当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure.

Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure.

Abstract：

:Gallic acid is a trihydroxybenzoic acid found in tea leaves and some plants. Here, we report the effect of gallic acid on cardiac dysfunction and fibrosis in a mouse model of pressure overload-induced heart failure and in primary rat cardiac fibroblasts, and compare the effects of gallic acid with those of drugs used in clinics. Gallic acid reduces cardiac hypertrophy, dysfunction, and fibrosis induced by transverse aortic constriction (TAC) stimuli in vivo and transforming growth factor β1 (TGF-β1) in vitro. It decreases left ventricular end-diastolic and end-systolic diameter, and recovers the reduced fractional shortening in TAC. In addition, it suppresses the expression of atrial natriuretic peptide, brain natriuretic peptide, skeletal α-actin, and β-myosin heavy chain. Administration of gallic acid decreases perivascular fibrosis, as determined by Trichrome II Blue staining, and reduces the expression of collagen type I and connective tissue growth factor. However, administration of losartan, carvedilol, and furosemide does not reduce cardiac dysfunction and fibrosis in TAC. Moreover, treatment with gallic acid inhibits fibrosis-related genes and deposition of collagen type I in TGF-β1-treated cardiac fibroblasts. These results suggest that gallic acid is a therapeutic agent for cardiac dysfunction and fibrosis in chronic heart failure.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Jin L,Sun S,Ryu Y,Piao ZH,Liu B,Choi SY,Kim GR,Kim HS,Kee HJ,Jeong MH

doi

10.1038/s41598-018-27599-4

subject

Has Abstract

pub_date

2018-06-18 00:00:00

pages

9302

issue

1

issn

2045-2322

pii

10.1038/s41598-018-27599-4

journal_volume

8

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Two-dimensional echocardiography after return of spontaneous circulation and its association with in-hospital survival after in-hospital cardiopulmonary resuscitation.

    abstract：:This retrospective cohort study investigated the association between in-hospital survival and two-dimensional (2D) echocardiography within 24 hours after the return of spontaneous circulation (ROSC) in patients who underwent in-hospital cardiopulmonary resuscitation (ICPR) after in-hospital cardiopulmonary arrest (IHC...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56153-z

    authors： Song IA,Cha JK,Oh TK,Jo YH,Yoon YE

    更新日期：2020-01-08 00:00:00

  • The effect of unilateral mean luminance on binocular combination in normal and amblyopic vision.

    abstract：:Luminance plays a modulating role in the processes of several visual tasks, which in turn provides significant information for the understanding of visual processing. Here, using a binocular phase combination paradigm, we studied the effect of unilateral changes in mean luminance on binocular combination in both norma...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep02012

    authors： Zhou J,Jia W,Huang CB,Hess RF

    更新日期：2013-01-01 00:00:00

  • In situ Scanning Electron Microscopy of Silicon Anode Reactions in Lithium-Ion Batteries during Charge/Discharge Processes.

    abstract：:A comprehensive understanding of the charge/discharge behaviour of high-capacity anode active materials, e.g., Si and Li, is essential for the design and development of next-generation high-performance Li-based batteries. Here, we demonstrate the in situ scanning electron microscopy (in situ SEM) of Si anodes in a con...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36153

    authors： Chen CY,Sano T,Tsuda T,Ui K,Oshima Y,Yamagata M,Ishikawa M,Haruta M,Doi T,Inaba M,Kuwabata S

    更新日期：2016-10-26 00:00:00

  • Structural colour in Chondrus crispus.

    abstract：:The marine world is incredibly rich in brilliant and intense colours. Photonic structures are found in many different species and provide extremely complex optical responses that cannot be achieved solely by pigments. In this study we examine the cuticular structure of the red alga Chondrus crispus (Irish Moss) using ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep11645

    authors： Chandler CJ,Wilts BD,Vignolini S,Brodie J,Steiner U,Rudall PJ,Glover BJ,Gregory T,Walker RH

    更新日期：2015-07-03 00:00:00

  • Controlling the Polarity of the Molecular Beam Epitaxy Grown In-Bi Atomic Film on the Si(111) Surface.

    abstract：:Synchrotron radiation core-level photoemission spectroscopy, scanning tunneling microscopy (STM), and first-principles calculations have been utilized to explore the growth processes and the atomic structure of the resulting films during the two-step molecular beam epitaxy (MBE) of In and Bi on the Si(111) surface. De...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37051-2

    authors： Lin CY,Hsu CH,Huang YZ,Hsieh SC,Chen HD,Huang L,Huang ZQ,Chuang FC,Lin DS

    更新日期：2019-01-24 00:00:00

  • Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation.

    abstract：:The inhibitors of CD26 (dipeptidyl peptidase-4; DPP4) have been widely prescribed to control glucose level in diabetic patients. DPP4-inhibitors, however, accumulate stromal cell-derived factor-1α (SDF-1α), a well-known inducer of vascular leakage and angiogenesis both of which are fundamental pathophysiology of diabe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep29393

    authors： Lee CS,Kim YG,Cho HJ,Park J,Jeong H,Lee SE,Lee SP,Kang HJ,Kim HS

    更新日期：2016-07-06 00:00:00

  • One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells.

    abstract：:Bispecific killer cells engagers (BiKEs) which can bind to natural killer (NK) cells through the activating receptor CD16A and guide them to cells expressing the HIV-1 envelope glycoprotein (Env) are a promising new weapon for elimination of infected cells and eradication of the virus. Here we report the design, gener...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-07966-3

    authors： Li W,Wu Y,Kong D,Yang H,Wang Y,Shao J,Feng Y,Chen W,Ma L,Ying T,Dimitrov DS

    更新日期：2017-08-22 00:00:00

  • Plasmodium spp. mixed infection leading to severe malaria: a systematic review and meta-analysis.

    abstract：:Mixed Plasmodium malaria infections can lead to severe malaria. This systematic review and meta-analysis aimed to explore the prevalence of severe mixed Plasmodium malaria infection and to compare it with the prevalence of severe P. falciparum malaria mono-infection across the included studies. Original English-langua...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41598-020-68082-3

    authors： Kotepui M,Kotepui KU,De Jesus Milanez G,Masangkay FR

    更新日期：2020-07-06 00:00:00

  • Injection of Fluoro-Gold into the tibial nerve leads to prolonged but reversible functional deficits in rats.

    abstract：:Tract tracing with neuronal tracers not only represents a straightforward approach to identify axonal projection connection between regions of the nervous system at distance but also provides compelling evidence for axonal regeneration. An ideal neuronal tracer meets certain criteria including high labeling efficacy, ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46285-7

    authors： Mi D,Yuan Y,Zhang Y,Niu J,Wang Y,Yan J,Yang Y,Hu W

    更新日期：2019-07-09 00:00:00

  • Synchronization of phase oscillators with frequency-weighted coupling.

    abstract：:Recently, the first-order synchronization transition has been studied in systems of coupled phase oscillators. In this paper, we propose a framework to investigate the synchronization in the frequency-weighted Kuramoto model with all-to-all couplings. A rigorous mean-field analysis is implemented to predict the possib...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep21926

    authors： Xu C,Sun Y,Gao J,Qiu T,Zheng Z,Guan S

    更新日期：2016-02-23 00:00:00

  • Scanning tunnelling microscope light emission: Finite temperature current noise and over cut-off emission.

    abstract：:The spectral distribution of light emitted from a scanning tunnelling microscope junction not only bears its intrinsic plasmonic signature but is also imprinted with the characteristics of optical frequency fluc- tuations of the tunnel current. Experimental spectra from gold-gold tunnel junctions are presented that sh...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03766-x

    authors： Kalathingal V,Dawson P,Mitra J

    更新日期：2017-06-14 00:00:00

  • Long-term isolation at a low effective population size greatly reduced genetic diversity in Gulf of California fin whales.

    abstract：:The Gulf of California, Mexico is home to many cetacean species, including a presumed resident population of fin whales, Balaenoptera physalus. Past studies reported very low levels of genetic diversity among Gulf of California fin whales and a significant level of genetic differentiation from con-specifics in the eas...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48700-5

    authors： Rivera-León VE,Urbán J,Mizroch S,Brownell RL Jr,Oosting T,Hao W,Palsbøll PJ,Bérubé M

    更新日期：2019-08-27 00:00:00

  • Optical pumping and readout of bismuth hyperfine states in silicon for atomic clock applications.

    abstract：:The push for a semiconductor-based quantum information technology has renewed interest in the spin states and optical transitions of shallow donors in silicon, including the donor bound exciton transitions in the near-infrared and the Rydberg, or hydrogenic, transitions in the mid-infrared. The deepest group V donor i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10493

    authors： Saeedi K,Szech M,Dluhy P,Salvail JZ,Morse KJ,Riemann H,Abrosimov NV,Nötzel N,Litvinenko KL,Murdin BN,Thewalt ML

    更新日期：2015-05-20 00:00:00

  • Radon emission from soil gases in the active fault zones in the Capital of China and its environmental effects.

    abstract：:The release of radon in active fault zones is a sustained radioactive pollution source of the atmospheric environment. The species, concentration and flux of radon emitted in soil gas in active fault zones in the Capital of China were investigated by in-situ field measurements. Two main species of radon discharging fr...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35262-1

    authors： Chen Z,Li Y,Liu Z,Wang J,Zhou X,Du J

    更新日期：2018-11-13 00:00:00

  • Structural and functional investigation of graphene oxide-Fe3O4 nanocomposites for the heterogeneous Fenton-like reaction.

    abstract：:Graphene oxide-iron oxide (GO-Fe3O4) nanocomposites were synthesised by co-precipitating iron salts onto GO sheets in basic solution. The results showed that formation of two distinct structures was dependent upon the GO loading. The first structure corresponds to a low GO loading up to 10 wt%, associated with the ben...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04594

    authors： Zubir NA,Yacou C,Motuzas J,Zhang X,Diniz da Costa JC

    更新日期：2014-04-04 00:00:00

  • Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics.

    abstract：:Heat shock protein 90 (HSP90) inhibition is an attractive strategy for cancer treatment. Several HSP90 inhibitors have shown promising effects in clinical oncology trials. However, little is known about HSP90 inhibition-mediated bladder cancer therapy. Here, we report a quantitative proteomic study that evaluates alte...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00143-6

    authors： Li QQ,Hao JJ,Zhang Z,Krane LS,Hammerich KH,Sanford T,Trepel JB,Neckers L,Agarwal PK

    更新日期：2017-03-15 00:00:00

  • An early granulocyte colony-stimulating factor treatment attenuates neuropathic pain through activation of mu opioid receptors on the injured nerve.

    abstract：:Several studies have shown that the mu opioid receptor (MOR) located in the peripheral nerves can be activated after nerve injury and that it attenuates peripheral nociceptive signals to the spinal dorsal horn. Various cytokines and phosphorylated-p38 (p-p38) activation in the dorsal horn also play an important role i...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25490

    authors： Liao MF,Yeh SR,Lo AL,Chao PK,Lee YL,Hung YH,Lu KT,Ro LS

    更新日期：2016-05-16 00:00:00

  • Cluster radioactivity of neutron-deficient nuclei in trans-tin region.

    abstract：:The possibility of cluster radioactivity (CR) of the neutron-deficient nuclei in the trans-tin region is explored by using the effective liquid drop model (ELDM), generalized liquid drop model (GLDM), and several sets of analytic formulas. It is found that the minimal half-lives are at Nd = 50 (Nd is the neutron numbe...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-65585-x

    authors： Gao Y,Cui J,Wang Y,Gu J

    更新日期：2020-06-04 00:00:00

  • Impact of floral characters, pollen limitation, and pollinator visitation on pollination success in different populations of Caragana korshinskii Kom.

    abstract：:Caragana korshinskii Kom. has a significant function in desert-grassland revegetation in arid regions. Plant reproduction in arid regions can be restricted due to inadequate pollen receipt and reduced pollen transfer. An assessment of pollination success as a result of pollen limitation and pollinator visitation in va...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-46271-z

    authors： Chen M,Zhao XY

    更新日期：2019-07-05 00:00:00

  • Experimental demonstration of plasmon enhanced energy transfer rate in NaYF4:Yb(3+),Er(3+) upconversion nanoparticles.

    abstract：:Energy transfer upconversion (ETU) is known to be the most efficient frequency upconversion mechanism. Surface plasmon can further enhance the upconversion process, opening doors to many applications. However, ETU is a complex process involving competing transitions between multiple energy levels and it has been diffi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep18894

    authors： Lu D,Mao C,Cho SK,Ahn S,Park W

    更新日期：2016-01-07 00:00:00

  • The effect of Pap smear screening on cervical cancer stage among southern Thai women.

    abstract：:Our study aimed to investigate the effect of Pap smear screening on stage at diagnosis of cervical cancer in a heterogeneous population of Thai women. Data was merged from the population-based cancer registry and screening registry based on unique identification numbers from 2006 to 2014. Patients being screened had l...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-52607-6

    authors： Niu L,Virani S,Bilheem S,Sriplung H

    更新日期：2019-11-15 00:00:00

  • Identification and local manipulation of bone marrow vasculature during intravital imaging.

    abstract：:Physiological regulation of blood flow in bone marrow is important to maintain oxygen and glucose supplies but also the physiological hypoxic state of the hematopoietic stem cell (HSC) niche. However, regulatory mechanisms underlying microcirculation in the bone marrow (BM) niche remain unclear. Here, we identify vess...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-63533-3

    authors： Morikawa T,Tamaki S,Fujita S,Suematsu M,Takubo K

    更新日期：2020-04-14 00:00:00

  • Fatty liver is associated with blood pathways of inflammatory response, immune system activation and prothrombotic state in Young Finns Study.

    abstract：:Fatty liver (FL) disease is the most common type of chronic liver disease. We hypothesized that liver's response to the process where large droplets of triglyceride fat accumulate in liver cells is reflected also in gene pathway expression in blood. Peripheral blood genome wide gene expression analysis and ultrasonic ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28563-y

    authors： Taipale T,Seppälä I,Raitoharju E,Mononen N,Lyytikäinen LP,Illig T,Waldenberger M,Juonala M,Hutri-Kähönen N,Oksala N,Kähönen M,Raitakari O,Lehtimäki T

    更新日期：2018-07-09 00:00:00

  • Trying to see, failing to focus: near visual impairment in Down syndrome.

    abstract：:The majority of individuals with Down syndrome (DS) do not exhibit accurate accommodation, with the aetiology of this deficit unknown. This study examines the mechanism underlying hypoaccommodation in DS by simultaneously investigating the 'near triad' - accommodation, vergence and pupillary response. An objective pho...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep20444

    authors： Doyle L,Saunders KJ,Little JA

    更新日期：2016-02-05 00:00:00

  • RNA-seq-based analysis of the hypertrophic scarring with and without pressure therapy in a Bama minipig model.

    abstract：:Pressure therapy has been proved to be an effective treatment for hypertrophic scars in a clinical setting. However, evidence-based data are controversial and the precise mechanism of action of this technique remains unknown. The aim of this study was to investigate the potential molecular mechanisms of pressure thera...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-29840-6

    authors： Liu B,Liu Y,Wang L,Hou C,An M

    更新日期：2018-08-07 00:00:00

  • MiR-198 represses tumor growth and metastasis in colorectal cancer by targeting fucosyl transferase 8.

    abstract：:In this study we investigated the biological role and mechanism of miR-198 in colorectal carcinoma (CRC). MiR-198 expression was shown to exhibit a strongly negative correlation with lymph node invasion, distant metastasis and patient survival in examinations of colorectal cancer tissues and paired normal colorectal m...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06145

    authors： Wang M,Wang J,Kong X,Chen H,Wang Y,Qin M,Lin Y,Chen H,Xu J,Hong J,Chen YX,Zou W,Fang JY

    更新日期：2014-09-01 00:00:00

  • Werner syndrome through the lens of tissue and tumour genomics.

    abstract：:Werner syndrome (WS) is the canonical adult human progeroid ('premature aging') syndrome. Patients with this autosomal recessive Mendelian disorder display constitutional genomic instability and an elevated risk of important age-associated diseases including cancer. Remarkably few analyses of WS patient tissue and tum...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep32038

    authors： Tokita M,Kennedy SR,Risques RA,Chun SG,Pritchard C,Oshima J,Liu Y,Bryant-Greenwood PK,Welcsh P,Monnat RJ

    更新日期：2016-08-25 00:00:00

  • Resistance of LPS-activated bone marrow derived macrophages to apoptosis mediated by dexamethasone.

    abstract：:Glucocorticoids (GC) display pleiotropic effects on the immune system. Macrophages are a major target for GC action. Here we show that dexamethasone (DEX), a synthetic GC, decreased viability of naïve bone marrow-derived macrophages (BMDM), involving an apoptotic mechanism. Administration of DEX together with lipopoly...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep04323

    authors： Haim YO,Unger ND,Souroujon MC,Mittelman M,Neumann D

    更新日期：2014-03-10 00:00:00

  • Comparative transcriptomic analysis of human and Drosophila extracellular vesicles.

    abstract：:Extracellular vesicles (EVs) are membrane-enclosed nanoparticles containing specific repertoires of genetic material. In mammals, EVs can mediate the horizontal transfer of various cargos and signaling molecules, notably miRNA and mRNA species. Whether this form of intercellular communication prevails in other metazoa...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27680

    authors： Lefebvre FA,Benoit Bouvrette LP,Perras L,Blanchet-Cohen A,Garnier D,Rak J,Lécuyer É

    更新日期：2016-06-10 00:00:00

  • Strong improvement of the transport characteristics of YBa2Cu3O7-x grain boundaries using ionic liquid gating.

    abstract：:For more than 30 years, the remarkable superconducting properties of REBa2Cu3O7-x (RE = rare earth) compounds have triggered research studies across the world. Accordingly, significant progresses have been made both from a basic understanding and a fabrication processes perspective. Yet, today, the major technological...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-36166-w

    authors： Fête A,Senatore C

    更新日期：2018-12-07 00:00:00