Abstract:
:Improving the prevention efficacy of health screening campaigns by increasing their attendance rate represents a challenge that calls for new strategies. This paper analyzes the response to a Pap test screening campaign of 155,000 women over the last decade. Using a mathematical model of statistical physics origins we derive a quantitative estimate of the mutual influence between participating groups. Different scenarios and possible actions are studied from the cost-benefit perspective. The performance of alternative strategies to improve participation are forecasted and compared. The results show that the standard strategies with incentives concentrated toward the low participating groups are outperformed by those toward pivotal groups with higher influence power. Our method provides a flexible tool useful to support policy maker decisions while complying with ethical regulations on privacy and confidentiality.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Burioni R,Contucci P,Fedele M,Vernia C,Vezzani Adoi
10.1038/srep09904subject
Has Abstractpub_date
2015-04-23 00:00:00pages
9904issn
2045-2322pii
srep09904journal_volume
5pub_type
杂志文章abstract::Polymer electrolyte membranes (PEM) and Pt-based catalysts are two crucial components which determine the properties and price of fuel cells. Even though, PEM faces problem of fuel crossover in liquid fuel cells such as direct methanol fuel cell (DMFC) and direct borohydride fuel cell (DBFC), which lowers power output...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00567
更新日期:2012-01-01 00:00:00
abstract::Structural isomers, molecules having the same chemical formula but with atoms bonded in different order, are hard to identify using conventional spectroscopy and mass spectrometry. They exhibit virtually indistinguishable mass spectra when ionized by electrons. Laser mass spectrometry based on photoionization of the i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22055-9
更新日期:2018-02-28 00:00:00
abstract::Asymmetric cell divisions are required for cellular diversity and defects can lead to altered daughter cell fates and numbers. In a genetic screen for C. elegans mutants with defects in dopaminergic head neuron specification or differentiation, we isolated a new allele of the transcription factor HAM-1 [HSN (Hermaphro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04375-4
更新日期:2017-06-28 00:00:00
abstract::Practical application of superhydrophobic surfaces is limited by the fragility of nanoscale asperities. Combining chemical etching and anodization, microscale pits and nanoscale pores, instead of the micro and nano protrusions on traditional superhydrophobic surfaces mimicking Lutos leaves, were fabricated on commerci...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20933
更新日期:2016-02-08 00:00:00
abstract::Dehydroascorbate reductase (DHAR) is a key enzyme involved in the recycling of ascorbate, which catalyses the glutathione (GSH)-dependent reduction of oxidized ascorbate (dehydroascorbate, DHA). As a result, DHAR regenerates a pool of reduced ascorbate and detoxifies reactive oxygen species (ROS). In previous experime...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19498
更新日期:2016-01-18 00:00:00
abstract::Bismuth has long been a prototypical system for investigating phase transformations and melting at high pressure. Despite decades of experimental study, however, the lattice-level response of Bi to rapid (shock) compression and the relationship between structures occurring dynamically and those observed during slow (s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-35260-3
更新日期:2018-11-16 00:00:00
abstract::Acoustic standing wave devices offer excellent potential applications in biological sciences for drug delivery, cell manipulation and tissue engineering. However, concerns have been raised about possible destructive effects on cells due to the applied acoustic field, in addition to other produced secondary factors. He...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65241-4
更新日期:2020-05-22 00:00:00
abstract::Epithelial-Mesenchymal Transition (EMT) is a biological program that plays key roles in various developmental and pathological processes. Although much work has been done on signaling pathways and transcription factors regulating EMT, the epigenetic regulation of EMT remains not well understood. Histone variants have ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19364-4
更新日期:2018-01-16 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) patients are at higher risk of developing lung cancer and its metastasis, but no suitable biomarker has been reported for differential diagnosis of these patients. Levels of serum biomarkers (VEGF, IL-8, MMP-9 and MMP-2) were analyzed in these patients, which were compared ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36065
更新日期:2016-11-04 00:00:00
abstract::We tested the hypothesis that epigenetic mechanisms in the brain and the immune system are associated with chronic pain. Genome-wide DNA methylation assessed in 9 months post nerve-injury (SNI) and Sham rats, in the prefrontal cortex (PFC) as well as in T cells revealed a vast difference in the DNA methylation landsca...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep19615
更新日期:2016-01-28 00:00:00
abstract::Changes in immune and coagulation systems and possible viral spread through the blood-brain barrier have been described in SARS-CoV-2 infection. In this study, we evaluated the possible retinal involvement and ocular findings in severe COVID-19 pneumonia patients. A cross-sectional study was conducted on 46 patients a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-74446-6
更新日期:2020-10-15 00:00:00
abstract::Understanding mechanisms mediating tumor metastasis is crucial for diagnostic and therapeutic targeting. Here, we take advantage of a transparent embryonic zebrafish xenograft model (eZXM) to visualize and track metastatic cells in real time using selective plane illumination microscopy (SPIM) for up to 30 h. Injected...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69956-2
更新日期:2020-08-06 00:00:00
abstract::People mimic each other's actions and postures during everyday interactions. It is widely believed this mimicry acts as a social glue, leading to increased rapport. We present two studies using virtual reality to rigorously test this hypothesis. In Study 1, 50 participants interacted with two avatars who either mimick...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35295
更新日期:2016-10-14 00:00:00
abstract::Scaling up atmospheric pressure glow discharge to large volume is desirable for low-temperature plasma applications. In this paper, an approach to generate a glow discharge in a planar shape with a fairly large volume is proposed in atmospheric pressure air through utilizing a direct-current excited rod array electrod...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03007-1
更新日期:2017-06-01 00:00:00
abstract::Sweet sorghum bagasse (SSB) is a promising raw material for silage fermentation due to its high residual nutritive, but the efficient fermentation strategy of SSB has not been reported yet. This study evaluated the effects of microbial inoculant on the fermentation quality, chemical composition and microbial community...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-57628-0
更新日期:2020-01-21 00:00:00
abstract::A p-i-n junction diode constructed by the locally doped network of single-walled carbon nanotubes (SWNTs) was investigated. In this diode, the two opposite ends of the SWNT-network channel were selectively doped by triethyloxonium hexachloroantimonate (OA) and polyethylenimine (PEI) to obtain the air-stable p- and n-t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23319
更新日期:2016-03-21 00:00:00
abstract::Competing phenomena in low dimensional systems can generate exotic electronic phases, either through symmetry breaking or a non-trivial topology. In two-dimensional (2D) systems, the interplay between superfluidity, disorder and repulsive interactions is especially fruitful in this respect although both the exact natu...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35834
更新日期:2016-10-27 00:00:00
abstract::A comprehensive identification of sphingoid bases and ceramides in wild Cordyceps was performed by integrating a sequential chromatographic enrichment procedure and an UHPLC-ultrahigh definition-Q-TOF-MS based sphingolipidomic approach. A total of 43 sphingoid bases and 303 ceramides were identified from wild Cordycep...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38641
更新日期:2016-12-14 00:00:00
abstract::5-hydroxymethylation (5-hmC) is an epigenetic modification on DNA that results from the conversion of 5-methylcytosine by Ten-Eleven Translocation (TET) proteins. 5-hmC is widely present in the brain and is subjected to dynamic regulation during development and upon neuronal activity. It was recently shown to be invol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-19806-z
更新日期:2018-01-26 00:00:00
abstract::In the surface-enhanced fluorescence (SEF) process, it is well known that the plasmonic nanostructure can enhance the light emission of fluorescent emitters. With the help of atomic force microscopy, a hybrid system consisting of a fluorescent nanodiamond and a gold nanoparticle was assembled step-by-step for in situ ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-22019-z
更新日期:2018-02-26 00:00:00
abstract::Investigating cytokines in tear fluid and saliva may offer valuable information for understanding the pathogenesis of primary Sjögren's syndrome (pSS). Cytokine profiles in both tear fluid and saliva of pSS patients, non-Sjögren's syndrome (non-SS) subjects with sicca symptoms, and healthy controls without sicca compl...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43714-5
更新日期:2019-05-13 00:00:00
abstract::The mechanism by which the HIV-1 MPER epitope is recognized by the potent neutralizing antibody 10E8 at membrane interfaces remains poorly understood. To solve this problem, we have optimized a 10E8 peptide epitope and analyzed the structure and binding activities of the antibody in membrane and membrane-like environm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38177
更新日期:2016-12-01 00:00:00
abstract::Carcinoembryonic antigen (CEA) is the only blood based protein biomarker at present, used for preoperative screening of advanced colorectal cancer (CRC) patients to determine the appropriate curative treatments and post-surveillance screening for tumour recurrence. Current diagnostics for CRC detection have several li...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80354-6
更新日期:2021-01-12 00:00:00
abstract::Human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) is biologically distinct from HPV-negative HNSCC. Outside of HPV-status, few tumor-intrinsic variables have been identified that correlate to improved survival. As part of exploratory analysis into the trace elemental composition of orop...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53268-1
更新日期:2019-11-18 00:00:00
abstract::Successful communication is critical to the fitness of individuals and maintenance of populations, but less is known regarding the social contexts and reactions to scent marking by other individuals in solitary carnivores, including pumas. We evaluated the responses of resident male pumas to visitation and scent marki...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27257
更新日期:2016-06-02 00:00:00
abstract::The Saccharomyces cerevisiae kinesin-5 Cin8 performs essential mitotic functions in spindle assembly and anaphase B spindle elongation. Recent work has shown that Cin8 is a bi-directional motor which moves towards the minus-end of microtubules (MTs) under high ionic strength (IS) conditions and changes directionality ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25597
更新日期:2016-05-24 00:00:00
abstract::Combining chemotherapy and targeted therapies has resulted in an enhanced survival in metastatic colorectal cancer (mCRC) patients. However, the result of this palliative treatment in patients with metachronous peritoneal carcinomatosis (PC) remains unknown. The current population-based study aims to investigate the u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18632
更新日期:2015-12-21 00:00:00
abstract::Although the perception of faces depends on low-level neuronal processes, it is also affected by high-level social processes. Faces from a social in-group, such as people of a similar age, receive more in-depth processing and are processed holistically. To explore whether own-age biases affect subconscious face percep...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-018-31129-7
更新日期:2018-08-23 00:00:00
abstract::We introduce multi-gradients including Laplace pressure gradient, wettable gradient and wettable different gradient on a high adhesion surface via special wedge-pattern and improved anodic oxidation method. As a result of the cooperative effect mentioned above, controlled directional motion of a droplet on a high adhe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45687
更新日期:2017-04-03 00:00:00
abstract::Haemodialysis effectively removes small solutes and smaller-sized middle molecules from the blood; however, the clearance of larger middle molecules, which have been associated with negative effects, is poor. The novel medium cut-off (MCO) dialysis membrane has larger pore sizes and a more open structure than other hi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43161-2
更新日期:2019-05-01 00:00:00