Abstract：
:Respiratory Distress Syndrome (RDS) is the commonest diagnosis after premature birth. We aimed to audit clinical practices before and after introduction of a national guideline in Wales on RDS management. Anonymised, prospective data on all infants born at <34 weeks of gestation and cared for at one of the participating neonatal units in Wales were collected in two six-month time periods in 2015 and 2018. A national guideline was introduced in 2016 by the Wales Neonatal Network. Data collection included areas of antenatal management, delivery room stabilisation, invasive and non-invasive respiratory support, surfactant treatment and elements of supportive care. Univariate and multivariate methods were used to compare data between the two epochs. Comparing care before and after introduction of the national guideline, areas of significant improvement include use of targeted tidal volume ventilation, use of caffeine therapy, oxygen therapy post-surfactant and increasing early use of parenteral nutrition. Areas of poorer management included levels of positive end expiratory pressures and timing of introduction of enteral feeds. Little variation was seen between level two and three units, although gestational age was a significant independent variable for several practices, including delayed cord clamping, stabilisation with intubation, early enteral feeding and caffeine administration. A national guideline for management of RDS in Wales has significantly improved practice in several areas. However, despite a large volume of high-quality evidence and robust guidance, there remains a significant variation in some elements of best practice for RDS management. Further work should focus on education and training, especially for elements requiring cross-departmental work.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Course C,Chakraborty Mdoi
10.1038/s41598-020-60091-6subject
Has Abstractpub_date
2020-02-26 00:00:00pages
3536issue
1issn
2045-2322pii
10.1038/s41598-020-60091-6journal_volume
10pub_type
杂志文章abstract：:We present here a combined theoretical and experimental investigation on effective excitation of microcantilever by using photoacoustic waves. The photoacoustic waves arose from a vibrating Al foil induced by an intensity-modulated laser. We demonstrate that, superior to photothermal excitation, this new configuration...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19935
更新日期：2016-01-27 00:00:00
abstract：:Some herbivore-induced-plant volatiles (HIPVs) compounds are vital for the functioning of an ecosystem, by triggering multi-trophic interactions for natural enemies, plants and herbivores. However, the effect of these chemicals, which play a crucial role in regulating the multi-trophic interactions between plant-herbi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40494
更新日期：2017-01-12 00:00:00
abstract：:Grain boundary (GB) oxidation of proton-irradiated 304 nuclear grade stainless steel in primary water of pressurized water reactor was investigated. The investigation was conducted by studying microstructure of the oxide and oxide precursor formed at GB on an "atom-by-atom" basis by a combination of atom-probe tomogra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80600-x
更新日期：2021-01-14 00:00:00
abstract：:Immunosuppression is critical for tumor growth and metastasis as well as obstacle to effective immunotherapy. Here, we demonstrate that host deficiency in caveolin-2, a member of caveolin protein family, increases M1-polarized tumor-associated macrophage (TAM) and CD8 T cell infiltration into subcutaneously implanted ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55368-4
更新日期：2019-12-12 00:00:00
abstract：:During spring of 2009, a new influenza virus AH1N1 spread in the world causing acute respiratory illness and death, resulting in the first influenza pandemic since 1968. Blood levels of potentially-toxic and essential elements of 40 pneumonia and confirmed AH1N1 were evaluated against two different groups of controls,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01284
更新日期：2013-01-01 00:00:00
abstract：:The vast majority of antibody-drug conjugates (ADC) are prepared through amine-to-thiol conjugation. To date, N-Succinimidyl-4-(maleimidomethyl) cyclohexanecarboxylate (SMCC) has been one of the most frequently applied reagents for the preparation of ADC and other functional conjugates. However, SMCC-based conjugates ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30835
更新日期：2016-08-09 00:00:00
abstract：:An optical radon detection method is presented. Radon decay is directly measured by observing the secondary radiolumines cence light that alpha particles excite in air, and the selectivity of coincident photon detection is further enhanced with online pulse-shape analysis. The sensitivity of a demonstration device was...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21532
更新日期：2016-02-12 00:00:00
abstract：:Overuse of nitrogen (N) fertilizer has led to low N use efficiency (NUE) and high N loss in single rice cropping systems in southeast China. Application of controlled-release urea (CRU) is considered as an effective N fertilizer practice for improving crop yields and NUE. Here, field experiments were conducted during ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67110-6
更新日期：2020-06-26 00:00:00
abstract：:To face the great challenges of ensuring food security and environmental sustainability, agricultural production must be improved by high yield and high resource utilization efficiency (HYHE). We recently addressed this challenge and evaluated yield potential by surveying 735 farmers in 2008-2012 and then conducting 6...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-02338-3
更新日期：2017-05-18 00:00:00
abstract：:One of the hallmarks of cancers is their ability to develop resistance against therapeutic agents. Therefore, developing effective in vitro strategies to identify drug resistance remains of paramount importance for successful treatment. One of the ways cancer cells achieve drug resistance is through the expression of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56273-6
更新日期：2019-12-27 00:00:00
abstract：:Long non-coding RNAs (lncRNAs) have been implicated in human pathology, however, their role in colorectal carcinogenesis have not been fully elucidated. In the current study, whole-transcriptome analysis was performed in 3 pairs of colorectal cancer (CRC) and matched normal mucosa (NM) by RNA sequencing (RNA-seq). Fol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18407-6
更新日期：2018-01-12 00:00:00
abstract：:Formic acid (FA) has been used for decades to control Varroa destructor, one of the most important parasites of the western honey bee, Apis mellifera. The rather unselective molecular mode of action of FA and its possible effects on honeybees have long been a concern of beekeepers, as it has undesirable side effects t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79057-9
更新日期：2020-12-14 00:00:00
abstract：:Komagataeibacter nataicola is an acetic acid bacterium (AAB) that can produce abundant bacterial cellulose and tolerate high concentrations of acetic acid. To globally understand its fermentation characteristics, we present a high-quality complete genome sequence of K. nataicola RZS01. The genome consists of a 3,485,1...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04589-6
更新日期：2017-06-30 00:00:00
abstract：:We demonstrate application of the method of higher-order operators to nonlinear standard optomechanics. It is shown that a symmetry breaking in frequency shifts exists, corresponding to inequivalency of red and blue side-bands. This arises from nonlinear higher-order processes leading to inequal detunings. Similarly, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30068-7
更新日期：2018-08-01 00:00:00
abstract：:The human foot and ankle system is equipped with structures that can produce mechanical work through elastic (e.g., Achilles tendon, plantar fascia) or viscoelastic (e.g., heel pad) mechanisms, or by active muscle contractions. Yet, quantifying the work distribution among various subsections of the foot and ankle can ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15218-7
更新日期：2017-11-13 00:00:00
abstract：:Biomarkers for the progression of lung function in COPD are currently scarce. Plasma fetuin-B (FETUB) was identified by iTRAQ-based proteomics and was verified by ELISA in another group. Information regarding acute exacerbation (AE) was collected in a one-year follow-up programme. FETUB concentrations (1652 ± 427 ng/m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30045
更新日期：2016-07-22 00:00:00
abstract：:Heparin is a widely used anticoagulant which inhibits factor Xa and thrombin through potentiation of antithrombin. We recently identified that the nucleic acid stain SYTOX reacts with platelet polyphosphate due to molecular similarities, some of which are shared by heparin. We attempted to study heparin in flowing blo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54818-3
更新日期：2019-12-04 00:00:00
abstract：:Low-losses and directionality effects exhibited by High Refractive Index Dielectric particles make them attractive for applications where radiation direction control is relevant. For instance, isolated metallo-dielectric core-shell particles or aggregates (dimers) of High Refractive Index Dielectric particles have bee...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26359-8
更新日期：2018-05-22 00:00:00
abstract：:Even though a number of different in vitro fusion assays have been developed to analyze protein mediated fusion, they still only partially capture the essential features of the in vivo situation. Here we established an in vitro fusion assay that mimics the fluidity and planar geometry of the cellular plasma membrane t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12006
更新日期：2015-07-13 00:00:00
abstract：:The one-step nucleic acid amplification (OSNA) assay is a molecular procedure that can identify deposits of breast cancer (BC) cells in the sentinel lymph node (SLN). We examined the consistency of the OSNA assay with a classic hematoxylin-eosin (H&E)-based immunohistochemistry (IHC) study and evaluated how OSNA-based...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05743
更新日期：2014-07-18 00:00:00
abstract：:We are reporting a 3D printable composite paste having strong thixotropic rheology. The composite has been designed and investigated with highly conductive silver nanowires. The optimized electrical percolation threshold from both simulation and experiment is shown from 0.7 vol. % of silver nanowires which is signific...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03365-w
更新日期：2017-06-12 00:00:00
abstract：:Understanding the role of morphogen in activating its target genes, otherwise epigenetically repressed, during change in cell fate specification is a very fascinating yet relatively unexplored domain. Our in vivo loss-of-function genetic analyses reveal that specifically during ectopic eye formation, the morphogen Dec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27270
更新日期：2016-06-07 00:00:00
abstract：:Anxiety and depression are commonly found in patients with diabetes, but little is known about how the anxiety and depression symptoms of diabetes patients and the health-related quality of life (HRQoL) over time influence each other. Therefore, we conducted a survey among patients with diabetes (T1) and repeated the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57647-x
更新日期：2020-05-20 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-22369-8
更新日期：2018-03-06 00:00:00
abstract：:Oxytocin has a conserved role in regulating animal social behaviour including parental-offspring interactions. Recently an oxytocin-like neuropeptide, nematocin, and its cognate receptors have been identified in the nematode Caenorhabditis elegans. We provide evidence for a pheromone signal produced by C. elegans larv...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09350-7
更新日期：2017-08-31 00:00:00
abstract：:A wide network of interconnected areas was previously found in neuroimaging studies involving normal as well as pathological subjects; however literature seems to suffer from a lack of investigation in glucose metabolism behaviour under olfactory condition. Thus, the present work describe for the first time a pure olf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05146
更新日期：2014-06-03 00:00:00
abstract：:Abnormal cardiac fibrosis indicates cardiac dysfunction and poor prognosis in myocardial infarction (MI) patients. Many studies have demonstrated that the ubiquitin proteasome system (UPS) plays a significant role in the pathogenesis of fibrosis. Ubiquitin C-terminal hydrolase L1 (UCHL1), a member of the UPS, is relat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67746-4
更新日期：2020-06-30 00:00:00
abstract：:Exchange bias (EB) of magnetic nanoparticles (MNPs) in the nanoscale regime has been extensively studied by researchers, which have opened up a novel approach in tuning the magnetic anisotropy properties of magnetic nanoparticles (MNPs) in prospective application of biomedical research such as magnetic hyperthermia. I...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75669-3
更新日期：2020-10-29 00:00:00
abstract：:Human lactoferrin (hLF) is a valuable protein for pharmaceutical products and functional foods, and worldwide demand for this protein has steadily increased. However, large-scale recombinant human lactoferrin (rhLF) production using current animal bioreactor techniques is limited by the low expression of foreign prote...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11462-z
更新日期：2017-09-06 00:00:00
abstract：:The same copper phosphate catalysts were synthesized by obtaining the methods involving solid state as well as liquid state reactions in this work. And then the optimised p-n hybrid junction photocatalysts have been synthesized following the same solid/liquid reaction pathways. The synthesized copper phosphate photoca...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21239-7
更新日期：2018-02-13 00:00:00
