Altered kynurenine pathway metabolites in a mouse model of human attention-deficit hyperactivity/autism spectrum disorders: A potential new biological diagnostic marker.

abstract：:Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IGRA results from Pub...

journal_title：Scientific reports

authors： Yamasue M,Komiya K,Usagawa Y,Umeki K,Nureki SI,Ando M,Hiramatsu K,Nagai H,Kadota JI

更新日期：2020-01-31 00:00:00

abstract：:The regular rise and fall of the sun resulted in the development of 24-h rhythms in virtually all organisms. In an evolutionary heartbeat, humans have taken control of their light environment with electric light. Humans are highly sensitive to light, yet most people now use light until bedtime. We evaluated the impact...

journal_title：Scientific reports

authors： Cain SW,McGlashan EM,Vidafar P,Mustafovska J,Curran SPN,Wang X,Mohamed A,Kalavally V,Phillips AJK

更新日期：2020-11-05 00:00:00

abstract：:Bioavailability of α-tocopherol varies with source, dose and duration of supplementation. The effect of source and dose of α-tocopherol on response of α-tocopherol stereoisomers in plasma and tissues of mink kits during the weaning period was studied. Twelve mink kits were euthanised in CO2 at the beginning of the exp...

journal_title：Scientific reports

authors： Lashkari S,Clausen TN,Foldager L,Jensen SK

更新日期：2021-01-29 00:00:00

abstract：:Wound healing is regulated by complex interactions between the keratinocytes and other cell types including fibroblasts. Recently, adipose-derived mesenchymal stromal/stem cells (ASCs) have been reported to influence wound healing positively via paracrine involvement. However, their roles in keratinocytes are still ob...

journal_title：Scientific reports

authors： Moriyama M,Sahara S,Zaiki K,Ueno A,Nakaoji K,Hamada K,Ozawa T,Tsuruta D,Hayakawa T,Moriyama H

更新日期：2019-12-04 00:00:00

abstract：:The investigation of chemical and structural dynamics in battery materials is essential to elucidation of structure-property relationships for rational design of advanced battery materials. Spatially resolved techniques, such as scanning/transmission electron microscopy (S/TEM), are widely applied to address this chal...

journal_title：Scientific reports

authors： Lin F,Markus IM,Doeff MM,Xin HL

更新日期：2014-07-16 00:00:00

abstract：:The cancer stem cell (CSC) hypothesis proposes a hierarchical organization of tumors, in which stem-like cells sustain tumors and drive metastasis. The molecular mechanisms underlying the acquisition of CSCs and metastatic traits are not well understood. SOX9 is a transcription factor linked to stem cell maintenance a...

journal_title：Scientific reports

authors： Carrasco-Garcia E,Lopez L,Aldaz P,Arevalo S,Aldaregia J,Egaña L,Bujanda L,Cheung M,Sampron N,Garcia I,Matheu A

更新日期：2016-08-30 00:00:00

abstract：:Progressive evolution, or the tendency towards increasing complexity, is a controversial issue in biology, which resolution entails a proper measurement of complexity. Genomes are the best entities to address this challenge, as they encode the historical information of a species' biotic and environmental interactions....

journal_title：Scientific reports

authors： Moya A,Oliver JL,Verdú M,Delaye L,Arnau V,Bernaola-Galván P,de la Fuente R,Díaz W,Gómez-Martín C,González FM,Latorre A,Lebrón R,Román-Roldán R

更新日期：2020-11-04 00:00:00

abstract：:We have studied the intrinsic fluorescence spectra of a monomeric variant of human transthyretin (M-TTR), a protein involved in the transport of the thyroid hormone and retinol and associated with various forms of amyloidosis, extending our analysis to the second order derivative of the spectra. This procedure allowed...

journal_title：Scientific reports

authors： Jazaj D,Ghadami SA,Bemporad F,Chiti F

更新日期：2019-07-29 00:00:00

abstract：:Personal values developed in adolescence may influence mental health and well-being over the life course. Using data from 684 respondents in the Youth Development Study (61.9% of respondents in the baseline survey), we explored the effects of work values at ages 14-15 on positive and negative emotions, as well as psyc...

journal_title：Scientific reports

authors： Fukasawa M,Watanabe K,Nishi D,Kawakami N

更新日期：2020-08-11 00:00:00

abstract：:Color vision requires the activity of cone photoreceptors to be compared in post-receptoral circuitry. Decades of psychophysical measurements have quantified the nature of these comparative interactions on a coarse scale. How such findings generalize to a cellular scale remains unclear. To answer that question, we qua...

journal_title：Scientific reports

authors： Schmidt BP,Sabesan R,Tuten WS,Neitz J,Roorda A

更新日期：2018-06-04 00:00:00

abstract：:Pathogenic meningococci have acquired a 24 kb capsule synthesis island (cps) by horizontal gene transfer which consists of a synthetic locus and associated capsule transport genes flanked by repetitive Regions D and D'. Regions D and D' contain an intact gene encoding a UDP-galactose epimerase (galE1) and a truncated ...

journal_title：Scientific reports

authors： Bartley SN,Mowlaboccus S,Mullally CA,Stubbs KA,Vrielink A,Maiden MC,Harrison OB,Perkins TT,Kahler CM

更新日期：2017-03-14 00:00:00

abstract：:Luminance plays a modulating role in the processes of several visual tasks, which in turn provides significant information for the understanding of visual processing. Here, using a binocular phase combination paradigm, we studied the effect of unilateral changes in mean luminance on binocular combination in both norma...

journal_title：Scientific reports

authors： Zhou J,Jia W,Huang CB,Hess RF

更新日期：2013-01-01 00:00:00

abstract：:We have observed that one in three patients admitted to the Neurological Rehabilitation Ward for Children and Adolescents due to a syndrome or disease associated with neurodysfunction is short of stature for their age. In order to identify the relationship between growth defects (short stature) and syndromes or diseas...

journal_title：Scientific reports

authors： Perenc L,Guzik A,Podgórska-Bednarz J,Drużbicki M

更新日期：2019-11-11 00:00:00

abstract：:COVID-19 caused by the SARS-CoV-2 is a current global challenge and urgent discovery of potential drugs to combat this pandemic is a need of the hour. 3-chymotrypsin-like cysteine protease (3CLpro) enzyme is the vital molecular target against the SARS-CoV-2. Therefore, in the present study, 1528 anti-HIV1compounds wer...

journal_title：Scientific reports

authors： Nand M,Maiti P,Joshi T,Chandra S,Pande V,Kuniyal JC,Ramakrishnan MA

更新日期：2020-11-23 00:00:00

abstract：:Staphylococcus aureus is a medically important pathogen with an abundance of virulence factors that are necessary for survival within a host, including the production of cytolytic toxins. The regulation of toxin production is mediated by the Agr quorum sensing system, and a poorly defined post-exponential growth phase...

journal_title：Scientific reports

authors： Stevens E,Laabei M,Gardner S,Somerville GA,Massey RC

更新日期：2017-10-23 00:00:00

abstract：:Oxygen-induced retinopathy (OIR) upregulates Müller cell vascular endothelial growth factor A (VEGFA) that causes intravitreal neovascularization similar to severe retinopathy of prematurity (ROP). Safety concerns exist with anti-VEGF treatment for ROP. We evaluated long-term knockdown of Müller cell-VEGFA with short-...

journal_title：Scientific reports

authors： Becker S,Wang H,Simmons AB,Suwanmanee T,Stoddard GJ,Kafri T,Hartnett ME

更新日期：2018-01-31 00:00:00

abstract：:Previous studies demonstrated distinct neural correlates underpinning impaired self-regulation (dysregulation) between individuals with autism spectrum disorder (ASD) and typically developing controls (TDC). However, the impacts of dysregulation on white matter (WM) microstructural property in ASD and TDC remain uncle...

journal_title：Scientific reports

authors： Ni HC,Lin HY,Tseng WI,Gau SS

更新日期：2020-08-14 00:00:00

abstract：:The presenilin 1 (PSEN1) L271V mutation causes early-onset familial Alzheimer's disease by disrupting the alternative splicing of the PSEN1 gene, producing some transcripts harboring the L271V point mutation and other transcripts lacking exon 8 (PS1(∆exon8)). We previously reported that PS1 L271V increased amyloid bet...

journal_title：Scientific reports

authors： Brautigam H,Moreno CL,Steele JW,Bogush A,Dickstein DL,Kwok JB,Schofield PR,Thinakaran G,Mathews PM,Hof PR,Gandy S,Ehrlich ME

更新日期：2015-11-26 00:00:00

abstract：:We conducted a prospective cohort study among HIV-negative MSM aged 18 years or older between 2007 and 2012 in Beijing, China to measure the rates of incident HIV and identify risk factors for infection. Among 5,800 participants evaluated at enrollment, we identified 486 prevalent cases of HIV (8.4%). Among the 3,625 ...

journal_title：Scientific reports

authors： Jia Z,Huang X,Wu H,Zhang T,Li N,Ding P,Sun Y,Liu Z,Wei F,Zhang H,Jiao Y,Ji Y,Zhang Y,Guo C,Li W,Mou D,Xia W,Li Z,Chen D,Yan H,Chen X,Zhao J,Meyers K,Cohen T,Mayer K,Salomon JA,Lu Z,Dye C

更新日期：2015-07-02 00:00:00

abstract：:Aim of this retrospective analysis was to evaluate the survival times after percutaneous irreversible electroporation (IRE) in inoperable liver tumors not amenable to thermal ablation. 71 patients (14 females, 57 males, median age 63.5 ± 10.8 years) with 103 liver tumors were treated in 83 interventions using IRE (Nan...

journal_title：Scientific reports

authors： Niessen C,Thumann S,Beyer L,Pregler B,Kramer J,Lang S,Teufel A,Jung EM,Stroszczynski C,Wiggermann P

更新日期：2017-03-07 00:00:00

abstract：:HIV-exposed uninfected (HEU) infants are disproportionately at a higher risk of morbidity and mortality, as compared to HIV-unexposed uninfected (HUU) infants. Here, we used transcriptional profiling of peripheral blood mononuclear cells to determine immunological signatures of in utero HIV exposure. We identified 262...

journal_title：Scientific reports

authors： Musimbi ZD,Rono MK,Otieno JR,Kibinge N,Ochola-Oyier LI,de Villiers EP,Nduati EW

更新日期：2019-12-02 00:00:00

abstract：:Coastal zones constitute one of the most heavily populated and developed land zones in the world. Despite the utility and economic benefits that coasts provide, there is no reliable global-scale assessment of historical shoreline change trends. Here, via the use of freely available optical satellite images captured si...

journal_title：Scientific reports

authors： Luijendijk A,Hagenaars G,Ranasinghe R,Baart F,Donchyts G,Aarninkhof S

更新日期：2018-04-27 00:00:00

abstract：:Searching, defined for the purpose of the present study as the displacement of an individual to locate resources, is a fundamental behavior of all mobile organisms. In humans this behavior underlies many aspects of everyday life, involving cognitive processes such as sustained attention, memory and inhibition. We expl...

journal_title：Scientific reports

authors： Rosetti MF,Ulloa RE,Vargas-Vargas IL,Reyes-Zamorano E,Palacios-Cruz L,de la Peña F,Larralde H,Hudson R

更新日期：2016-01-25 00:00:00

abstract：:High temperature inhibits wheat grain filling. Polyamines (PAs) are closely associated with plant resistance caused by abiotic stress. However, little is known about the effect of PAs on the grain filling of wheat under heat stress. Two wheat varieties differing in heat resistance were used, and endogenous PAs levels ...

journal_title：Scientific reports

authors： Jing J,Guo S,Li Y,Li W

更新日期：2020-05-04 00:00:00

abstract：:In this work, CoMoO4@NiMoO4·xH2O core-shell heterostructure electrode is directly grown on carbon fabric (CF) via a feasible hydrothermal procedure with CoMoO4 nanowires (NWs) as the core and NiMoO4 nanosheets (NSs) as the shell. This core-shell heterostructure could provide fast ion and electron transfer, a large num...

journal_title：Scientific reports

authors： Wang J,Zhang L,Liu X,Zhang X,Tian Y,Liu X,Zhao J,Li Y

更新日期：2017-01-20 00:00:00

abstract：:Enzymes that cleave polysaccharides in lignocellulose, i. e., cellulases, xylanases, and accessory enzymes, play crucial roles in the natural decomposition of plant-derived biomass and its efficient and sustainable processing into biofuels or other bulk chemicals. The analysis of open reading frame cthe_2195 from the ...

journal_title：Scientific reports

authors： Heinze S,Mechelke M,Kornberger P,Liebl W,Schwarz WH,Zverlov VV

更新日期：2017-09-11 00:00:00

abstract：:Phytic acid (PA) is the primary phosphorus (P) storage compound in the seeds of cereals and legumes. Low PA crops, which are considered an effective way to improve grain nutrient availability and combat environmental issues relating to seed P have been developed using mutational and reverse genetics approaches. Here, ...

journal_title：Scientific reports

authors： Perera I,Fukushima A,Akabane T,Horiguchi G,Seneweera S,Hirotsu N

更新日期：2019-10-16 00:00:00

abstract：:The S385Y/D469T/R520Q variant of E. coli transketolase was evolved previously with three successive smart libraries, each guided by different structural, bioinformatical or computational methods. Substrate-walking progressively shifted the target acceptor substrate from phosphorylated aldehydes, towards a non-phosphor...

journal_title：Scientific reports

authors： Affaticati PE,Dai SB,Payongsri P,Hailes HC,Tittmann K,Dalby PA

更新日期：2016-10-21 00:00:00

abstract：:We developed hybrid slot antenna structures for microbial sensing in the THz frequency range, where silver nanowires (AgNWs) were employed to increase the sensitivity. In order to fabricate the hybrid devices, we partially etched the AgNW in the slot antenna region, where we can expect the field enhancement effect at ...

journal_title：Scientific reports

authors： Hong JT,Jun SW,Cha SH,Park JY,Lee S,Shin GA,Ahn YH

更新日期：2018-10-19 00:00:00

abstract：:Internet gaming disorder (IGD) has been conceptualized as a behavioral addiction and shares clinical, neuropsychological, and personality characteristics with alcohol use disorder (AUD), but IGD dose not entail brain exposure to toxic agents, which renders it different from AUD. To achieve a clear understanding of the...

journal_title：Scientific reports

authors： Yoon EJ,Choi JS,Kim H,Sohn BK,Jung HY,Lee JY,Kim DJ,Park SW,Kim YK

更新日期：2017-07-18 00:00:00