Abstract：
:A novel dinuclear Ir(III) complex 5 was discovered to be specific to G-quadruplex DNA, and was utilized in a label-free G-quadruplex-based detection platform for transcription factor activity. The principle of this assay was demonstrated by using HIF-1α as a model protein. Moreover, this HIF-1α detection assay exhibited potential use for biological sample analysis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lu L,Wang M,Mao Z,Kang TS,Chen XP,Lu JJ,Leung CH,Ma DLdoi
10.1038/srep22458subject
Has Abstractpub_date
2016-03-02 00:00:00pages
22458issn
2045-2322pii
srep22458journal_volume
6pub_type
杂志文章abstract：:The mammalian cochlea has historically resisted attempts at high-resolution, non-invasive imaging due to its small size, complex three-dimensional structure, and embedded location within the temporal bone. As a result, little is known about the relationship between an individual's cochlear pathology and hearing functi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33288
更新日期：2016-09-16 00:00:00
abstract：:The westerly wind burst (WWB) is an important triggering mechanism of El Niño and typically occurs in the western Pacific Ocean. The Fourier spectrum of the wind field over the western tropical Pacific is characterised by a large variety of peaks distributed from intra-seasonal to decadal time scales, suggesting that ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79655-7
更新日期：2021-01-13 00:00:00
abstract：:The systematics of Oriental freshwater mussels (Bivalvia: Unionidae) is poorly known. Here, we present an integrative revision of the genus Trapezoideus Simpson, 1900 to further understanding of freshwater mussel diversity in the region. We demonstrate that Trapezoideus as currently circumscribed is non-monophyletic, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39365-1
更新日期：2019-03-11 00:00:00
abstract：:Mid-infrared spectroscopy is of great importance in many areas and its integration with thin-film technology can economically enrich the functionalities of many existing devices. In this paper we propose a graphene-based ultra-compact spectrometer (several micrometers in size) that is compatible with complementary met...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32616
更新日期：2016-08-30 00:00:00
abstract：:Over the past few decades, two-dimensional (2D) and layered materials have emerged as new fields. Due to the zero-band-gap nature of graphene and the low photocatalytic performance of MoS2, more advanced semiconducting 2D materials have been prompted. As a result, semiconductor black phosphorus (BP) is a derived cutti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08691
更新日期：2015-03-03 00:00:00
abstract：:The Fukushima Daiichi nuclear power plant accident caused serious radiocesium (137Cs) contamination of the soil in multiple terrestrial ecosystems. Soil is a complex system where minerals, organic matter, and microorganisms interact with each other; therefore, an improved understanding of the interactions of 137Cs wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43499-7
更新日期：2019-05-07 00:00:00
abstract：:Directional replacement and directional non-replacement models are two alternative paradigms for community development in primary successional environments. The first model emphasizes turnover in species between early and late successional niches. The second emphasizes accumulation of additional diversity over time. T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26360
更新日期：2016-05-31 00:00:00
abstract：:Although cholecystectomy has been reported to be associated with increased risk of developing hepatocellular carcinoma (HCC), the association between cholecystectomy and prognosis of HCC patients underwent curative resection has never been examined. Through retrospective analysis of the data of 3933 patients underwent...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep28229
更新日期：2016-06-20 00:00:00
abstract：:The gene encoding the cytosolic β-glucosidase GBA3 shows pseudogenization due to a truncated allele (rs358231) that is polymorphic in humans. Since this enzyme is involved in the transformation of many plant β-glycosides, this particular case of gene loss may have been influenced by dietary adaptations during evolutio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68106-y
更新日期：2020-07-14 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-22369-8
更新日期：2018-03-06 00:00:00
abstract：:Boehmeria tricuspis includes sexually reproducing diploid and apomictic triploid individuals. Previously, we established that triploid B. tricuspis reproduces through obligate diplospory. To understand the molecular basis of apomictic development in B. tricuspis, we sequenced and compared transcriptomic profiles of th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46043
更新日期：2017-04-06 00:00:00
abstract：:Spontaneous isopeptide bond formation, a stabilizing posttranslational modification that can be found in gram-positive bacterial cell surface proteins, has previously been used to develop a peptide-peptide ligation technology that enables the polymerization of tagged-proteins catalyzed by SpyLigase. Here we adapted th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39291
更新日期：2016-12-16 00:00:00
abstract：:Divalent metal-ion transporter 1 (DMT1) has been found to play an important role in the iron metabolism and hemogenesis. However, little is known about the potential role of DMT1 in the pathogenesis of anemia from patients with inflammatory bowel disease (IBD). Herein, we investigated expression of DMT1 in the intesti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16344
更新日期：2015-11-17 00:00:00
abstract：:DNA methylation is an essential epigenetic marker associated with the silencing of gene expression. Although various genome-wide studies revealed aberrantly methylated gene targets as molecular biomarkers for early detection, the survival rate of lung cancer patients is still poor. In order to identify methylation-dri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42573
更新日期：2017-02-15 00:00:00
abstract：:Phthalates are commonly included as ingredients in personal care products such as cosmetics, shampoos and perfumes. Diethyl phthalate (DEP) has been found to be anti-androgenic and linked with adverse reproductive effects on males, but effects on females are poorly understood. We designed an integrative and translatio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63904-w
更新日期：2020-04-27 00:00:00
abstract：:The quest to 'forward-engineer' and fabricate biological machines remains a grand challenge. Towards this end, we have fabricated locomotive "bio-bots" from hydrogels and cardiomyocytes using a 3D printer. The multi-material bio-bot consisted of a 'biological bimorph' cantilever structure as the actuator to power the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00857
更新日期：2012-01-01 00:00:00
abstract：:Despite important progress, uncertainty persists regarding the ecological forces driving microbial community assembly. Here, we present the first study to use phylogenetic information to interpret the structure and diversity of diatom communities. We examined local phylogenetic divergence and beta- phylogenetic divers...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48125-0
更新日期：2019-08-12 00:00:00
abstract：:We quantitatively evaluated breast tumor movement and volume changes between magnetic resonance imaging (MRI) scans in prone and supine positions. Twenty-seven breast tumor patients who received neoadjuvant systemic therapy (NST) for breast-conserving surgery were studied. Before and after NST, MRI scans in prone and ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61802-9
更新日期：2020-03-17 00:00:00
abstract：:Elucidating arbuscular mycorrhizal (AM) fungal responses to elevation changes is critical to improve understanding of microbial function in ecosystems under global asymmetrical climate change scenarios. Here we examined AM fungal community in a two-year reciprocal translocation of vegetation-intact soil blocks along a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36606
更新日期：2016-11-09 00:00:00
abstract：:Nanoporous electrodes have received great attention because of their unique electrochemical properties. Here, the electrocatalytic oxygen evolution reaction (OER) activities at porous Pt layers with pore dimensions in the microporous range were examined. The OER activity of the porous Pt layers in acidic media increas...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15688-9
更新日期：2017-11-13 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, ranging from steatosis to non-alcoholic steatohepatitis (NASH). Recently, cerium oxide nanoparticles (CeO2NPs) have emerged as a new antioxidant agent with hepatoprotective properties in experimental liver disease. T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49262-2
更新日期：2019-09-06 00:00:00
abstract：:Bipolar disorder (BD) is a debilitating mental disorder that cannot be diagnosed by objective laboratory-based modalities. Our previous studies have independently used nuclear magnetic resonance (NMR)-based and gas chromatography-mass spectrometry (GC-MS)-based metabonomic methods to characterize the urinary metabolic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05855
更新日期：2014-07-28 00:00:00
abstract：:Influenza vaccines of H7N9 subtype are consistently less immunogenic in humans than vaccines developed for other subtypes. Although prior immunoinformatic analysis identified T-cell epitopes in H7 hemagglutinin (HA) which potentially enhance regulatory T cell response due to conservation with the human genome, the lin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01372-5
更新日期：2017-04-28 00:00:00
abstract：:Several lines of evidence indicate that Fibronectin Extra Domain A (EDA) promotes metastatic capacity of tumor cells by engaging cell surface α9β1 integrins. This interaction mediated by the C-C loop of EDA activates pro-oncogenic signaling pathways leading to epithelial to mesenchymal transition (EMT) of tumor cells,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37151
更新日期：2016-11-16 00:00:00
abstract：:A singular adaptive phenotype of a parthenogenetic insect species (Acyrthosiphon pisum) was selected in cold conditions and is characterized by a remarkable apparition of a greenish colour. The aphid pigments involve carotenoid genes well defined in chloroplasts and cyanobacteria and amazingly present in the aphid gen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00579
更新日期：2012-01-01 00:00:00
abstract：:In recent years, there has been an impressively fast technological progress in the development of highly efficient lead halide perovskite solar cells. However, the stability of perovskite films and respective solar cells is still an open point of concern and calls for advanced characterization methods. In this work, w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35973
更新日期：2016-10-27 00:00:00
abstract：:The Paleozoic Dniepr-Donets Basin in Belarus, Ukraine, and Russia forms a major hydrocarbon province. Although well- and seismic data have established a 20 km thick stratigraphy, field-studies of its sediments are scarce. The inverted Donbas segment (Ukraine) exposes the middle Carboniferous part of the basin's strati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09099
更新日期：2015-03-20 00:00:00
abstract：:Junctophilin-2 (JPH2) is a part of the junctional membrane complex that facilitates calcium-handling in the cardiomyocyte. Previously, missense variants in JPH2 have been linked to hypertrophic cardiomyopathy; however, pathogenic "loss of function" (LOF) variants have not been described. Family-based genetic analysis ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44987-6
更新日期：2019-06-21 00:00:00
abstract：:All models of evolution of human behaviour depend on the correct identification and interpretation of bone surface modifications (BSM) on archaeofaunal assemblages. Crucial evolutionary features, such as the origin of stone tool use, meat-eating, food-sharing, cooperation and sociality can only be addressed through co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24071-1
更新日期：2018-04-10 00:00:00
abstract：:The electric field control of functional properties is an important goal in oxide-based electronics. To endow devices with memory, ferroelectric gating is interesting, but usually weak compared to volatile electrolyte gating. Here, we report a very large ferroelectric field-effect in perovskite heterostructures combin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02834
更新日期：2013-10-03 00:00:00
