Hepatocellular carcinoma-targeting oncolytic adenovirus overcomes hypoxic tumor microenvironment and effectively disperses through both central and peripheral tumor regions.

abstract：:HSV-2 is one of the most common sexually transmitted pathogens worldwide and HSV-2 infection triggers cytokine and chemokine production. However, little is known about which HSV-2 genes engage in the regulation of NF-κB signaling and what mechanisms are involved. In a screen of the unique short (Us) regions of HSV-2, ...

journal_title：Scientific reports

authors： Lu X,Huang C,Zhang Y,Lin Y,Wang X,Li Q,Liu S,Tang J,Zhou L

更新日期：2017-08-21 00:00:00

abstract：:The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...

journal_title：Scientific reports

authors： Lopes-Marques M,Serrano C,Cardoso AR,Salazar R,Seixas S,Amorim A,Azevedo L,Prata MJ

更新日期：2020-07-14 00:00:00

abstract：:Organic photodetectors are interesting for low cost, large area optical sensing applications. Combining organic semiconductors with discrete absorption bands outside the visible wavelength range with transparent and conductive electrodes allows for the fabrication of visibly transparent photodetectors. Visibly transpa...

journal_title：Scientific reports

authors： Zhang H,Jenatsch S,De Jonghe J,Nüesch F,Steim R,Véron AC,Hany R

更新日期：2015-03-24 00:00:00

abstract：:The intermediate filament protein nestin is expressed during embryonic development, but considered largely restricted to areas of regeneration in the adult. Here, we perform a body-wide transcriptome and protein-profiling analysis to reveal that nestin is constitutively, and highly-selectively, expressed in adult huma...

journal_title：Scientific reports

authors： Dusart P,Fagerberg L,Perisic L,Civelek M,Struck E,Hedin U,Uhlén M,Trégouët DA,Renné T,Odeberg J,Butler LM

更新日期：2018-10-02 00:00:00

abstract：:Controlling thickness and tightness of surface passivation shells is crucial for many applications of core-shell nanoparticles (NP). Usually, to determine shell thickness, core and core/shell particle are measured individually requiring the availability of both nanoobjects. This is often not fulfilled for functional n...

journal_title：Scientific reports

authors： Weigert F,Müller A,Häusler I,Geißler D,Skroblin D,Krumrey M,Unger W,Radnik J,Resch-Genger U

更新日期：2020-11-26 00:00:00

abstract：:Increasing population has posed insurmountable challenges to agriculture in the provision of future food security, particularly in the Middle East and North Africa (MENA) region where biophysical conditions are not well-suited for agriculture. Iran, as a major agricultural country in the MENA region, has long been in ...

journal_title：Scientific reports

authors： Mesgaran MB,Madani K,Hashemi H,Azadi P

更新日期：2017-08-09 00:00:00

abstract：:Coral reefs around the world are undergoing severe decline in the past few decades. Mass coral mortalities have predominantly been reported to be caused by coral bleaching or disease outbreaks. Temporary hypoxic conditions caused by algal blooms can trigger mass coral mortalities though are reported rarely. In this st...

journal_title：Scientific reports

authors： Raj KD,Mathews G,Obura DO,Laju RL,Bharath MS,Kumar PD,Arasamuthu A,Kumar TKA,Edward JKP

更新日期：2020-12-17 00:00:00

abstract：:Bone marrow mesenchymal stem cells (BM-MSCs) are used in tissue engineering because of their migration characters. However, BM-MSCs have limitations in terms of reaching injuries and self-renewal. Therefore, enhancement of BM-MSC migration is important for therapeutic applications. Here, we assessed whether galectin-3...

journal_title：Scientific reports

authors： Gao Q,Xia Y,Liu L,Huang L,Liu Y,Zhang X,Xu K,Wei J,Hu Y,Mu Y,Li K

更新日期：2016-05-24 00:00:00

abstract：:Multiple predatory insect lineages have developed a raptorial lifestyle by which they strike and hold prey using modified forelegs armed with spine-like structures and other integumentary specialisations. However, how structures enabling the raptorial function evolved in insects remains largely hypothetical or inferre...

journal_title：Scientific reports

authors： Pérez-de la Fuente R,Peñalver E

更新日期：2019-09-13 00:00:00

abstract：:The TMPRSS2:ERG gene fusion is one of a series of highly promising prostate cancer (PCa) biomarker alternatives to the controversial serum PSA. Current methods for detecting TMPRSS2:ERG are limited in terms of long processing time, high cost and the need for specialized equipment. Thus, there is an unmet need for less...

journal_title：Scientific reports

authors： Koo KM,Wee EJ,Mainwaring PN,Trau M

更新日期：2016-07-29 00:00:00

abstract：:Despite numerous advances in genomics and bioinformatics, technological hurdles remain to examine host-microbe transcriptomics. Sometimes the transcriptome of either or both can be ascertained merely by generating more sequencing reads. However, many cases exist where bacterial mRNA needs to be enriched further to ena...

journal_title：Scientific reports

authors： Kumar N,Lin M,Zhao X,Ott S,Santana-Cruz I,Daugherty S,Rikihisa Y,Sadzewicz L,Tallon LJ,Fraser CM,Dunning Hotopp JC

更新日期：2016-10-07 00:00:00

abstract：:Pectins, the major components of cell walls in plants, are synthesized and secreted to cell walls as highly methyl-esterified polymers and then demethyl-esterified by pectin methylesterases (PMEs). The PMEs are spatially regulated by pectin methylesterase inhibitors (PMEIs). In this study, 43 and 49 putative PME and P...

journal_title：Scientific reports

authors： Zhang P,Wang H,Qin X,Chen K,Zhao J,Zhao Y,Yue B

更新日期：2019-12-27 00:00:00

abstract：:Malachite green is a common environmental pollutant that poses a great threat to non-target organisms, including humans. This study reports the characterization of a bacterial strain, Pseudomonas veronii JW3-6, which was isolated from a malachite green enrichment culture. This strain degraded malachite green efficient...

journal_title：Scientific reports

authors： Song J,Han G,Wang Y,Jiang X,Zhao D,Li M,Yang Z,Ma Q,Parales RE,Ruan Z,Mu Y

更新日期：2020-03-11 00:00:00

abstract：:Murraya koenigii (MK) leaf being a rich source of bioactive secondary metabolites has received inordinate attention in drug development research. Formation of secondary plant metabolite(s) in medicinal plants depends on several factors and in this study the cause of variation in bioavailability and content of a vital ...

journal_title：Scientific reports

authors： Kandimalla R,Das M,Barge SR,Sarma PP,Koiri DJ,Devi A,Karki AK,Kumar A,Devi R,Pal BC,Talukdar NC,Samanta SK

更新日期：2020-11-18 00:00:00

abstract：:Hot days in summer (involving a few hours at particularly high temperatures) are expected to become more common under climate change. How such events at different life stages affect survival and reproduction remains unclear in most organisms. Here, we investigated how an exposure to 40 °C at different life stages in t...

journal_title：Scientific reports

authors： Zhang W,Chang XQ,Hoffmann A,Zhang S,Ma CS

更新日期：2015-05-22 00:00:00

abstract：:We explored the potential relevance of aqueous lysophosphatidic acid (LPA) and autotaxin (ATX) levels on postoperative outcomes of trabeculectomy, and the effects of ATX on fibrotic response in cultured human conjunctiva fibroblast (HCF) cells. We enrolled 70 glaucomatous eyes which underwent trabeculectomy, and quant...

journal_title：Scientific reports

authors： Igarashi N,Honjo M,Kurano M,Yatomi Y,Igarashi K,Kano K,Aoki J,Aihara M

更新日期：2018-07-27 00:00:00

abstract：:Recent studies have shown inconsistent results regarding the value of desmoteplase for treating acute ischemic stroke (AIS) when administered within an extended time window. We performed a meta-analysis to explore the value of desmoteplase in AIS treatment. The MEDLINE, EMBASE, and Cochrane Library databases were sear...

journal_title：Scientific reports

authors： Shi L,Liang F,Li Y,Shao A,Zhou K,Yu J,Zhang J

更新日期：2016-09-27 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： de Oliveira GL,Marques AH,da Fonseca VF,Pozzolo BA,Panacioni F,Santos TC,Guedes AA,Mocelin AG,Bertin RL,Ulbrich AZ

更新日期：2020-10-28 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma with diverse outcomes. Concurrent translocation of MYC and BCL-2 and/or BCL-6, and concurrent immunohistochemical (IHC) high expression of MYC and BCL-2, have been linked to unfavorable treatment responses. TP53-mutated DLBCL has also been linked to worse...

journal_title：Scientific reports

authors： Peroja P,Pedersen M,Mantere T,Nørgaard P,Peltonen J,Haapasaari KM,Böhm J,Jantunen E,Turpeenniemi-Hujanen T,Rapakko K,Karihtala P,Soini Y,Vasala K,Kuittinen O

更新日期：2018-10-04 00:00:00

abstract：:Accurate detection of accelerometer non-wear time is crucial for calculating physical activity summary statistics. In this study, we evaluated three epoch-based non-wear algorithms (Hecht, Troiano, and Choi) and one raw-based algorithm (Hees). In addition, we performed a sensitivity analysis to provide insight into th...

journal_title：Scientific reports

authors： Syed S,Morseth B,Hopstock LA,Horsch A

更新日期：2020-04-03 00:00:00

abstract：:Plant cis-elements play important roles in global regulation of gene expression. Based on microarray data from rice flag leaves during early senescence, we identified W-box and G-box cis-elements as positive regulators of senescence in the important rice variety Minghui 63. Both cis-elements were bound by leaf senesce...

journal_title：Scientific reports

authors： Liu L,Xu W,Hu X,Liu H,Lin Y

更新日期：2016-02-11 00:00:00

abstract：:Interaction between the epithelium and mesenchyme coordinates patterning and differentiation of oral cavity structures including teeth, palatal rugae and tongue papillae. SHH is one of the key signaling molecules for this interaction. Epithelial expression of Shh in the tooth buds and tongue papillae is regulated by a...

journal_title：Scientific reports

authors： Sagai T,Amano T,Maeno A,Kiyonari H,Seo H,Cho SW,Shiroishi T

更新日期：2017-10-11 00:00:00

abstract：:The effects of gradual vascular occlusion on the blood supply of perfused areas are poorly described. Information relating to the comparison of flap monitoring techniques is lacking. Varying stenotic conditions (0%, 25%, 50%, 75% and 100%) were generated on purpose at the A. and V. femoralis in the rat model. Analyses...

journal_title：Scientific reports

authors： Mücke T,Hapfelmeier A,Schmidt LH,Fichter AM,Kanatas A,Wolff KD,Ritschl LM

更新日期：2020-01-22 00:00:00

abstract：:We report efficient detection of alpha radiation on highly textured and vertically aligned along (002) Gallium-doped Zinc Oxide (ZnO:Ga) nanorods on a glass substrate with an average diameter ~150 ± 10 nm. Photoluminescence measurement showed near band emission 393 nm, in agreement with the bandgap value ~3.22 eV, mea...

journal_title：Scientific reports

authors： Sahani RM,Kumari C,Pandya A,Dixit A

更新日期：2019-08-06 00:00:00

abstract：:This corrects the article DOI: 10.1038/srep23458. ...

journal_title：Scientific reports

authors： Sharma R,Aljayyoussi G,Tyrer HE,Gamble J,Hayward L,Guimaraes AF,Davies J,Waterhouse D,Cook DAN,Myhill LJ,Clare RH,Cassidy A,Steven A,Johnston KL,Ford L,Turner JD,Ward SA,Taylor MJ

更新日期：2018-01-08 00:00:00

abstract：:Two-photon polymerization (TPP) is capable of fabricating 3D structures with dimensions from sub-µm to a few hundred µm. As a direct laser writing (DLW) process, fabrication time of 3D TPP structures scale with the third order, limiting its use in large volume fabrication. Here, we report on a scalable fabrication met...

journal_title：Scientific reports

authors： Maibohm C,Silvestre OF,Borme J,Sinou M,Heggarty K,Nieder JB

更新日期：2020-05-26 00:00:00

abstract：:Molybdenum disulfide (MoS2) has been attracting much attentions due to its excellent electrical and optical properties. We report here the synthesis of large-scale and uniform MoS2 nanosheets with vertically standing morphology using chemical vapor deposition method. TEM observations clearly reveal the growth mechanis...

journal_title：Scientific reports

authors： Li H,Wu H,Yuan S,Qian H

更新日期：2016-02-18 00:00:00

abstract：:EU biodiversity conservation policy is based on the Habitats Directive (92/43/EC), which aims that habitat types and species of Community interest should reach 'favourable conservation status'. To this end, Member States are obliged to perform periodic assessment of species and habitat conservation status through biod...

journal_title：Scientific reports

authors： Kallimanis AS,Panitsa M,Dimopoulos P

更新日期：2017-08-21 00:00:00

abstract：:We have developed a plasma cell treatment device called Plasma-on-Chip that enables the real-time monitoring of a single cell culture during plasma treatment. The device consists of three parts: 1) microwells for cell culture, 2) a microplasma device for generating reactive oxygen and nitrogen species (RONS) for use i...

journal_title：Scientific reports

authors： Oh JS,Kojima S,Sasaki M,Hatta A,Kumagai S

更新日期：2017-02-08 00:00:00

abstract：:Enterovirus A71 (EV-A71), which belongs to the family Picornaviridae, can invade the central nervous system (CNS) and cause severe CNS complications or death. The EV-A71 antigen has been detected in the neurons in the brains of humans who died from EV-A71 infection. However, the effect of EV-A71 infection on human neu...

journal_title：Scientific reports

authors： Lin JY,Huang HI

更新日期：2020-09-17 00:00:00