Fluorescent Biocompatible Platinum-Porphyrin-Doped Polymeric Hybrid Particles for Oxygen and Glucose Biosensing.

Abstract:

:Near infrared (NIR) fluorophores like Pt-porphyrin along with analyte specific enzymes require co-encapsulation in biocompatible and biodegradable carriers in order to be transformed into implantable biosensors for efficient and continuous monitoring of analytes in patients. The main objective of this research is to develop natural, biodegradable, biocompatible and a novel co-encapsulated system of Pt-porphyrin encapsulated polymeric nanoparticle and nano-micro hybrid carriers. A sequential emulsification-solvent evaporation and an air driven atomization technique was used for developing above matrices and testing them for fluorescence based oxygen and glucose biosensing. The results indicate Pt-porphyrin can be efficiently encapsulated in Poly-lactic acid (PLA) nanoparticles and PLA-alginate nano-micro particles with sizes ~450 nm and 10 µm, respectively. Biosensing studies have showed a linear fluorescent response in oxygen concentrations ranging from of 0-6 mM (R2 = 0.992). The Oxygen sensitivity was transformed into a linear response of glucose catalytic reaction in the range of 0-10 mM (R2 = 0.968) with a response time of 4 minutes and a stability over 15 days. We believe that the investigated NIR fluorophores like Pt-Porphyrin based nano/nano-micro hybrid carrier systems are novel means of developing biocompatible biodegradable carriers for developing implantable glucose biosensors which can efficiently manage glucose levels in diabetes.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Pandey G,Chaudhari R,Joshi B,Choudhary S,Kaur J,Joshi A

doi

10.1038/s41598-019-41326-7

subject

Has Abstract

pub_date

2019-03-22 00:00:00

pages

5029

issue

1

issn

2045-2322

pii

10.1038/s41598-019-41326-7

journal_volume

9

pub_type

杂志文章
  • Pushing the limit: examining factors that affect anoxia tolerance in a single genotype of adult D. melanogaster.

    abstract::Drosophila melanogaster is a promiscuous species that inhabits a large range of harsh environments including flooded habitats and varying temperature changes. To survive these environments, fruit flies have adapted mechanisms of tolerance that allow them to thrive. During exposure to anoxic stress, fruit flies and oth...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09204

    authors: Benasayag-Meszaros R,Risley MG,Hernandez P,Fendrich M,Dawson-Scully K

    更新日期:2015-03-17 00:00:00

  • A novel function for Egr4 in posterior hindbrain development.

    abstract::Segmentation of the vertebrate hindbrain is an evolutionarily conserved process. Here, we identify the transcription factor early growth response 4 (egr4) as a novel regulator of posterior hindbrain development in Xenopus. egr4 is specifically and transiently expressed in rhombomeres 5 and 6 (r5/r6), and Egr4 knockdow...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07750

    authors: Bae CJ,Jeong J,Saint-Jeannet JP

    更新日期:2015-01-13 00:00:00

  • High percentages and activity of synovial fluid NK cells present in patients with advanced stage active Rheumatoid Arthritis.

    abstract::Rheumatoid Arthritis (RA) causes chronic inflammation of joints. The cytokines TNFα and IFNγ are central players in RA, however their source has not been fully elucidated. Natural Killer (NK) cells are best known for their role in elimination of viral-infected and transformed cells, and they secrete pro-inflammatory c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37448-z

    authors: Yamin R,Berhani O,Peleg H,Aamar S,Stein N,Gamliel M,Hindi I,Scheiman-Elazary A,Gur C

    更新日期:2019-02-04 00:00:00

  • Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations.

    abstract::Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an inherited disorder that causes progressive kidney damage and renal failure. Mutations in the UMOD gene, encoding uromodulin, lead to ADTKD-UMOD related. Uromodulin is a GPI-anchored protein exclusively produced by epithelial cells of the thick ascendin...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-07804-6

    authors: Trudu M,Schaeffer C,Riba M,Ikehata M,Brambilla P,Messa P,Martinelli-Boneschi F,Rastaldi MP,Rampoldi L

    更新日期:2017-08-07 00:00:00

  • Evolving pneumococcal serotypes and sequence types in relation to high antibiotic stress and conditional pneumococcal immunization.

    abstract::In Taiwan, beginning in 2013, the 13-valent pneumococcal conjugate vaccine (PCV13) was provided free of charge to children 2-5 years of age. In 2014, this was extended to children 1-5 years old. During 2012-2014, 953 cases of culture-confirmed pneumococcal disease (CCPD), including 104 invasive pneumococcal disease (I...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15843

    authors: Su LH,Kuo AJ,Chia JH,Li HC,Wu TL,Feng Y,Chiu CH

    更新日期:2015-11-02 00:00:00

  • Prognostic Influence of Preoperative Mammographic Breast Density in Operable Invasive Female Breast Cancer.

    abstract::We aimed to investigate the potential of preoperative mammographic breast density (MBD) as a prognostic factor in breast cancer. Data of 969 patients with primary breast cancer were analyzed. We defined low MBD as fatty or fibroglandular breast, and high MBD as heterogeneously dense or extremely dense breast, respecti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34297-8

    authors: Hwang KT,Chu AJ,Kim J,Lee JY,Chang JH,Oh S,Kim YA,Jung J,Oh B

    更新日期:2018-10-30 00:00:00

  • Fermionic order by disorder in a van der Waals antiferromagnet.

    abstract::CeTe3 is a unique platform to investigate the itinerant magnetism in a van der Waals (vdW) coupled metal. Despite chemical pressure being a promising route to boost quantum fluctuation in this system, a systematic study on the chemical pressure effect on Ce3+(4f1) states is absent. Here, we report on the successful gr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-72300-3

    authors: Okuma R,Ueta D,Kuniyoshi S,Fujisawa Y,Smith B,Hsu CH,Inagaki Y,Si W,Kawae T,Lin H,Chuang FC,Masuda T,Kobayashi R,Okada Y

    更新日期:2020-09-17 00:00:00

  • Factors associated with false negative interferon-γ release assay results in patients with tuberculosis: A systematic review with meta-analysis.

    abstract::Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IGRA results from Pub...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/s41598-020-58459-9

    authors: Yamasue M,Komiya K,Usagawa Y,Umeki K,Nureki SI,Ando M,Hiramatsu K,Nagai H,Kadota JI

    更新日期:2020-01-31 00:00:00

  • New information of dopaminergic agents based on quantum chemistry calculations.

    abstract::Dopamine is an important neurotransmitter that plays a key role in a wide range of both locomotive and cognitive functions in humans. Disturbances on the dopaminergic system cause, among others, psychosis, Parkinson's disease and Huntington's disease. Antipsychotics are drugs that interact primarily with the dopamine ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78446-4

    authors: Goode-Romero G,Winnberg U,Domínguez L,Ibarra IA,Vargas R,Winnberg E,Martínez A

    更新日期:2020-12-09 00:00:00

  • Spatio-temporal processes drive fine-scale genetic structure in an otherwise panmictic seabird population.

    abstract::When and where animals breed can shape the genetic structure and diversity of animal populations. The importance of drivers of genetic diversity is amplified in island populations that tend to have more delineated gene pools compared to continental populations. Studies of relatedness as a function of the spatial distr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77517-w

    authors: Garrett LJH,Myatt JP,Sadler JP,Dawson DA,Hipperson H,Colbourne JK,Dickey RC,Weber SB,Reynolds SJ

    更新日期:2020-11-26 00:00:00

  • Comparative transcriptomic analysis of Tibetan Gynaephora to explore the genetic basis of insect adaptation to divergent altitude environments.

    abstract::Adaptation of insects to different altitudes remain largely unknown, especially those endemic to the Tibetan Plateau (TP). Here, we generated the transcriptomes of Gynaephora menyuanensis and G. alpherakii, inhabiting different high altitudes on the TP, and used these and the previously available transcriptomic and ge...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17051-4

    authors: Zhang QL,Zhang L,Yang XZ,Wang XT,Li XP,Wang J,Chen JY,Yuan ML

    更新日期:2017-12-05 00:00:00

  • Impact of hot events at different developmental stages of a moth: the closer to adult stage, the less reproductive output.

    abstract::Hot days in summer (involving a few hours at particularly high temperatures) are expected to become more common under climate change. How such events at different life stages affect survival and reproduction remains unclear in most organisms. Here, we investigated how an exposure to 40 °C at different life stages in t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10436

    authors: Zhang W,Chang XQ,Hoffmann A,Zhang S,Ma CS

    更新日期:2015-05-22 00:00:00

  • Modality-specific improvements in sensory processing among baseball players.

    abstract::Long-term skills training is known to induce neuroplastic alterations, but it is still debated whether these changes are always modality-specific or can be supramodal components. To address this issue, we compared finger-targeted somatosensory-evoked and auditory-evoked potentials under both Go (response) and Nogo (re...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81852-x

    authors: Yamashiro K,Yamazaki Y,Siiya K,Ikarashi K,Baba Y,Otsuru N,Onishi H,Sato D

    更新日期:2021-01-26 00:00:00

  • MicroRNA-130b improves renal tubulointerstitial fibrosis via repression of Snail-induced epithelial-mesenchymal transition in diabetic nephropathy.

    abstract::MicroRNA-130b (miR-130b) downregulation has been identified in diabetes, but the role and mechanisms for miR-130b in mediating renal tubulointerstitial fibrosis in diabetic nephropathy (DN) remain unknown. We demonstrated that plasma miR-130b downregulation exhibited clinical and biological relevance as it was linked ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20475

    authors: Bai X,Geng J,Zhou Z,Tian J,Li X

    更新日期:2016-02-03 00:00:00

  • A high-content image analysis approach for quantitative measurements of chemosensitivity in patient-derived tumor microtissues.

    abstract::Organotypic, three-dimensional (3D) cancer models have enabled investigations of complex microtissues in increasingly realistic conditions. However, a drawback of these advanced models remains the poor biological relevance of cancer cell lines, while higher clinical significance would be obtainable with patient-derive...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-06544-x

    authors: Ahonen I,Åkerfelt M,Toriseva M,Oswald E,Schüler J,Nees M

    更新日期:2017-07-26 00:00:00

  • Host genetics determine susceptibility to avian influenza infection and transmission dynamics.

    abstract::Host-genetic control of influenza virus infection has been the object of little attention. In this study we determined that two inbred lines of chicken differing in their genetic background , Lines 0 and C-B12, were respectively relatively resistant and susceptible to infection with the low pathogenicity influenza vir...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26787

    authors: Ruiz-Hernandez R,Mwangi W,Peroval M,Sadeyen JR,Ascough S,Balkissoon D,Staines K,Boyd A,McCauley J,Smith A,Butter C

    更新日期:2016-06-09 00:00:00

  • Beyond Homozygosity Mapping: Family-Control analysis based on Hamming distance for prioritizing variants in exome sequencing.

    abstract::A major challenge in current exome sequencing in autosomal recessive (AR) families is the lack of an effective method to prioritize single-nucleotide variants (SNVs). AR families are generally too small for linkage analysis, and length of homozygous regions is unreliable for identification of causative variants. Vario...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep12028

    authors: Imai A,Nakaya A,Fahiminiya S,Tétreault M,Majewski J,Sakata Y,Takashima S,Lathrop M,Ott J

    更新日期:2015-07-06 00:00:00

  • Nonlinear increase of X-ray intensities from thin foils irradiated with a 200 TW femtosecond laser.

    abstract::We report, for the first time, that the energy of femtosecond optical laser pulses, E, with relativistic intensities I > 10(21)  W/cm(2) is efficiently converted to X-ray radiation, which is emitted by "hot" electron component in collision-less processes and heats the solid density plasma periphery. As shown by direct...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep13436

    authors: Faenov AY,Colgan J,Hansen SB,Zhidkov A,Pikuz TA,Nishiuchi M,Pikuz SA,Skobelev IY,Abdallah J,Sakaki H,Sagisaka A,Pirozhkov AS,Ogura K,Fukuda Y,Kanasaki M,Hasegawa N,Nishikino M,Kando M,Watanabe Y,Kawachi T,Masuda S

    更新日期:2015-09-02 00:00:00

  • Morphological and biomechanical characterization of immature and mature nasoseptal cartilage.

    abstract::Nasoseptal cartilage has been assumed to be isotropic, unlike the well-defined zonal organization of articular cartilage attributed to postnatal biomechanical loading. We know from clinical experience that malrotation of surgical nasoseptal cartilage grafts can lead to increased graft absorption. Other studies have al...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-48578-3

    authors: Jessop ZM,Zhang Y,Simoes IN,Al-Sabah A,Badiei N,Gazze SA,Francis L,Whitaker IS

    更新日期:2019-08-28 00:00:00

  • Responses to soil pH gradients of inorganic phosphate solubilizing bacteria community.

    abstract::Soil pH is commonly considered a dominant factor affecting the function of microbiota. Few studies, however, have focused on communities of bacteria able to solubilize inorganic phosphate (iPSB), which are important for the mobilization of soil phosphorus (P), because finding an effective method to assess the abundanc...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37003-w

    authors: Zheng BX,Zhang DP,Wang Y,Hao XL,Wadaan MAM,Hozzein WN,Peñuelas J,Zhu YG,Yang XR

    更新日期:2019-01-10 00:00:00

  • Inhibition of PGE2/EP4 receptor signaling enhances oxaliplatin efficacy in resistant colon cancer cells through modulation of oxidative stress.

    abstract::The platinum-based chemotherapeutic agent, oxaliplatin, is used to treat advanced colorectal cancer (CRC). Unfortunately, nearly all patients acquire resistance to oxaliplatin after long-term use, limiting its therapeutic efficacy. Since COX-2 and PGE2 signaling can impact colon cancer cell proliferation and survival,...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40848-4

    authors: Huang H,Aladelokun O,Ideta T,Giardina C,Ellis LM,Rosenberg DW

    更新日期:2019-03-20 00:00:00

  • Rap1 and Cdc13 have complementary roles in preventing exonucleolytic degradation of telomere 5' ends.

    abstract::Telomere DNA ends with a single-stranded 3' overhang. Long 3' overhangs may cause aberrant DNA damage responses and accelerate telomere attrition, which is associated with cancer and aging, respectively. Genetic studies have indicated several important players in preventing 5' end hyper-resection, yet detailed knowled...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08663-x

    authors: Runnberg R,Narayanan S,Cohn M

    更新日期:2017-08-18 00:00:00

  • Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer.

    abstract::Genetic alterations identified in adjacent normal appearing tissue in bladder cancer patients are indicative of a field disease. Here we assessed normal urothelium transformation and intra-tumour heterogeneity (ITH) in four patients with bladder cancer. Exome sequencing identified private acquired mutations in a lymph...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11291-0

    authors: Thomsen MBH,Nordentoft I,Lamy P,Vang S,Reinert L,Mapendano CK,Høyer S,Ørntoft TF,Jensen JB,Dyrskjøt L

    更新日期:2017-09-15 00:00:00

  • Association of induced abortion with preterm birth risk in first-time mothers.

    abstract::Women who have previously had an induced abortion (IA) before their first birth have been associated with preterm birth (PTB). However, previous studies on the PTB are inconsistent. Therefore, the aim of this study was to clarify the association between IA and PTB and low birth weight (LBW) for first-time mothers. A t...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23695-7

    authors: Ke L,Lin W,Liu Y,Ou W,Lin Z

    更新日期:2018-03-29 00:00:00

  • Optimized Spiral Metal-Gallium-Nitride Nanowire Cavity for Ultra-High Circular Dichroism Ultraviolet Lasing at Room Temperature.

    abstract::Circularly polarized laser sources with small footprints and high efficiencies can possess advanced functionalities in optical communication and biophotonic integrated systems. However, the conventional lasers with additional circular-polarization converters are bulky and hardly compatible with nanophotonic circuits, ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26578

    authors: Liao WC,Liao SW,Chen KJ,Hsiao YH,Chang SW,Kuo HC,Shih MH

    更新日期:2016-05-25 00:00:00

  • Image Fiber-Based Miniature Suspended Solid Sensor with High Accuracy and a Large Dynamic Range.

    abstract::An image fiber-based miniature suspended solid sensor has been demonstrated. The diameter of the sensor is only a few millimeters. A superhydrophobic material is coated on the end of the image fiber to avoid the adsorption of suspended solids and bubbles. Multiple parameters, including mass concentration, morphology a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-17003-y

    authors: Qi P,Lin L,Huang R,Zhao S,Tian H,Li S,Zhang Q,Liu W

    更新日期:2017-12-01 00:00:00

  • RNAseq analysis reveals drought-responsive molecular pathways with candidate genes and putative molecular markers in root tissue of wheat.

    abstract::Drought is one of the major impediments in wheat productivity. Traditional breeding and marker assisted QTL introgression had limited success. Available wheat genomic and RNA-seq data can decipher novel drought tolerance mechanisms with putative candidate gene and marker discovery. Drought is first sensed by root tiss...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-49915-2

    authors: Iquebal MA,Sharma P,Jasrotia RS,Jaiswal S,Kaur A,Saroha M,Angadi UB,Sheoran S,Singh R,Singh GP,Rai A,Tiwari R,Kumar D

    更新日期:2019-09-26 00:00:00

  • A Machine-learning Approach to Forecast Aggravation Risk in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Clinical Indicators.

    abstract::Patients with chronic obstructive pulmonary disease (COPD) repeat acute exacerbations (AE). Global Initiative for Chronic Obstructive Lung Disease (GOLD) is only available for patients in stable phase. Currently, there is a lack of assessment and prediction methods for acute exacerbation of chronic obstructive pulmona...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-60042-1

    authors: Peng J,Chen C,Zhou M,Xie X,Zhou Y,Luo CH

    更新日期:2020-02-20 00:00:00

  • Form and function of the human and chimpanzee forefoot: implications for early hominin bipedalism.

    abstract::During bipedal walking, modern humans dorsiflex their forefoot at the metatarsophalangeal joints (MTPJs) prior to push off, which tightens the plantar soft tissues to convert the foot into a stiff propulsive lever. Particular features of metatarsal head morphology such as "dorsal doming" are thought to facilitate this...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30532

    authors: Fernández PJ,Holowka NB,Demes B,Jungers WL

    更新日期:2016-07-28 00:00:00

  • Ingestion of Bt corn pollen containing Cry1Ab/2Aj or Cry1Ac does not harm Propylea japonica larvae.

    abstract::Propylea japonica (Thunberg) (Coleoptera: Coccinellidae) is a prevalent pollen consumer in corn fields and is therefore exposed to insecticidal proteins contained in the pollen of insect-resistant transgenic corn cultivars expressing Cry proteins derived from Bacillus thuringiensis (Bt). In the present study, the pote...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23507

    authors: Liu Y,Liu Q,Wang Y,Chen X,Song X,Romeis J,Li Y,Peng Y

    更新日期:2016-03-23 00:00:00