Physiologic heart rate dependency of the PQ interval and its sex differences.


:On standard electrocardiogram (ECG) PQ interval is known to be moderately heart rate dependent, but no physiologic details of this dependency have been established. At the same time, PQ dynamics is a clear candidate for non-invasive assessment of atrial abnormalities including the risk of atrial fibrillation. We studied PQ heart rate dependency in 599 healthy subjects (aged 33.5 ± 9.3 years, 288 females) in whom drug-free day-time 12-lead ECG Holters were available. Of these, 752,517 ECG samples were selected (1256 ± 244 per subject) to measure PQ and QT intervals and P wave durations. For each measured ECG sample, 5-minute history of preceding cardiac cycles was also obtained. Although less rate dependent than the QT intervals (36 ± 19% of linear slopes), PQ intervals were found to be dependent on underlying cycle length in a highly curvilinear fashion with the dependency significantly more curved in females compared to males. The PQ interval also responded to the heart rate changes with a delay which was highly sex dependent (95% adaptation in females and males after 114.9 ± 81.1 vs 65.4 ± 64.3 seconds, respectively, p < 0.00001). P wave duration was even less rate dependent than the PQ interval (9 ± 10% of linear QT/RR slopes). Rate corrected P wave duration was marginally but significantly shorter in females than in males (106.8 ± 8.4 vs 110.2 ± 7.9 ms, p < 0.00001). In addition to establishing physiologic standards, the study suggests that the curvatures and adaptation delay of the PQ/cycle-length dependency should be included in future non-invasive studies of atrial depolarizations.


Sci Rep


Scientific reports


Toman O,Hnatkova K,Smetana P,Huster KM,Šišáková M,Barthel P,Novotný T,Schmidt G,Malik M




Has Abstract


2020-02-13 00:00:00












  • Whole genome sequencing of a banana wild relative Musa itinerans provides insights into lineage-specific diversification of the Musa genus.

    abstract::Crop wild relatives are valuable resources for future genetic improvement. Here, we report the de novo genome assembly of Musa itinerans, a disease-resistant wild banana relative in subtropical China. The assembled genome size was 462.1 Mb, covering 75.2% of the genome (615.2Mb) and containing 32, 456 predicted protei...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wu W,Yang YL,He WM,Rouard M,Li WM,Xu M,Roux N,Ge XJ

    更新日期:2016-08-17 00:00:00

  • Remote monitoring of building oscillation modes by means of real-time Mid Infrared Digital Holography.

    abstract::Non-destructive measurements of deformations are a quite common application of holography but due to the intrinsic limits in the interferometric technique, those are generally confined only to small targets and in controlled environment. Here we present an advanced technique, based on Mid Infrared Digital Holography (...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Poggi P,Locatelli M,Pugliese E,Delle Donne D,Lacanna G,Meucci R,Ripepe M

    更新日期:2016-04-01 00:00:00

  • Publisher Correction: Natural and directed antigenic drift of the H1 influenza virus hemagglutinin stalk domain.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Anderson CS,Ortega S,Chaves FA,Clark AM,Yang H,Topham DJ,DeDiego ML

    更新日期:2018-03-06 00:00:00

  • A RANKL mutant used as an inter-species vaccine for efficient immunotherapy of osteoporosis.

    abstract::Anti-cytokine therapeutic antibodies have been demonstrated to be effective in the treatment of several auto-immune disorders. However, The problems in antibody manufacture and the immunogenicity caused by multiple doses of antibodies inspire people to use auto-cytokine as immunogen to induce anti-cytokine antibodies....

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Liu C,Zhao Y,He W,Wang W,Chen Y,Zhang S,Ma Y,Gohda J,Ishida T,Walter TS,Owens RJ,Stuart DI,Ren J,Gao B

    更新日期:2015-09-28 00:00:00

  • Effects of pirfenidone targeting the tumor microenvironment and tumor-stroma interaction as a novel treatment for non-small cell lung cancer.

    abstract::Targeting cancer-associated fibroblasts (CAFs), as well as the crosstalk between stroma and cancer cells, could be of value in managing cancers. Pirfenidone (PFD) is an anti-fibrotic agent for idiopathic pulmonary fibrosis. This study aimed to investigate the possibility that PFD might exert an anti-tumor effect throu...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Fujiwara A,Funaki S,Fukui E,Kimura K,Kanou T,Ose N,Minami M,Shintani Y

    更新日期:2020-07-02 00:00:00

  • The effect of anxiety on brain activation patterns in response to inspiratory occlusions: an fMRI study.

    abstract::Respiratory sensations such as breathlessness are prevalent in many diseases and are amplified by increased levels of anxiety. Cortical activation in response to inspiratory occlusions in high- and low-anxious individuals was found different in previous studies using the respiratory-related evoked potential method. Ho...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chan PS,Wu YT,Hsu AL,Li CW,Wu CW,von Leupoldt A,Hsu SC

    更新日期:2019-10-21 00:00:00

  • Reconstruction of noisy images via stochastic resonance in nematic liquid crystals.

    abstract::We employ nematic liquid crystals as the nonlinear medium to recover noisy images via stochastic resonance, in which nonlinear coupling allows signals to grow at the expense of noise. The process is theoretically analyzed and the cross-correlation is numerically calculated. It is found that the quality of output image...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Feng X,Liu H,Huang N,Wang Z,Zhang Y

    更新日期:2019-03-08 00:00:00

  • Mirror-backed Dark Alumina: A Nearly Perfect Absorber for Thermoelectronics and Thermophotovotaics.

    abstract::We present here a broadband, wide-angle, and polarization-independent nearly perfect absorber consisting of mirror-backed nanoporous alumina. By electrochemically anodizing the disordered multicomponent aluminum and properly tailoring the thickness and air-filling fraction of nanoporous alumina, according to the Maxwe...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Farhat M,Cheng TC,Le KQ,Cheng MM,Bağcı H,Chen PY

    更新日期:2016-01-28 00:00:00

  • An investigation into non-covalent functionalization of a single-walled carbon nanotube and a graphene sheet with protein G:A combined experimental and molecular dynamics study.

    abstract::Investigation of non-covalent interaction of hydrophobic surfaces with the protein G (PrG) is necessary due to their frequent utilization in immunosensors and ELISA. It has been confirmed that surfaces, including carbonous-nanostructures (CNS) could orient proteins for a better activation. Herein, PrG interaction with...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ebrahim-Habibi MB,Ghobeh M,Mahyari FA,Rafii-Tabar H,Sasanpour P

    更新日期:2019-02-04 00:00:00

  • Photoluminescent organisms: how to make fungi glow through biointegration with lanthanide metal-organic frameworks.

    abstract::We show that filamentous fungi can emit green or red light after the accumulation of particulate lanthanide metal-organic frameworks over the cell wall. These new biohybrids present photoluminescence properties that are unaffected by the components of the cell wall. In addition, the fungal cells internalise lanthanide...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Rosário J,da Luz LL,Geris R,Ramalho JGS,da Silva AF,Júnior SA,Malta M

    更新日期:2019-05-13 00:00:00

  • Harvesting more grain zinc of wheat for human health.

    abstract::Increasing grain zinc (Zn) concentration of cereals for minimizing Zn malnutrition in two billion people represents an important global humanitarian challenge. Grain Zn in field-grown wheat at the global scale ranges from 20.4 to 30.5 mg kg-1, showing a solid gap to the biofortification target for human health (40 mg ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Chen XP,Zhang YQ,Tong YP,Xue YF,Liu DY,Zhang W,Deng Y,Meng QF,Yue SC,Yan P,Cui ZL,Shi XJ,Guo SW,Sun YX,Ye YL,Wang ZH,Jia LL,Ma WQ,He MR,Zhang XY,Kou CL,Li YT,Tan DS,Cakmak I,Zhang FS,Zou CQ

    更新日期:2017-08-01 00:00:00

  • Zn1-xTex Ovonic Threshold Switching Device Performance and its Correlation to Material Parameters.

    abstract::We have experimentally demonstrated a strong correlation between the electrical properties of Zn1-xTex Ovonic threshold switching (OTS) selector device and the material properties analysed by X-ray diffraction (XRD), spectroscopic ellipsometry, and X-ray photoelectron spectroscopy (XPS). The correlation and the key ma...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Koo Y,Hwang H

    更新日期:2018-08-07 00:00:00

  • Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation.

    abstract::Low socioeconomic status (SES) is associated with earlier onset of age-related chronic conditions and reduced life-expectancy, but the underlying biomolecular mechanisms remain unclear. Evidence of DNA-methylation differences by SES suggests a possible association of SES with epigenetic age acceleration (AA). We inves...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Fiorito G,Polidoro S,Dugué PA,Kivimaki M,Ponzi E,Matullo G,Guarrera S,Assumma MB,Georgiadis P,Kyrtopoulos SA,Krogh V,Palli D,Panico S,Sacerdote C,Tumino R,Chadeau-Hyam M,Stringhini S,Severi G,Hodge AM,Giles GG,Mar

    更新日期:2017-11-24 00:00:00

  • Deletion of metal transporter Zip14 (Slc39a14) produces skeletal muscle wasting, endotoxemia, Mef2c activation and induction of miR-675 and Hspb7.

    abstract::Skeletal muscle represents the largest pool of body zinc, however, little is known about muscle zinc homeostasis or muscle-specific zinc functions. Zip14 (Slc39a14) was the most highly expressed zinc transporter in skeletal muscle of mice in response to LPS-induced inflammation. We compared metabolic parameters of ske...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Kim J,Aydemir TB,Jimenez-Rondan FR,Ruggiero CH,Kim MH,Cousins RJ

    更新日期:2020-03-04 00:00:00

  • PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease.

    abstract::Alcoholic liver disease (ALD) causes significant morbidity and mortality, and pharmacological treatment options are limited. In this study, we evaluated the PCSK9 inhibitor alirocumab, a monoclonal antibody that robustly reduces low-density lipoprotein cholesterol (LDL-C), for the treatment of ALD using a rat model of...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lee JS,Mukhopadhyay P,Matyas C,Trojnar E,Paloczi J,Yang YR,Blank BA,Savage C,Sorokin AV,Mehta NN,Vendruscolo JCM,Koob GF,Vendruscolo LF,Pacher P,Lohoff FW

    更新日期:2019-11-20 00:00:00

  • Development of a rapid and economic in vivo electrocardiogram platform for cardiovascular drug assay and electrophysiology research in adult zebrafish.

    abstract::Zebrafish is a popular and favorable model organism for cardiovascular research, with an increasing number of studies implementing functional assays in the adult stage. For example, the application of electrocardiography (ECG) in adult zebrafish has emerged as an important tool for cardiac pathophysiology, toxicity, a...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lin MH,Chou HC,Chen YF,Liu W,Lee CC,Liu LY,Chuang YJ

    更新日期:2018-10-30 00:00:00

  • Amorphous Carbon Dots and their Remarkable Ability to Detect 2,4,6-Trinitrophenol.

    abstract::Apparently mundane, amorphous nanostructures of carbon have optical properties which are as exotic as their crystalline counterparts. In this work we demonstrate a simple and inexpensive mechano-chemical method to prepare bulk quantities of self-passivated, amorphous carbon dots. Like the graphene quantum dots, the wa...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Siddique AB,Pramanick AK,Chatterjee S,Ray M

    更新日期:2018-06-27 00:00:00

  • Vertical-type two-dimensional hole gas diamond metal oxide semiconductor field-effect transistors.

    abstract::Power semiconductor devices require low on-resistivity and high breakdown voltages simultaneously. Vertical-type metal-oxide-semiconductor field-effect transistors (MOSFETs) meet these requirements, but have been incompleteness in diamond. Here we show vertical-type p-channel diamond MOSFETs with trench structures and...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Oi N,Inaba M,Okubo S,Tsuyuzaki I,Kageura T,Onoda S,Hiraiwa A,Kawarada H

    更新日期:2018-07-13 00:00:00

  • Evaluation of short interval cortical inhibition and intracortical facilitation from the dorsolateral prefrontal cortex in patients with schizophrenia.

    abstract::GABAergic and glutamatergic dysfunction in the dorsolateral prefrontal cortex (DLPFC) are thought to be the core pathophysiological mechanisms of schizophrenia. Recently, we have established a method to index these functions from the DLPFC using the paired transcranial magnetic stimulation (TMS) paradigms of short int...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Noda Y,Barr MS,Zomorrodi R,Cash RFH,Farzan F,Rajji TK,Chen R,Daskalakis ZJ,Blumberger DM

    更新日期:2017-12-06 00:00:00

  • Appropriate reference region selection of 18F-florbetaben and 18F-flutemetamol beta-amyloid PET expressed in Centiloid.

    abstract::The Centiloid (CL) is a method for standardizing amyloid beta (Aβ) quantification through different ligands and methods. To find the most appropriate reference region to reduce the variance in the Aβ CL unit between 18F-florbetaben (FBB) and 18F-flutemetamol (FMM), we conducted head-to-head comparisons from 56 partici...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Cho SH,Choe YS,Park S,Kim YJ,Kim HJ,Jang H,Kim SJ,Kim JP,Jung YH,Kim BC,Na DL,Moon SH,Seo SW

    更新日期:2020-09-11 00:00:00

  • Nano silica diaphragm in-fiber cavity for gas pressure measurement.

    abstract::We demonstrate an ultrahigh-sensitivity gas pressure sensor based on the Fabry-Perot interferometer employing a fiber-tip diaphragm-sealed cavity. The cavity is comprised of a silica capillary and ultrathin silica diaphragm with a thickness of 170 nm, with represents the thinnest silica diaphragm fabricated thus far b...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Liu S,Wang Y,Liao C,Wang Y,He J,Fu C,Yang K,Bai Z,Zhang F

    更新日期:2017-04-11 00:00:00

  • Conformations and molecular interactions of poly-γ-glutamic acid as a soluble microbial product in aqueous solutions.

    abstract::Soluble microbial products (SMPs) are of significant concern in the natural environment and in engineered systems. In this work, poly-γ-glutamic acid (γ-PGA), which is predominantly produced by Bacillus sp., was investigated in terms of pH-induced conformational changes and molecular interactions in aqueous solutions;...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Wang LL,Chen JT,Wang LF,Wu S,Zhang GZ,Yu HQ,Ye XD,Shi QS

    更新日期:2017-10-06 00:00:00

  • Changes in diving behaviour and habitat use of provisioned whale sharks: implications for management.

    abstract::Whale shark (Rhincodon typus) tourism is increasingly popular at predictable aggregations around the world, but only a few use provisioning to ensure close interactions. Understanding the effects of provisioning on the behaviour of this endangered species is critical to manage this growing industry. We recorded the di...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Araujo G,Labaja J,Snow S,Huveneers C,Ponzo A

    更新日期:2020-10-12 00:00:00

  • Composite materials with enhanced dimensionless Young's modulus and desired Poisson's ratio.

    abstract::We have designed a new type of composite materials which not only has a Young's modulus much larger than the Voigt limit, but also is always nearly isotropic. Moreover, its Poisson's ratio can be designed at a desired value, e.g. positive, or negative, or zero. We have also demonstrated that structural hierarchy can h...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhu HX,Fan TX,Zhang D

    更新日期:2015-09-11 00:00:00

  • Stable semiconductor black phosphorus (BP)@titanium dioxide (TiO2) hybrid photocatalysts.

    abstract::Over the past few decades, two-dimensional (2D) and layered materials have emerged as new fields. Due to the zero-band-gap nature of graphene and the low photocatalytic performance of MoS2, more advanced semiconducting 2D materials have been prompted. As a result, semiconductor black phosphorus (BP) is a derived cutti...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lee HU,Lee SC,Won J,Son BC,Choi S,Kim Y,Park SY,Kim HS,Lee YC,Lee J

    更新日期:2015-03-03 00:00:00

  • Author Correction: A global mass budget for positively buoyant macroplastic debris in the ocean.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Lebreton L,Egger M,Slat B

    更新日期:2020-01-30 00:00:00

  • Straight and rigid flagellar hook made by insertion of the FlgG specific sequence into FlgE.

    abstract::The bacterial flagellar hook connects the helical flagellar filament to the rotary motor at its base. Bending flexibility of the hook allows the helical filaments to form a bundle behind the cell body to produce thrust for bacterial motility. The hook protein FlgE shows considerable sequence and structural similaritie...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Hiraoka KD,Morimoto YV,Inoue Y,Fujii T,Miyata T,Makino F,Minamino T,Namba K

    更新日期:2017-04-21 00:00:00

  • A Silk Fibroin Bio-Transient Solution Processable Memristor.

    abstract::Today's electronic devices are fabricated using highly toxic materials and processes which limits their applications in environmental sensing applications and mandates complex encapsulation methods in biological and medical applications. This paper proposes a fully resorbable high density bio-compatible and environmen...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yong J,Hassan B,Liang Y,Ganesan K,Rajasekharan R,Evans R,Egan G,Kavehei O,Li J,Chana G,Nasr B,Skafidas E

    更新日期:2017-11-07 00:00:00

  • Silicon-Nanographite Aerogel-Based Anodes for High Performance Lithium Ion Batteries.

    abstract::To increase the energy storage density of lithium-ion batteries, silicon anodes have been explored due to their high capacity. One of the main challenges for silicon anodes are large volume variations during the lithiation processes. Recently, several high-performance schemes have been demonstrated with increased life...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Phadatare M,Patil R,Blomquist N,Forsberg S,Örtegren J,Hummelgård M,Meshram J,Hernández G,Brandell D,Leifer K,Sathyanath SKM,Olin H

    更新日期:2019-10-10 00:00:00

  • Strong plasmonic enhancement of biexciton emission: controlled coupling of a single quantum dot to a gold nanocone antenna.

    abstract::Multiexcitonic transitions and emission of several photons per excitation comprise a very attractive feature of semiconductor quantum dots for optoelectronics applications. However, these higher-order radiative processes are usually quenched in colloidal quantum dots by Auger and other nonradiative decay channels. To ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Matsuzaki K,Vassant S,Liu HW,Dutschke A,Hoffmann B,Chen X,Christiansen S,Buck MR,Hollingsworth JA,Götzinger S,Sandoghdar V

    更新日期:2017-02-14 00:00:00