当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Kaempferol stimulates gene expression of low-density lipoprotein receptor through activation of Sp1 in cultured hepatocytes.

Kaempferol stimulates gene expression of low-density lipoprotein receptor through activation of Sp1 in cultured hepatocytes.

Abstract：

:A high level of plasma low-density lipoprotein (LDL) cholesterol is considered a risk factor for atherosclerosis. Because the hepatic LDL receptor (LDLR) is essential for clearing plasma LDL cholesterol, activation of LDLR is a promising therapeutic target for patients with atherosclerotic disease. Here we demonstrated how the flavonoid kaempferol stimulated the gene expression and activity of LDLR in HepG2 cells. The kaempferol-mediated stimulation of LDLR gene expression was completely inhibited by knockdown of Sp1 gene expression. Treatment of HepG2 cells with kaempferol stimulated the recruitment of Sp1 to the promoter region of the LDLR gene, as well as the phosphorylation of Sp1 on Thr-453 and Thr-739. Moreover, these kaempferol-mediated processes were inhibited in the presence of U0126, an ERK pathway inhibitor. These results suggest that kaempferol may increase the activity of Sp1 through stimulation of Sp1 phosphorylation by ERK1/2 and subsequent induction of LDLR expression and activity.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Ochiai A,Miyata S,Iwase M,Shimizu M,Inoue J,Sato R

doi

10.1038/srep24940

subject

Has Abstract

pub_date

2016-04-25 00:00:00

pages

24940

issn

2045-2322

pii

srep24940

journal_volume

6

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Aspirin might reduce the incidence of pancreatic cancer: A meta-analysis of observational studies.

    abstract：:Although there is evidence that non-steroidal anti-inflammatory drugs (NSAIDs) might be able to prevent pancreatic cancer, the findings from epidemiological studies have been inconsistent. In this paper, we conducted a meta-analysis of observational studies to examine this possibility. We searched PubMed and Embase fo...

    journal_title：Scientific reports

    pub_type： 杂志文章,meta分析

    doi：10.1038/srep15460

    authors： Zhang YP,Wan YD,Sun YL,Li J,Zhu RT

    更新日期：2015-10-21 00:00:00

  • Evaluating digestion efficiency in full-scale anaerobic digesters by identifying active microbial populations through the lens of microbial activity.

    abstract：:Anaerobic digestion is a common technology to biologically stabilize wasted solids produced in municipal wastewater treatment. Its efficiency is usually evaluated by calculating the reduction in volatile solids, which assumes no biomass growth associated with digestion. To determine whether this assumption is valid an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34090

    authors： Mei R,Narihiro T,Nobu MK,Kuroda K,Liu WT

    更新日期：2016-09-26 00:00:00

  • Principles and development of collagen-mediated tissue fusion induced by laser irradiation.

    abstract：:The mechanism underlying tissue fusion mediated by laser irradiation remains unclear. We clarify the mechanisms underlying laser-mediated tissue fusion using a novel model. Microscopic examinations of morphological changes within the adventitia of a bovine carotid artery and a collagen sheet prepared from bovine dermi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45486-4

    authors： Sasaki S,Ikeda T,Okihara SI,Nishimura S,Nakadate R,Saeki H,Oki E,Mori M,Hashizume M,Maehara Y

    更新日期：2019-06-28 00:00:00

  • Systematic biology analysis on photosynthetic carbon metabolism of maize leaf following sudden heat shock under elevated CO2.

    abstract：:Plants would experience more complex environments, such as sudden heat shock (SHS) stress combined with elevated CO2 in the future, and might adapt to this stressful condition by optimizing photosynthetic carbon metabolism (PCM). It is interesting to understand whether this acclimation process would be altered in diff...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-26283-x

    authors： Qu M,Chen G,Bunce JA,Zhu X,Sicher RC

    更新日期：2018-05-18 00:00:00

  • CD4+CD28null T Lymphocytes are Associated with the Development of Atrial Fibrillation after Elective Cardiac Surgery.

    abstract：:Post-operative atrial fibrillation (POAF) is postulated as a complex interaction of different pathogenic factors, suggesting inflammatory processes as a main trigger of this particular type of atrial fibrillation. Therefore, the study sought to assess the impact of cellular immunity on the development of POAF. Compari...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-018-28046-0

    authors： Sulzgruber P,Thaler B,Koller L,Baumgartner J,Pilz A,Steininger M,Schnaubelt S,Fleck T,Laufer G,Steinlechner B,Winter MP,Goliasch G,Wojta J,Niessner A

    更新日期：2018-06-25 00:00:00

  • Morphology of muscle attachment sites in the modern human hand does not reflect muscle architecture.

    abstract：:Muscle attachment sites (entheses) on dry bones are regularly used by paleontologists to infer soft tissue anatomy and to reconstruct behaviors of extinct organisms. This method is commonly applied to fossil hominin hand bones to assess their abilities to participate in Paleolithic stone tool behaviors. Little is know...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28353

    authors： Williams-Hatala EM,Hatala KG,Hiles S,Rabey KN

    更新日期：2016-06-23 00:00:00

  • Cholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection.

    abstract：:Immune responses are critical for defense against pathogens. However, prolonged viral infection can result in defective T cell immunity, leading to chronic viral infection. We studied immune activation in response to arenavirus infection during cholestasis using bile duct ligation (BDL). We monitored T cell responses,...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30627-y

    authors： Lang E,Pozdeev VI,Shinde PV,Xu HC,Sundaram B,Zhuang Y,Poschmann G,Huang J,Stühler K,Pandyra AA,Keitel V,Häussinger D,Lang KS,Lang PA

    更新日期：2018-08-15 00:00:00

  • Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion.

    abstract：:Neurotransmission and secretion of hormones involve a sequence of protein/lipid interactions with lipid turnover impacting on vesicle trafficking and ultimately fusion of secretory vesicles with the plasma membrane. We previously demonstrated that sphingosine, a sphingolipid metabolite, promotes formation of the SNARE...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-05948-z

    authors： Darios FD,Jorgacevski J,Flašker A,Zorec R,García-Martinez V,Villanueva J,Gutiérrez LM,Leese C,Bal M,Nosyreva E,Kavalali ET,Davletov B

    更新日期：2017-07-20 00:00:00

  • QTL mapping of cucumber fruit flesh thickness by SLAF-seq.

    abstract：:Cucumber is an agriculturally and economically important vegetable crop worldwide. Fruit flesh thickness is an important trait for cucumber and also a central determinant of yield, yet little is known about the underlying mechanism of this trait. In this study, bulked segregant analysis (BSA) combined with specific le...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep15829

    authors： Xu X,Lu L,Zhu B,Xu Q,Qi X,Chen X

    更新日期：2015-10-28 00:00:00

  • Characterisation of small molecule ligands 4CMTB and 2CTAP as modulators of human FFA2 receptor signalling.

    abstract：:Short chain fatty acids (SCFAs) are protective against inflammatory diseases. Free fatty acid receptor 2 (FFA2), is a target of SCFAs however, their selectivity for FFA2 over other FFA receptors is limited. This study aimed to functionally characterise 2-(4-chlorophenyl)-3-methyl-N-(thiazole-2-yl)butanamide (4CMTB) an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-36242-1

    authors： Schofield ZV,Croker D,Robertson AAB,Massey NL,Donovan C,Tee E,Edwards D,Woodruff TM,Halai R,Hansbro PM,Cooper MA

    更新日期：2018-12-13 00:00:00

  • Histone H4 acetylation required for chromatin decompaction during DNA replication.

    abstract：:Faithful DNA replication is a prerequisite for cell proliferation. Several cytological studies have shown that chromosome structures alter in the S-phase of the cell cycle. However, the molecular mechanisms behind the alteration of chromosome structures associated with DNA replication have not been elucidated. Here, w...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep12720

    authors： Ruan K,Yamamoto TG,Asakawa H,Chikashige Y,Kimura H,Masukata H,Haraguchi T,Hiraoka Y

    更新日期：2015-07-30 00:00:00

  • Fine-tuning the expression of target genes using a DDI2 promoter gene switch in budding yeast.

    abstract：:Tuned gene expression is crucial to the proper growth and response to the environmental changes of an organism. To enable tunable gene expression as designed is desirable in both scientific research and industrial application. Here, we introduce a novel promoter switching method based on the DDI2 promoter (PDDI2) that...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-49000-8

    authors： Wang Y,Zhang K,Li H,Xu X,Xue H,Wang P,Fu YV

    更新日期：2019-08-29 00:00:00

  • Communicative mind-reading in preverbal infants.

    abstract：:Pragmatic theories of communication assume that humans evolved a species-unique inferential capacity to express and recognize intentions via communicative actions. We show that 13-month-old non-verbal infants can interpret the turn-taking exchange of variable tone sequences between unfamiliar agents as indicative of c...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-27804-4

    authors： Tauzin T,Gergely G

    更新日期：2018-06-22 00:00:00

  • The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations.

    abstract：:Etomoxir (ETO) is a widely used small-molecule inhibitor of fatty acid oxidation (FAO) through its irreversible inhibitory effects on the carnitine palmitoyl-transferase 1a (CPT1a). We used this compound to evaluate the role of fatty acid oxidation in rapidly proliferating T cells following costimulation through the C...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24676-6

    authors： O'Connor RS,Guo L,Ghassemi S,Snyder NW,Worth AJ,Weng L,Kam Y,Philipson B,Trefely S,Nunez-Cruz S,Blair IA,June CH,Milone MC

    更新日期：2018-04-19 00:00:00

  • Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax.

    abstract：:Central to intrinsic apoptosis signaling is the release of cytochrome c from mitochondria, which depends on the pro-apoptotic effector proteins Bax, Bak or Bok. These pore-forming effector proteins share four Bcl-2 homology (BH) domains, a functionally essential and conserved sequence of hydrophobic amino acids in the...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-30603-6

    authors： Stehle D,Grimm M,Einsele-Scholz S,Ladwig F,Johänning J,Fischer G,Gillissen B,Schulze-Osthoff K,Essmann F

    更新日期：2018-08-20 00:00:00

  • Revised role for Hfq bacterial regulator on DNA topology.

    abstract：:Hfq is a pleiotropic regulator that mediates several aspects of bacterial RNA metabolism. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, usually via its interaction with small regulatory RNA. Besides these RNA-related functions, Hfq has also been described as one of the n...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-35060-9

    authors： Malabirade A,Partouche D,El Hamoui O,Turbant F,Geinguenaud F,Recouvreux P,Bizien T,Busi F,Wien F,Arluison V

    更新日期：2018-11-14 00:00:00

  • Discrimination of three Ephedra species and their geographical origins based on multi-element fingerprinting by inductively coupled plasma mass spectrometry.

    abstract：:Discrimination of species and geographical origins of traditional Chinese medicine (TCM) is essential to prevent adulteration and inferior problems. We studied Ephedra sinica Stapf, Ephedra intermedia Schrenk et C.A.Mey. and Ephedra przewalskii Bge. to investigate the relationship between inorganic element content and...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-28558-9

    authors： Ma X,Fan L,Mao F,Zhao Y,Yan Y,Tian H,Xu R,Peng Y,Sui H

    更新日期：2018-07-06 00:00:00

  • Multiple specialised goose-type lysozymes potentially compensate for an exceptional lack of chicken-type lysozymes in Atlantic cod.

    abstract：:Previous analyses of the Atlantic cod genome showed unique combinations of lacking and expanded number of genes for the immune system. The present study examined lysozyme activity, lysozyme gene distribution and expression in cod. Enzymatic assays employing specific bacterial lysozyme inhibitors provided evidence for ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep28318

    authors： Seppola M,Bakkemo KR,Mikkelsen H,Myrnes B,Helland R,Irwin DM,Nilsen IW

    更新日期：2016-06-21 00:00:00

  • Distinct forms of motion sensitivity impairments in Alzheimer's disease.

    abstract：:Motion sensitivity impairment in Alzheimer's disease (AD) is often characterized as elevated coherence threshold. An alternative way to measure motion sensitivity is the direction threshold, i.e., the minimal angle of motion direction that can be discriminated. So far, it is less clear whether and how the direction th...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-48942-3

    authors： Liu Y,Feng D,Wang H

    更新日期：2019-09-10 00:00:00

  • Enhancing the methanol tolerance of platinum nanoparticles for the cathode reaction of direct methanol fuel cells through a geometric design.

    abstract：:Mastery over the structure of nanoparticles might be an effective way to enhance their performance for a given application. Herein we demonstrate the design of cage-bell nanostructures to enhance the methanol tolerance of platinum (Pt) nanoparticles while remaining their catalytic activity for oxygen reduction reactio...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep16219

    authors： Feng Y,Ye F,Liu H,Yang J

    更新日期：2015-11-18 00:00:00

  • Investigation of Electric Field Induced Mixing in Silicon Micro Ring Resonators.

    abstract：:In this paper we present a detailed theoretical investigation of the electric field induced mixing effect, in which the up and down frequency-conversion processes are obtained by inducing an effective second order susceptibility via the periodic spatial distribution of reversed biased p-i-n junctions. The possibility ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03485-3

    authors： De Leonardis F,Soref RA,Passaro VMN

    更新日期：2017-06-13 00:00:00

  • Y-box protein-associated acidic protein (YBAP1/C1QBP) affects the localization and cytoplasmic functions of YB-1.

    abstract：:The Y-box proteins are multifunctional nucleic acid-binding proteins involved in various aspects of gene regulation. The founding member of the Y-box protein family, YB-1, functions as a transcription factor as well as a principal component of messenger ribonucleoprotein particles (mRNPs) in somatic cells. The nuclear...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-24401-3

    authors： Matsumoto K,Kose S,Kuwahara I,Yoshimura M,Imamoto N,Yoshida M

    更新日期：2018-04-18 00:00:00

  • Disorder versus two transport lifetimes in a strongly correlated electron liquid.

    abstract：:We report on angle-dependent measurements of the sheet resistances and Hall coefficients of electron liquids in SmTiO3/SrTiO3/SmTiO3 quantum well structures, which were grown by molecular beam epitaxy on (001) DyScO3. We compare their transport properties with those of similar structures grown on LSAT [(La0.3Sr0.7)(Al...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-10841-w

    authors： Marshall PB,Kim H,Stemmer S

    更新日期：2017-09-04 00:00:00

  • Experimental, quantum chemical and molecular dynamic simulations studies on the corrosion inhibition of mild steel by some carbazole derivatives.

    abstract：:Five selected carbazole derivatives, namely carbazole, 3,6-dibromocarbazole, 2-hydroxycarbazole, 1,2,3,4-tetrahydrocarbazole and 9-(2-ethylhexyl)carbazole-3,6-dicarboxaldehyde were investigated for their inhibitive effects on Desulfovibrio vulgaris (D. vulgaris) induced corrosion of mild steel and in 1 M HCl medium us...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02446-0

    authors： Nwankwo HU,Olasunkanmi LO,Ebenso EE

    更新日期：2017-05-26 00:00:00

  • Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation.

    abstract：:Complex associations exist between inflammation and thrombosis, with the inflammatory state tending to promote coagulation. Fibrinogen, an acute phase protein, has been shown to interact with the amyloidogenic ß-amyloid protein of Alzheimer's disease. However, little is known about the association between fibrinogen a...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-39056-x

    authors： Page MJ,Thomson GJA,Nunes JM,Engelbrecht AM,Nell TA,de Villiers WJS,de Beer MC,Engelbrecht L,Kell DB,Pretorius E

    更新日期：2019-02-28 00:00:00

  • Observation selection bias in contact prediction and its implications for structural bioinformatics.

    abstract：:Next Generation Sequencing is dramatically increasing the number of known protein sequences, with related experimentally determined protein structures lagging behind. Structural bioinformatics is attempting to close this gap by developing approaches that predict structure-level characteristics for uncharacterized prot...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36679

    authors： Orlando G,Raimondi D,Vranken WF

    更新日期：2016-11-18 00:00:00

  • Distinct climate influences on the risk of typhoid compared to invasive non-typhoid Salmonella disease in Blantyre, Malawi.

    abstract：:Invasive Salmonella diseases, both typhoid and invasive non-typhoidal Salmonella (iNTS), are seasonal bloodstream infections causing important morbidity and mortality globally in Africa. The reservoirs and transmission of both are not fully understood. We hypothesised that differences in the time-lagged relationships ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-56688-1

    authors： Thindwa D,Chipeta MG,Henrion MYR,Gordon MA

    更新日期：2019-12-30 00:00:00

  • Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury.

    abstract：:Although pneumococcal infection is a serious problem worldwide and has a high mortality rate, the molecular mechanisms underlying the lethality caused by pneumococcus remain elusive. Here, we show that BLT2, a G protein-coupled receptor for leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid (12-HHT), protects mice...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34560

    authors： Shigematsu M,Koga T,Ishimori A,Saeki K,Ishii Y,Taketomi Y,Ohba M,Jo-Watanabe A,Okuno T,Harada N,Harayama T,Shindou H,Li JD,Murakami M,Hoka S,Yokomizo T

    更新日期：2016-10-05 00:00:00

  • Tactile perception of randomly rough surfaces.

    abstract：:Most everyday surfaces are randomly rough and self-similar on sufficiently small scales. We investigated the tactile perception of randomly rough surfaces using 3D-printed samples, where the topographic structure and the statistical properties of scale-dependent roughness were varied independently. We found that the t...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-72890-y

    authors： Sahli R,Prot A,Wang A,Müser MH,Piovarči M,Didyk P,Bennewitz R

    更新日期：2020-09-25 00:00:00

  • Smoking Gun or Circumstantial Evidence? Comparison of Statistical Learning Methods using Functional Annotations for Prioritizing Risk Variants.

    abstract：:Although technology has triumphed in facilitating routine genome sequencing, new challenges have been created for the data-analyst. Genome-scale surveys of human variation generate volumes of data that far exceed capabilities for laboratory characterization. By incorporating functional annotations as predictors, stati...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep13373

    authors： Gagliano SA,Ravji R,Barnes MR,Weale ME,Knight J

    更新日期：2015-08-24 00:00:00