Visual salience of the stop signal affects the neuronal dynamics of controlled inhibition.

Abstract:

:The voluntary control of movement is often tested by using the countermanding, or stop-signal task that sporadically requires the suppression of a movement in response to an incoming stop-signal. Neurophysiological recordings in monkeys engaged in the countermanding task have shown that dorsal premotor cortex (PMd) is implicated in movement control. An open question is whether and how the perceptual demands inherent the stop-signal affects inhibitory performance and their underlying neuronal correlates. To this aim we recorded multi-unit activity (MUA) from the PMd of two male monkeys performing a countermanding task in which the salience of the stop-signals was modulated. Consistently to what has been observed in humans, we found that less salient stimuli worsened the inhibitory performance. At the neuronal level, these behavioral results were subtended by the following modulations: when the stop-signal was not noticeable compared to the salient condition the preparatory neuronal activity in PMd started to be affected later and with a less sharp dynamic. This neuronal pattern is probably the consequence of a less efficient inhibitory command useful to interrupt the neural dynamic that supports movement generation in PMd.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Pani P,Giarrocco F,Giamundo M,Montanari R,Brunamonti E,Ferraina S

doi

10.1038/s41598-018-32669-8

subject

Has Abstract

pub_date

2018-09-24 00:00:00

pages

14265

issue

1

issn

2045-2322

pii

10.1038/s41598-018-32669-8

journal_volume

8

pub_type

杂志文章
  • Segmentation of biological multivariate time-series data.

    abstract::Time-series data from multicomponent systems capture the dynamics of the ongoing processes and reflect the interactions between the components. The progression of processes in such systems usually involves check-points and events at which the relationships between the components are altered in response to stimuli. Det...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep08937

    authors: Omranian N,Mueller-Roeber B,Nikoloski Z

    更新日期:2015-03-11 00:00:00

  • MicroPattern: a web-based tool for microbe set enrichment analysis and disease similarity calculation based on a list of microbes.

    abstract::The microbiota colonized on human body is renowned as "a forgotten organ" due to its big impacts on human health and disease. Recently, microbiome studies have identified a large number of microbes differentially regulated in a variety of conditions, such as disease and diet. However, methods for discovering biologica...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep40200

    authors: Ma W,Huang C,Zhou Y,Li J,Cui Q

    更新日期:2017-01-10 00:00:00

  • Inhibition of hypoxia inducible factor-1α attenuates abdominal aortic aneurysm progression through the down-regulation of matrix metalloproteinases.

    abstract::Hypoxia inducible factor-1α (HIF-1α) pathway is associated with many vascular diseases, including atherosclerosis, arterial aneurysms, pulmonary hypertension and chronic venous diseases. Significant HIF-1α expression could be found at the rupture edge at human abdominal aortic aneurysm (AAA) tissues. While our initial...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep28612

    authors: Tsai SH,Huang PH,Hsu YJ,Peng YJ,Lee CH,Wang JC,Chen JW,Lin SJ

    更新日期:2016-07-01 00:00:00

  • Differential evolution algorithm based photonic structure design: numerical and experimental verification of subwavelength λ/5 focusing of light.

    abstract::Photonic structure designs based on optimization algorithms provide superior properties compared to those using intuition-based approaches. In the present study, we numerically and experimentally demonstrate subwavelength focusing of light using wavelength scale absorption-free dielectric scattering objects embedded i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30871

    authors: Bor E,Turduev M,Kurt H

    更新日期:2016-08-01 00:00:00

  • Early prediction of necrotizing pneumonia from mycoplasma pneumoniae pneumonia with large pulmonary lesions in children.

    abstract::To compare the different features of necrotizing pneumonia (NP) and non-NP (NNP) caused by Mycoplasma pneumoniae pneumonia (MPP) with large pulmonary lesions, and explore the predictor for NP to differentiate from MPP. A retrospective study of MPP patients with large pulmonary lesions hospitalized from January 2008 to...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76083-5

    authors: Zhou Y,Hu M,Ye B,Chen Z,Zhang Y

    更新日期:2020-11-04 00:00:00

  • Enhancing Intrinsic Stability of Hybrid Perovskite Solar Cell by Strong, yet Balanced, Electronic Coupling.

    abstract::In the past few years, the meteoric development of hybrid organic-inorganic perovskite solar cells (PSC) astonished the community. The efficiency has already reached the level needed for commercialization; however, the instability hinders its deployment on the market. Here, we report a mechanism to chemically stabiliz...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep30305

    authors: El-Mellouhi F,Bentria el T,Rashkeev SN,Kais S,Alharbi FH

    更新日期:2016-07-26 00:00:00

  • Bioinformatic discovery of a toxin family in Chryseobacterium piperi with sequence similarity to botulinum neurotoxins.

    abstract::Clostridial neurotoxins (CNTs), which include botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT), are the most potent toxins known to science and are the causative agents of botulism and tetanus, respectively. The evolutionary origins of CNTs and their relationships to other proteins remains an intriguing que...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37647-8

    authors: Mansfield MJ,Wentz TG,Zhang S,Lee EJ,Dong M,Sharma SK,Doxey AC

    更新日期:2019-02-07 00:00:00

  • Preferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulation.

    abstract::Autoimmune diseases mediated by a type of white blood cell-T lymphocytes-are currently treated using mainly broad-spectrum immunosuppressants that can lead to adverse side effects. Antioxidants represent an alternative approach for therapy of autoimmune disorders; however, dietary antioxidants are insufficient to play...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep33808

    authors: Huq R,Samuel EL,Sikkema WK,Nilewski LG,Lee T,Tanner MR,Khan FS,Porter PC,Tajhya RB,Patel RS,Inoue T,Pautler RG,Corry DB,Tour JM,Beeton C

    更新日期:2016-09-22 00:00:00

  • Meta-genomic analysis of toilet waste from long distance flights; a step towards global surveillance of infectious diseases and antimicrobial resistance.

    abstract::Human populations worldwide are increasingly confronted with infectious diseases and antimicrobial resistance spreading faster and appearing more frequently. Knowledge regarding their occurrence and worldwide transmission is important to control outbreaks and prevent epidemics. Here, we performed shotgun sequencing of...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11444

    authors: Nordahl Petersen T,Rasmussen S,Hasman H,Carøe C,Bælum J,Schultz AC,Bergmark L,Svendsen CA,Lund O,Sicheritz-Pontén T,Aarestrup FM

    更新日期:2015-07-10 00:00:00

  • Elemental and Molecular Segregation in Oil Paintings due to Lead Soap Degradation.

    abstract::The formation of Pb, Zn, and Cu carboxylates (soaps) has caused visible deterioration in hundreds of oil paintings dating from the 15th century to the present. Through transport phenomena not yet understood, free fatty acids in the oil binding medium migrate through the paint and react with pigments containing heavy m...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11525-1

    authors: Chen-Wiegart YK,Catalano J,Williams GJ,Murphy A,Yao Y,Zumbulyadis N,Centeno SA,Dybowski C,Thieme J

    更新日期:2017-09-14 00:00:00

  • Quasi-Static Pull-in: an Instability in Electrostatic Actuators.

    abstract::We identify a new instability in electrostatic actuators dubbed quasi-static pull-in. We report experimental evidence of the instability and study its characteristics in two types of micro actuators operating in ambient air. We found that the underlying mechanism is a fast-slow dynamic interaction between slowly-varyi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-61534-w

    authors: Al-Ghamdi MS,Khater ME,Abdel-Rahman EM,Nepomuceno EG

    更新日期:2020-03-19 00:00:00

  • 3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained.

    abstract::The potential of a spheroid tumor model composed of cells in different proliferative and metabolic states for the development of new anticancer strategies has been amply demonstrated. However, there is little or no information in the literature on the problems of reproducibility of data originating from experiments us...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep19103

    authors: Zanoni M,Piccinini F,Arienti C,Zamagni A,Santi S,Polico R,Bevilacqua A,Tesei A

    更新日期:2016-01-11 00:00:00

  • Effect of annealing on a pseudogap state in untwinned YBa2Cu3O7-δ single crystals.

    abstract::The effect of annealing both in the oxygen atmosphere and at room temperatures on physical properties such as the pseudogap (Δ*(T)) and excess conductivity (σ'(T)) of untwined YBa2Cu3O7-δ (YBCO) single crystal with a small deviation from oxygen stoichiometry is studied. It was revealed that as the charge carrier densi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45286-w

    authors: Solovjov AL,Petrenko EV,Omelchenko LV,Vovk RV,Goulatis IL,Chroneos A

    更新日期:2019-06-25 00:00:00

  • Driving forces of researchers mobility.

    abstract::Starting from the dataset of the publication corpus of the APS during the period 1955-2009, we reconstruct the individual researchers trajectories, namely the list of the consecutive affiliations for each scholar. Crossing this information with different geographic datasets we embed these trajectories in a spatial fra...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04860

    authors: Gargiulo F,Carletti T

    更新日期:2014-05-07 00:00:00

  • Asynchronous c-VEP communication tools-efficiency comparison of low-target, multi-target and dictionary-assisted BCI spellers.

    abstract::Keyboards and smartphones allow users to express their thoughts freely via manual control. Hands-free communication can be realized with brain-computer interfaces (BCIs) based on code-modulated visual evoked potentials (c-VEPs). Various variations of such spellers have been developed: Low-target systems, multi-target ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74143-4

    authors: Gembler FW,Benda M,Rezeika A,Stawicki PR,Volosyak I

    更新日期:2020-10-13 00:00:00

  • Water and Blood Repellent Flexible Tubes.

    abstract::A top-down scalable method to produce flexible water and blood repellent tubes is introduced. The method is based on replication of overhanging nanostructures from an aluminum tube template to polydimethylsiloxane (PDMS) via atomic layer deposition (ALD) assisted sacrificial etching. The nanostructured PDMS/titania tu...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16369-3

    authors: Hoshian S,Kankuri E,Ras RHA,Franssila S,Jokinen V

    更新日期:2017-11-22 00:00:00

  • Phenology, mobility and behaviour of the arcto-alpine species Boloria napaea in its arctic habitat.

    abstract::Arctic and alpine environments present extreme, but different, challenges to survival. We therefore studied the ecological adaptation of the arctic-alpine fritillary Boloria napaea in northern Sweden and compared these results with the eastern Alps. Using mark-release-recapture, we analysed phenology, mobility, activi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-40508-7

    authors: Ehl S,Holzhauer SIJ,Ryrholm N,Schmitt T

    更新日期:2019-03-07 00:00:00

  • Electro-echocardiographic Indices to Predict Cardiac Resynchronization Therapy Non-response on Non-ischemic Cardiomyopathy.

    abstract::Cardiac resynchronization therapy (CRT) threw lights on heart failure treatment, however, parts of patients showed nonresponse to CRT. Unfortunately, it lacks effective parameters to predict CRT non-response. In present study, we try to seek effective electro-echocardiographic predictors on CRT non-response. This is a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep44009

    authors: Yu Z,Chen X,Han F,Qin S,Li M,Wu Y,Su Y,Ge J

    更新日期:2017-03-10 00:00:00

  • Application of a Limit-Cycle Oscillator Model for Prediction of Circadian Phase in Rotating Night Shift Workers.

    abstract::Practical alternatives to gold-standard measures of circadian timing in shift workers are needed. We assessed the feasibility of applying a limit-cycle oscillator model of the human circadian pacemaker to estimate circadian phase in 25 nursing and medical staff in a field setting during a transition from day/evening s...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47290-6

    authors: Stone JE,Aubert XL,Maass H,Phillips AJK,Magee M,Howard ME,Lockley SW,Rajaratnam SMW,Sletten TL

    更新日期:2019-07-30 00:00:00

  • Expression of Female Sex Hormone Receptors, Connective Tissue Growth Factor and HER2 in Gallbladder Cancer.

    abstract::Gallbladder cancer (GBC) is a highly malignant tumor with poorly understood etiology. An insight into phenotypic features of this malignancy may add to the knowledge of its carcinogenesis and pave the way to new therapeutic approaches. We assessed the expression of female sex hormone receptors (ERα, ERβ, PR), connecti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-58777-y

    authors: Hryciuk B,Pęksa R,Bieńkowski M,Szymanowski B,Radecka B,Winnik K,Żok J,Cichowska N,Iliszko M,Duchnowska R

    更新日期:2020-02-05 00:00:00

  • Simultaneous Analysis of Secondary Structure and Light Scattering from Circular Dichroism Titrations: Application to Vectofusin-1.

    abstract::Circular Dichroism data are often decomposed into their constituent spectra to quantify the secondary structure of peptides or proteins but the estimation of the secondary structure content fails when light scattering leads to spectral distortion. If peptide-induced liposome self-association occurs, subtracting contro...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39450

    authors: Vermeer LS,Marquette A,Schoup M,Fenard D,Galy A,Bechinger B

    更新日期:2016-12-22 00:00:00

  • Utilization of the zebrafish model to unravel the harmful effects of biomass burning during Amazonian wildfires.

    abstract::Amazonian wildfires in 2019 have raised awareness about rainforest burning due to increased emissions of particulate matter and carbon. In the context of these emissions, by-products of lignin thermal degradation (i.e. methoxyphenols) are often neglected. Methoxyphenols entering the atmosphere may form intermediates w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-021-81789-1

    authors: Babić S,Čižmek L,Maršavelski A,Malev O,Pflieger M,Strunjak-Perović I,Popović NT,Čož-Rakovac R,Trebše P

    更新日期:2021-01-28 00:00:00

  • Thin films of formamidinium lead iodide (FAPI) deposited using aerosol assisted chemical vapour deposition (AACVD).

    abstract::Formamidinium lead iodide (CH(NH2)2PbI3, FAPI) thin films have been deposited on glass substrates at 150 °C using ambient pressure aerosol assisted chemical vapour deposition (AACVD). The films have been analysed by a range of techniques including powder X-ray diffraction (pXRD), scanning electron microscopy (SEM), en...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-79291-1

    authors: Alam F,Lewis DJ

    更新日期:2020-12-17 00:00:00

  • Corrigendum: Resisting majesty: Apis cerana, has lower antennal sensitivity and decreased attraction to queen mandibular pheromone than Apis mellifera.

    abstract::This corrects the article DOI: 10.1038/srep44640. ...

    journal_title:Scientific reports

    pub_type: 杂志文章,已发布勘误

    doi:10.1038/srep46872

    authors: Dong S,Wen P,Zhang Q,Li X,Tan K,Nieh J

    更新日期:2017-06-30 00:00:00

  • Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in adenosine generation and turn-over.

    abstract::Extracellular adenosine, generated via the concerted action of CD39 and CD73, contributes to T-cell differentiation and function. Adenosine concentrations are furthermore influenced by adenosine deaminase binding protein CD26. Because aberrant T-cell phenotypes had been reported in anti-neutrophil cytoplasmic auto-ant...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-12011-4

    authors: Kling L,Benck U,Breedijk A,Leikeim L,Heitzmann M,Porubsky S,Krämer BK,Yard BA,Kälsch AI

    更新日期:2017-09-15 00:00:00

  • High-efficiency exfoliation of large-area mono-layer graphene oxide with controlled dimension.

    abstract::In this work, we introduce a novel and facile method of exfoliating large-area, single-layer graphene oxide using a shearing stress. The shearing stress reactor consists of two concentric cylinders, where the inner cylinder rotates at controlled speed while the outer cylinder is kept stationary. We found that the form...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-16649-y

    authors: Park WK,Yoon Y,Song YH,Choi SY,Kim S,Do Y,Lee J,Park H,Yoon DH,Yang WS

    更新日期:2017-11-27 00:00:00

  • Assessment of BDNF serum levels as a diagnostic marker in children with autism spectrum disorder.

    abstract::There has been a significant increase in autism spectrum disorder (ASD) in the last decades that cannot be exclusively attributed to better diagnosis and an increase in the communication of new cases. Patients with ASD often show dysregulation of proteins associated with synaptic plasticity, notably brain-derived neur...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74239-x

    authors: Barbosa AG,Pratesi R,Paz GSC,Dos Santos MAAL,Uenishi RH,Nakano EY,Gandolfi L,Pratesi CB

    更新日期:2020-10-15 00:00:00

  • Skin-on-a-chip model simulating inflammation, edema and drug-based treatment.

    abstract::Recent advances in microfluidic cell cultures enable the construction of in vitro human skin models that can be used for drug toxicity testing, disease study. However, current in vitro skin model have limitations to emulate real human skin due to the simplicity of model. In this paper, we describe the development of '...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep37471

    authors: Wufuer M,Lee G,Hur W,Jeon B,Kim BJ,Choi TH,Lee S

    更新日期:2016-11-21 00:00:00

  • Effects of a contoured foot orthosis and flat insole on plantar pressure and tibial acceleration while walking in defence boots.

    abstract::This study investigated the effects of a contoured, prefabricated foot orthosis and a flat insole on plantar pressure and tibial acceleration while walking in defence boots. Twenty-eight adults walked along an 8-metre walkway in a: (i) defence boot (control condition), (ii) defence boot with a flat insole, and (iii) d...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35830-5

    authors: Bonanno DR,Ledchumanasarma K,Landorf KB,Munteanu SE,Murley GS,Menz HB

    更新日期:2019-02-08 00:00:00

  • Author Correction: Lithospheric mantle buoyancy: the role of tectonic convergence and mantle composition.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-020-57833-x

    authors: Boonma K,Kumar A,Garcia-Castellanos D,Jiménez-Munt I,Fernández M

    更新日期:2020-01-15 00:00:00