pH-responsive Virus-like Nanoparticles with Enhanced Tumour-targeting Ligands for Cancer Drug Delivery.

abstract：:We herein present a novel and sustainable technology for mercury recycling, with the maximum observed uptake capacity. Facile synthesis of the most efficient (~1.9 gg-1) nano-trap, made of montmorillonite-Fe-iron oxides, was performed to instantaneously remove mercury(II) ions from water. Elemental Hg was recovered fr...

journal_title：Scientific reports

authors： Ganguly M,Dib S,Ariya PA

更新日期：2018-11-02 00:00:00

abstract：:Osteochondral defects contain damage to both the articular cartilage and underlying subchon- dral bone, which remains a significant challenge in orthopedic surgery. Layered structure of bone, cartilage and the bone-cartilage interface must be taken into account in the case of biofabrication of the osteochondral (OC) i...

journal_title：Scientific reports

authors： Ayan B,Wu Y,Karuppagounder V,Kamal F,Ozbolat IT

更新日期：2020-08-04 00:00:00

abstract：:Organ regenerative therapy aims to reproduce fully functional organs to replace organs that have been lost or damaged as a result of disease, injury, or aging. For the fully functional regeneration of ectodermal organs, a concept has been proposed in which a bioengineered organ is developed by reproducing the embryoni...

journal_title：Scientific reports

authors： Asakawa K,Toyoshima KE,Ishibashi N,Tobe H,Iwadate A,Kanayama T,Hasegawa T,Nakao K,Toki H,Noguchi S,Ogawa M,Sato A,Tsuji T

更新日期：2012-01-01 00:00:00

abstract：:Cisplatin (CDDP) is potent anticancer agent used for several tumor types. Thymoquinone (TQ) is naturally occurring compound drawing great attention as anticancer and chemomodulator for chemotherapies. Herein, we studied the potential cytotoxicity of thymoquinone, CDDP and their combination against human oral squamous ...

journal_title：Scientific reports

authors： Alaufi OM,Noorwali A,Zahran F,Al-Abd AM,Al-Attas S

更新日期：2017-10-13 00:00:00

abstract：:Allicin (diallylthiosulfinate) is a defence molecule from garlic (Allium sativum L.) with broad antimicrobial activities in the low µM range against Gram-positive and -negative bacteria, including antibiotic resistant strains, and fungi. Allicin reacts with thiol groups and can inactivate essential enzymes. However, a...

journal_title：Scientific reports

authors： Leontiev R,Hohaus N,Jacob C,Gruhlke MCH,Slusarenko AJ

更新日期：2018-04-30 00:00:00

abstract：:Prognosis of patients with advanced sarcoma after progression from FDA approved therapies remains grim. In this study, clinical outcomes of 100 patients with advanced sarcoma who received treatment on novel targeted therapy trials were evaluated. Outcomes of interest included best response, clinical benefit rate, prog...

journal_title：Scientific reports

authors： Subbiah V,Hess KR,Khawaja MR,Wagner MJ,Tang C,Naing A,Fu S,Janku F,Piha-Paul S,Tsimberidou AM,Herzog CE,Ludwig JA,Patel S,Ravi V,Benjamin RS,Meric-Bernstam F,Hong DS

更新日期：2016-10-17 00:00:00

abstract：:The centrosome is the microtubule organizing center of human cells and facilitates a myriad of cellular functions including organization of the mitotic spindle to ensure faithful chromosome segregation during mitosis, cell polarization and migration, and primary cilia formation. A numerical increase in centrosomes, or...

journal_title：Scientific reports

authors： Denu RA,Burkard ME

更新日期：2020-07-17 00:00:00

abstract：:The values of physiological indices and the enzymes activities involved in the overwintering stage were studied in D. armandi larvae in each month from October 2014 to March 2015. The sorbitol, trehalose and glycerol values initially tended to increase as the ambient temperature decreased, before declining until the e...

journal_title：Scientific reports

authors： Wang J,Zhang RR,Gao GQ,Ma MY,Chen H

更新日期：2016-10-05 00:00:00

abstract：:On standard electrocardiogram (ECG) PQ interval is known to be moderately heart rate dependent, but no physiologic details of this dependency have been established. At the same time, PQ dynamics is a clear candidate for non-invasive assessment of atrial abnormalities including the risk of atrial fibrillation. We studi...

journal_title：Scientific reports

authors： Toman O,Hnatkova K,Smetana P,Huster KM,Šišáková M,Barthel P,Novotný T,Schmidt G,Malik M

更新日期：2020-02-13 00:00:00

abstract：:We have studied differentially regulated nuclear proteome of the clinical tissue specimens of glioblastoma (GBM, WHO Grade IV) and lower grades of gliomas (Grade II and III) using high resolution mass spectrometry- based quantitative proteomics approach. The results showed altered expression of many regulatory protein...

journal_title：Scientific reports

authors： Gupta MK,Polisetty RV,Sharma R,Ganesh RA,Gowda H,Purohit AK,Ankathi P,Prasad K,Mariswamappa K,Lakshmikantha A,Uppin MS,Sundaram C,Gautam P,Sirdeshmukh R

更新日期：2019-07-29 00:00:00

abstract：:Glucagon is a pancreatic hormone and increases the blood glucose levels. It may be incorporated in a dual hormone artificial pancreas, a device to automatically and continuously control blood glucose levels of individuals with diabetes. Artificial pancreas systems have been developed for use in the subcutaneous tissue...

journal_title：Scientific reports

authors： Åm MK,Dirnena-Fusini I,Fougner AL,Carlsen SM,Christiansen SC

更新日期：2020-08-13 00:00:00

abstract：:Oil palm (Elaeis guinensis Jacquin) is the most important source of vegetable oil and fat. Several linkage maps had been constructed using dominant and co-dominant markers to facilitate mapping of QTL. However, dominant markers are not easily transferable among different laboratories. We constructed a consensus linkag...

journal_title：Scientific reports

authors： Lee M,Xia JH,Zou Z,Ye J,Rahmadsyah,Alfiko Y,Jin J,Lieando JV,Purnamasari MI,Lim CH,Suwanto A,Wong L,Chua NH,Yue GH

更新日期：2015-02-04 00:00:00

abstract：:Mycobacterium spp. are renowned for being the causative agent of diseases like leprosy, Buruli ulcer and tuberculosis in human beings. With more and more mycobacterial genomes being sequenced, any knowledge generated from comparative genomic analysis would provide better insights into the biology, evolution, phylogeny...

journal_title：Scientific reports

authors： Choo SW,Ang MY,Dutta A,Tan SY,Siow CC,Heydari H,Mutha NV,Wee WY,Wong GJ

更新日期：2015-12-15 00:00:00

abstract：:Accounting for about 1.5 million deaths annually, lung cancer is the prevailing cause of cancer deaths worldwide, mostly associated with long-term smoking effects. Numerous small-animal studies are performed currently in order to better understand the pathogenesis of the disease and to develop treatment strategies. Wi...

journal_title：Scientific reports

authors： Scherer K,Yaroshenko A,Bölükbas DA,Gromann LB,Hellbach K,Meinel FG,Braunagel M,Berg JV,Eickelberg O,Reiser MF,Pfeiffer F,Meiners S,Herzen J

更新日期：2017-03-24 00:00:00

abstract：:Intracellular ion channels are involved in multiple signaling processes, including such crucial ones as regulation of cellular motility and fate. With 95% of the cellular membrane belonging to intracellular organelles, it is hard to overestimate the importance of intracellular ion channels. Multiple studies have been ...

journal_title：Scientific reports

authors： Shapovalov G,Ritaine A,Bidaux G,Slomianny C,Borowiec AS,Gordienko D,Bultynck G,Skryma R,Prevarskaya N

更新日期：2017-10-26 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Mathur P,Medicherla KM,Chaudhary S,Patel M,Bagali P,Suravajhala P

更新日期：2018-09-11 00:00:00

abstract：:An increase in mechanical load in the heart causes cardiac hypertrophy, either physiologically (heart development, exercise and pregnancy) or pathologically (high blood pressure and heart-valve regurgitation). Understanding cardiac hypertrophy is critical to comprehending the mechanisms of heart development and treatm...

journal_title：Scientific reports

authors： Yang H,Schmidt LP,Wang Z,Yang X,Shao Y,Borg TK,Markwald R,Runyan R,Gao BZ

更新日期：2016-02-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Hegde A,Suresh S,Mitra R

更新日期：2020-10-06 00:00:00

abstract：:Pharmacotherapy provision based on Nicotine Metabolite Ratio (NMR) status (slow/normal metabolism) may improve smoking cessation rates. However, it is unclear whether NMR status is consistent across patient characteristics and current treatment choice. Data come from 1,826 participants attending Stop Smoking Services ...

journal_title：Scientific reports

authors： Shahab L,Mortimer E,Bauld L,McGowan JA,McNeill A,Tyndale RF

更新日期：2017-12-14 00:00:00

abstract：:The photoactive Orange Carotenoid Protein (OCP) plays a key role in cyanobacterial photoprotection. In OCP, a single non-covalently bound keto-carotenoid molecule acts as a light intensity sensor, while the protein is responsible for forming molecular contacts with the light-harvesting antenna, the fluorescence of whi...

journal_title：Scientific reports

authors： Maksimov EG,Protasova EA,Tsoraev GV,Yaroshevich IA,Maydykovskiy AI,Shirshin EA,Gostev TS,Jelzow A,Moldenhauer M,Slonimskiy YB,Sluchanko NN,Friedrich T

更新日期：2020-07-16 00:00:00

abstract：:Previous reports suggest that offspring of mothers who smoke during pregnancy have greater risk of developing depression. However, it is unclear whether this is due to intrauterine effects. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) from the UK (N = 2,869), the Nord-Trøndelag health s...

journal_title：Scientific reports

authors： Taylor AE,Carslake D,de Mola CL,Rydell M,Nilsen TIL,Bjørngaard JH,Horta BL,Pearson R,Rai D,Galanti MR,Barros FC,Romundstad PR,Davey Smith G,Munafò MR

更新日期：2017-10-03 00:00:00

abstract：:Equine athletes have a pattern of exercise which is analogous to human athletes and the cardiovascular risks in both species are similar. Both species have a propensity for atrial fibrillation (AF), which is challenging to detect by ECG analysis when in paroxysmal form. We hypothesised that the proarrhythmic backgroun...

journal_title：Scientific reports

authors： Alexeenko V,Fraser JA,Bowen M,Huang CL,Marr CM,Jeevaratnam K

更新日期：2020-04-22 00:00:00

abstract：:This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004-2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH < 7.30) and severe (pH < 7.1). Two multiple logistic regression models ...

journal_title：Scientific reports

authors： Cherubini V,Skrami E,Ferrito L,Zucchini S,Scaramuzza A,Bonfanti R,Buono P,Cardella F,Cauvin V,Chiari G,D Annunzio G,Frongia AP,Iafusco D,Patera IP,Toni S,Tumini S,Rabbone I,Lombardo F,Carle F,Gesuita R,Diabetes St

更新日期：2016-12-19 00:00:00

abstract：:In this study, dye-sensitized solar cells (DSSCs) has been assembled with poly(1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VAc)) gel polymer electrolytes (GPEs) which have been incorporated with binary salt and an ionic liquid. The potential of this combination was studied and reported. The binary salt system GPEs w...

journal_title：Scientific reports

authors： Ming NH,Ramesh S,Ramesh K

更新日期：2016-06-08 00:00:00

abstract：:Trypanosoma cruzi is the etiological agent of Chagas disease, a neglected and emerging tropical disease, endemic to South America and present in non-endemic regions due to human migration. The MASP multigene family is specific to T. cruzi, accounting for 6% of the parasite's genome and plays a key role in immune evasi...

journal_title：Scientific reports

authors： De Pablos LM,Díaz Lozano IM,Jercic MI,Quinzada M,Giménez MJ,Calabuig E,Espino AM,Schijman AG,Zulantay I,Apt W,Osuna A

更新日期：2016-06-08 00:00:00

abstract：:Soluble starch synthase I (SSI) is a key enzyme in the biosynthesis of plant amylopectin. In this study, the gene named IbSSI, was cloned from sweet potato, an important starch crop. A high expression level of IbSSI was detected in the leaves and storage roots of the sweet potato. Its overexpression significantly incr...

journal_title：Scientific reports

authors： Wang Y,Li Y,Zhang H,Zhai H,Liu Q,He S

更新日期：2017-05-24 00:00:00

abstract：:In photosynthesis Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) catalyses the often rate limiting CO2-fixation step in the Calvin cycle. This makes Rubisco both the gatekeeper for carbon entry into the biosphere and a target for functional improvement to enhance photosynthesis and plant growth. Encumbering...

journal_title：Scientific reports

authors： Wilson RH,Alonso H,Whitney SM

更新日期：2016-03-01 00:00:00

abstract：:Virtual planning of open cranial vault reconstruction is used to simulate and define an pre-operative plan for craniosynostosis surgery. However, virtual planning techniques are subjective and dependent on the experience and preferences of the surgical team. To develop an objective automated 3D pre-operative planning ...

journal_title：Scientific reports

authors： Tolhuisen ML,de Jong GA,van Damme RJM,van der Heijden F,Delye HHK

更新日期：2018-02-20 00:00:00

abstract：:Antigens from Mycobacterium tuberculosis (M.tb), have been shown to stimulate human B cell responses to unrelated recall antigens in vitro. However, it is not known whether natural M.tb infection or whether vaccination with, Mycobacterium bovis BCG, has a similar effect. This study investigated the effects of M.tb inf...

journal_title：Scientific reports

authors： Kimuda SG,Andia-Biraro I,Sebina I,Egesa M,Nalwoga A,Smith SG,Bagaya BS,Levin J,Elliott AM,Raynes JG,Cose S

更新日期：2020-08-31 00:00:00

abstract：:Bacterial NhaB Na+/H+ exchangers belonging to the Ion Transporter superfamily are poorly characterized in contrast to Na+/H+ exchangers of the Cation Proton Antiporter superfamily which have NhaA from Escherichia coli as a prominent member. For a more detailed understanding of the intricacies of the exchanger's transp...

journal_title：Scientific reports

authors： Patiño-Ruiz M,Fendler K,Călinescu O

更新日期：2019-10-28 00:00:00