： Liu M,Wang H,Tang Q,Zhao X,Tong Y,Liu Y

更新日期：2018-11-09 00:00:00

abstract：:Once activated, the intracellular receptor NLRP3 assembles an inflammasome protein complex that facilitates the caspase-1-mediated maturation of IL-1β and IL-18. Inactive NLRP3 is guarded by a protein complex containing Hsp90. In response to stress stimuli, Hsp90 is released, and NLRP3 can be activated to promote infl...

journal_title：Scientific reports

authors： Piippo N,Korhonen E,Hytti M,Skottman H,Kinnunen K,Josifovska N,Petrovski G,Kaarniranta K,Kauppinen A

更新日期：2018-04-30 00:00:00

abstract：:Near infrared (NIR) fluorophores like Pt-porphyrin along with analyte specific enzymes require co-encapsulation in biocompatible and biodegradable carriers in order to be transformed into implantable biosensors for efficient and continuous monitoring of analytes in patients. The main objective of this research is to d...

journal_title：Scientific reports

authors： Pandey G,Chaudhari R,Joshi B,Choudhary S,Kaur J,Joshi A

更新日期：2019-03-22 00:00:00