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Characterization of donor and recipient CD8+ tissue-resident memory T cells in transplant nephrectomies.

Abstract：

:Tissue-resident memory T (TRM) cells are characterized by their surface expression of CD69 and can be subdivided in CD103+ and CD103- TRM cells. The origin and functional characteristics of TRM cells in the renal allograft are largely unknown. To determine these features we studied TRM cells in transplant nephrectomies. TRM cells with a CD103+ and CD103- phenotype were present in all samples (n = 13) and were mainly CD8+ T cells. Of note, donor-derived TRM cells were only detectable in renal allografts that failed in the first month after transplantation. Grafts, which failed later, mainly contained recipient derived TRM cells. The gene expression profiles of the recipient derived CD8+ TRM cells were studied in more detail and showed a previously described signature of tissue residence within both CD103+ and CD103- TRM cells. All CD8+ TRM cells had strong effector abilities through the production of IFNγ and TNFα, and harboured high levels of intracellular granzyme B and low levels of perforin. In conclusion, our results demonstrate that donor and recipient TRM cells reside in the rejected renal allograft. Over time, the donor-derived TRM cells are replaced by recipient TRM cells which have features that enables these cells to aggressively respond to the allograft.

journal_name

Sci Rep

journal_title

Scientific reports

authors

de Leur K,Dieterich M,Hesselink DA,Corneth OBJ,Dor FJMF,de Graav GN,Peeters AMA,Mulder A,Kimenai HJAN,Claas FHJ,Clahsen-van Groningen MC,van der Laan LJW,Hendriks RW,Baan CC

doi

10.1038/s41598-019-42401-9

subject

Has Abstract

pub_date

2019-04-12 00:00:00

pages

5984

issue

1

issn

2045-2322

pii

10.1038/s41598-019-42401-9

journal_volume

9

pub_type

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