Abstract：
:Cellular reprogramming involves profound alterations in genome-wide gene expression that is precisely controlled by a hypothetical epigenetic code. Small molecules have been shown to artificially induce epigenetic modifications in a sequence independent manner. Recently, we showed that specific DNA binding hairpin pyrrole-imidazole polyamides (PIPs) could be conjugated with chromatin modifying histone deacetylase inhibitors like SAHA to epigenetically activate certain pluripotent genes in mouse fibroblasts. In our steadfast progress to improve the efficiency of SAHA-PIPs, we identified a novel compound termed, δ that could dramatically induce the endogenous expression of Oct-3/4 and Nanog. Genome-wide gene analysis suggests that in just 24 h and at nM concentration, δ induced multiple pluripotency-associated genes including Rex1 and Cdh1 by more than ten-fold. δ treated MEFs also rapidly overcame the rate-limiting step of epithelial transition in cellular reprogramming by switching "[Formula: see text]" the complex transcriptional gene network.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Pandian GN,Nakano Y,Sato S,Morinaga H,Bando T,Nagase H,Sugiyama Hdoi
10.1038/srep00544subject
Has Abstractpub_date
2012-01-01 00:00:00pages
544issn
2045-2322journal_volume
2pub_type
杂志文章abstract：:We report on a novel electrically tunable hybrid graphene-gold Fano resonator. The proposed metamaterial consists of a square graphene patch and a square gold frame. The destructive interference between the narrow- and broadband dipolar surface plasmons, which are induced respectively on the surfaces of the graphene p...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-09-14 00:00:00
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pub_type： 杂志文章
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更新日期：2017-08-16 00:00:00
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pub_type： 杂志文章
doi：10.1038/srep05871
更新日期：2014-07-29 00:00:00
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pub_type： 杂志文章
doi：10.1038/srep11800
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pub_type： 历史文章,杂志文章
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pub_type： 杂志文章
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更新日期：2016-03-24 00:00:00
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更新日期：2016-11-22 00:00:00
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pub_type： 杂志文章
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更新日期：2021-01-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35927-x
更新日期：2019-01-24 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40013-x
更新日期：2019-02-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-03-09 00:00:00
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pub_type： 已发布勘误
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更新日期：2017-09-12 00:00:00
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更新日期：2018-03-06 00:00:00
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