Abstract：
:The aim of this study was to fabricate a novel polymer-free everolimus-eluting stent with nanostructure using a femtosecond laser (FSL). The stent were coated with everolimus (EVL) using FSL and electrospinning processes. The surface was rendered hydrophobic, which negatively affected both platelet adhesion (82.1%) and smooth muscle cell response. Animal study was performed using a porcine coronary restenosis model. The study groups were divided into 1) bare metal stent (BMS), 2) poly(L-lactide) (PLA)-based EVL drug eluting stent (DES), 3) commercial EVL-eluting DES, and 4) FSL-EVL-DES. After four weeks of stent implantation, various analyses were performed. Quantitative analysis showed that the amount of in-stent restenosis was higher in the BMS group (BMS; 27.8 ± 2.68%, PLA-based DES; 12.2 ± 0.57%, commercial DES; 9.8 ± 0.28%, and FSL-DES; 9.3 ± 0.25%, n = 10, p < 0.05). Specifically, the inflammation score was reduced in the FSL-DES group (1.9 ± 0.39, n = 10, p < 0.05). The increment in re-endothelialization in the FSL-DES group was confirmed by immunofluorescence analysis. Taken together, the novel polymer-free EVL-eluting stent fabricated using FSL can be an innovative DES with reduced risk of ISR, thrombosis, and inflammation.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bae IH,Jeong MH,Lim KS,Park DS,Shim JW,Park JK,Oh KH,Jin MR,Sim DSdoi
10.1038/s41598-018-25629-9subject
Has Abstractpub_date
2018-05-09 00:00:00pages
7383issue
1issn
2045-2322pii
10.1038/s41598-018-25629-9journal_volume
8pub_type
杂志文章abstract：:We aimed to assess the ankle-brachial index (ABI) in patients with Graves' disease. In the cross-sectional assessments, 81 patients with drug-naïve Graves' disease and 235 with euthyroidism were enrolled. ABI and vascular cell adhesion molecule-1 (VCAM-1) levels were assessed. In the prospective follow-up, 32 patients...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74267-7
更新日期：2020-10-13 00:00:00
abstract：:Labeling nuclear proteins with electron dense probes in living cells has been a major challenge due to their inability to penetrate into nuclei. We developed a lipid-based approach for delivering antibodies coupled to 0.8 nm ultrasmall gold particles into the nucleus to label RNA polymerase II. Focussed Ion Beam slici...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08324
更新日期：2015-02-09 00:00:00
abstract：:There are no clinical guidelines for the timing of cholecystectomy (CCY) after performing therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis. We tried to analyze the clinical practice patterns, medical expenses, and subsequent outcomes between the early CCY, delayed CCY, and no C...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38428-z
更新日期：2019-02-18 00:00:00
abstract：:Nuclear factor κB (NF-κB) plays an essential role in regulation of innate immunity. In mammals, NF-κB factors can form homodimers and heterodimers to activate gene expression. In insects, three NF-κB factors, Dorsal, Dif and Relish, have been identified to activate antimicrobial peptide (AMP) gene expression. However,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20654
更新日期：2016-02-05 00:00:00
abstract：:Single molecule microarrays have been used in quantitative proteomics, in particular, single cell analysis requiring high sensitivity and ultra-low limits of detection. In this paper, several image analysis methods are evaluated for their ability to accurately enumerate single molecules bound to a microarray spot. Cru...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18303-z
更新日期：2017-12-20 00:00:00
abstract：:Little is known regarding the interplays between the mechanical and molecular bases for vein graft restenosis. We elucidated the stenosis initiation using a high-frequency ultrasonic (HFU) echogenicity platform and estimated the endothelium yield stress from von-Mises stress computation to predict the damage locations...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22147
更新日期：2016-02-26 00:00:00
abstract：:Reactive oxygen species (ROS) participate in various physiological and pathological functions following generation from different types of cells. Here we explore ROS functions on spontaneous tail regeneration using gecko model. ROS were mainly produced in the skeletal muscle after tail amputation, showing a temporal i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20752
更新日期：2016-02-08 00:00:00
abstract：:Methicillin-resistant Staphylococcus aureus (MRSA), are the most frequent cause of sepsis, which urgently demanding new drugs for treating infection. Two homologous insect CSαβ peptides-DLP2 and DLP4 from Hermetia illucens were firstly expressed in Pichia pastoris, with the yields of 873.5 and 801.3 mg/l, respectively...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10839-4
更新日期：2017-09-21 00:00:00
abstract：:The FGF receptor signaling pathway is recurrently involved in the leukemogenic processes. Oncogenic fusions of FGFR1 with various fusion partners were described in myeloid proliferative neoplasms, and overexpression and mutations of FGFR3 are common in multiple myeloma. In addition, fibroblast growth factors are abund...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-38169-z
更新日期：2019-02-12 00:00:00
abstract：:Real-time quantitative polymerase chain reaction (qPCR) data are found to display periodic patterns in the fluorescence intensity as a function of sample number for fixed cycle number. This behavior is seen for technical replicate datasets recorded on several different commercial instruments; it occurs in the baseline...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38951
更新日期：2016-12-13 00:00:00
abstract：:This paper presented a conformal smoothing theory, and smoothing capability evaluation was established on the proposed theory. According to pressure distribution model, processing parameters have been optimized and the CPP sample with a size of 340 × 340 mm was applied in conformal smoothing. The middle spatial freque...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59484-4
更新日期：2020-02-13 00:00:00
abstract：:Current saliva testing methods rely on cutting edge yet expensive techniques for the detection and analysis of genetic material, proteins and biomarkers for clinical use. However, these techniques are limited in scope and often cannot be used with complex food materials. We propose an efficient ex-vivo tool for evalua...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31625-w
更新日期：2018-09-06 00:00:00
abstract：:Pneumocystis jirovecii pneumonia (PJP) is a potentially life-threatening infection that occurs in immunocompromised patients. The aim of this study was to evaluate risk factors for PJP in kidney transplantation recipients. We conducted a retrospective analysis of patient data from 500 consecutive kidney transplants pe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01818-w
更新日期：2017-05-08 00:00:00
abstract：:Irreversible electroporation (IRE) is an emerging focal therapy which is demonstrating utility in the treatment of unresectable tumors where thermal ablation techniques are contraindicated. IRE uses ultra-short duration, high-intensity monopolar pulsed electric fields to permanently disrupt cell membranes within a wel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14999
更新日期：2015-10-13 00:00:00
abstract：:Glutathione-S-transferases mu 2 (GSTM2), a kind of important Phase II antioxidant enzyme of eukaryotes, is degraded by nonsense mediated mRNA decay due to a C27T substitution in the fifth exon of pigs. As a reproductive performance-related gene, GSTM2 is involved in embryo implantation, whereas, functional deficiency ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38254
更新日期：2016-12-01 00:00:00
abstract：:Next generation sequencing has disrupted genetic testing, allowing far more scope in the tests applied. The appropriate sections of the genome to be tested can now be readily selected, from single mutations to whole-genome sequencing. One product offering within this spectrum are focused exomes, targeting ~5,000 genes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60215-y
更新日期：2020-02-24 00:00:00
abstract：:In social interactions, including cooperation and conflict, individuals can adjust their behaviour over the shorter term through learning within a generation, and natural selection can change behaviour over the longer term of many generations. Here we investigate the evolution of cognitive bias by individuals investin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52781-7
更新日期：2019-11-08 00:00:00
abstract：:This study aims to understand through statistical learning the basic biophysical mechanisms behind three-dimensional folding of epigenomes. The 3DEpiLoop algorithm predicts three-dimensional chromatin looping interactions within topologically associating domains (TADs) from one-dimensional epigenomics and transcriptio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23276-8
更新日期：2018-03-26 00:00:00
abstract：:The aim of this study was to estimate the influence of regenerated tobacco on the extraction of Cd from two acidic soils as well as to address the problem of how to deal with contaminated leaves following phytoextraction. Results showed that a coppicing tobacco led to a decline in Cd concentration in regenerated leave...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05834-8
更新日期：2017-08-03 00:00:00
abstract：:We developed an optimal noninvasive index comprising routine laboratory parameters for predicting cirrhosis in chronic hepatitis B (CHB) and chronic hepatitis C (CHC) patients. This study included 992 CHB patients and 1,284 CHC patients who received liver biopsy. We developed the new index, named modified Fibrosis-4 (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03589-w
更新日期：2017-06-12 00:00:00
abstract：:Causal Structure Discovery (CSD) is the problem of identifying causal relationships from large quantities of data through computational methods. With the limited ability of traditional association-based computational methods to discover causal relationships, CSD methodologies are gaining popularity. The goal of the st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-59669-x
更新日期：2020-02-19 00:00:00
abstract：:We investigated high-efficiency two-terminal tandem photovoltaic (PV) devices consisting of a p/i/n thin film silicon top sub-cell (p/i/n-TFS) and a heterojunction with an intrinsic thin-layer (HIT) bottom sub-cell. We used computer simulations and experimentation. The short-circuit current density (Jsc) of the top su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33734-y
更新日期：2018-10-18 00:00:00
abstract：:Toxin-antitoxin (TA) systems were initially discovered as plasmid addiction systems on low-copy-number plasmids. Thousands of TA loci have since been identified on chromosomes, plasmids and mobile elements in bacteria and archaea with diverse roles in bacterial physiology and in maintenance of genetic elements. Here, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46318-1
更新日期：2019-07-08 00:00:00
abstract：:An accurate and efficient solution of the radiative transport equation is proposed for modeling the propagation of photons in the three-dimensional anisotropically scattering half-space medium. The exact refractive index mismatched boundary condition is considered and arbitrary rotationally invariant scattering functi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02018
更新日期：2013-01-01 00:00:00
abstract：:Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries. In this study, two inbred chicken lines with different responses to NDV, Fayoumi and Leghorn, were challenged with LaSota N...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19754-8
更新日期：2018-01-19 00:00:00
abstract：:The access and recycling of the base cations are essential processes for the long-lasting functioning of forest ecosystems. While the role of soil bacterial communities has been demonstrated in mineral weathering and tree nutrition, our understanding of the link between the availability of base cations and the functio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50730-y
更新日期：2019-10-07 00:00:00
abstract：:Dengue virus (DENV) causes a wide range of illnesses in humans, including dengue fever and dengue haemorrhagic fever. Current animal models of DENV infection are limited for understanding infectious diseases in humans. Bonnet monkeys (Macaca radiata), a type of Old World monkey, have been used to study experimental an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21582-9
更新日期：2018-02-21 00:00:00
abstract：:Laser speckle flowmetry suffers from a debated quantification of the inverse relation between decorrelation time (τc) and blood flow velocity (V), i.e. 1/τc = αV. Using a modified microcirculation imager (integrated sidestream dark field - laser speckle contrast imaging [SDF-LSCI]), we experimentally investigate on th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25258
更新日期：2016-04-29 00:00:00
abstract：:A reduction in the particle size is expected to improve the properties and increase the application potential of high-entropy alloys. Therefore, in this study, a novel sol-gel autocombustion technique was first used to synthesize high-entropy alloys. The average grain size of the prepared nanocrystalline CoCrCuNiAl hi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03644-6
更新日期：2017-06-13 00:00:00
abstract：:Colloidal quantum dots (QDs) are an emerging class of new materials due to their unique physical properties. In particular, colloidal QD based light emitting diodes (QDLEDs) have been extensively studied and developed for the next generation displays and solid-state lighting. Among a number of approaches to improve pe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08968
更新日期：2015-03-10 00:00:00
