Abstract：
:Clostridium difficile infection (CDI) is associated with risk for severe disease and high mortality. Little is known about the extent of hospital-acquired CDI in Mainland China. In this study, we aimed to investigate the annual CDI incidence, bacterial genotypes, risk factors for severe CDI and survival over a 7-year period. A total of 307 hospital-acquired CDI patients were enrolled, and 70.7% of these cases were male. CDI incidence was 3.4 per 10,000 admissions. Thirty-three different sequence types (STs) were identified, among which ST-54 (18.2%), ST-35 (16.6%) and ST-37 (12.1%) were the most prevalent. During the follow-up period, 66 (21.5%) patients developed severe CDI and 32 (10.4%) patients died in 30 days. Multivariate analysis revealed that bloodstream infection, pulmonary infection and C-reactive protein were significantly associated with severe CDI. After adjustment for potential confounders, old age, bloodstream infection, fever, mechanical ventilation, connective tissue disease, macrolide use and hypoalbuminaemia were independently associated with 30-day mortality in patients with CDI. The CDI prevalence has been low and stable in our center, and STs of Clostridium difficile were different from dominant STs in Western countries. Our data emphasize the need of continued education and surveillance of CDI to reduce the CDI burden in China.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xu Q,Chen Y,Gu S,Lv T,Zheng B,Shen P,Quan J,Fang Y,Li Ldoi
10.1038/s41598-017-09961-0subject
Has Abstractpub_date
2017-08-29 00:00:00pages
9645issue
1issn
2045-2322pii
10.1038/s41598-017-09961-0journal_volume
7pub_type
杂志文章abstract：:Artificial photosynthesis, specifically H2O dissociation for CO2 reduction with solar energy, is regarded as one of the most promising methods for sustainable energy and utilisation of environmental resources. However, a highly efficient conversion still remains extremely challenging. The hydrogenation of CO2 is regar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04503
更新日期：2014-03-28 00:00:00
abstract：:Antimicrobial stewardship programmes (ASP) are aimed at optimising antimicrobial utilization. However, only few studies have focused on paediatric intensive care units (PICU), where inappropriate antibiotic use occurs frequently. We assessed the effect and safety of a once weekly paediatric infectious disease (PID) wa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65671-0
更新日期：2020-06-01 00:00:00
abstract：:Membrane fouling, i.e. accumulation of unwanted material on the surface of the membrane is a significant problem in filtration processes since it commonly degrades membrane performance and increases operating costs. Therefore, the advantages of early stage monitoring and control of fouling are widely recognized. In th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29268-y
更新日期：2018-07-23 00:00:00
abstract：:The Lhasa terrane is a key region for understanding the paleoelevation of the southern Tibetan Plateau after India-Asia collision. The Gerze Basin, located in the northern part of the Lhasa terrane, is a shortening-related basin. We discovered Lagena laevis (Bandy) fossils in upper Eocene strata of the Gerze Basin. Th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27508
更新日期：2016-06-08 00:00:00
abstract：:The striatum plays important motor, associative and cognitive roles in brain functions. However, the rodent dorsolateral (the primate putamen) and dorsomedial (the primate caudate nucleus) striatum are not anatomically separated, making it difficult to distinguish their functions. By contrast, anatomical separation ex...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35809
更新日期：2016-11-02 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-75277-1
更新日期：2020-10-20 00:00:00
abstract：:The Japanese murrelet (Synthliboramphus wumizusume) is an endangered small seabird species in Japan. Molecular sexing using PCR targeting of the gene encoding chromodomain helicase DNA-binding protein 1(CHD1) has been used for sex identification. Specifically, PCR using any of three commonly used primer sets (CHD1F/1R...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65206-7
更新日期：2020-05-22 00:00:00
abstract：:After HSP70 binds to the J domain of the substrate and co-chaperone protein, ATP is hydrolyzed to ADP, and the nucleotide exchange factors (NEFs) promote the release of ADP. Under physiological conditions, the nucleotide exchange step is the rate-limiting step, which is accelerated by NEFs. In this study, the promoter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74381-6
更新日期：2020-10-14 00:00:00
abstract：:We analyze the ferroelectric domain-wall induced negative capacitance (NC) effect in Metal-FE-Insulator-Metal (MFIM) and Metal-FE-Insulator-Semiconductor (MFIS) stacks through phase-field simulations by self-consistently solving time-dependent Ginzburg Landau equation, Poisson's equation and semiconductor charge equat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-66313-1
更新日期：2020-06-23 00:00:00
abstract：:Zika virus (ZIKV) causes significant public health concerns because of its association with congenital malformations, neurological disorders in adults, and, more recently, death. Considering the necessity to mitigate ZIKV-associated diseases, antiviral interventions are an urgent necessity. Sofosbuvir, a drug in clini...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09797-8
更新日期：2017-08-25 00:00:00
abstract：:Bacterial microcompartments (BMCs) are promising natural protein structures for applications that require the segregation of certain metabolic functions or molecular species in a defined microenvironment. To understand how endogenous cargos are packaged inside the protein shell is key for using BMCs as nano-scale reac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33074-x
更新日期：2018-10-10 00:00:00
abstract：:The reproductive performance of Octopus vulgaris broodstocks fed two different diets (mixed fish [F group, BW 1,048.14 g] or mixed crustaceans [C group, BW 998.44 g]) was analyzed using an experimental recirculating aquaculture system consisting of a tank equipped with spawning and incubation chambers. A total of 8 fe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72151-y
更新日期：2020-09-17 00:00:00
abstract：:Gram-negative bacteria belonging to the genus Klebsiella are important nosocomial pathogens, readily acquiring resistance to all known antibiotics. Bacteriocins, non-antibiotic antibacterial proteins, have been earlier proposed as potential therapeutic agents for control of other Gram-negative species such as Escheric...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51969-1
更新日期：2019-10-28 00:00:00
abstract：:The sedimentary record, and associated micropalaeontological proxies, is one tool that has been employed to quantify a region's tropical cyclone history. Doing so has largely relied on the identification of allochthonous deposits (sediments and microfossils), sourced from deeper water and entrained by tropical cyclone...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24846
更新日期：2016-04-29 00:00:00
abstract：:Saliva, as a non-invasive and easily accessible biofluid, has been shown to contain RNA biomarkers for prediction and diagnosis of several diseases. However, systematic analysis done by our group identified two problematic issues not coherently described before: (1) most of the isolated RNA originates from the oral mi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67825-6
更新日期：2020-07-07 00:00:00
abstract：:Algae-bacteria interaction is one of the main factors underlying the formation of harmful algal blooms (HABs). The aim of this study was to develop a genome-wide high-throughput screening method to identify HAB-influenced specific interactive bacterial metabolites using a comprehensive collection of gene-disrupted E. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67322-w
更新日期：2020-06-30 00:00:00
abstract：:The newly designed fentanyl derivative [( ±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide] (NFEPP) was recently shown to produce analgesia selectively via peripheral mu-opioid receptors (MOR) at acidic pH in rat inflamed tissues. Here, we examined the pH-dependency of NFEPP binding to brain MOR and it...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75509-4
更新日期：2020-10-29 00:00:00
abstract：:Juvenile hormone (JH) plays crucial roles in many aspects of the insect life. All the JH actions are initiated by transport of JH in the hemolymph as a complex with JH-binding protein (JHBP) to target tissues. Here, we report structural mechanism of JH delivery by JHBP based upon the crystal and solution structures of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00133
更新日期：2011-01-01 00:00:00
abstract：:The Pax3/7 transcription factor family is integral to developmental gene networks contributing to important innovations in vertebrate evolution, including the neural crest. The basal chordate lineage of amphioxus is ideally placed to understand the dynamics of the gene regulatory network evolution that produced these ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27700-x
更新日期：2018-06-20 00:00:00
abstract：:The annotation of genomic ranges of interest represents a recurring task for bioinformatics analyses. These ranges can originate from various sources, including peaks called for transcription factor binding sites (TFBS) or histone modification ChIP-seq experiments, chromatin structure and accessibility experiments (su...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02464-y
更新日期：2017-06-01 00:00:00
abstract：:Soybean is an important source of protein, oil and carbohydrates, as well as other beneficial nutrients. A major function of proteins in nutrition is to supply adequate amounts of amino acids. Although they are essential for human nutrition, the sulfur-containing amino acids cysteine (Cys) and methionine (Met) are oft...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78907-w
更新日期：2020-12-11 00:00:00
abstract：:A current threat to the marine ecosystem is the high level of solar ultraviolet radiation (UV). Large whales have recently been shown to suffer sun-induced skin damage from continuous UV exposure. Genotoxic consequences of such exposure remain unknown for these long-lived marine species, as does their capacity to coun...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02386
更新日期：2013-01-01 00:00:00
abstract：:A large volcanic sulfate increase observed in ice core records around 1450 C.E. has been attributed in previous studies to a volcanic eruption from the submarine Kuwae caldera in Vanuatu. Both EPMA-WDS (electron microprobe analysis using a wavelength dispersive spectrometer) and SEM-EDS (scanning electron microscopy a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50939-x
更新日期：2019-10-08 00:00:00
abstract：:Chondrichthyes - sharks, rays, skates, and chimeras, are among the most threatened and data deficient vertebrate species. Global demand for shark and ray derived products, drives unregulated and exploitative fishing practices, which are in turn facilitated by the lack of ecological data required for effective conserva...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40940-9
更新日期：2019-03-14 00:00:00
abstract：:Idiopathic pulmonary fibrosis (IPF) involves alveolar epithelial injury and abnormal collagen production caused by activated fibroblasts; transforming growth factor (TGF)-β1 is implicated in this activation. In this study, we screened for chemicals capable of inhibiting TGF-β1-induced collagen production in cultured f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03676-y
更新日期：2017-06-13 00:00:00
abstract：:Although numerous reports on nonprecious metal catalysts for replacing expensive Pt-based catalysts have been published, few of these studies have demonstrated their practical application in fuel cells. In this work, we report graphitic carbon nitride and carbon nanofiber hybrid materials synthesized by a facile and g...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08376
更新日期：2015-03-02 00:00:00
abstract：:Acyl-CoA:diacylglycerol acyltransferase I (DGAT1) is a key enzyme in lipogenesis which is increased in metabolically active cells to meet nutrient requirements. DGAT1 has been recognized as an anti-obesity target; however, its role in the tumor microenvironment remains unclear. We postulated that, in prostate cancer (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39537-z
更新日期：2019-02-28 00:00:00
abstract：:Tumor cell invasion requires the molecular and physical adaptation of both the cell and its microenvironment. Here we show that tumor cells are able to switch between the use of microvesicles and invadopodia to facilitate invasion through the extracellular matrix. Invadopodia formation accompanies the mesenchymal mode...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14748
更新日期：2015-10-13 00:00:00
abstract：:This study is to investigate the frequencies of T-helper (Th)22, Th17 and Th1 cells and the levels of related cytokines in subchondral bone marrow in patients with rheumatoid arthritis (RA). Bone marrow and peripheral blood samples were collected from RA, osteoarthritis (OA) patients and healthy controls. The frequenc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05014-8
更新日期：2017-07-06 00:00:00
abstract：:Adult neurogenesis occurs in the dentate gyrus of the hippocampus during adulthood and contributes to sustaining the hippocampal formation. To investigate whether neurogenesis-related pathways are associated with hippocampal volume, we performed gene-set enrichment analysis using summary statistics from a large-scale ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50507-3
更新日期：2019-10-10 00:00:00
