Genetic variation determines VEGF-A plasma levels in cancer patients.

abstract：:Current research on the influence of environmental and physicochemical factors in shaping the soil bacterial structure has seldom been approached from a pedological perspective. We studied the bacterial communities of eight soils selected along a pedogenic gradient at the local scale in a Mediterranean calcareous moun...

journal_title：Scientific reports

authors： Sánchez-Marañón M,Miralles I,Aguirre-Garrido JF,Anguita-Maeso M,Millán V,Ortega R,García-Salcedo JA,Martínez-Abarca F,Soriano M

更新日期：2017-11-06 00:00:00

abstract：:The pathophysiological implications of plasminogen activator inhibitor-1 (PAI-1) in HCV infection remain obscure. This prospective study evaluated 669 HCV patients, of whom 536 had completed a course of anti-HCV therapy and had pre-, peri- and post-therapy measurements of various profiles, including PAI-1 levels. Mult...

journal_title：Scientific reports

authors： Chang ML,Lin YS,Pao LH,Huang HC,Chiu CT

更新日期：2017-02-13 00:00:00

abstract：:We aimed to predict molecular subtypes of breast cancer using radiomics signatures extracted from synthetic mammography reconstructed from digital breast tomosynthesis (DBT). A total of 365 patients with invasive breast cancer with three different molecular subtypes (luminal A + B, luminal; HER2-positive, HER2; triple...

journal_title：Scientific reports

authors： Son J,Lee SE,Kim EK,Kim S

更新日期：2020-12-09 00:00:00

abstract：:Using a non-targeted metabolomics platform, we recently identified C-mannosyltryptophan and pseudouridine as non-traditional kidney function markers. The aims of this study were to obtain absolute concentrations of both metabolites in blood and urine from individuals with and without CKD to provide reference ranges an...

journal_title：Scientific reports

authors： Sekula P,Dettmer K,Vogl FC,Gronwald W,Ellmann L,Mohney RP,Eckardt KU,Suhre K,Kastenmüller G,Oefner PJ,Köttgen A

更新日期：2017-12-12 00:00:00

abstract：:Layered Sn-based chalcogenides and heterostructures are widely used in batteries and photocatalysis, but its utilizations in a supercapacitor is limited by its structural instability and low conductivity. Here, SnSx thin films are directly and conformally deposited on a three-dimensional (3D) Ni-foam (NF) substrate by...

journal_title：Scientific reports

authors： Ansari MZ,Parveen N,Nandi DK,Ramesh R,Ansari SA,Cheon T,Kim SH

更新日期：2019-07-15 00:00:00

abstract：:Density functional theory predictions have been combined with the microwave-plasma chemical vapor deposition technique to explore metastable synthesis of boron-rich boron-carbide materials. A thin film synthesis of high-hardness (up to 37 GPa) B50C2 via chemical vapor deposition was achieved. Characterization of the e...

journal_title：Scientific reports

authors： Baker PA,Chen WC,Chen CC,Catledge SA,Vohra YK

更新日期：2020-03-10 00:00:00

abstract：:Application of metabolic magnetic resonance imaging measures such as cerebral blood flow in translational medicine is limited by the unknown link of observed alterations to specific neurophysiological processes. In particular, the sensitivity of cerebral blood flow to activity changes in specific neurotransmitter syst...

journal_title：Scientific reports

authors： Dukart J,Holiga Š,Chatham C,Hawkins P,Forsyth A,McMillan R,Myers J,Lingford-Hughes AR,Nutt DJ,Merlo-Pich E,Risterucci C,Boak L,Umbricht D,Schobel S,Liu T,Mehta MA,Zelaya FO,Williams SC,Brown G,Paulus M,Honey GD,

更新日期：2018-03-06 00:00:00

abstract：:Pre-clinical monitoring of tumor growth and identification of distal metastasis requires a balance between accuracy and expediency. Bioluminescence imaging (BLI) is often used to track tumor growth but is primarily limited to planar 2-dimensional (2D) imaging. Consistent subject placement within a standard top-mounted...

journal_title：Scientific reports

authors： Brannen A,Eggert M,Nahrendorf M,Arnold R,Panizzi P

更新日期：2018-02-20 00:00:00

abstract：:Large consortia efforts and genome-wide association studies (GWASs) have linked a number of genetic variants within the 6p21 chromosomal region to non-Hodgkin lymphoma (NHL). Complementing these efforts, we genotyped previously reported SNPs in the human leukocyte antigen (HLA) class I (rs6457327) and class II (rs9271...

journal_title：Scientific reports

authors： Ten LC,Chin YM,Tai MC,Chin EF,Lim YY,Suthandiram S,Chang KM,Ong TC,Bee PC,Mohamed Z,Gan GG,Ng CC

更新日期：2017-01-31 00:00:00

abstract：:Animals thriving in hot deserts rely on extraordinary adaptations and thermoregulatory capacities to cope with heat. Uncovering such adaptations, and how they may be favoured by selection, is essential for predicting climate change impacts. Recently, the arid-adapted zebra finch was discovered to program their offspri...

journal_title：Scientific reports

authors： Pessato A,McKechnie AE,Buchanan KL,Mariette MM

更新日期：2020-11-03 00:00:00

abstract：:We developed an optimized Dipheylthiocarbazone or Dithizone (DTZ) with improved physical and chemical properties to characterize human islets and insulin-producing cells differentiated from embryonic stem cells. Application of the newly formulated iDTZ (i stands for islet) over a range of temperatures, time intervals ...

journal_title：Scientific reports

authors： Khiatah B,Qi M,Wu Y,Chen KT,Perez R,Valiente L,Omori K,Isenberg JS,Kandeel F,Yee JK,Al-Abdullah IH

更新日期：2019-06-26 00:00:00

abstract：:Amplification and sequencing of 16S amplicons are widely used for profiling the structure of oral microbiota. However, it remains not clear whether and to what degree DNA extraction and targeted 16S rRNA hypervariable regions influence the analysis. Based on a mock community consisting of five oral bacterial species i...

journal_title：Scientific reports

authors： Teng F,Darveekaran Nair SS,Zhu P,Li S,Huang S,Li X,Xu J,Yang F

更新日期：2018-11-05 00:00:00

abstract：:Transgenic rice producing insecticidal proteins from Bacillus thuringiensis (Bt) could help protect the plants from damage by lepidopteran pests. However, one concern is the potential of Bt rice to harm non-target natural enemies, which play a vital role in pest control. In the present study, the potential effects of ...

journal_title：Scientific reports

authors： Tian JC,Romeis J,Liu K,Zhang FC,Zheng XS,Xu HX,Chen GH,He XC,Lu ZX

更新日期：2017-08-10 00:00:00

abstract：:Embryo implantation requires a hospitable uterine environment. A key metabolic change that occurs during the peri-implantation period, and throughout early pregnancy, is the rise in endometrial glycogen content. Glycogen accumulation requires prior cellular uptake of glucose. Here we show that both human and murine en...

journal_title：Scientific reports

authors： Salker MS,Singh Y,Zeng N,Chen H,Zhang S,Umbach AT,Fakhri H,Kohlhofer U,Quintanilla-Martinez L,Durairaj RRP,Barros FSV,Vrljicak P,Ott S,Brucker SY,Wallwiener D,Vrhovac Madunić I,Breljak D,Sabolić I,Koepsell H,Brosens

更新日期：2017-10-03 00:00:00

abstract：:The dynamics of networks of neuronal cultures has been recently shown to be strongly dependent on the network geometry and in particular on their dimensionality. However, this phenomenon has been so far mostly unexplored from the theoretical point of view. Here we reveal the rich interplay between network geometry and...

journal_title：Scientific reports

authors： Millán AP,Torres JJ,Bianconi G

更新日期：2018-07-02 00:00:00

abstract：:The aim of this study was to fabricate a novel polymer-free everolimus-eluting stent with nanostructure using a femtosecond laser (FSL). The stent were coated with everolimus (EVL) using FSL and electrospinning processes. The surface was rendered hydrophobic, which negatively affected both platelet adhesion (82.1%) an...

journal_title：Scientific reports

authors： Bae IH,Jeong MH,Lim KS,Park DS,Shim JW,Park JK,Oh KH,Jin MR,Sim DS

更新日期：2018-05-09 00:00:00

abstract：:The ability to predict others' behaviour represents a crucial mechanism which allows individuals to react faster and more appropriately. To date, several studies have investigated humans' ability to predict conspecifics' behaviour, but little is known on our ability to predict behaviour in other species. Here, we aime...

journal_title：Scientific reports

authors： Donnier S,Kovács G,Oña LS,Bräuer J,Amici F

更新日期：2020-12-04 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Li H,Wu S,Ma X,Chen W,Zhang J,Duan S,Gao Y,Kui L,Huang W,Wu P,Shi R,Li Y,Wang Y,Li J,Guo X,Luo X,Li Q,Xiong C,Liu H,Gui M,Sheng J,Dong Y

更新日期：2020-05-18 00:00:00

abstract：:We demonstrate a comprehensive quantitative analysis of vector beam states (VBSs) by using a vector field reconstruction (VFR) technique integrating interferometry and imaging polarimetry, where the analysis is given by a cylindrically polarized Laguerre-Gaussian (LG) mode expansion of VBSs. From test examples of cyli...

journal_title：Scientific reports

authors： Suzuki M,Yamane K,Oka K,Toda Y,Morita R

更新日期：2019-07-10 00:00:00

abstract：:The number of magnetoelectric multiferroic materials reported to date is scarce, as magnetic structures that break inversion symmetry and induce an improper ferroelectric polarization typically arise through subtle competition between different magnetic interactions. The (NH4)2[FeCl5(H2O)] compound is a rare case wher...

journal_title：Scientific reports

authors： Alberto Rodríguez-Velamazán J,Fabelo Ó,Millán Á,Campo J,Johnson RD,Chapon L

更新日期：2015-09-29 00:00:00

abstract：:One-carbon metabolism is essential for multiple cellular processes and can be assessed by the concentration of folate metabolites in the blood. One-carbon metabolites serve as methyl donors that are required for epigenetic regulation. Deficiencies in these metabolites are associated with a variety of poor health outco...

journal_title：Scientific reports

authors： Knight AK,Park HJ,Hausman DB,Fleming JM,Bland VL,Rosa G,Kennedy EM,Caudill MA,Malysheva O,Kauwell GPA,Sokolow A,Fisher S,Smith AK,Bailey LB

更新日期：2018-11-15 00:00:00

abstract：:Rotator cuff tears are common and are associated with shoulder pain, disability, and dysfunction. Previous studies that have reported different arthroscopic techniques are controversial. A network meta-analysis with indirect and direct evidence was performed to compare the effectiveness of arthroscopic techniques for ...

journal_title：Scientific reports

authors： Xu B,Chen L,Zou J,Gu Y,Hao L,Peng K

更新日期：2019-03-11 00:00:00

abstract：:Parathyroid Hormone-Like Hormone (PTHLH) is an autocrine/paracrine ligand that is up-regulated in head and neck squamous cell carcinoma (HNSCC). However, the cellular function and regulatory mechanism in HNSCC remains obscure. We investigated the clinical significance of PTHLH in HNSCC patients, and verified the role ...

journal_title：Scientific reports

authors： Chang WM,Lin YF,Su CY,Peng HY,Chang YC,Hsiao JR,Chen CL,Chang JY,Shieh YS,Hsiao M,Shiah SG

更新日期：2017-01-25 00:00:00

abstract：:CRISPR-Cas9-mediated gene interference (CRISPRi) and activation (CRISPRa) approaches hold promise for functional gene studies and genome-wide screens in human pluripotent stem cells (hPSCs). However, in contrast to CRISPR-Cas9 nuclease approaches, the efficiency of CRISPRi/a depends on continued expression of the dead...

journal_title：Scientific reports

authors： Hazelbaker DZ,Beccard A,Angelini G,Mazzucato P,Messana A,Lam D,Eggan K,Barrett LE

更新日期：2020-01-20 00:00:00

abstract：:Because histologic types are subjective and difficult to reproduce between pathologists, tissue morphology often takes a back seat to molecular testing for the selection of breast cancer treatments. This work explores whether a deep-learning algorithm can learn objective histologic H&E features that predict the clinic...

journal_title：Scientific reports

authors： Rawat RR,Ortega I,Roy P,Sha F,Shibata D,Ruderman D,Agus DB

更新日期：2020-04-29 00:00:00

abstract：:The miniaturization of future electronic devices requires the knowledge of interfacial properties between two-dimensional channel materials and high-κ dielectrics in the limit of one atomic layer thickness. In this report, by combining particle-swarm optimization method with first-principles calculations, we present a...

journal_title：Scientific reports

authors： Song TT,Yang M,Chai JW,Callsen M,Zhou J,Yang T,Zhang Z,Pan JS,Chi DZ,Feng YP,Wang SJ

更新日期：2016-07-06 00:00:00

abstract：:Glucose homeostasis is regulated by insulin, which is produced in the β-cells of the pancreas. The synthesis of insulin is controlled by several transcription factors including PDX-1, USF1 and USF2. Both, PDX-1 and USF1 were identified as substrates for protein kinase CK2. Here, we have analysed the interplay of PDX-1...

journal_title：Scientific reports

authors： Spohrer S,Groß R,Nalbach L,Schwind L,Stumpf H,Menger MD,Ampofo E,Montenarh M,Götz C

更新日期：2017-11-27 00:00:00

abstract：:The neural hard-wired pathways in which the lymphoid organs are innervated by the nervous system is of special interest with respect to suggested afferent and sensory systems informing the central nervous system about the status of the immune system. Until today efferent also like afferent innervation seem to be unspe...

journal_title：Scientific reports

authors： Wülfing C,Günther HS

更新日期：2015-11-19 00:00:00

abstract：:Shigella spp., emerging from multiple origins of Escherichia coli, poses a significant health threat as a causative agent of bacillary dysentery. While multiple serotypes of four different species have evolved via independent lineages, Shigella spp. are designated as a single pathotype, primarily because of their comm...

journal_title：Scientific reports

authors： Thomas AK,Preetha S,Omanakuttan A,Vidyullata L,Ashokan A,Rajachandran V,Chattopadhyay S

更新日期：2019-03-01 00:00:00

abstract：:Two cabbage (Brassica oleracea) cultivars 'Tekila' and 'Kilaherb' were identified as resistant to several pathotypes of Plasmodiophora brassicae. In this study, we identified a clubroot resistance gene (Rcr7) in 'Tekila' for resistance to pathotype 3 of P. brassicae from a segregating population derived from 'Tekila' ...

journal_title：Scientific reports

authors： Dakouri A,Zhang X,Peng G,Falk KC,Gossen BD,Strelkov SE,Yu F

更新日期：2018-12-05 00:00:00