Abstract：
:Central visual field (CVF) loss has been linked to poorer vision-related quality of life in eyes with open-angle glaucoma (OAG) and can occur even in early-stage OAG eyes. The present study investigated whether the detection of choroidal microvasculature dropout (CMvD) during follow-up, which may be a sign of perfusion deficiency in the optic nerve head, is associated with rapid rate of CVF loss in early-stage OAG eyes. This study included 44 Korean OAG eyes with CMvD, identified by optical coherence tomography angiography, and 44 Korean OAG eyes without CMvD matched for age and severity of visual field loss at initial presentation. The rates of mean threshold changes in global and CVF were compared in eyes with and without CMvD using a linear mixed model. Clinical variables associated with rapid rate of CVF progression were also identified using a linear mixed model. The CVF progression rate was significantly higher in eyes with CMvD than in those without CMvD (-0.584 dB/year vs. -0.190 dB/year; P < 0.001) and detection of CMvD during follow-up was an independent predictor of rapid CVF progression rate. The presence of CMvD may aid in identification of high-risk patients who may show faster CVF progression and require more aggressive treatment.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Jo YH,Kwon J,Jeong D,Shon K,Kook MSdoi
10.1038/s41598-019-44942-5subject
Has Abstractpub_date
2019-06-12 00:00:00pages
8525issue
1issn
2045-2322pii
10.1038/s41598-019-44942-5journal_volume
9pub_type
杂志文章abstract：:Interactions between microalgae and bacteria are often obligatory for harmful algal blooms (HABs). Here, we investigated the specific bacterial communities associated with Alexandrium tamarense and Cochlodinium polykrikoides, which cause ecological and economic damage during their blooms. To this end, the bacterial me...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23634-6
更新日期：2018-03-28 00:00:00
abstract：:Minimally invasive surgery (MIS) has shown satisfactory surgical results for the treatment of thoracic myelopathy (TM) caused by ossification of the ligamentum flavum (OLF). This study investigated the prognostic factors following MIS and was based on the retrospective analysis of OLF patients who underwent percutaneo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58198-x
更新日期：2020-01-28 00:00:00
abstract：:A layered nanoreactor (zinc hydroxide gallate/nitrate nanohybrid) has been designed as a nano-vessel to confine the gallate/nitrate reaction inside zinc hydroxide layers for production of metal/nitrogen-doped carbon catalysts. Metals (Fe2+, Co2+ and Ni2+) doped and bare zinc hydroxide nitrates (ZHN) were synthesized a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21782-3
更新日期：2018-02-21 00:00:00
abstract：:Unusual protein-like, partially reversible associative behaviour has recently been observed in solutions of the water soluble carbohydrates known as 6-deoxy-6-(ω-aminoalkyl)aminocelluloses, which produce controllable self-assembling films for enzyme immobilisation and other biotechnological applications. Now, for the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03861
更新日期：2014-01-24 00:00:00
abstract：:Thermoelectric properties of Graphene nano-ribbons (GNRs) with nanopores (NPs) are explored for a range of pore dimensions in order to achieve a high performance two-dimensional nano-scale thermoelectric device. We reduce thermal conductivity of GNRs by introducing pores in them in order to enhance their thermoelectri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11297
更新日期：2015-06-17 00:00:00
abstract：:Myeloid-derived suppressor cells (MDSCs) are highly prevalent inflammatory cells that play a key role in tumor development and are considered therapeutic targets. MDSCs promote tumor growth by blocking T-cell-mediated anti-tumoral immune response through depletion of arginine that is essential for T-cell proliferation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31397
更新日期：2016-08-10 00:00:00
abstract：:Zika virus (ZIKV) causes significant public health concerns because of its association with congenital malformations, neurological disorders in adults, and, more recently, death. Considering the necessity to mitigate ZIKV-associated diseases, antiviral interventions are an urgent necessity. Sofosbuvir, a drug in clini...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09797-8
更新日期：2017-08-25 00:00:00
abstract：:The importance of metallurgy for social and economic development is indisputable. Although copper (Cu) was essential for the wealth of pre- and post-colonial societies in the Andes, the onset of extensive Cu metallurgy in South America is still debated. Comprehensive archaeological findings point to first sophisticate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41855
更新日期：2017-01-31 00:00:00
abstract：:MCR-1 is a phosphoethanolamine (pEtN) transferase that modifies the pEtN moiety of lipid A, conferring resistance to colistin, which is an antibiotic belonging to the class of polypeptide antibiotics known as polymyxins and is the last-line antibiotic used to treat multidrug resistant bacterial infections. Here we det...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38793
更新日期：2016-12-13 00:00:00
abstract：:Pyrazinamide (PZA) is an important first-line drug in all existing and new tuberculosis (TB) treatment regimens. PZA-resistance in M. tuberculosis is increasing, especially among M/XDR cases. Noted issues with PZA Drug Susceptibility Testing (DST) have driven the search for alternative tests. This study provides a com...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03452-y
更新日期：2017-06-19 00:00:00
abstract：:Vitiligo is characterized by death or functional defects of epidermal melanocytes through still controversial pathogenic process. Previously, we showed that mitochondria-driven pre-senescent phenotype diminishes the capability of vitiligo melanocytes to cope with stressful stimuli. In the current study, we investigate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13961-5
更新日期：2017-10-20 00:00:00
abstract：:A great deal of attention has been recently focused on Electrochromic (EC) materials and EC based devices, promoting mainly applications related to display technology. In this case, EC based displays are usually actuated by the application of low dc bias voltages, changing their appearance from transparent to opaque. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28839
更新日期：2016-06-30 00:00:00
abstract：:Acute heart failure (AHF) emerges either de novo or from worsening of chronic heart failure (CHF). The aim of the present study was to evaluate the association between worsening of CHF and mortality in AHF patients. Out of 152 included AHF patients, 47 (30.9%) were de novo AHF patients and 105 (69%) were AHF patients ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28027-3
更新日期：2018-06-25 00:00:00
abstract：:DNA methylation is an important epigenetic mark that regulates gene expression. Dnmt1 plays an important role in maintaining DNA methylation patterns on daughter DNA strands. Studies have shed light into the functional role of Dnmt1 regulation in the hematopoietic and epidermal systems. Here we show that Dnmt1 is requ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35355
更新日期：2016-10-18 00:00:00
abstract：:Structural materials used for safety critical applications require high strength and simultaneously high resistance against crack growth, referred to as damage tolerance. However, the two properties typically exclude each other and research efforts towards ever stronger materials are hampered by drastic loss of fractu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33228
更新日期：2016-09-14 00:00:00
abstract：:Rapid diagnostic tests (RDTs) have been developed to detect influenza A virus for the swift diagnosis and management of patients. However, despite the simplicity and convenience, the low sensitivity of RDTs remains a limitation for their use in point of care testing (POCT). In this study, we developed a rapid fluoresc...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-018-31786-8
更新日期：2018-09-07 00:00:00
abstract：:Working memory (WM) impairments in ADHD have been consistently reported along with deficits in attentional control. Yet, it is not clear which specific WM processes are affected in this condition. A deficient coupling between attention and WM has been reported. Nevertheless, most studies focus on the capacity to retai...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64678-x
更新日期：2020-05-08 00:00:00
abstract：:MicroRNAs (miRNAs) are noncoding RNAs which control gene expression by the suppression of translation or the degradation of mRNAs. Dre-miR-21 (miR-21) has been reported to impact cardiac valvulogenesis in zebrafish embryos. However, the target genes of miR-21 are still largely unknown. Here a tandem isobaric mass tag ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04166-x
更新日期：2017-06-22 00:00:00
abstract：:Canine distemper virus (CDV) is the cause of a multisystem disease in domestic dogs and wild animals, infecting more than 20 carnivore and non-carnivore families and even infecting human cell lines in in vitro conditions. Phylogenetic classification based on the hemagglutinin gene shows 17 lineages with a phylogeograp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-52345-9
更新日期：2019-10-31 00:00:00
abstract：:The protective effects of statins against stenosis for permanent hemodialysis access have been repeatedly demonstrated in animal studies, but remain controversial in human studies. This study aims to evaluate the association between statin use and permanent hemodialysis access patency using a nationwide hemodialysis c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22197
更新日期：2016-02-23 00:00:00
abstract：:Biomodels made of poly(vinyl alcohol) (PVA) are demanded because they can represent the geometries and mechanical properties of human tissues realistically. Injecting and molding, commonly used in three-dimensional (3D) modeling, help to represent the blood vessels accurately. However, these techniques sometimes requi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34986-4
更新日期：2018-11-08 00:00:00
abstract：:The metastable-to-stable phase-transition is commonly observed in many fields of science, as an uncontrolled independent process, highly sensitive to microscopic fluctuations. In particular, self-assembled lipid suspensions exhibit phase-transitions, where the underlying driving mechanisms and dynamics are not well un...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09481
更新日期：2015-03-30 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-61396-2
更新日期：2020-03-06 00:00:00
abstract：:Microtubules (MTs) are cytoskeletal structures that play a central role in a variety of cell functions including cell division and cargo transfer. MTs are also nonlinear electrical transmission lines that produce and conduct electrical oscillations elicited by changes in either electric field and/or ionic gradients. T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48677-1
更新日期：2019-08-27 00:00:00
abstract：:Gallic acid is a trihydroxybenzoic acid found in tea leaves and some plants. Here, we report the effect of gallic acid on cardiac dysfunction and fibrosis in a mouse model of pressure overload-induced heart failure and in primary rat cardiac fibroblasts, and compare the effects of gallic acid with those of drugs used ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27599-4
更新日期：2018-06-18 00:00:00
abstract：:Disc degeneration (DD) is a multifaceted chronic process that alters the structure and function of intervertebral discs. The pathophysiology of degeneration is not completely understood, but the consensus is that changes in genes encoding extracellular matrix (ECM) proteins in the disc are the leading factors contribu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04384-3
更新日期：2017-06-23 00:00:00
abstract：:Three dimensional single particle trapping and manipulation is an outstanding challenge in various fields ranging from basic physics to life sciences. By monitoring the response of a trapped particle to a designed environment one can extract its characteristics. In addition, quantum dynamics of a spatially scanned wel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16669
更新日期：2015-11-12 00:00:00
abstract：:Patient misidentification in imaging examinations has become a serious problem in clinical settings. Such misidentification could be prevented if patient characteristics such as sex, age, and body weight could be predicted based on an image of the patient, with an alert issued when a mismatch between the predicted and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43656-y
更新日期：2019-05-10 00:00:00
abstract：:The ability to measure biomolecular dynamics within cells and tissues is very important to understand fundamental physiological processes including cell adhesion, signalling, movement, division or metabolism. Usually, such information is obtained using particle tracking methods or single point fluctuation spectroscopy...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07048
更新日期：2014-11-14 00:00:00
abstract：:Abscisic acid (ABA) is an ancient stress hormone and is detectable in a wide variety of organisms where it regulates innate immunity and inflammation. Previously, we showed that oral supplementation with ABA decreased parasitemia in a mouse model of malaria, decreased liver and spleen pathology and reduced parasite tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27073-1
更新日期：2018-06-11 00:00:00
