Conserved miR-26b enhances ovarian granulosa cell apoptosis through HAS2-HA-CD44-Caspase-3 pathway by targeting HAS2.

abstract：:Riverine and atmospheric inputs are often considered as the main terrestrial sources of dissolved inorganic nitrogen (DIN), phosphorus (DIP), and silicon (DSi) in the ocean. However, the fluxes of nutrients via submarine groundwater discharge (SGD) often exceed riverine inputs in different local and regional scale set...

journal_title：Scientific reports

authors： Cho HM,Kim G,Kwon EY,Moosdorf N,Garcia-Orellana J,Santos IR

更新日期：2018-02-05 00:00:00

abstract：:Contact heat evoked potentials (CHEPs) have become an acknowledged research tool in the assessment of the integrity of the nociceptive system and gained importance in the diagnostic work-up of patients with suspected small fiber neuropathy. For the latter, normative values for CHEP amplitude and latency are indispensa...

journal_title：Scientific reports

authors： Rosner J,Hostettler P,Scheuren PS,Sirucek L,Rinert J,Curt A,Kramer JLK,Jutzeler CR,Hubli M

更新日期：2018-07-20 00:00:00

abstract：:TP53 mutation (i.e., loss of normal-p53) may evoke epithelial-mesenchymal transition (EMT), which was previously attributed to loss of certain miRNAs. However, not all epithelial cells undergo EMT upon TP53 mutation, and the p53-miRNA axis may not fully explain p53 function in epithelial integrity. We here show two mo...

journal_title：Scientific reports

authors： Oikawa T,Otsuka Y,Onodera Y,Horikawa M,Handa H,Hashimoto S,Suzuki Y,Sabe H

更新日期：2018-01-25 00:00:00

abstract：:The continuous search for natural products that attenuate age-related losses has increasingly gained notice; among them, those applicable for skin care have drawn significant attention. The bioester generated from the Chenopodium quinoa's oil is a natural-origin ingredient described to produce replenishing skin effect...

journal_title：Scientific reports

authors： Camillo-Andrade AC,Santos MDM,Fischer JSG,Swinka BB,Bosquetti B,Schuck DC,Pincerati MR,Lorencini M,Carvalho PC

更新日期：2020-11-10 00:00:00

abstract：:Asthma is characterized by airway inflammation, mucus secretion, remodeling and hyperresponsiveness (AHR). Recent research has established the bronchodilatory effect of bitter taste receptor (TAS2R) agonists in various models. Comprehensive pre-clinical studies aimed at establishing effectiveness of TAS2R agonists in ...

journal_title：Scientific reports

authors： Sharma P,Yi R,Nayak AP,Wang N,Tang F,Knight MJ,Pan S,Oliver B,Deshpande DA

更新日期：2017-04-11 00:00:00

abstract：:Remote photoplethysmography (PPG) is an optical measurement technique with established applications in vital signs monitoring. Recently, the consensual understanding of blood volume variations (BVVs) as the origin of PPG signals was challenged, raising validity concerns about the remote SpO2 methodology. Recognizing t...

journal_title：Scientific reports

authors： Moço AV,Stuijk S,de Haan G

更新日期：2018-05-31 00:00:00

abstract：:Sample pooling enabled by dedicated indexes is a common strategy for cost-effective and robust high-throughput sequencing. Index misassignment leading to mutual contamination between pooled samples has however been described as a general problem of the latest Illumina sequencing instruments utilizing exclusion amplifi...

journal_title：Scientific reports

authors： Vodák D,Lorenz S,Nakken S,Aasheim LB,Holte H,Bai B,Myklebost O,Meza-Zepeda LA,Hovig E

更新日期：2018-03-28 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute to hepatic fibrosis, but the role of BMP signaling in the development of NAFLD is unclear. In this study, treatment with either of two BMP inhibitors reduced hepa...

journal_title：Scientific reports

authors： Thayer TE,Lino Cardenas CL,Martyn T,Nicholson CJ,Traeger L,Wunderer F,Slocum C,Sigurslid H,Shakartzi HR,O'Rourke C,Shelton G,Buswell MD,Barnes H,Neitzel LR,Ledsky CD,Li JP,Burke MF,Farber-Eger E,Perrien DS,Kumar R,

更新日期：2020-06-19 00:00:00

abstract：:The mechanical behavior of a single phase (fcc) Al0.3CoCrFeNi high-entropy alloy (HEA) was studied in the low and high strain-rate regimes. The combination of multiple strengthening mechanisms such as solid solution hardening, forest dislocation hardening, as well as mechanical twinning leads to a high work hardening ...

journal_title：Scientific reports

authors： Li Z,Zhao S,Diao H,Liaw PK,Meyers MA

更新日期：2017-02-17 00:00:00

abstract：:IL-37 is a novel pro-angiogenic cytokine that potently promotes endothelial cell activation and pathological angiogenesis in our previous study, but the mechanisms behind the pro-angiogenic effect of IL-37 are less well understood. Extending our observations, we found that TGF-β interacts with IL-37, and potently enha...

journal_title：Scientific reports

authors： Zhao M,Hu Y,Jin J,Yu Y,Zhang S,Cao J,Zhai Y,Wei R,Shou J,Cai W,Liu S,Yang X,Xu GT,Yang J,Corry DB,Su SB,Liu X,Yang T

更新日期：2017-07-21 00:00:00

abstract：:Alumina toughened zirconia (ATZ) and zirconia toughened alumina (ZTA) are currently the materials of choice to meet the need for tough, strong, and bioinert ceramics for medical devices. However, the mechanical properties of ZrO2/Al2O3 dispersion ceramics could be considerably increased by reducing the corresponding g...

journal_title：Scientific reports

authors： Bartolomé JF,Smirnov A,Kurland HD,Grabow J,Müller FA

更新日期：2016-02-05 00:00:00

abstract：:Tinnitus (phantom auditory perception associated with hearing loss) can seriously affect wellbeing. Its neural substrate is unknown however it has been linked with abnormal activity in auditory pathways. Though no cure currently exists, repetitive transcranial magnetic stimulation (rTMS) has been shown to reduce tinni...

journal_title：Scientific reports

authors： Mulders WH,Vooys V,Makowiecki K,Tang AD,Rodger J

更新日期：2016-12-01 00:00:00

abstract：:Virus pseudotyping is a useful and safe technique for studying entry of emerging strains of influenza virus. However, few studies have compared different reassortant combinations in pseudoparticle systems, or compared entry kinetics of native viruses and their pseudotyped analogs. Here, vesicular stomatitis virus (VSV...

journal_title：Scientific reports

authors： Hsu HL,Millet JK,Costello DA,Whittaker GR,Daniel S

更新日期：2016-10-18 00:00:00

abstract：:Colorectal cancer (CRC) treatment is associated with a high morbidity which may result in a reduced health-related quality of life (HRQoL). The pre-operative measurement of handgrip strength (HGS) might be a tool to predict the patient's outcome after CRC surgery. The aim of this study was to evaluate the association ...

journal_title：Scientific reports

authors： van Heinsbergen M,Konsten JL,Bours MJL,Bouvy ND,Weijenberg MP,Janssen-Heijnen ML

更新日期：2020-08-03 00:00:00

abstract：:Keloid is the abnormal wound healing puzzled by the aggressive growth and high recurrence rate due to its unrevealed key pathogenic mechanism. MicroRNAs contribute to a series of biological processes including epithelial-mesenchymal transition (EMT) and cells stemness involved in fibrotic disease. Here, using microRNA...

journal_title：Scientific reports

authors： Yan L,Cao R,Liu Y,Wang L,Pan B,Lv X,Jiao H,Zhuang Q,Sun X,Xiao R

更新日期：2016-09-06 00:00:00

abstract：:Japan has often been viewed as an Asian country that possesses a genetically homogenous community. The basis for partitioning the country into prefectures has largely been geographical, although cultural and linguistic differences still exist between some of the districts/prefectures, especially between Okinawa and th...

journal_title：Scientific reports

authors： Saw WY,Liu X,Khor CC,Takeuchi F,Katsuya T,Kimura R,Nabika T,Ohkubo T,Tabara Y,Yamamoto K,Yokota M,Japanese Genome Variation Consortium.,Teo YY,Kato N

更新日期：2015-12-09 00:00:00

abstract：:FcRn mediates recycling and transcytosis of IgG and albumin in various cell types. The MHC-class-I-like protein of the FcRn heterodimer is encoded by FCGRT. Few determinants of variable FCGRT expression in humans have been identified so far. In this study, we investigated the presence of DNA methylation in regulatory ...

journal_title：Scientific reports

authors： Cejas RB,Ferguson DC,Quiñones-Lombraña A,Bard JE,Blanco JG

更新日期：2019-06-17 00:00:00

abstract：:As part of efforts to reduce pressure on the Amazon and other biomes, one approach considered by Brazilian authorities and scientists is more intensive use of the soils of the interior of the northeast of the country, which are generally sandy, with low contents of organic matter and low water holding capacity and are...

journal_title：Scientific reports

authors： Batista EMCC,Shultz J,Matos TTS,Fornari MR,Ferreira TM,Szpoganicz B,de Freitas RA,Mangrich AS

更新日期：2018-07-16 00:00:00

abstract：:This present paper was focused on the manufacture of activated carbon (AC) and its application in the electrokinetic remediation (EKR) technology on removal of the heavy metals (HMs) from the municipal solid waste incineration fly ash. AC was produced from Neosinocalamus affinis (NF) by chemical activation with H3PO4 ...

journal_title：Scientific reports

authors： Liu K,Huang T,Huang X,Yu L,Muhammad F,Jiao B,Li D

更新日期：2016-12-21 00:00:00

abstract：:Studies have reported that neck and/or shoulder pain (NSP) was prevalent and a non-ignorable occupational health problem in healthcare providers. Considering data deficiency on NSP, we aimed to investigate the prevalence and sick leave absence of NSP among public hospital workers in Shandong, China and to explore the ...

journal_title：Scientific reports

authors： Dong H,Zhang Q,Liu G,Shao T

更新日期：2020-07-23 00:00:00

abstract：:Recently, the use of a liquid biopsy has shown promise in monitoring tumor burden. While point mutations have been extensively studied, chromosomal rearrangements have demonstrated greater tumor specificity. Such rearrangements can be identified in the tumor and subsequently detected in the plasma of patients using qu...

journal_title：Scientific reports

authors： Harris FR,Kovtun IV,Smadbeck J,Multinu F,Jatoi A,Kosari F,Kalli KR,Murphy SJ,Halling GC,Johnson SH,Liu MC,Mariani A,Vasmatzis G

更新日期：2016-07-20 00:00:00

abstract：:The metal-to-insulator transition (MIT) closest to room temperature of 68-70 °C as shown by vanadium oxide (VO2), compared with other transition metal oxides, makes it a potential candidate for smart window coating. We have successfully fabricated a potential smart window device after the optimum design of a multilaye...

journal_title：Scientific reports

authors： Behera MK,Williams LC,Pradhan SK,Bahoura M

更新日期：2020-02-04 00:00:00

abstract：:Automatic release and vertical transferring of silicon/silicon oxide nanowire arrays with a high integrity are demonstrated by an Ag-assisted ammonia etching method. By adding a water steaming step between Ag-assisted HF/H2O2 and ammonia etching to form a SiOx protective layer sheathing Si nanowires, we can tune the c...

journal_title：Scientific reports

authors： Wu L,Li S,He W,Teng D,Wang K,Ye C

更新日期：2014-02-03 00:00:00

abstract：:Plant litter is an important component in wetland ecosystems, and the role of plant litter decomposition is considered to be important for wetland ecosystem functions and services. However, the consequences of litter inputs have seldom been experimentally tested in real ecosystems such as constructed wetlands (CWs). T...

journal_title：Scientific reports

authors： Ping Y,Pan X,Li W,Wang J,Cui L

更新日期：2019-09-25 00:00:00

abstract：:Vocal expression of emotions has been suggested to be conserved throughout evolution. However, since vocal indicators of emotions have never been compared between closely related species using similar methods, it remains unclear whether this is the case. Here, we investigated vocal indicators of emotional valence (neg...

journal_title：Scientific reports

authors： Maigrot AL,Hillmann E,Anne C,Briefer EF

更新日期：2017-08-18 00:00:00

abstract：:We describe a spin wave modulator - spintronic device aimed to control spin wave propagation by an electric field. The modulator consists of a ferromagnetic film serving as a spin wave bus combined with a synthetic multiferroic comprising piezoelectric and magnetostrictive materials. Its operation is based on the stre...

journal_title：Scientific reports

authors： Balinskiy M,Chavez AC,Barra A,Chiang H,Carman GP,Khitun A

更新日期：2018-07-18 00:00:00

abstract：:Inhibitors of PD-1 signaling have revolutionized cancer therapy. PD-1 and PD-L1 antibodies have been approved for the treatment of cancer. To date, therapeutic PD-1 inhibitors have not been compared in a functional assay. We used an efficient T cell reporter platform to evaluate the efficacy of five clinically used PD...

journal_title：Scientific reports

authors： De Sousa Linhares A,Battin C,Jutz S,Leitner J,Hafner C,Tobias J,Wiedermann U,Kundi M,Zlabinger GJ,Grabmeier-Pfistershammer K,Steinberger P

更新日期：2019-08-07 00:00:00

abstract：:Rejuvenation is the configurational excitation of amorphous materials and is one of the more promising approaches for improving the deformability of amorphous metals that usually exhibit macroscopic brittle fracture modes. Here, we propose a method to control the level of rejuvenation through systematic thermal proces...

journal_title：Scientific reports

authors： Wakeda M,Saida J,Li J,Ogata S

更新日期：2015-05-26 00:00:00

abstract：:When exploited as cell factories, Saccharomyces cerevisiae cells are exposed to harsh environmental stresses impairing titer, yield and productivity of the fermentative processes. The development of robust strains therefore represents a pivotal challenge for the implementation of cost-effective bioprocesses. Altering ...

journal_title：Scientific reports

authors： Martani F,Marano F,Bertacchi S,Porro D,Branduardi P

更新日期：2015-12-14 00:00:00

abstract：:Due to the substantial limitation of study population, Spindle cell sarcoma (SCS) was unexplored comprehensively. In this study, we investigated the clinical characteristics and disease specific prognostic factors of SCS. 3299 SCS cases were identified and extracted from Surveillance, Epidemiology, and End Results (SE...

journal_title：Scientific reports

authors： Feng L,Wang M,Yibulayin F,Zhang H,Yang YL,Ren F,Wushou A

更新日期：2018-03-22 00:00:00