Abstract:
:The Kidney Donor Profile Index (KDPI) was introduced in the United States in 2014 to guide the decision making of clinicians with respect to accepting or declining a donated kidney. To evaluate whether the KDPI can be applied to a European cohort, we retrospectively assessed 580 adult patients who underwent renal transplantation (brain-dead donors) between January 2007 and December 2014 at our center and compared their KDPIs with their short- and long-term outcomes. This led to the observation of two associations: one between the KDPI and the estimated glomerular filtration rate at one year (1-y-eGFR) and the other between the KDPI and the death-censored allograft survival rate (both p < 0.001). Following this, the individual input factors of the KDPI were analyzed to assess their potential to evaluate the quality of a donor organ. We found that a donor's age alone is significantly predictive in terms of 1-y-eGFR and death-censored allograft survival (both p < 0.001). Therefore, a donor's age may serve as a simple reference for future graft function. Furthermore, we found that an organ with a low KDPI or from a young donor has an improved graft survival rate whereas kidneys with a high KDPI or from an older donor yield an inferior performance, but they are still acceptable. Therefore, we would not encourage defining a distinct KDPI cut-off in the decision-making process of accepting or declining a kidney graft.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Dahmen M,Becker F,Pavenstädt H,Suwelack B,Schütte-Nütgen K,Reuter Sdoi
10.1038/s41598-019-47772-7subject
Has Abstractpub_date
2019-08-02 00:00:00pages
11234issue
1issn
2045-2322pii
10.1038/s41598-019-47772-7journal_volume
9pub_type
杂志文章abstract::Schizophrenia is one of the most prevalent psychiatric disorders with complex genetic etiology. Accumulating evidence suggests that energy metabolism and oxidative stress play important roles in the pathophysiology of schizophrenia. Dysfunction of mitochondrial respiratory chain and altered expression of complex I sub...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11076
更新日期:2015-06-08 00:00:00
abstract::Although habitat transformation is one of the main causes of biodiversity loss, there are many examples of species successfully occupying and even proliferating in highly human-modified habitats such are the cities. Thus, there is an increasing interest in understanding the drivers favoring urban life for some species...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03853-z
更新日期:2017-06-14 00:00:00
abstract::Classical swine fever virus (CSFV) non-structural protein 3 (NS3) is a multifunctional non-structural protein that plays a major role in viral replication. However, how exactly NS3 exerts these functions remains unknown. Here, we identified tumour necrosis factor receptor-associated factor 6 (TRAF6) as a novel NS3-int...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06934-1
更新日期:2017-07-27 00:00:00
abstract::Morphological phylogenies stand in a major conflict with molecular hypotheses regarding the phylogeny of Cryptodira, the most diverse and widely distributed clade of extant turtles. However, molecular hypotheses are often considered a better estimate of phylogeny given that it is more consistent with the stratigraphic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16299
更新日期:2015-11-10 00:00:00
abstract::Since its first implementation in otolaryngological surgery nearly a century ago, the surgical microscope has improved the accuracy and the safety of microsurgeries. However, the microscope shows only a magnified surface view of the surgical region. To overcome this limitation, either optical coherence tomography (OCT...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35176
更新日期:2016-10-12 00:00:00
abstract::We delineate the four principal surface plasmon polariton coupling and interaction mechanisms in subwavelength gratings, and demonstrate their significant roles in shaping the optical response of plasmonic gratings. Within the framework of width-graded metal-insulator-metal nano-gratings, electromagnetic field confine...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79815-9
更新日期:2021-01-12 00:00:00
abstract::The distinguishing of the multiphoton quantum interference effect from the classical one forms one of the most important issues in modern quantum mechanics and experimental quantum optics. For a long time, the two-photon interference (TPI) of correlated photons has been recognized as a pure quantum effect that cannot ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54504-4
更新日期:2019-12-05 00:00:00
abstract::Membranes with selective superwettability for oil/water separation have received significant attention during the past decades. Hierarchical structures and surface roughness are believed to improve the oil repellency and the stability of Cassie-Baxter state. Diatoms, unicellular photosynthetic algae, possess sophistic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-01642-2
更新日期:2017-05-03 00:00:00
abstract::Spreading rumors on the Internet has become increasingly pervasive due to the proliferation of online social media. This paper investigates how rumors are amplified by a group of users who share similar interests or views, dubbed as an echo chamber. To this end, we identify and analyze 'rumor' echo chambers, each of w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57272-3
更新日期:2020-01-15 00:00:00
abstract::Bif-1 is a membrane-curvature inducing protein that is implicated in the regulation of autophagy and tumorigenesis. Here, we report that Bif-1 plays a critical role in regulating lipid catabolism to control the size of lipid droplets and prevent the development of obesity and insulin resistance upon aging or dietary c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20453
更新日期:2016-02-09 00:00:00
abstract::Nitrogen-doped hierarchical porous carbons were synthesized successfully by a controllable one-pot method using glucose and dicyandiamide as carbon source and nitrogen source via hydrothermal carbonization process. The nitrogen-doped materials, possessing high nitrogen content (up to 7 wt%), large surface area (>320 m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21365
更新日期:2016-02-25 00:00:00
abstract::The development of microstructure during melting, reactive wetting and solidification of solder pastes on Cu-plated printed circuit boards has been studied by synchrotron radiography. Using Sn-3.0Ag-0.5Cu/Cu and Sn-0.7Cu/Cu as examples, we show that the interfacial Cu6Sn5 layer is present within 0.05 s of wetting, and...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40010
更新日期:2017-01-12 00:00:00
abstract::This study aimed to evaluate the effects of ischemia-reperfusion injury (IRI) on the risk of hepatocellular carcinoma (HCC) recurrence after liver transplantation. Data of 195 patients were retrospectively analysed. Post-reperfusion aspartate (AST), alanine transaminase, and lactate dehydrogenase (LDH) levels were the...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27319-y
更新日期:2018-06-12 00:00:00
abstract::Despite recent advances in drug delivery, the targeted treatment of unhealthy cells or tissues continues to remain a priority. In cancer (much like other pathologies), delivery vectors are designed to exploit physical and biological features of unhealthy tissues that are not always homogenous across the disease. In so...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-55909-x
更新日期:2020-01-13 00:00:00
abstract::Today's electronic devices are fabricated using highly toxic materials and processes which limits their applications in environmental sensing applications and mandates complex encapsulation methods in biological and medical applications. This paper proposes a fully resorbable high density bio-compatible and environmen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15395-5
更新日期:2017-11-07 00:00:00
abstract::Using second-generation sequencing (SGS) RNA-Seq strategies, extensive alterative splicing prediction is impractical and high variability of isoforms expression quantification is inevitable in organisms without true reference dataset. we report the development of a novel analysis method, termed hybrid sequencing and m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43793
更新日期:2017-03-08 00:00:00
abstract::Statins present many beneficial effects in chronic liver disease, but concerns about safety exist. We evaluated the hepatic effects of a nitric oxide-releasing atorvastatin (NCX 6560) compared to conventional statins. Simvastatin, atorvastatin and NCX 6560 were evaluated in four-week bile duct-ligated rats (BDL) simul...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40461
更新日期:2017-01-13 00:00:00
abstract::Cellvibrio mixtus strain J3-8 is a gram-negative, xylanase-producing aerobic soil bacterium isolated from giant snails in Singapore. It is able to produce up to 10.1 U ml(-1) of xylanase, which is comparable to xylanase production from known bacterial and fungal strains. Genome sequence analysis of strain J3-8 reveals...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10521
更新日期:2015-05-21 00:00:00
abstract::Annually averaged solar radiation in the McMurdo Dry Valleys, Antarctica has varied by over 20 W m-2 during the past three decades; however, the drivers of this variability are unknown. Because small differences in radiation are important to water availability and ecosystem functioning in polar deserts, determining th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23390-7
更新日期:2018-03-22 00:00:00
abstract::The near complete genome sequences of ten field avian orthoreovirus (ARV) strains collected from young chicken between 2002 and 2011 in Hungary have been determined in order to explore the genetic diversity and evolutionary mechanisms affecting ARVs in this region. Sequence analyses and phylogenetic calculations revea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36960
更新日期:2016-11-10 00:00:00
abstract::We show that the width of an arbitrary function and the width of the distribution of its values cannot be made arbitrarily small simultaneously. In the case of ergodic stochastic processes, an ensuing uncertainty relationship is then demonstrated for the product of correlation length and variance. A closely related un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-64539-7
更新日期:2020-05-12 00:00:00
abstract::Pigment organelles known as melanosomes disperse or aggregate in a melanophore in response to hormones. These movements are mediated by the microtubule motors kinesin-2 and cytoplasmic dynein. However, the force generation mechanism of dynein, unlike that of kinesin, is not well understood. In this study, to address t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41458-w
更新日期:2019-03-25 00:00:00
abstract::Quantum cryptography is commonly used to generate fresh secure keys with quantum signal transmission for instant use between two parties. However, research shows that the relatively low key generation rate hinders its practical use where a symmetric cryptography component consumes the shared key. That is, the security...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep46302
更新日期:2017-04-13 00:00:00
abstract::The aim of the study was to determine damage severity of wood-destroying insects on logs stored in forest depots. The Bevan damage classification (BDC) system, developed in 1987, was utilized to determine damage severity in log depots in 21 locations throughout seven provinces in Turkey. Pheromone traps were placed in...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70696-6
更新日期:2020-08-13 00:00:00
abstract::The late Ediacaran witnessed an increase in metazoan diversity and ecological complexity, marking the inception of the Cambrian Explosion. To constrain the drivers of this diversification, we combine redox and nutrient data for two shelf transects, with an inventory of biotic diversity and distribution from the Nama G...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59335-2
更新日期:2020-02-10 00:00:00
abstract::M2BP (also called 90K) is an interferon-stimulated gene product that is upregulated in HIV-1 infection. A recent study revealed that M2BP reduces the infectivity of HIV-1 by inhibiting the processing of the viral envelope protein. Here we report that in addition to reducing viral infectivity, M2BP inhibits HIV-1 virio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32736
更新日期:2016-09-08 00:00:00
abstract::The secretion of glucagon by pancreatic alpha cells is regulated by a number of external and intrinsic factors. While the electrophysiological processes linking a lowering of glucose concentrations to an increased glucagon release are well characterized, the evidence for the identity and function of the glucose sensor...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76863-z
更新日期:2020-11-19 00:00:00
abstract::Boulders are ubiquitously found on the surfaces of small rocky bodies in the inner solar system and their spatial and size distributions give insight into the geological evolution and collisional history of the parent bodies. Using images acquired by the Chang'e-2 spacecraft, more than 200 boulders have been identifie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16029
更新日期:2015-11-02 00:00:00
abstract::With modern scanning probe microscopes, it is possible to manipulate surface structures even at the atomic level. However, manipulation of nanoscale objects such as clusters is often more relevant and also more challenging due to the complicated interactions between the surface, cluster and apparatus. We demonstrate t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01270
更新日期:2013-01-01 00:00:00
abstract::Perovskite solar cells based on series of inorganic cesium lead bromide and iodide mixture, CsPbBr3-xI x , where x varies between 0, 0.1, 0.2, and 0.3 molar ratio were synthesized by two step-sequential deposition at ambient condition to design the variations of wide band gap light absorbers. A device with high overal...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20228-0
更新日期:2018-02-06 00:00:00