3D Printed Auxetic Mechanical Metamaterial with Chiral Cells and Re-entrant Cores.

abstract：:Photodynamic therapy (PDT) is an efficacious treatment for some types of cancers. However, PDT-induced tumor hypoxia as a result of oxygen consumption and vascular damage can reduce the efficacy of this therapy. Measuring and monitoring intrinsic and PDT-induced tumor hypoxia in vivo during PDT is of high interest for...

journal_title：Scientific reports

authors： Tong X,Srivatsan A,Jacobson O,Wang Y,Wang Z,Yang X,Niu G,Kiesewetter DO,Zheng H,Chen X

更新日期：2016-08-22 00:00:00

abstract：:The inhibitors of CD26 (dipeptidyl peptidase-4; DPP4) have been widely prescribed to control glucose level in diabetic patients. DPP4-inhibitors, however, accumulate stromal cell-derived factor-1α (SDF-1α), a well-known inducer of vascular leakage and angiogenesis both of which are fundamental pathophysiology of diabe...

journal_title：Scientific reports

authors： Lee CS,Kim YG,Cho HJ,Park J,Jeong H,Lee SE,Lee SP,Kang HJ,Kim HS

更新日期：2016-07-06 00:00:00

abstract：:The functions of purinergic P2 receptors (P2Rs) for extracellular adenosine triphosphate (ATP) are poorly understood. Here, for the first time, we show that activation of P2Rs in an important arousal region, the basal forebrain (BF), promotes wakefulness, whereas inhibition of P2Rs promotes sleep. Infusion of a non-hy...

journal_title：Scientific reports

authors： Yang C,Larin A,McKenna JT,Jacobson KA,Winston S,Strecker RE,Kalinchuk A,Basheer R,Brown RE

更新日期：2018-07-16 00:00:00

abstract：:Brain natriuretic peptide (BNP) is the most effective predictor of outcomes in chronic heart failure (CHF). This study sought to determine the qualitative relationship between the BNP levels at discharge and on the day of cardiovascular events in CHF patients. We devised a mathematical probabilistic model between the ...

journal_title：Scientific reports

authors： Fukuda H,Suwa H,Nakano A,Sakamoto M,Imazu M,Hasegawa T,Takahama H,Amaki M,Kanzaki H,Anzai T,Mochizuki N,Ishii A,Asanuma H,Asakura M,Washio T,Kitakaze M

更新日期：2016-11-15 00:00:00

abstract：:The Ah receptor (AhR) is a ligand-dependent transcription factor belonging to the basic helix-loop-helix Per-Arnt-Sim (bHLH-PAS) superfamily. Binding to and activation of the AhR by a variety of chemicals results in the induction of expression of diverse genes and production of a broad spectrum of biological and toxic...

journal_title：Scientific reports

authors： Giani Tagliabue S,Faber SC,Motta S,Denison MS,Bonati L

更新日期：2019-07-23 00:00:00

abstract：:Deleterious mutations in patchd1 domain containing 1 (PTCHD1) gene have been identified in patients with intellectual disability and/or autism spectrum disorder (ASD). To clarify the causal relationship between Ptchd1 deficiency and behavioral defects relevant to neurodevelopmental disorders, we generated global Ptchd...

journal_title：Scientific reports

authors： Murakami Y,Imamura Y,Saito K,Sakai D,Motoyama J

更新日期：2019-09-12 00:00:00

abstract：:The GS Junior sequencer provides simplified procedures for library preparation and data processing. Errors in pyrosequencing generate some biases during library construction and emulsion PCR amplification. False-positive mutations are identified by related characteristics described in the manufacturer's manual, and so...

journal_title：Scientific reports

authors： Yang Z,Sun G

更新日期：2017-10-23 00:00:00

abstract：:Clostridium difficile infection (CDI) is associated with risk for severe disease and high mortality. Little is known about the extent of hospital-acquired CDI in Mainland China. In this study, we aimed to investigate the annual CDI incidence, bacterial genotypes, risk factors for severe CDI and survival over a 7-year ...

journal_title：Scientific reports

authors： Xu Q,Chen Y,Gu S,Lv T,Zheng B,Shen P,Quan J,Fang Y,Li L

更新日期：2017-08-29 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Liu J,Huang W,Ren C,Wen Q,Liu W,Yang X,Wang L,Zhu B,Zeng L,Feng X,Zhang C,Chen H,Jia W,Zhang L,Xia X,Chen Y

更新日期：2020-04-20 00:00:00

abstract：:The aim of this study was to test the hypothesis that duplication/hybridization of functional domains of naturally occurring pellicle peptides amplified the inhibitory effect of hydroxyapatite crystal growth, which is related to enamel remineralization and dental calculus formation. Histatin 3, statherin, their functi...

journal_title：Scientific reports

authors： Valente MT,Moffa EB,Crosara KTB,Xiao Y,de Oliveira TM,Machado MAAM,Siqueira WL

更新日期：2018-02-28 00:00:00

abstract：:The general model presented here for the formation of chromatin domains, LADs and TADs, is primarily based on the 3-D structures of the corresponding DNA sequences, the GC-poor and GC-rich isochores. Indeed, the low-heterogeneity GC-poor isochores locally are intrinsically stiff and curved because of the presence of i...

journal_title：Scientific reports

authors： Bernardi G

更新日期：2018-12-13 00:00:00

abstract：:Protein aggregation is a process by which misfolded proteins polymerizes into aggregates and forms fibrous structures with a β-sheet conformation, known as amyloids. It is an undesired outcome, as it not only causes numerous neurodegenerative diseases, but is also a major deterrent in the development of protein biopha...

journal_title：Scientific reports

authors： Rajan R,Matsumura K

更新日期：2017-04-04 00:00:00

abstract：:There is increasing interest in applications which use the 30 to 90 GHz frequency range, including automotive radar, 5 G cellular networks and wireless local area links. This study investigated pulsed 30-90 GHz radiation penetration into the human ear canal and tympanic membrane using computational phantoms. Modelling...

journal_title：Scientific reports

authors： Vilagosh Z,Lajevardipour A,Wood A

更新日期：2020-01-30 00:00:00

abstract：:ERF transcription factors play critical roles in plant immune responses. Here, we report the function of AtERF014, a nucleus-localized transcriptional activator, in Arabidopsis immunity. Expression of AtERF014 was induced by Pseudomonas syringae pv. tomato (Pst) and Botrytis cinerea (Bc). AtERF014-overexpressing (OE) ...

journal_title：Scientific reports

authors： Zhang H,Hong Y,Huang L,Li D,Song F

更新日期：2016-07-22 00:00:00

abstract：:Adiponectin is an adipokine that regulates apoptosis, glucose and lipid metabolism, and insulin sensitivity in metabolic diseases. As recent studies have associated changes in adipokines and other metabolites in the central nervous system with a risk for Alzheimer's disease (AD), we investigated the effects of adipone...

journal_title：Scientific reports

authors： Wang M,Jo J,Song J

更新日期：2019-06-20 00:00:00

abstract：:Optimal mental workload plays a key role in driving performance. Thus, driver-assisting systems that automatically adapt to a drivers current mental workload via brain-computer interfacing might greatly contribute to traffic safety. To design economic brain computer interfaces that do not compromise driver comfort, it...

journal_title：Scientific reports

authors： Geissler CF,Schneider J,Frings C

更新日期：2021-01-12 00:00:00

abstract：:Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoichiometry and composition of tmTNF during TNFR2 activation, we constructed dif...

journal_title：Scientific reports

authors： Fischer R,Marsal J,Guttà C,Eisler SA,Peters N,Bethea JR,Pfizenmaier K,Kontermann RE

更新日期：2017-07-26 00:00:00

abstract：:The brain is possibly the most complex system known to mankind, and its complexity has been called upon to explain the emergence of consciousness. However, complexity has been defined in many ways by multiple different fields: here, we investigate measures of algorithmic and process complexity in both the temporal and...

journal_title：Scientific reports

authors： Varley TF,Luppi AI,Pappas I,Naci L,Adapa R,Owen AM,Menon DK,Stamatakis EA

更新日期：2020-01-23 00:00:00

abstract：:We have investigated the emission from InGaN/GaN quantum disks grown on the tip of GaN nanorods. The emission at 3.21 eV from the InGaN quantum disk doesn't show a Stark shift, and it is linearly polarized when excited perpendicular to the growth direction. The degree of linear polarization is about 39.3% due to the a...

journal_title：Scientific reports

authors： Park Y,Chan CCS,Nuttall L,Puchtler TJ,Taylor RA,Kim N,Jo Y,Im H

更新日期：2018-05-25 00:00:00

abstract：:Pseudoalteromonas haloplanktis TAC125 is among the most commonly studied bacteria adapted to cold environments. Aside from its ecological relevance, P. haloplanktis has a potential use for biotechnological applications. Due to its importance, we decided to take advantage of next generation sequencing (Illumina) and th...

journal_title：Scientific reports

authors： Qi W,Colarusso A,Olombrada M,Parrilli E,Patrignani A,Tutino ML,Toll-Riera M

更新日期：2019-11-11 00:00:00

abstract：:The formation of amyloid-β plaques is one of the hallmarks of Alzheimer's disease. The presence of an amphiphatic cell membrane can accelerate the formation of amyloid-β aggregates, making it a potential druggable target to delay the progression of Alzheimer's disease. We have prepared unsaturated anionic membranes ma...

journal_title：Scientific reports

authors： Khondker A,Alsop RJ,Himbert S,Tang J,Shi AC,Hitchcock AP,Rheinstädter MC

更新日期：2018-08-17 00:00:00

abstract：:In situ tissue engineering within a stroke cavity is gradually emerging as a novel therapeutic paradigm. Considering the varied lesion topology within each subject, the placement and distribution of cells within the lesion cavity is challenging. The use of multiple cell types to reconstruct damaged tissue illustrates ...

journal_title：Scientific reports

authors： Nicholls FJ,Ling W,Ferrauto G,Aime S,Modo M

更新日期：2015-09-30 00:00:00

abstract：:Neutrophils are the first immune cells to kill invading microbes at sites of infection using a variety of processes, including the release of proteases, phagocytosis and the production of neutrophil extracellular traps (NETs). NET formation, or NETosis, is a specific and highly efficient process, which is induced by a...

journal_title：Scientific reports

authors： Sofoluwe A,Bacchetta M,Badaoui M,Kwak BR,Chanson M

更新日期：2019-11-12 00:00:00

abstract：:Aberrant regulation of BCL-2 family members enables evasion of apoptosis and tumor resistance to chemotherapy. BCL-2 and functionally redundant counterpart, MCL-1, are frequently over-expressed in high-risk diffuse large B-cell lymphoma (DLBCL). While clinical inhibition of BCL-2 has been achieved with the BH3 mimetic...

journal_title：Scientific reports

authors： Dey J,Deckwerth TL,Kerwin WS,Casalini JR,Merrell AJ,Grenley MO,Burns C,Ditzler SH,Dixon CP,Beirne E,Gillespie KC,Kleinman EF,Klinghoffer RA

更新日期：2017-12-21 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) involves alveolar epithelial injury and abnormal collagen production caused by activated fibroblasts; transforming growth factor (TGF)-β1 is implicated in this activation. In this study, we screened for chemicals capable of inhibiting TGF-β1-induced collagen production in cultured f...

journal_title：Scientific reports

authors： Tanaka KI,Niino T,Ishihara T,Takafuji A,Takayama T,Kanda Y,Sugizaki T,Tamura F,Kurotsu S,Kawahara M,Mizushima T

更新日期：2017-06-13 00:00:00

abstract：:Biological samples are frequently stained with heavy metals in preparation for examining the macro, micro and ultra-structure using X-ray microtomography and electron microscopy. A single X-ray microtomography scan reveals detailed 3D structure based on staining density, yet it lacks both material composition and func...

journal_title：Scientific reports

authors： Katchalski T,Case T,Kim KY,Ramachandra R,Bushong EA,Deerinck TJ,Haberl MG,Mackey MR,Peltier S,Castillon GA,Fujikawa N,Lawrence AR,Ellisman MH

更新日期：2018-05-15 00:00:00

abstract：:The interest in nanostructures of silicon and its dopants has significantly increased. We report the creation of an ultimately-shallow junction at the surface of n-type silicon with excellent electrical and optical characteristics made by depositing an atomically thin boron layer at a relatively low temperature where ...

journal_title：Scientific reports

authors： Mohammadi V,Nihtianov S,Fang C

更新日期：2017-10-16 00:00:00

abstract：:In this work, we report the self-assembled growth of vertically aligned columnar Cu2O + Cu4O3 nanocomposite thin films on glass and silicon substrates by reactive sputtering at room temperature. Microstructure analyses show that each phase in nanocomposite films has the columnar growth along the whole thickness, while...

journal_title：Scientific reports

authors： Wang Y,Ghanbaja J,Bruyère S,Soldera F,Horwat D,Mücklich F,Pierson JF

更新日期：2017-09-11 00:00:00

abstract：:Although plants are essentially sessile in nature, these organisms are very much in tune with their environment and are capable of a variety of movements. This may come as a surprise to many non-botanists, but not to Charles Darwin, who reported that plants do produce movements. Following Darwin's specific interest on...

journal_title：Scientific reports

authors： Guerra S,Peressotti A,Peressotti F,Bulgheroni M,Baccinelli W,D'Amico E,Gómez A,Massaccesi S,Ceccarini F,Castiello U

更新日期：2019-11-12 00:00:00

abstract：:Traditional diagnostic detection of chronic wasting disease (CWD) relies on immunodetection of misfolded CWD prion protein (PrP(CWD)) by western blotting, ELISA, or immunohistochemistry (IHC). These techniques require separate sample collections (frozen and fixed) which may result in discrepancies due to variation in ...

journal_title：Scientific reports

authors： Hoover CE,Davenport KA,Henderson DM,Pulscher LA,Mathiason CK,Zabel MD,Hoover EA

更新日期：2016-05-09 00:00:00