Novel Polymer-Free Everolimus-Eluting Stent Fabricated using Femtosecond Laser Improves Re-endothelialization and Anti-inflammation.

Abstract:

:The aim of this study was to fabricate a novel polymer-free everolimus-eluting stent with nanostructure using a femtosecond laser (FSL). The stent were coated with everolimus (EVL) using FSL and electrospinning processes. The surface was rendered hydrophobic, which negatively affected both platelet adhesion (82.1%) and smooth muscle cell response. Animal study was performed using a porcine coronary restenosis model. The study groups were divided into 1) bare metal stent (BMS), 2) poly(L-lactide) (PLA)-based EVL drug eluting stent (DES), 3) commercial EVL-eluting DES, and 4) FSL-EVL-DES. After four weeks of stent implantation, various analyses were performed. Quantitative analysis showed that the amount of in-stent restenosis was higher in the BMS group (BMS; 27.8 ± 2.68%, PLA-based DES; 12.2 ± 0.57%, commercial DES; 9.8 ± 0.28%, and FSL-DES; 9.3 ± 0.25%, n = 10, p < 0.05). Specifically, the inflammation score was reduced in the FSL-DES group (1.9 ± 0.39, n = 10, p < 0.05). The increment in re-endothelialization in the FSL-DES group was confirmed by immunofluorescence analysis. Taken together, the novel polymer-free EVL-eluting stent fabricated using FSL can be an innovative DES with reduced risk of ISR, thrombosis, and inflammation.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Bae IH,Jeong MH,Lim KS,Park DS,Shim JW,Park JK,Oh KH,Jin MR,Sim DS

doi

10.1038/s41598-018-25629-9

subject

Has Abstract

pub_date

2018-05-09 00:00:00

pages

7383

issue

1

issn

2045-2322

pii

10.1038/s41598-018-25629-9

journal_volume

8

pub_type

杂志文章
  • NLRP3 Deficiency Reduces Macrophage Interleukin-10 Production and Enhances the Susceptibility to Doxorubicin-induced Cardiotoxicity.

    abstract::NLRP3 inflammasomes recognize non-microbial danger signals and induce release of proinflammatory cytokine interleukin (IL)-1β, leading to sterile inflammation in cardiovascular disease. Because sterile inflammation is involved in doxorubicin (Dox)-induced cardiotoxicity, we investigated the role of NLRP3 inflammasomes...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26489

    authors: Kobayashi M,Usui F,Karasawa T,Kawashima A,Kimura H,Mizushina Y,Shirasuna K,Mizukami H,Kasahara T,Hasebe N,Takahashi M

    更新日期:2016-05-26 00:00:00

  • Temporal variations of 90Sr and 137Cs in atmospheric depositions after the Fukushima Daiichi Nuclear Power Plant accident with long-term observations.

    abstract::We have measured artificial radionuclides, such as 90Sr and 137Cs, in atmospheric depositions since 1957 in Japan. We observed the variations in 90Sr and 137Cs, which were emitted from atmospheric nuclear tests and nuclear power plant accidents, due to their diffusion, deposition, and resuspension. In March 2011, the ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-78312-3

    authors: Kinase T,Adachi K,Sekiyama TT,Kajino M,Zaizen Y,Igarashi Y

    更新日期:2020-12-10 00:00:00

  • Hybrid surgery versus anterior cervical discectomy and fusion for multilevel cervical degenerative disc diseases: a meta-analysis.

    abstract::The objective of this meta-analysis is to compare hybrid surgery (HS) and cervical discectomy and fusion (ACDF) for multilevel cervical degenerative disc diseases (DDD). Systematic searches of all published studies through March 2015 were identified from Cochrane Library, Medline, PubMed, Embase, ScienceDirect, CNKI, ...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析,评审

    doi:10.1038/srep13454

    authors: Tian P,Fu X,Li ZJ,Sun XL,Ma XL

    更新日期:2015-08-26 00:00:00

  • Inhibition of protein aggregation by zwitterionic polymer-based core-shell nanogels.

    abstract::Protein aggregation is a process by which misfolded proteins polymerizes into aggregates and forms fibrous structures with a β-sheet conformation, known as amyloids. It is an undesired outcome, as it not only causes numerous neurodegenerative diseases, but is also a major deterrent in the development of protein biopha...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45777

    authors: Rajan R,Matsumura K

    更新日期:2017-04-04 00:00:00

  • Link Prediction based on Quantum-Inspired Ant Colony Optimization.

    abstract::Incomplete or partial observations of network structures pose a serious challenge to theoretical and engineering studies of real networks. To remedy the missing links in real datasets, topology-based link prediction is introduced into the studies of various networks. Due to the complexity of network structures, the ac...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-31254-3

    authors: Cao Z,Zhang Y,Guan J,Zhou S

    更新日期:2018-09-06 00:00:00

  • Correlative electron and fluorescence microscopy of magnetotactic bacteria in liquid: toward in vivo imaging.

    abstract::Magnetotactic bacteria biomineralize ordered chains of uniform, membrane-bound magnetite or greigite nanocrystals that exhibit nearly perfect crystal structures and species-specific morphologies. Transmission electron microscopy (TEM) is a critical technique for providing information regarding the organization of cell...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep06854

    authors: Woehl TJ,Kashyap S,Firlar E,Perez-Gonzalez T,Faivre D,Trubitsyn D,Bazylinski DA,Prozorov T

    更新日期:2014-10-31 00:00:00

  • Morphological Detection and Functional Assessment of Regenerated Nerve after Neural Prosthesis with a PGLA Nerve Conduit.

    abstract::This study aimed to observe the morphological characteristics of a PGLA [poly(glycolide-co-L-lactide)] nerve conduit and regenerated nerve bundle in the human body using high-frequency ultrasound and examine functional recovery of the regenerated nerve using functional magnetic resonance imaging (fMRI) after neural pr...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/srep46403

    authors: Gao D,Jiang JJ,Gu SH,Lu JZ,Xu L

    更新日期:2017-04-13 00:00:00

  • Hepatic steatosis and liver fat contents in liver transplant recipients are associated with serum adipokines and insulin resistance.

    abstract::Our data about pathogenesis of hepatic steatosis after liver transplantation is scarce. This study aimed to investigate the association between serum adipokines and insulin resistance with hepatic steatosis in liver transplant recipients. We investigated the association between insulin resistance, serum adiponectin, i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-69571-1

    authors: Eshraghian A,Nikeghbalian S,Shamsaeefar A,Kazemi K,Fattahi MR,Malek-Hosseini SA

    更新日期:2020-07-29 00:00:00

  • Toward Enhanced State of Charge Estimation of Lithium-ion Batteries Using Optimized Machine Learning Techniques.

    abstract::State of charge (SOC) is a crucial index used in the assessment of electric vehicle (EV) battery storage systems. Thus, SOC estimation of lithium-ion batteries has been widely investigated because of their fast charging, long-life cycle, and high energy density characteristics. However, precise SOC assessment of lithi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61464-7

    authors: Hannan MA,Lipu MSH,Hussain A,Ker PJ,Mahlia TMI,Mansor M,Ayob A,Saad MH,Dong ZY

    更新日期:2020-03-13 00:00:00

  • CRISPR/Cas9-mediated knock-in of alligator cathelicidin gene in a non-coding region of channel catfish genome.

    abstract::CRISPR/Cas9-based gene knockout in animal cells, particularly in teleosts, has proven to be very efficient with regards to mutation rates, but the precise insertion of exogenous DNA or gene knock-in via the homology-directed repair (HDR) pathway has seldom been achieved outside of the model organisms. Here, we succeed...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79409-5

    authors: Simora RMC,Xing,Bangs MR,Wang W,Ma X,Su B,Khan MGQ,Qin Z,Lu C,Alston V,Hettiarachchi D,Johnson A,Li S,Coogan M,Gurbatow J,Terhune JS,Wang X,Dunham RA

    更新日期:2020-12-17 00:00:00

  • Viral-mediated fusion of mesenchymal stem cells with cells of the infarcted heart hinders healing via decreased vascularization and immune modulation.

    abstract::Cell fusion can occur between mesenchymal stem cells (MSCs) transplanted to improve cardiac function and cells of the recipient. The therapeutic benefit or detriment of resultant cell hybrids is unknown. Here we augment fusion of transplanted MSCs with recipient cardiac cell types via viral fusogens to determine how c...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20283

    authors: Freeman BT,Ogle BM

    更新日期:2016-02-05 00:00:00

  • TGFβ1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness.

    abstract::Here we report exquisitely distinct material properties of primary vascular smooth muscle (VSM) cells isolated from the thoracic aorta of adult (8 months) vs. aged (30 months) F344XBN rats. Individual VSM cells derived from the aged animals showed a tense internal network of the actin cytoskeleton (CSK), exhibiting in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-20763-w

    authors: Zhu W,Kim BC,Wang M,Huang J,Isak A,Bexiga NM,Monticone R,Ha T,Lakatta EG,An SS

    更新日期:2018-02-08 00:00:00

  • Persistence Increases in the Absence of the Alarmone Guanosine Tetraphosphate by Reducing Cell Growth.

    abstract::Most bacterial cells are stressed, and as a result, some become tolerant to antibiotics by entering a dormant state known as persistence. The key intracellular metabolite that has been linked to this persister state is guanosine tetraphosphate (ppGpp), the alarmone that was first linked to nutrient stress. In Escheric...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep20519

    authors: Chowdhury N,Kwan BW,Wood TK

    更新日期:2016-02-03 00:00:00

  • Differential roles of caspase-1 and caspase-11 in infection and inflammation.

    abstract::Caspase-1, also known as interleukin-1β (IL-1β)-converting enzyme (ICE), regulates antimicrobial host defense, tissue repair, tumorigenesis, metabolism and membrane biogenesis. On activation within an inflammasome complex, caspase-1 induces pyroptosis and converts pro-IL-1β and pro-IL-18 into their biologically active...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep45126

    authors: Man SM,Karki R,Briard B,Burton A,Gingras S,Pelletier S,Kanneganti TD

    更新日期:2017-03-27 00:00:00

  • Epithelial to mesenchymal transition is mediated by both TGF-β canonical and non-canonical signaling during axolotl limb regeneration.

    abstract::Axolotls have the amazing ability to regenerate. When compared to humans, axolotls display a very fast wound closure, no scarring and are capable to replace lost appendages perfectly. Understanding the signaling mechanism leading to this perfect healing is a key step to help develop regenerative treatments for humans....

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-38171-5

    authors: Sader F,Denis JF,Laref H,Roy S

    更新日期:2019-02-04 00:00:00

  • Magma transport in sheet intrusions of the Alnö carbonatite complex, central Sweden.

    abstract::Magma transport through the Earth's crust occurs dominantly via sheet intrusions, such as dykes and cone-sheets, and is fundamental to crustal evolution, volcanic eruptions and geochemical element cycling. However, reliable methods to reconstruct flow direction in solidified sheet intrusions have proved elusive. Aniso...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep27635

    authors: Andersson M,Almqvist BS,Burchardt S,Troll VR,Malehmir A,Snowball I,Kübler L

    更新日期:2016-06-10 00:00:00

  • Epidural Dexmedetomidine Reduces the Requirement of Propofol during Total Intravenous Anaesthesia and Improves Analgesia after Surgery in Patients undergoing Open Thoracic Surgery.

    abstract::The aim of this study was to assess the systemic and analgesic effects of epidural dexmedetomidine in thoracic epidural anaesthesia (TEA) combined with total intravenous anaesthesia during thoracic surgery. Seventy-one patients undergoing open thoracotomy were included in this study and randomly divided into three gro...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-017-04382-5

    authors: Zeng X,Jiang J,Yang L,Ding W

    更新日期:2017-06-21 00:00:00

  • No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis.

    abstract::In recent years, genome-wide association studies have identified 58 independent risk loci for coronary artery disease (CAD) on the autosome. However, due to the sex-specific data structure of the X chromosome, it has been excluded from most of these analyses. While females have 2 copies of chromosome X, males have onl...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析

    doi:10.1038/srep35278

    authors: Loley C,Alver M,Assimes TL,Bjonnes A,Goel A,Gustafsson S,Hernesniemi J,Hopewell JC,Kanoni S,Kleber ME,Lau KW,Lu Y,Lyytikäinen LP,Nelson CP,Nikpay M,Qu L,Salfati E,Scholz M,Tukiainen T,Willenborg C,Won HH,Zeng L

    更新日期:2016-10-12 00:00:00

  • Innovative methods for random field establishment and statistical parameter inversion exemplified with 6082-T6 aluminum alloy.

    abstract::This paper aims to eliminate the disharmony between simulation and experiment, and takes the mechanical properties of 6082-T6 Al alloy as an example. In order to obtain the equivalent distribution of material properties after considering the randomicity of materials, a new inversion method combining with stochastic fi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54046-9

    authors: Zheng K,Yang K,Shi J,Yuan J,Zhou G

    更新日期:2019-11-28 00:00:00

  • Author Correction: Intact glycosphingolipidomic analysis of the cell membrane during differentiation yields extensive glycan and lipid changes.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-78291-5

    authors: Wong M,Xu G,Park D,Barboza M,Lebrilla CB

    更新日期:2020-12-01 00:00:00

  • Estimating sleep parameters using an accelerometer without sleep diary.

    abstract::Wrist worn raw-data accelerometers are used increasingly in large-scale population research. We examined whether sleep parameters can be estimated from these data in the absence of sleep diaries. Our heuristic algorithm uses the variance in estimated z-axis angle and makes basic assumptions about sleep interruptions. ...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1038/s41598-018-31266-z

    authors: van Hees VT,Sabia S,Jones SE,Wood AR,Anderson KN,Kivimäki M,Frayling TM,Pack AI,Bucan M,Trenell MI,Mazzotti DR,Gehrman PR,Singh-Manoux BA,Weedon MN

    更新日期:2018-08-28 00:00:00

  • Solution structure of Gaussia Luciferase with five disulfide bonds and identification of a putative coelenterazine binding cavity by heteronuclear NMR.

    abstract::Gaussia luciferase (GLuc) is a small luciferase (18.2 kDa; 168 residues) and is thus attracting much attention as a reporter protein, but the lack of structural information is hampering further application. Here, we report the first solution structure of a fully active, recombinant GLuc determined by heteronuclear mul...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76486-4

    authors: Wu N,Kobayashi N,Tsuda K,Unzai S,Saotome T,Kuroda Y,Yamazaki T

    更新日期:2020-11-18 00:00:00

  • Linearly polarized photoluminescence of InGaN quantum disks embedded in GaN nanorods.

    abstract::We have investigated the emission from InGaN/GaN quantum disks grown on the tip of GaN nanorods. The emission at 3.21 eV from the InGaN quantum disk doesn't show a Stark shift, and it is linearly polarized when excited perpendicular to the growth direction. The degree of linear polarization is about 39.3% due to the a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26642-8

    authors: Park Y,Chan CCS,Nuttall L,Puchtler TJ,Taylor RA,Kim N,Jo Y,Im H

    更新日期:2018-05-25 00:00:00

  • Ecology, threats and conservation status of Carex buekii (Cyperaceae) in Central Europe.

    abstract::Carex buekii is a tall sedge, forming large stands in wetlands, particularly in river floodplains across Central Europe and thus on many sites determining the typical appearance of riverine habitats. Our paper aims at increasing the knowledge on ecology of C. buekii and its role in the wetlands. Field data were collec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47563-0

    authors: Więcław H,Šumberová K,Bosiacka B,Hrivnák R,Dajdok Z,Mesterházy A,Minuzzo C,Martinetto E,Koopman J

    更新日期:2019-08-01 00:00:00

  • Analysis of Breast Cancer Patients with T1-2 Tumors and 1-3 Positive Lymph Nodes Treated with or without Postmastectomy Radiation Therapy.

    abstract::The use of postmastectomy radiation therapy (PMRT) has been recommended for patients with 4 or more positive lymph nodes, however, its role in patients with 1-3 positive lymph nodes remains unclear. The purpose of this study is to evaluate oncological outcomes for breast cancer patients with T1-2 tumors and 1-3 positi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-66495-8

    authors: Gilmore RC,Sebai ME,Psoter KJ,Prasath V,Siotos C,Broderick KP,Jacobs LK,Harvey SC,Habibi M

    更新日期:2020-06-18 00:00:00

  • Giant photoluminescence emission in crystalline faceted Si grains.

    abstract::Empowering an indirect band-gap material like Si with optical functionalities, firstly light emission, represents a huge advancement constantly pursued in the realization of any integrated photonic device. We report the demonstration of giant photoluminescence (PL) emission by a newly synthesized material consisting o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep02674

    authors: Faraci G,Pennisi AR,Alberti A,Ruggeri R,Mannino G

    更新日期:2013-01-01 00:00:00

  • Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies.

    abstract::Honokiol, derived from Magnolia officinalis, has various pharmacological properties. Platelet activation plays a critical role in cardiovascular diseases. Honokiol has been reported to inhibit collagen-stimulated rabbit platelet aggregation. However, detailed further studies on the characteristics and functional activ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40002

    authors: Lee TY,Chang CC,Lu WJ,Yen TL,Lin KH,Geraldine P,Li JY,Sheu JR

    更新日期:2017-01-05 00:00:00

  • A new approach to prevent cervical stenosis in postmenopausal women after loop electrosurgical excision procedure: a randomized controlled trial.

    abstract::To determine whether regular cervical dilatation is effective for preventing cervical stenosis, and to identify the associated risk factors, in postmenopausal women after LEEP. This was a prospective randomized clinical trial in postmenopausal women who underwent LEEP at our hospital between August 2018 and May 2019. ...

    journal_title:Scientific reports

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41598-020-65170-2

    authors: Lin J,Meng Y,Chen Y,Li Z,Xu Y,Wu D

    更新日期:2020-05-22 00:00:00

  • Dihydromyricetin Induces Apoptosis and Reverses Drug Resistance in Ovarian Cancer Cells by p53-mediated Downregulation of Survivin.

    abstract::Ovarian cancer is one of the leading causes of death in gynecological malignancies, and the resistance to chemotherapeutic agents remains a major challenge to successful ovarian cancer chemotherapy. Dihydromyricetin (DHM), a natural flavonoid derived from Ampeopsis Grossdentata, has been widely applied in food industr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46060

    authors: Xu Y,Wang S,Chan HF,Lu H,Lin Z,He C,Chen M

    更新日期:2017-04-24 00:00:00

  • Simulating of the measurement-device independent quantum key distribution with phase randomized general sources.

    abstract::We present a model on the simulation of the measurement-device independent quantum key distribution (MDI-QKD) with phase randomized general sources. It can be used to predict experimental observations of a MDI-QKD with linear channel loss, simulating corresponding values for the gains, the error rates in different bas...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04612

    authors: Wang Q,Wang XB

    更新日期:2014-04-14 00:00:00